1. The document summarizes the principles and practice of open fracture care, including debridement and lavage of the wound, early stable internal fixation of the bone, and reconstruction of soft tissues to prevent infection.
2. It discusses that open fractures expose the bone to contamination and complicate reconstruction with soft tissue injury as well, requiring specialists. The goal of treatment is to prevent contamination from developing into infection through proper surgical management.
3. Key aspects of surgical management are thorough debridement to remove non-viable tissue, profuse lavage to reduce bacteria, stable fixation to allow soft tissue healing, and reconstructing soft tissues to protect the injury from infection.
Open fractures involve a break in the bone that communicates with the external environment through a break in the skin and soft tissue. They are often caused by high-energy trauma like traffic accidents or falls. The initial management involves thorough debridement to remove all non-viable tissue, irrigation to clean the wound, fracture stabilization, and antibiotic treatment. Further debridement may be needed over subsequent days to fully clean the wound. The goal is to prevent infection while stabilizing the fracture and achieving soft tissue coverage. Outcomes depend on adequate initial management and reconstruction as needed.
This document discusses wound classification, phases of wound healing, methods of wound closure, and complications. It covers:
1) Classification of wounds based on several factors like cleanliness, thickness, and time since injury. The main phases of wound healing are inflammation, proliferation, and remodeling.
2) Methods of wound closure include primary closure, secondary closure, and delayed primary closure. Sutures, staples, and adhesives can be used for closure.
3) Common complications are wound infection, hematoma, seroma, dehiscence, hypertrophic scarring, contracture, and more. Their causes, diagnosis, and treatments are outlined.
This document discusses the principles of operative fracture management for open fractures. It defines open fracture classifications according to the Gustilo system and outlines approaches for emergency assessment, wound excision and debridement, antibiotic therapy, wound management, soft tissue coverage, fracture stabilization, and rehabilitation. The key goals are to prevent infection, promote soft tissue and bone healing without complications, and restore function of the injured extremity.
This lecture covers the basics of suturing i.e wound healing, indications and contraindications of suturing, wound assessment, wound aftercare, suture and needle types, suturing techniques, knot types.
Open fractures occur when a bone fracture communicates with the external environment through a break in the skin. They were classified and early management was discussed, including irrigation, debridement, antibiotics, tetanus prophylaxis, and splinting. Options for fracture stabilization include external fixation, plating, and intramedullary nails. Wound closure considerations involve primary versus delayed closure, skin grafting, and flaps. The goal is thorough debridement and stable fixation to prevent infection while obtaining soft tissue coverage.
An open fracture occurs when a broken bone pierces the skin, exposing the fracture site. Left untreated, open fractures can lead to high rates of infection, wound complications, and failure of the bone to heal properly. Gustilo-Anderson classification grades open fractures based on wound size, soft tissue damage, level of contamination, and fracture pattern, with higher grades indicating more severe injuries associated with worse outcomes. Proper management of open fractures involves emergency wound care, antibiotics, splinting or stabilization of the fracture, and often surgical debridement and irrigation to reduce the risk of infection.
Management of ulcers,physical therapy interventions, characteristics, how to asses different ulcer,examination, prognosis, evidence based medicine, drug therapy and other therapies
Open fractures involve a break in the bone that communicates with the external environment through a break in the skin and soft tissue. They are often caused by high-energy trauma like traffic accidents or falls. The initial management involves thorough debridement to remove all non-viable tissue, irrigation to clean the wound, fracture stabilization, and antibiotic treatment. Further debridement may be needed over subsequent days to fully clean the wound. The goal is to prevent infection while stabilizing the fracture and achieving soft tissue coverage. Outcomes depend on adequate initial management and reconstruction as needed.
This document discusses wound classification, phases of wound healing, methods of wound closure, and complications. It covers:
1) Classification of wounds based on several factors like cleanliness, thickness, and time since injury. The main phases of wound healing are inflammation, proliferation, and remodeling.
2) Methods of wound closure include primary closure, secondary closure, and delayed primary closure. Sutures, staples, and adhesives can be used for closure.
3) Common complications are wound infection, hematoma, seroma, dehiscence, hypertrophic scarring, contracture, and more. Their causes, diagnosis, and treatments are outlined.
This document discusses the principles of operative fracture management for open fractures. It defines open fracture classifications according to the Gustilo system and outlines approaches for emergency assessment, wound excision and debridement, antibiotic therapy, wound management, soft tissue coverage, fracture stabilization, and rehabilitation. The key goals are to prevent infection, promote soft tissue and bone healing without complications, and restore function of the injured extremity.
This lecture covers the basics of suturing i.e wound healing, indications and contraindications of suturing, wound assessment, wound aftercare, suture and needle types, suturing techniques, knot types.
Open fractures occur when a bone fracture communicates with the external environment through a break in the skin. They were classified and early management was discussed, including irrigation, debridement, antibiotics, tetanus prophylaxis, and splinting. Options for fracture stabilization include external fixation, plating, and intramedullary nails. Wound closure considerations involve primary versus delayed closure, skin grafting, and flaps. The goal is thorough debridement and stable fixation to prevent infection while obtaining soft tissue coverage.
An open fracture occurs when a broken bone pierces the skin, exposing the fracture site. Left untreated, open fractures can lead to high rates of infection, wound complications, and failure of the bone to heal properly. Gustilo-Anderson classification grades open fractures based on wound size, soft tissue damage, level of contamination, and fracture pattern, with higher grades indicating more severe injuries associated with worse outcomes. Proper management of open fractures involves emergency wound care, antibiotics, splinting or stabilization of the fracture, and often surgical debridement and irrigation to reduce the risk of infection.
Management of ulcers,physical therapy interventions, characteristics, how to asses different ulcer,examination, prognosis, evidence based medicine, drug therapy and other therapies
This document provides an overview of the management of open fractures. It defines an open fracture as a soft tissue injury complicated by a broken bone with communication to the external environment. The history of open fracture treatment is discussed, from ancient practices like debridement to modern advances with antibiotics and fixation methods. Classification systems for open fractures are presented, including the Gustilo-Anderson classification which correlates the degree of soft tissue injury with infection risk. Key steps in managing open fractures are described, including thorough debridement and irrigation, antibiotic administration, fracture stabilization options like external or internal fixation depending on the injury, and wound management. Overall infection rates and healing times are correlated with the classification of the soft tissue injury.
The document discusses normal wound healing processes and phases including haemostatic, inflammatory, proliferative, and remodelling phases. It also discusses abnormal healing processes and managing different types of acute and chronic wounds. Specific topics covered include normal healing in bone, nerve, tendon tissues and abnormal healing processes. Management strategies for different wound types such as bites, puncture wounds, haematomas, degloving injuries, and compartment syndromes are provided. Chronic wounds including leg ulcers and pressure sores are also summarized.
This document provides an overview of wound management. It begins with objectives of defining wounds, classifying them, explaining wound healing and general management. It then covers wound classification including by origin, bacterial contamination and shape. The stages of wound healing - hemostasis, proliferation and remodeling - are outlined. Wound management techniques like irrigation, debridement, closure methods and dressings are described. Potential complications are also mentioned.
This document discusses abdominal wall incisions and closures. It describes the anatomy of the abdominal wall and various types of incisions including vertical, transverse and oblique incisions. Factors in choosing an incision include access and cosmesis. Common incisions described include midline, paramedian and transverse incisions. Methods of fascial closure include continuous versus interrupted sutures using absorbable suture materials. Temporary abdominal closure techniques in damage control surgery are also outlined, including absorbable meshes, vacuum-assisted closure and the Bogota bag. Postoperative wound management and treatment of complications like dehiscence are also summarized.
Various methods of debridement, by Dr Kalimullah WardakKalimullah Wardak
Debridement is the removal of devitalized tissue from a wound to promote healing. There are several methods of debridement including autolytic, biological using maggots, enzymatic using collagenase, surgical with sharp instruments, and mechanical. The key steps are to remove nonviable tissue through debridement, manage infection and inflammation, maintain a moist wound environment, and assess for reepithelialization. Debridement is essential for wound healing by removing barriers to healing like necrotic tissue but the method used depends on factors like wound severity, infection status, and patient factors.
This document discusses open fractures and mangled extremities. It covers the goals of treatment which are to preserve life, limb and function while preventing infection and restoring stability and soft tissue coverage. Open fractures require urgent assessment and debridement to remove non-viable tissue which can be aided by lavage and the use of tourniquets. Skeletal stabilization is also important. Scores can help determine if limb salvage is possible or if amputation is required based on the extent of soft tissue and bone damage. Proper antibiotic use, wound coverage and further reconstruction are also outlined.
Type 1 open fractures have a small wound less than 1cm with minimal soft tissue damage. Type 2 fractures have a wound over 1cm with moderate soft tissue damage. Type 3 fractures are high energy injuries with severe soft tissue damage and bone comminution. The classification correlates with infection risk, healing time, and need for flap coverage. For open fractures, the goals of treatment are to preserve life and limb through debridement, antibiotics, fracture stabilization, and early wound coverage.
This document discusses wounds and the wound healing process. It defines a wound and describes different types of wounds such as incisions, lacerations, contusions, abrasions, avulsions, puncture wounds, and amputations. It then explains the three main phases of wound healing: inflammatory, proliferative, and remodeling. Factors that promote wound healing and management of patients with wounds are also covered.
The document discusses principles of surgical techniques including patient positioning and safety, skin and abdominal incisions, wound closure, and anastomoses. It covers proper patient transfer and positioning to prevent injury, factors to consider for incision planning like skin tension lines and access needs, techniques for skin and abdominal incisions, desired characteristics and types of suture materials and closure techniques, and examples of specific incisions like midline and Pfannenstiel. Safety is emphasized including use of universal precautions and checklists.
This document discusses different types and classifications of surgical wounds based on degree of contamination and risk of infection. It describes Class I wounds as clean wounds with no infection present, Class II wounds as wounds where hollow viscus are opened but with controlled circumstances and minimal spillage, and Class III wounds as more contaminated wounds involving major breaks in sterile technique or wounds treated after a significant delay. It also discusses treatment options for hypertrophic scars, which include pressure garments, silicone sheets, laser therapy, and re-excision. Finally, it outlines principles for examining and treating open wounds, including tetanus prophylaxis, hemostasis, analgesia, thorough debridement with irrigation, adequate antibiotics and dressings.
The document discusses principles of oral surgery, including developing a surgical diagnosis through accurate data collection, the basic necessities of adequate visibility and assistance during surgery, techniques for incisions, flap design, tissue handling, hemostasis, dead space management, decontamination, edema control, and the importance of a patient's general health and nutrition for proper wound healing. Proper surgical techniques and preoperative optimization of a patient's health can help improve wound healing outcomes.
This document contains a presentation on chronic wound care given by Honelet Debebe. The presentation covers the definition of chronic wounds and their causes, classifications, treatment and management. It also discusses the stages of wound healing, factors that affect healing, complications, principles of wound care including cleansing and dressing. The objectives are to define wound care, classify wounds, describe healing stages and complications, and demonstrate dressing application.
This document discusses the management of open fractures. It begins by defining an open fracture and classifying open fractures using the Gustilo and Tscherne systems. It then outlines the treatment principles of open fractures which include antibiotic prophylaxis, wound debridement, and fracture stabilization. The initial management, primary surgery including further debridement, irrigation, and skeletal stabilization are described. Factors determining limb salvage versus amputation are provided. The document concludes with discussions on external fixation, internal fixation, and wound closure approaches.
The document discusses wound healing principles and treatment. It begins by defining wounds and describing the different types, such as acute and chronic wounds. It then explains the four phases of normal wound healing: inflammation, proliferation, maturation, and remodeling. It discusses factors that can delay or prevent healing, leading to chronic wounds. The document also covers wound bed preparation principles like debridement and infection control. It provides details on various wound dressing types and their indications and contraindications.
This document provides information on wound management. It defines different types of wounds such as incised wounds, abrasions, punctured wounds, and burns. Wounds are classified as clean, contaminated, or infected. The stages of wound healing are hemostasis, proliferation, and remodeling. Factors that can affect healing include ischemia, infection, and patient health issues. Proper wound management includes irrigation, debridement, closure methods like sutures, and dressing. Complications to watch for are infection, scarring, and tissue necrosis.
Features of surgical treatment of wounds of the maxillofacial region Features...KritzSingh
This document outlines key features of surgical treatment for wounds in the maxillofacial region. It discusses developing a surgical diagnosis, maintaining aseptic technique, proper incision making and flap design to prevent complications like necrosis and dehiscence. It also covers tissue handling, hemostasis, dead space management, decontamination, debridement, controlling inflammation, and the importance of a patient's general health for wound healing.
Dr. kushagra case study, supported by TRIAGE MEDITECH NPWT INDIASiddharth Mandal
This study compared the effectiveness of vacuum assisted wound therapy (VAC) to standard wound therapy for treating open musculoskeletal injuries. 30 patients were randomly assigned to receive either VAC or standard saline dressings after surgical debridement. Wound size reductions were measured after 8 days of treatment. VAC resulted in greater wound size reductions of over 5 mm compared to less than 5 mm for standard therapy. VAC facilitated more rapid formation of healthy granulation tissue, potentially shortening healing time and reducing needs for further soft tissue procedures. The study concluded that VAC therapy is effective for open musculoskeletal wounds and produces better outcomes than standard wound care.
This document provides an overview of the management of open fractures. It defines an open fracture as a soft tissue injury complicated by a broken bone with communication to the external environment. The history of open fracture treatment is discussed, from ancient practices like debridement to modern advances with antibiotics and fixation methods. Classification systems for open fractures are presented, including the Gustilo-Anderson classification which correlates the degree of soft tissue injury with infection risk. Key steps in managing open fractures are described, including thorough debridement and irrigation, antibiotic administration, fracture stabilization options like external or internal fixation depending on the injury, and wound management. Overall infection rates and healing times are correlated with the classification of the soft tissue injury.
The document discusses normal wound healing processes and phases including haemostatic, inflammatory, proliferative, and remodelling phases. It also discusses abnormal healing processes and managing different types of acute and chronic wounds. Specific topics covered include normal healing in bone, nerve, tendon tissues and abnormal healing processes. Management strategies for different wound types such as bites, puncture wounds, haematomas, degloving injuries, and compartment syndromes are provided. Chronic wounds including leg ulcers and pressure sores are also summarized.
This document provides an overview of wound management. It begins with objectives of defining wounds, classifying them, explaining wound healing and general management. It then covers wound classification including by origin, bacterial contamination and shape. The stages of wound healing - hemostasis, proliferation and remodeling - are outlined. Wound management techniques like irrigation, debridement, closure methods and dressings are described. Potential complications are also mentioned.
This document discusses abdominal wall incisions and closures. It describes the anatomy of the abdominal wall and various types of incisions including vertical, transverse and oblique incisions. Factors in choosing an incision include access and cosmesis. Common incisions described include midline, paramedian and transverse incisions. Methods of fascial closure include continuous versus interrupted sutures using absorbable suture materials. Temporary abdominal closure techniques in damage control surgery are also outlined, including absorbable meshes, vacuum-assisted closure and the Bogota bag. Postoperative wound management and treatment of complications like dehiscence are also summarized.
Various methods of debridement, by Dr Kalimullah WardakKalimullah Wardak
Debridement is the removal of devitalized tissue from a wound to promote healing. There are several methods of debridement including autolytic, biological using maggots, enzymatic using collagenase, surgical with sharp instruments, and mechanical. The key steps are to remove nonviable tissue through debridement, manage infection and inflammation, maintain a moist wound environment, and assess for reepithelialization. Debridement is essential for wound healing by removing barriers to healing like necrotic tissue but the method used depends on factors like wound severity, infection status, and patient factors.
This document discusses open fractures and mangled extremities. It covers the goals of treatment which are to preserve life, limb and function while preventing infection and restoring stability and soft tissue coverage. Open fractures require urgent assessment and debridement to remove non-viable tissue which can be aided by lavage and the use of tourniquets. Skeletal stabilization is also important. Scores can help determine if limb salvage is possible or if amputation is required based on the extent of soft tissue and bone damage. Proper antibiotic use, wound coverage and further reconstruction are also outlined.
Type 1 open fractures have a small wound less than 1cm with minimal soft tissue damage. Type 2 fractures have a wound over 1cm with moderate soft tissue damage. Type 3 fractures are high energy injuries with severe soft tissue damage and bone comminution. The classification correlates with infection risk, healing time, and need for flap coverage. For open fractures, the goals of treatment are to preserve life and limb through debridement, antibiotics, fracture stabilization, and early wound coverage.
This document discusses wounds and the wound healing process. It defines a wound and describes different types of wounds such as incisions, lacerations, contusions, abrasions, avulsions, puncture wounds, and amputations. It then explains the three main phases of wound healing: inflammatory, proliferative, and remodeling. Factors that promote wound healing and management of patients with wounds are also covered.
The document discusses principles of surgical techniques including patient positioning and safety, skin and abdominal incisions, wound closure, and anastomoses. It covers proper patient transfer and positioning to prevent injury, factors to consider for incision planning like skin tension lines and access needs, techniques for skin and abdominal incisions, desired characteristics and types of suture materials and closure techniques, and examples of specific incisions like midline and Pfannenstiel. Safety is emphasized including use of universal precautions and checklists.
This document discusses different types and classifications of surgical wounds based on degree of contamination and risk of infection. It describes Class I wounds as clean wounds with no infection present, Class II wounds as wounds where hollow viscus are opened but with controlled circumstances and minimal spillage, and Class III wounds as more contaminated wounds involving major breaks in sterile technique or wounds treated after a significant delay. It also discusses treatment options for hypertrophic scars, which include pressure garments, silicone sheets, laser therapy, and re-excision. Finally, it outlines principles for examining and treating open wounds, including tetanus prophylaxis, hemostasis, analgesia, thorough debridement with irrigation, adequate antibiotics and dressings.
The document discusses principles of oral surgery, including developing a surgical diagnosis through accurate data collection, the basic necessities of adequate visibility and assistance during surgery, techniques for incisions, flap design, tissue handling, hemostasis, dead space management, decontamination, edema control, and the importance of a patient's general health and nutrition for proper wound healing. Proper surgical techniques and preoperative optimization of a patient's health can help improve wound healing outcomes.
This document contains a presentation on chronic wound care given by Honelet Debebe. The presentation covers the definition of chronic wounds and their causes, classifications, treatment and management. It also discusses the stages of wound healing, factors that affect healing, complications, principles of wound care including cleansing and dressing. The objectives are to define wound care, classify wounds, describe healing stages and complications, and demonstrate dressing application.
This document discusses the management of open fractures. It begins by defining an open fracture and classifying open fractures using the Gustilo and Tscherne systems. It then outlines the treatment principles of open fractures which include antibiotic prophylaxis, wound debridement, and fracture stabilization. The initial management, primary surgery including further debridement, irrigation, and skeletal stabilization are described. Factors determining limb salvage versus amputation are provided. The document concludes with discussions on external fixation, internal fixation, and wound closure approaches.
The document discusses wound healing principles and treatment. It begins by defining wounds and describing the different types, such as acute and chronic wounds. It then explains the four phases of normal wound healing: inflammation, proliferation, maturation, and remodeling. It discusses factors that can delay or prevent healing, leading to chronic wounds. The document also covers wound bed preparation principles like debridement and infection control. It provides details on various wound dressing types and their indications and contraindications.
This document provides information on wound management. It defines different types of wounds such as incised wounds, abrasions, punctured wounds, and burns. Wounds are classified as clean, contaminated, or infected. The stages of wound healing are hemostasis, proliferation, and remodeling. Factors that can affect healing include ischemia, infection, and patient health issues. Proper wound management includes irrigation, debridement, closure methods like sutures, and dressing. Complications to watch for are infection, scarring, and tissue necrosis.
Features of surgical treatment of wounds of the maxillofacial region Features...KritzSingh
This document outlines key features of surgical treatment for wounds in the maxillofacial region. It discusses developing a surgical diagnosis, maintaining aseptic technique, proper incision making and flap design to prevent complications like necrosis and dehiscence. It also covers tissue handling, hemostasis, dead space management, decontamination, debridement, controlling inflammation, and the importance of a patient's general health for wound healing.
Dr. kushagra case study, supported by TRIAGE MEDITECH NPWT INDIASiddharth Mandal
This study compared the effectiveness of vacuum assisted wound therapy (VAC) to standard wound therapy for treating open musculoskeletal injuries. 30 patients were randomly assigned to receive either VAC or standard saline dressings after surgical debridement. Wound size reductions were measured after 8 days of treatment. VAC resulted in greater wound size reductions of over 5 mm compared to less than 5 mm for standard therapy. VAC facilitated more rapid formation of healthy granulation tissue, potentially shortening healing time and reducing needs for further soft tissue procedures. The study concluded that VAC therapy is effective for open musculoskeletal wounds and produces better outcomes than standard wound care.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
Mercurius is named after the roman god mercurius, the god of trade and science. The planet mercurius is named after the same god. Mercurius is sometimes called hydrargyrum, means ‘watery silver’. Its shine and colour are very similar to silver, but mercury is a fluid at room temperatures. The name quick silver is a translation of hydrargyrum, where the word quick describes its tendency to scatter away in all directions.
The droplets have a tendency to conglomerate to one big mass, but on being shaken they fall apart into countless little droplets again. It is used to ignite explosives, like mercury fulminate, the explosive character is one of its general themes.
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
1. JOURNAL READING
THE PRINCIPLES AND PRACTICE
OF OPEN FRACTURE CARE
AMNA DIWANA, KYLE R. EBERLIN B, RAYMOND MALCOLM SMITH
CHINESE JOURNAL OFTRAUMATOLOGY 2018
Disusun oleh :
Sebastian Ahmad
Hanna Kalita Mahandhani
2. Abstract
• The principles of open fracture management are to manage the overall injury and
specifically prevent primary contamination becoming frank infection.
• The surgical management of these complex injuries includes debridement &
lavage of the open wound with combined bony and soft tissue reconstruction.
• Good results depend on early high quality definitive surgery usually with early
stable internal fixation and associated soft tissue repair.
• Data suggests that the best results are obtained when the whole surgical
reconstruction is completed within 48-72 h.
3. Introduction
• Management of an open injury is much more difficult as the wound exposes the
fracture haematoma to contamination and adds a potentially complex soft tissue
component to the required reconstruction. It is well established that the most
serious open injuries should be dealt with by specialists but these injuries present
to any surgeon providing emergency care so a universal understanding of their
management essential.
4. Important Concepts
• The guiding specific principle in the management of the open fracture is the
prevention of infection. The presence of a wound implies contamination but not
primary infection, it is the key to treatment to prevent this contamination
becoming established infection.
• Factors that make progression to infection more likely include the presence of
shock, local haematoma, dead space, fracture instability, none viable tissue and
major co-morbidities including diabetes, reduced immuno-resistance and
ischaemia.
• The principles of clinical management involve the application of basic surgical
fracture management principles to reduce the chance of infection.These are;
appropriate primary assessment, wound management, gross fracture reduction
and splintage, tetanus cover and early antibiotics followed by early effective
surgical management.
5. Cont..
• The surgical principles of open fracture care involve wound debridement to
remove any dead or doubtful tissue, profuse lavage of the wound to reduce the
size of the inoculum, fracture stabilisation to allow good soft tissue healing and
reconstruction of the soft tissue envelope to protect the zone of injury from
infection
6. Surgical Principles of Open Fracture
Management
1. Debridement and lavage
2. Fracture stabilisation
3. Healthy soft tissue closure
7. Primary Assessment and Management
1. Assessment, tetanus, antibiotics and splintage
“Tetanus and antibiotics should be given urgently”
• It is accepted that the earlier the antibiotics are given the better but it must be
emphasised that this is an adjuvant to surgical treatment and does not provide an
increased window allowing surgical treatment to be delayed.
• Today for minor wounds a cephalosporin is given while for more major wounds,
severe crush injuries, or agricultural injuries a Penicillin, and gram negative
coverage perhaps with Gentamycin and anaerobic cover with Metronidazole can
be added
8. Surgical Management
“Wound debridement and lavage”
• Good tissue assessment and adequate debridement the most critical and most
difficult element of open fracture care.
• The most common error is inadequate debridement. The debridement should be
considered in parallel with the subsequent soft tissue reconstruction and in the
most severe injuries done in conjunction with the surgeon who will perform the
soft tissue reconstruction.
• Primary assessment and debridement should be done as soon as possible after
injury and traditionally within 6 h following a philosophy that the earlier the
bacterial contamination is reduced the less likely it is that infection will supervene.
9. Surgical Management
• All non-viable tissue must be removed. As the injury becomes more severe this
can involve removal of significant areas of skin, subcutaneous tissue and muscle.
• If during primary surgery a very extensive debridement is required and several
compartments are lost it may become clear that reconstruction may be futile and
amputation the best option.
• In destructive injury, primary completion amputation should be performed
immediately or if the nature of the problem has been confirmed at primary
surgery it is reasonable to perform a lifesaving debridement and temporary
stabilisation with a view to discussion with the patient and family prior to early
definitive surgical care as indicated.
10. Surgical Management
• In parallel with debridement, a profuse wound lavage should be performed. The
method and specific fluid that should be used was considered in the “Flow” study.
It is now well established that a large volume of low pressure isotonic fluid should
be used and that high pressure pulsatile lavage or special soaps are not required.
• Complete wound assessment and formal classification cannot be done before
exploration and debridement and in the most complex wounds this initial
procedure is best done as a combined case between the orthopaedic and plastic
surgeons so that the appropriate plan can be made for both hard and soft tissue
reconstruction
11. Fracture Stabilisation
• Early stabilisation of the open fracture is essential, because any motion or major
forces will disrupt local tissues and precent tissue healing.
• Temporary external fixation often used if primary definitive care is not possible,
which is the use of any implant suitable for the fracture such as intra medullary
nail, etc
• External fixation may good for temporary control but it is a poor choice for
definitive soft tissue construction, causing plastic surgical reconstruction difficult.
Where some study find that the outcome of major limb reconstruction with an
external fixator after severe open fracture produce poot result.
12. Wound closure, timing, and techniques
• How and when to close the wound is a subject of intense debate. Clearly, the
wound closure only can be completed after an adequate debridement and after
the bone reconstruction is stable.
• All injured tissues will swell, if closed to tightly additional tissue can be recruited to
the area of necrosis producing wound breakdown and infection. Howevre, leaving
wounds open allows the edges to dry and may recruit additional area of necrotic
tissue into the wound
• Modern wound protection with sealed negative pressure wound dressing leaves a
much tidier wound but alone does not help in preventing infection or extending
the time until definitve coverage is provided
13. WoundAssessment and classification
• Wound are graded after debridement, the comprehensive system available area
Gustillo andAnderson open fracture classification
• O-I = Low energy, minimal soft tissue damage, wound <1cm
• O-II = Higher energy, laceration 1 – 10 cm but no flaps/crushing/gross contamination
• O-IIIA = High energy comminution/segmental/contaminated but adequate soft tissue
cover
• O-IIIB = High energy comminution/segmenta/contaminated but inadequate soft tissue
civer
• O-IIIC = Open fracture complicated by vascular injury requiring repair for limb viability
14. Specific soft tissue injury patterns
• Grade I = wound are low energy, tiny puncture with minimal zone of injury.Where the
debridement required is minimal and after fracture stabilisation, the surgical extension can
be directly closed with little risk of swelling and wound necrosis
• Grade II = wound are low energy but, the wound is a laceration less than 10 cm but healthy
deep tissue, with minimal devitalisation, no gross contamination, no large of zone of injury
and no degloving
• Grade III = the injury are all high energy, it is defined that the soft tissue reconstruction is
needed for closure or the presence of an associated limb threatening vascular injury.The
most at risk is III-C where there is a vascular injury that requires repair of limb viability,
where its required combined orthopaedic & vascular surgical procedure
• Technique available for vascular repair are like intra-vascular shunting to provide
temporary blood supply
15. Cont…
• Grade III-A injuries are high energy but there is still adequate healthy soft tissue
for direct reconstruction after debridement, while in grade III-B some of the tissue
is inadequate
16. Summary
• Major open fracture care is complex and requires early acces to specialis surgical
techniques for early bony and soft tissue reconstruction.The aim of treatment is
to prevent contamination becoming infection which can become disastrous with
extremely severe consequences for the patient. Obtaining an excellent result and
avoiding major complications requires high levels of surgical skill and often
teamwork between orthopaedic and plastic surgery that employs basic surgical
principles of good debridement, provision of bony stability and early healthy soft
tissue reconstruction and closure.With high quality early care excellent results can
be achieved