There are significant gender differences in hepatitis B and C virus infections. Men are more likely than women to become chronic carriers of HBV and to develop hepatocellular carcinoma. Women have slower progression of HCV infection to cirrhosis and lower risk of developing HCC. Viral and host factors likely contribute to these disparities, including sex hormones like testosterone and estradiol. Testosterone enhances HBV replication while estradiol reduces HCV production and promotes immune response. Understanding these gender differences can help improve treatment and prevention strategies.
Higher expression of SATB2 in hepatocellular carcinoma of African Americans d...rakeshsrivastava89
Abstract
In the United States, Hepatocellular Carcinoma (HCC) incidence has tripled over the past two decades. The disease has disproportionately affected minority and disadvantaged
populations. The purpose of this study was to examine the expression of SATB2 gene in HCC cells derived from African Americans (AA) and Caucasian Americans (CA) and assess its oncogenic potential by measuring cell viability, spheroid
formation, epithelial‐mesenchymal transition (EMT), stem cell markers and pluripotency maintaining factors in cancer stem cells (CSCs). We compared the expression of SATB2 in human primary hepatocytes, HCC cells derived from AA and CA, and
HCC CSCs. Hepatocellular carcinoma cells derived from AA expressed the higher level of SATB2 than those from CA. By comparison, normal human hepatocytes did
not express SATB2. Higher expression of SATB2 in HCC cells from AA was associated with greater growth rate, cell viability, colony formation and EMT characteristics than those from CA. Knockout of SATB2 in CSCs by Crispr/Cas9 technique significantly inhibited the expression of SATB2 gene, stem cell markers (CD24, CD44 and CD133), pluripotency maintaining factors (c‐Myc, KLF4, SOX2 and OCT4), and EMT
compared with non‐targeting control group. The expression of SATB2 was negatively correlated with miR34a. SATB2 rescued the miR‐34a‐mediated inhibition of CSC's viability. These data suggest that SATB2 is an oncogenic factor, and its higher expression may explain the disparity in HCC outcomes among AA.
Wei Yu1 | Sanjit K. Roy2 | Yiming Ma1 | Thomas A. LaVeist3 | Sharmila Shankar1,2,4 |
Rakesh K. Srivastava1,2,4
Evolution and Revolution: Current Issues in HIV and HCV Co-infection
Chapter 1 – HIV-Hepatitis C Virus Co-infection: An evolving epidemic
Chapter 2 - Management of HIV infection in HIV/HCV co-infected patients
Chapter 3 - Management of HCV in co-infected patients
Chapter 4 - HCV Therapy: Direct acting antiviral agents in co-infected individuals
Chapter 5 - Drug interactions with directly acting antivirals for HCV: Overview & challenges in HIV/HCV Co-infection
Chapter 6 - Complicated cases
Chapter 7 - Future trials of Hepatitis C therapy in the HIV co-infected
Chapter 8 - HCV infection in marginalized populations
Chapter 9 - HIV/HCV Co-infection: Through the eyes of a co-infected hemophiliac
Dr. Rakesh K. Srivastava
Dr. Rakesh K. Srivastava (Ph.D., FRSM, FRSPH) is the name which has highest value that holds as the professor and scientist. He has the years of the expertise in the field of science and medicine. Dr. Srivastava understands the science in such way that will help the others to know the best.
Higher expression of SATB2 in hepatocellular carcinoma of African Americans d...rakeshsrivastava89
Abstract
In the United States, Hepatocellular Carcinoma (HCC) incidence has tripled over the past two decades. The disease has disproportionately affected minority and disadvantaged
populations. The purpose of this study was to examine the expression of SATB2 gene in HCC cells derived from African Americans (AA) and Caucasian Americans (CA) and assess its oncogenic potential by measuring cell viability, spheroid
formation, epithelial‐mesenchymal transition (EMT), stem cell markers and pluripotency maintaining factors in cancer stem cells (CSCs). We compared the expression of SATB2 in human primary hepatocytes, HCC cells derived from AA and CA, and
HCC CSCs. Hepatocellular carcinoma cells derived from AA expressed the higher level of SATB2 than those from CA. By comparison, normal human hepatocytes did
not express SATB2. Higher expression of SATB2 in HCC cells from AA was associated with greater growth rate, cell viability, colony formation and EMT characteristics than those from CA. Knockout of SATB2 in CSCs by Crispr/Cas9 technique significantly inhibited the expression of SATB2 gene, stem cell markers (CD24, CD44 and CD133), pluripotency maintaining factors (c‐Myc, KLF4, SOX2 and OCT4), and EMT
compared with non‐targeting control group. The expression of SATB2 was negatively correlated with miR34a. SATB2 rescued the miR‐34a‐mediated inhibition of CSC's viability. These data suggest that SATB2 is an oncogenic factor, and its higher expression may explain the disparity in HCC outcomes among AA.
Wei Yu1 | Sanjit K. Roy2 | Yiming Ma1 | Thomas A. LaVeist3 | Sharmila Shankar1,2,4 |
Rakesh K. Srivastava1,2,4
Evolution and Revolution: Current Issues in HIV and HCV Co-infection
Chapter 1 – HIV-Hepatitis C Virus Co-infection: An evolving epidemic
Chapter 2 - Management of HIV infection in HIV/HCV co-infected patients
Chapter 3 - Management of HCV in co-infected patients
Chapter 4 - HCV Therapy: Direct acting antiviral agents in co-infected individuals
Chapter 5 - Drug interactions with directly acting antivirals for HCV: Overview & challenges in HIV/HCV Co-infection
Chapter 6 - Complicated cases
Chapter 7 - Future trials of Hepatitis C therapy in the HIV co-infected
Chapter 8 - HCV infection in marginalized populations
Chapter 9 - HIV/HCV Co-infection: Through the eyes of a co-infected hemophiliac
Dr. Rakesh K. Srivastava
Dr. Rakesh K. Srivastava (Ph.D., FRSM, FRSPH) is the name which has highest value that holds as the professor and scientist. He has the years of the expertise in the field of science and medicine. Dr. Srivastava understands the science in such way that will help the others to know the best.
BCC4: Pierre Janin on 4 Newer Agents for Hepatitis CSMACC Conference
Janin speaks on the dawn of a revolution for treating Hepatitis C. This was recorded at Bedside Critical Care Conference 4. Full postings can be found at www.intensivecarenetwork.com
HIv risks and vulnerabilities among Gay, Bisexuals and Others MSM, Stefan BaralMSMGF
MSMGF held the Civil Society Hearings Side Event,: Unfinished Business – Taking bolder action to address HIV among gay and bisexual men and other men who have sex with men, at the United Nations in New York City in close consultation with the Global Platform to Fast Track the HIV and Human Rights Responses Among Gay, Bisexual Men and Other Men Who Have Sex with Men (The Platform), and supported by UNAIDS, UNDP, OGAC/PEPFAR, and the Global Fund.
Seroprevalence among blood donors is a major public health problem, both in
developed and developing countries, in its magnitude. The aim of this study
was to determine the seroprevalence of hepatitis B in blood donors. This is a
descriptive study carried out in the city of Mbuji-Mayi at the General Hospital
of Dipumba in blood donors (family, volunteer and remunerated) recorded
from 01/to31/December 2016; the data were collected in a transverse fashion.
The following observations were made: During the study period, 1584 blood
donors were registered. After analyzing the data, the seroprevalence of hepatitis
B in blood donors was 2.2%, 77.8% were male (sex ratio M/F 3.5 and voluntary
donors were 50.4%.
Need of Dual Antiviral Treatment in Chronic Hepatitis BJohnJulie1
The primary indication for an esophagectomy is esophageal cancer or Barrett’s esophagus with high-grade dysplasia. Patients undergoing esophagectomy often present with dysphagia, side effects from chemotherapy, decreased appetite, and weight loss. Esophagectomy may be an operation involving the abdomen, neck, and/or chest requiring 5 to 7 days of NPO status to permit healing of the anastomosis between the upper esophagus and new esophageal conduit (usually the stomach).
Need of Dual Antiviral Treatment in Chronic Hepatitis BJohnJulie1
Approximately one third of the world’s population has serological evidence of past or present infection with the hepatitis B virus (HBV). An estimated 350-400 million people are surface HBV antigen (HBsAg) carriers. India has 40 million HBV carriers i.e. 10–15% share of total pool of HBV carriers of the world. In India.
Approximately one third of the world’s population has serological evidence of past or present infection with the hepatitis B virus (HBV). An estimated 350-400 million people are surface HBV antigen (HBsAg) carriers. India has 40 million HBV carriers i.e. 10–15% share of total pool of HBV carriers of the world. In India.
BCC4: Pierre Janin on 4 Newer Agents for Hepatitis CSMACC Conference
Janin speaks on the dawn of a revolution for treating Hepatitis C. This was recorded at Bedside Critical Care Conference 4. Full postings can be found at www.intensivecarenetwork.com
HIv risks and vulnerabilities among Gay, Bisexuals and Others MSM, Stefan BaralMSMGF
MSMGF held the Civil Society Hearings Side Event,: Unfinished Business – Taking bolder action to address HIV among gay and bisexual men and other men who have sex with men, at the United Nations in New York City in close consultation with the Global Platform to Fast Track the HIV and Human Rights Responses Among Gay, Bisexual Men and Other Men Who Have Sex with Men (The Platform), and supported by UNAIDS, UNDP, OGAC/PEPFAR, and the Global Fund.
Seroprevalence among blood donors is a major public health problem, both in
developed and developing countries, in its magnitude. The aim of this study
was to determine the seroprevalence of hepatitis B in blood donors. This is a
descriptive study carried out in the city of Mbuji-Mayi at the General Hospital
of Dipumba in blood donors (family, volunteer and remunerated) recorded
from 01/to31/December 2016; the data were collected in a transverse fashion.
The following observations were made: During the study period, 1584 blood
donors were registered. After analyzing the data, the seroprevalence of hepatitis
B in blood donors was 2.2%, 77.8% were male (sex ratio M/F 3.5 and voluntary
donors were 50.4%.
Need of Dual Antiviral Treatment in Chronic Hepatitis BJohnJulie1
The primary indication for an esophagectomy is esophageal cancer or Barrett’s esophagus with high-grade dysplasia. Patients undergoing esophagectomy often present with dysphagia, side effects from chemotherapy, decreased appetite, and weight loss. Esophagectomy may be an operation involving the abdomen, neck, and/or chest requiring 5 to 7 days of NPO status to permit healing of the anastomosis between the upper esophagus and new esophageal conduit (usually the stomach).
Need of Dual Antiviral Treatment in Chronic Hepatitis BJohnJulie1
Approximately one third of the world’s population has serological evidence of past or present infection with the hepatitis B virus (HBV). An estimated 350-400 million people are surface HBV antigen (HBsAg) carriers. India has 40 million HBV carriers i.e. 10–15% share of total pool of HBV carriers of the world. In India.
Approximately one third of the world’s population has serological evidence of past or present infection with the hepatitis B virus (HBV). An estimated 350-400 million people are surface HBV antigen (HBsAg) carriers. India has 40 million HBV carriers i.e. 10–15% share of total pool of HBV carriers of the world. In India.
Genetic polymorphisms of HLA-DP and isolated anti-HBc are important subsets o...UniversitasGadjahMada
Occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the serum and/or liver in HBsAg-negative individuals. OBI is associated with the risk of viral transmission, especially in developing countries, and with progressive liver disease and reactivation in immunosuppressive patients. The objective of this study was to evaluate the relation of OBI to HLA-DP single nucleotide polymorphisms (SNPs) encoding antigen-binding sites for the immune response to HBV infection. As HLA-DP variants affect the mRNA expression of HLA-DPA1 and HLA-DPB1 in the liver, we hypothesised that high levels of HLA-DPA1 and HLA-DPB1 expression favour OBI development. This study enrolled 456 Indonesian healthy blood donors (HBsAg negative). OBI was defined as the presence of HBV-DNA in at least two of four open reading frames (ORFs) of the HBV genome detected by nested PCR. SNPs in HLA-DPA1 (rs3077) and HLA-DPB1 (rs3135021, rs9277535, and rs2281388) were genotyped using real-time Taqman® genotyping assays. Of 122 samples positive for anti-HBs and/or anti-HBc, 17 were determined as OBI. The minor allele in rs3077 was significantly correlated with OBI [odds ratio (OR) = 3.87, 95% confidence interval (CI) = 1.58–9.49, p = 0.0015]. The
prevalence of the minor allele (T) was significantly higher in subjects with OBI than in those without (59% and 33%, respectively). The combination of haplotype markers (TGA for rs3077–rs3135021–rs9277535) was associated with increased risk of OBI (OR = 4.90, 95%CI = 1.12–21.52 p = 0.038). The prevalence of OBI was highest in the isolated anti-HBc group among the three seropositive categories: anti-HBs <500 mIU/ml, anti-HBs ≥500 mIU/ml, and isolated anti-HBc (29.41%, p = 0.014).In conclusion, genetic variants of HLA-DP and the presence of anti-HBc are important predictors of OBI in Indonesian blood donors.
ABSTRACT- Introduction: Blood group antigens have been reported to be associated with many diseased conditions
severally. Studies have suggested that ABO blood groups have an impact on infection status of the individuals
possessing a particular blood group due to the significant associations observed when analyzed. However there is
limited information on the relationship between these blood group antigens with haemoglobin genotype and CD4 cell
count in Human Immunodeficiency Virus (HIV) infection, hence the need for this study.
Materials and Method: Exactly 240 newly enrolled seropositive patients attending the HIV Clinic of LAUTECH
Teaching Hospital, Osogbo, Nigeria and 120 healthy blood donors were recruited for this study. Antibodies to HIV
were determined using determine rapid HIV 1/HIV 2 test kit (Abbott), enzyme linked immunosorbent assay (ELISA)
(GenScreen plus HIV Ag-Ab test kit, Paris) and Western blot (New-LAV Blot 1, BioRad, France) for confirmatory test.
ABO and Rhesus blood grouping was determined by standard tile and tube techniques. Haemoglobin genotype
determined by alkaline cellulose acetate haemoglobin electrophoresis while CD4 cell count was estimated with Partec
Cyflow analyser.
Result: There is no significant association between the ABO/Rh antigens and haemoglobin genotypes of the test and
control groups (P<0.05). All participants in the control group had CD4 count >200cells/mm3 while 198 (55%) HIV
infected subjects had CD4 count ≥200cells/mm3 and 42 (11.7%) had CD4 count <200cells/mm3. A significant
association was observed between the CD4 cell count of the patients and their ABO blood group antigens (P<0.05) with
blood group A and AB having the highest CD4count.
Conclusion: The outcome of this study reiterates the fact that blood group antigens are involved in immune protection
against infectious disease. Blood group A which has been implicated to confer susceptibility in some diseased condition
has been observed to confer immunity in this study.
Key-words- CD4 cells, Blood Group Antigens, HIV and Haemoglobin Genotype
Epidemiological Profile and Clinical Spectrum of Hepatitis B-Ten Years Experi...JohnJulie1
Hepatitis B virus (HBV) infection, a pan global health problem, has already effected one-third of the world popula- tion. India harbours around 40 million HBV carriers, thus account- ing for 10–15% share of total pool of HBV carriers of the world. Every year over 100,000 Indians die due to illnesses related to HBV infection
ARV Therapy and the Role of Early Intervention presented by Dr. Rachel Baden, Harvard Medical Faculty Physician at the Fenway Health Center community education conference: An End To AIDS - How A State Bill Can Change Everything hosted by SearchForACure.org, the Fenway Health Center, and the MA Dept. of Public Health
Background & Objective: Worldwide, nearly 350 and125 million persons have chronic hepatitis B &C virus (HBV& HCV) infections, respectively. This study aimed to bridge the gap between knowledge of HBV & HCV infections and theirs prevalence among pregnant women, through assessing the impact of an educational intervention on knowledge of pregnant women toward HBV & HCV infections.
Methods: The study was a quasi-experimental one, 100 pregnant women were enrolled in the study they were in third trimester. Structured interviewing sheet, laboratory investigations, educational interventions and pre & posttest formats were utilized for the study.
e632 www.thelancet.comhiv Vol 6 September 2019ViewpoiAlyciaGold776
e632 www.thelancet.com/hiv Vol 6 September 2019
Viewpoint
The disconnect between individual-level and population-level
HIV prevention benefits of antiretroviral treatment
Stefan Baral, Amrita Rao, Patrick Sullivan, Nancy Phaswana-Mafuya, Daouda Diouf, Greg Millett, Helgar Musyoki, Elvin Geng, Sharmistha Mishra
In 2019, the HIV pandemic is growing and soon over 40 million people will be living with HIV. Effective population-
based approaches to decrease HIV incidence are as relevant as ever given modest reductions observed over the past
decade. Treatment as prevention is often heralded as the path to improve HIV outcomes and to reduce HIV
incidence. Although treatment of an individual does eliminate onward transmission to serodifferent partners
(unde tectable=untransmittable or U=U), population-level observational and experimental data have not shown a similar
effect with scale-up of treatment on reducing HIV incidence. This disconnect might be the result of little attention given
to heterogeneities of HIV acquisition and transmission risks that exist in people at risk for and living with HIV, even in
the most broadly generalised epidemics. Available data suggest that HIV treatment is treatment, HIV prevention is
prevention, and specificity of HIV treatment approaches towards people at highest risk of onward transmission drives
the intersection between the two. All people living with HIV deserve HIV treatment, but both more accurately estimating
and optimising the potential HIV prevention effects of universal treatment approaches necessitates understanding who
is being supported with treatment rather than a focus on treatment targets such as 90-90-90 or 95-95-95.
Introduction
In 2019, we are at a pivotal time in the global HIV response
in that many people believe that the HIV pandemic is
over given the advances in HIV treatment.1 Yet the HIV
pandemic continues to grow as defined by numbers of
people living with HIV. Specifically, given the encouraging
decreases in overall mortality among people living with
HIV, in the context of universal treat ment as prevention,
approximately 930 000 more people annually (1·7 million
new infections minus 770 000 deaths of people living with
HIV) require anti retroviral therapy (ART) and many more
would need to change ART regimens. At the current rate
of new infections, over 40 million people will be living
with HIV by 2025.2 The global optimism about the HIV
pandemic has not been matched by decreases in new
HIV infections. New infections have declined by less than
2% per year since 2005, which means that between
1·8 and 2·5 million people acquired HIV in 2017.2,3 To
date, just over 60% of the 37·9 million people living with
HIV are on ART; of those 37·9 million, just over half
(20·1 million) are estimated to have achieved viral sup
pression.2 Taken together, these data suggest that an
estimated 18 million people living with HIV require ART
or improved ART regimens giv ...
A Mathematical Model of the Dynamics of Hepatitis B Virus (HBV) Infection wit...ijtsrd
In this model we study the dynamics and control of hepatitis B virus (HBV) infection which is a major health problem worldwide by considering condom, vaccination and treatment as control measures. Initially we determined the basic reproduction number R_0 for the model and observe that once R_0 http://www.ijtsrd.com/mathemetics/other/18164/a-mathematical-model-of-the-dynamics-of-hepatitis-b-virus-hbv-infection-with-controls/titus-ifeanyi-chinebu
The Prevalence of Hcv Infection among Renal Failure Patients Before Starting ...CrimsonpublishersMedical
HCV infection is common and associated with significant morbidity and mortality among heamodialysis (HD) patients [1]. Heamodialysis is a trusted intermediate procedure for management of chronic kidney disease (CKD) patients. As such CKD is an immunedeficient state, hence blood borne viral infection particularly HCV pose great risk to patients treated by heamodialysis [2]. A high prevalence of HCV infection in heamodialysis patients has been reported in heamodialysis units since the introduction of heamodialysis therapy. Risk factors such as the number of blood transfusions or duration on heamodialysis. The prevalence of HCV infection in patients undergoing dialysis is greater than that in the general population, suggesting that patients on dialysis may be at higher risk of acquiring HCV infection.
Austin Journal of Robotics & Automation is an international scholarly, peer review, Open Access journal, initiated with an aim to promote the research in Robotics & Automation, which deals with design, construction, operation, and application of robots.
Austin Journal of Robotics & Automation is a comprehensive Open Access peer reviewed scientific journal that covers multidisciplinary fields. We provide limitless access towards accessing our literature hub with colossal range of articles. The journal aims to publish high quality varied article types such as Research, Review, Short Communications, Case Reports, Perspectives (Editorials).
Austin Journal of Robotics & Automation supports the scientific modernization and enrichment in Robotics & Automation research community by magnifying access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, collaborative and promotion of multidisciplinary technology.
Austin Journal of Multiple Sclerosis & Neuroimmunology is an open access, peer review Journal publishing original research & review articles on aetiology, epidemiology, and pathogenesis of inflammatory demyelinating diseases of the central nervous system. Austin Journal of Multiple Sclerosis & Neuroimmunology is aimed to provide a strong platform for challenging cases that includes but not excludes the damage of insulating covers of both central nervous system and spine. It is a grounding platform for all neurologists, neuroimmunologists, neurovirologists, researchers, medical doctors, health professionals, scientists, and scholars to publish their research work & update the latest research information.
Topics include but not limited to Clinical Neurology, Biomarkers, Glial, Myelin Chemistry, Neuroimaging, Neuropathology, Neuroepidemiology, Therapeutics, Genetics/Transcriptomics, Experimental Models, Pathobiology, Neuroimmunology, Neuropsychology, Neurorehabilitation, Pathobiology of the Brain, Psychology, Measurement Scales, Teaching, and Neuroethics.
Austin Journal of Multiple Sclerosis & Neuroimmunology supports the scientific transformation and fortification in Medical and Clinical research community by magnifying access to peer reviewed scientific literary works. Austin also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, collaborative and promotion of multidisciplinary science.
Austin Leukemia is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Leukemia.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Leukemia. Austin Leukemia accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Leukemia.
Austin Leukemia strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Autism & Related Disabilities is a developmental disorder that affects the brain's normal development of social and communication skills. It is also known as a complex developmental disability. Austin Journal of Autism & Related Disabilities is an open access, peer reviewed scholarly journal committed to publication of unique contributions concerned with Autism & Related Disabilities.
Austin Journal of Autism & Related Disabilities accepts original research articles, review articles, case reports, clinical images and rapid communication on all the aspects of Autism & Related Disabilities.
Austin Journal of Asthma: Open Access is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Asthma.
The journal aims to promote latest information and provide a forum for doctors, researchers, physicians, and healthcare professionals to find most recent advances in the areas of Asthma. Austin Journal of Asthma: Open Access accepts research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Asthma.
Austin Journal of Asthma: Open Access strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing.
Austin Journal of Anesthesia and Analgesia is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of anesthesiology and pain management.
The aim of the journal is to provide a forum for anesthesiologists, researchers, physicians, and other health professionals to find most recent advances in the areas of anesthesiology. Austin Journal of Anesthesia and Analgesia accepts original research articles, review articles, case reports and rapid communication on all the aspects of anesthesiology and pain management.
Austin Journal of Anesthesia and Analgesia strongly supports the scientific upgradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Journal of Accounting, Audit and Finance Management is a peer reviewed open access journal in publishes manuscripts from all the areas of accounting, accountancy, finance, auditing.
Austin Journal of Accounting, Audit and Finance Management Original Articles, Review, Discussion, Editorials, Letter, type of manuscripts from all the areas of the accounting, accountancy, finance, auditing.
Austin Virology and Retrovirology is an international scholarly peer reviewed Open Access journal, aims to promote the research in the field of Virology.
Austin Virology and Retrovirology is a comprehensive Open Access peer reviewed scientific Journal that covers multidisciplinary fields. We provide limitless access towards accessing our literature hub with colossal range of articles. The journal aims to publish high quality varied article types such as Research, Review, Case Reports, Short Communications, Perspectives (Editorials), Clinical Images
Austin Virology and Retrovirology supports the scientific modernization and enrichment in virology research community by magnifying access to peer reviewed scientific literary works. Austin also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, collaborative and promotion of multidisciplinary science.
Austin Journal of Urology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of Urology.
The aim of the journal is to provide a forum for urologists, nephrologists, research scholars, physicians, and other healthcare professionals to find most recent advances in the field of Urology.
Austin Journal of Urology accepts original research articles, review articles, case reports and short communication on all the aspects of Urology and relevant basic science issues.
Annals of Thyroid Research is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts in all related aspects of thyroid hormones and thyroid diseases and their interaction with the cardiovascular system, pulmonary system, gastroenteron system, metabolic and nervous systems. The journal also focuses upon all the thyroid disease symptoms and treatments, including hyperthyroid and hypothyroid, plus a range of other thyroid problems including thyroid cancer.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and medicine with intent to bridge the gap between academia and research access.
Annals of Thyroid Research accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all related aspects of all related aspects of thyroid hormones and thyroid diseases.
Austin Journal of Robotics & Automation is an international scholarly, peer review, Open Access journal, initiated with an aim to promote the research in Robotics & Automation, which deals with design, construction, operation, and application of robots.
Austin Journal of Robotics & Automation is a comprehensive Open Access peer reviewed scientific journal that covers multidisciplinary fields. We provide limitless access towards accessing our literature hub with colossal range of articles. The journal aims to publish high quality varied article types such as Research, Review, Short Communications, Case Reports, Perspectives (Editorials).
Austin Journal of Robotics & Automation supports the scientific modernization and enrichment in Robotics & Automation research community by magnifying access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, collaborative and promotion of multidisciplinary technology.
Austin Journal of Orthopedics & Rheumatology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of Orthopedics.
The aim of the journal is to provide a forum for orthopedicians, researchers, physicians, and other health professionals to find most recent advances in the areas of Orthopedics.
Austin Journal of Orthopedics & Rheumatology accepts original research articles, review articles, case reports and rapid communication on all the aspects of Orthopedics and its related areas.
Austin Pediatrics is an open access, peer reviewed, scholarly journal committed to publish articles in all areas of science and practice of Pediatrics.
The aspire of the journal is to present a platform for scientists and academicians all over the world to encourage, distribute, and discuss various new issues and developments in different areas of Pediatrics and to promote responsible and balanced debate on controversial issues that influence child health, including non-clinical areas such as ethics, law, surroundings and economics.
Austin Pediatrics accepts innovative research articles, review articles, case reports and rapid communication on all the aspects of Pediatrics.
Austin Pediatrics is an open access, peer reviewed, scholarly journal committed to publish articles in all areas of science and practice of Pediatrics.
Austin Otolaryngology is an open access, peer review journal publishing original research & review articles in all the fields of Otolaryngology. Otolaryngology deals with the study of ear, nose and throat. Austin Otolaryngology provides a new platform for students to publish their research work & update the latest research information in Otolaryngology.
Austin Otolaryngology is a comprehensive Open Access peer reviewed scientific Journal that covers multidisciplinary fields. We provide limitless access towards accessing our literature hub with colossal range of articles. The journal aims to publish high quality varied article types such as Research, Review, Short Communications, Case Reports, Perspectives (Editorials), Clinical Images.
Austin Otolaryngology supports the scientific modernization and enrichment in Otolaryngology research community by magnifying access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, collaborative and promotion of multidisciplinary science.
Clinics in Oncology Research is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of oncology.
The journal aims to promote latest information and provide a forum for oncologists, doctors, researchers, physicians, and healthcare professionals to find most recent advances in the areas of oncology. Clinics in Oncology Research accepts research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of oncology.
Clinics in Oncology Research strongly support the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing.
Austin Journal of Obesity & Metabolic Syndrome is an international scholarly peer reviewed Open Access journal, aims to promote the research in all the related fields of Metabolic Syndrome.
Austin Journal of Obesity & Metabolic Syndrome is a comprehensive Open Access peer reviewed scientific Journal that covers multidisciplinary fields. We provide limitless access towards accessing our literature hub with colossal range of articles. The journal aims to publish high quality varied article types such as Research, Review, Short Communications, Case Reports, Perspectives (Editorials), Clinical Images.
Austin Journal of Obesity & Metabolic Syndrome supports the scientific modernization and enrichment in Metabolic Syndromes research community by magnifying access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, collaborative and promotion of multidisciplinary science.
Austin Journal of Nutrition and Food sciences is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of nutrition and food sciences
The aim of the journal is to provide a forum for dietitians, researchers, physicians, and other health professionals to find most recent advances in the areas of clinical nutrition and nutritional disorders.
Austin Journal of Nutrition and Food sciences accepts original research articles, review articles, case reports and rapid communication on all the aspects of internal medicine.
Austin Journal of Clinical Neurology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of neurology, neurophysiology and stroke.
The aim of the journal is to provide a forum for neurologists, researchers, physicians, and other health professionals to find most recent advances in the areas of clinical and experimental neurology. Austin Journal of Clinical Neurology accepts original research articles, review articles, case reports, clinical images and rapid communication on all the aspects of clinical neurology and nervous system diseases.
Austin Journal of Clinical Neurology strongly supports the scientific upgradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Journal of Clinical Neurology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of neurology, neurophysiology and stroke.
Austin Journal of Musculoskeletal Disorders is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts in all related aspects of diseases and disorders that may adversely affect the function and overall effectiveness of the musculoskeletal system. The Journal focuses upon all the related aspects of musculoskeletal system disorders and the new advancements in the related treatments including Complex issues and injuries involving the musculoskeletal system and surgeries.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and technology with intent to bridge the gap between academia and research access.
Austin Journal of Musculoskeletal Disorders accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all related aspects of diseases and disorders that may adversely affect the function and overall effectiveness of the musculoskeletal system.
Austin Hypertension is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Hypertension.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Hypertension. Austin Hypertension accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of hypertension.
Austin Hypertension strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
The Importance of Community Nursing Care.pdfAD Healthcare
NDIS and Community 24/7 Nursing Care is a specific type of support that may be provided under the NDIS for individuals with complex medical needs who require ongoing nursing care in a community setting, such as their home or a supported accommodation facility.
LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to CareVITASAuthor
This webinar helps clinicians understand the unique healthcare needs of the LGBTQ+ community, primarily in relation to end-of-life care. Topics include social and cultural background and challenges, healthcare disparities, advanced care planning, and strategies for reaching the community and improving quality of care.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
International Cancer Survivors Day is celebrated during June, placing the spotlight not only on cancer survivors, but also their caregivers.
CANSA has compiled a list of tips and guidelines of support:
https://cansa.org.za/who-cares-for-cancer-patients-caregivers/
The global radiation oncology market size reached US$ 8.1 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 14.5 Billion by 2032, exhibiting a growth rate (CAGR) of 6.5% during 2024-2032.
More Info:- https://www.imarcgroup.com/radiation-oncology-market
COVID-19 PCR tests remain a critical component of safe and responsible travel in 2024. They ensure compliance with international travel regulations, help detect and control the spread of new variants, protect vulnerable populations, and provide peace of mind. As we continue to navigate the complexities of global travel during the pandemic, PCR testing stands as a key measure to keep everyone safe and healthy. Whether you are planning a business trip, a family vacation, or an international adventure, incorporating PCR testing into your travel plans is a prudent and necessary step. Visit us at https://www.globaltravelclinics.com/
This document is designed as an introductory to medical students,nursing students,midwives or other healthcare trainees to improve their understanding about how health system in Sri Lanka cares children health.
Trauma Outpatient Center is a comprehensive facility dedicated to addressing mental health challenges and providing medication-assisted treatment. We offer a diverse range of services aimed at assisting individuals in overcoming addiction, mental health disorders, and related obstacles. Our team consists of seasoned professionals who are both experienced and compassionate, committed to delivering the highest standard of care to our clients. By utilizing evidence-based treatment methods, we strive to help our clients achieve their goals and lead healthier, more fulfilling lives.
Our mission is to provide a safe and supportive environment where our clients can receive the highest quality of care. We are dedicated to assisting our clients in reaching their objectives and improving their overall well-being. We prioritize our clients' needs and individualize treatment plans to ensure they receive tailored care. Our approach is rooted in evidence-based practices proven effective in treating addiction and mental health disorders.
Health Education on prevention of hypertensionRadhika kulvi
Hypertension is a chronic condition of concern due to its role in the causation of coronary heart diseases. Hypertension is a worldwide epidemic and important risk factor for coronary artery disease, stroke and renal diseases. Blood pressure is the force exerted by the blood against the walls of the blood vessels and is sufficient to maintain tissue perfusion during activity and rest. Hypertension is sustained elevation of BP. In adults, HTN exists when systolic blood pressure is equal to or greater than 140mmHg or diastolic BP is equal to or greater than 90mmHg. The
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
Letter to MREC - application to conduct studyAzreen Aj
Application to conduct study on research title 'Awareness and knowledge of oral cancer and precancer among dental outpatient in Klinik Pergigian Merlimau, Melaka'
2. J Hepat Res 2(3): id1028 (2015) - Page - 02
Anna Ruggieri Austin Publishing Group
Submit your Manuscript | www.austinpublishinggroup.com
In fact, in post-menopausal women fibrosis, liver inflammation and
pro-inflammatory cytokine concentrations are more elevated than in
women in reproductive age.
Sex is variably associated also with higher and lower Sustained
Virological Response (SVR) to anti- HCV therapy based on
pegylated interferon and ribavirin [24] and to the efficacy of standard
therapy. In fact, pre-menopausal women have shown a higher rate
of SVR to the standard therapy compared to men and experience
more adverse reactions to therapy [25]. According to the above, in
postmenopausal women therapy is less effective [26]. Investigations
on the mechanisms responsible for the disparity in response to
HCV treatment highlighted the possibility that interferon signaling
pathway could be more active in pre-menopausal patients than in
post-menopausal patients as well as in males. Furthermore, MxA
expression (a marker for JAK/STAT pathway activation) was found
up-regulated in pre-menopausal women compared to males and
post-menopausal women This is probably related to the reported
different production of interferon upon toll-like receptor 7 agonists,
greater in pre-menopausal women [27].
Although sex differences in hepatitis B and C virus infection are
becoming evident, investigation of the host and viral mechanisms
involved are often neglected and only partially clarified. From the
revised literature it appears that HBV and HCV infection have worse
outcome and faster progression in men than in women. Women also
display a better response to therapy and to anti- HBV vaccination. In
addition, sex hormones not only directly affect viral replication but,
also, exert potent immunomodulating effects. Estrogens potentiate
immune response, both humoral and innate, whereas androgens
are mainly immunosuppressive [28,29]. Improving our knowledge
on gender differences as concern hepatitis virus pathogenesis and
progression will improve treatments and vaccination schedules,
leading to point out more adequate doses and quality of vaccines and
drugs, also in post-menopausal women. This will probably represent
a pre-requisite for a mandatory objective of the modern medicine: the
appropriateness and the personalization of the cures.
References
1. Baggio G, Corsini A, Floreani A, Giannini S, Zagonel V. Gender medicine: a
task for the third millennium. Clin Chem Lab Med. 2013; 51: 713-727.
2. Rosen SE, Henry S, Bond R, Pearte C, Mieres JH. Sex-Specific Disparities
in Risk Factors for Coronary Heart Disease. Curr Atheroscler Rep. 2015; 17:
523.
3. Zhang Y1. Understanding the gender disparity in bladder cancer risk: the
impact of sex hormones and liver on bladder susceptibility to carcinogens. J
Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2013; 31: 287-304.
4. Zhao L, Woody SK, Chhibber A. Estrogen receptor ß in Alzheimer’s disease:
from mechanisms to therapeutics. Ageing Res Rev. 2015; S1568-1637:
30014-3.
5. Klein SL. Sex influences immune responses to viruses, and efficacy of
prophylaxis and treatments for viral diseases. Bioessays. 2012; 34: 1050-
1059.
6. Bartosch B. Hepatitis B and C viruses and hepatocellular carcinoma. Viruses.
2010; 2: 1504-1509.
7. Rapti I, Hadziyannis S. Risk for hepatocellular carcinoma in the course of
chronic hepatitis B virus infection and the protective effect of therapy with
nucleos(t)ide analogues. World J Hepatol. 2015; 7: 1064-1073.
8. WHO. Hepatitis C: Surveillance and Control. Global Alert and Response.
9. Shepard CW, Simard EP, Finelli L, Fiore AE, Bell BP. Hepatitis B virus
infection: epidemiology and vaccination. Epidemiol Rev. 2006; 28: 112-125.
10. Sharma NaK, Sherker AH. Epidemiology, Risk Factors, and Natural History of
Chronic Hepatitis. Shetty CK, Wu GY, editors. In: Clinical Gastroenterology:
Chronic Viral Hepatitis C. Humana Press, a part of Springer Science Business
Media, LLC 2009.
11. Blumberg BS, Sutnick AI, London WT, Melartin L. Sex distribution of Australia
antigen. Arch Intern Med. 1972; 130: 227-231.
12. Tsay PK, Tai DI, Chen YM, Yu CP, Wan SY, Shen YJ, et al. Impact of gender,
viral transmission and aging in the prevalence of hepatitis B surface antigen.
Chang Gung Med J. 2009; 32: 155-164.
13. Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, et al. Risk of Hepatocellular
Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA
Level. JAMA. 2006; 295: 65-73.
14. White DL, FiroziA, El-Serag HB. Epidemiology of hepatocellular carcinoma.
In: Hepatocellular carcinoma Diagnosis and treatment. 2nd
edn. Brian I. Carr
editor, Humana Press. 2010.
15. Wang SH, Chen PJ, Yeh SH. Gender disparity in chronic hepatitis B:
Mechanisms of sex hormones. J Gastroenterol Hepatol. 2015; 30: 1237-
1245.
16. Xu BY, Tan WT, Tan S, Dan YJ, Luo XL, Deng GH. Serum testosterone
levels and androgen receptor CAG polymorphism correlate with hepatitis B
virus (HBV)-related acute liver failure in male HBV carriers. PLoS One. 2013;
8: e84213.
17. Wang SH, Yeh SH, Lin WH, Wang HY, Chen DS, Chen PJ. Identification
of androgen response elements in the enhancer I of hepatitis B virus: a
mechanism for sex disparity in chronic hepatitis B. Hepatology. 2009; 50:
1392-1402.
18. Yang WJ, Chang CJ, Yeh SH, Lin WH, Wang SH, Tsai TF, et al. Hepatitis B
virus X protein enhances the transcriptional activity of the androgen receptor
through c-Src and glycogen synthase kinase-3beta kinase pathways.
Hepatology. 2009; 49: 1515-1524.
19. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al.
Gender disparity in Liver Cancer due to sex differences in MyD88-Dependent
IL-6 Production. Science. 2007; 317: 121-124.
20. Lee SA, Kim H, Won YS, Seok SH, NaYR, Shin HB, et al. Male-specific
hepatitis B virus large surface protein variant W4P potentiates tumorigenicity
and induces gender disparity. Molecular Cancer. 2015; 14: 23.
21. Ruggieri A, Barbati C, Malorni W. Cellular and molecular mechanisms
involved in hepatocellular carcinoma gender disparity. Int J Cancer. 2010;
127: 499-504.
22. Bakr I, Rekacewicz C, El Hosseiny M, Ismail S, El Daly M, El-Kafrawy S, et
al. Higher clearance of hepatitis C virus infection in females compared with
males. Gut. 2006; 55: 1183-1187.
23. Hayashida K, Shoji I, Deng L, Jiang DP, Ide YH, Hotta H. 17β-estradiol
inhibits the production of infectious particles of hepatitis C virus. Microbiol
Immunol. 2010; 54: 684-690.
24. Narciso-Schiavon JL, Schiavon Lde L, Carvalho-Filho RJ, Sampaio JP, Batah
PN, Barbosa DV, et al. Gender influence on treatment of chronic hepatitis C
genotype 1. Rev Soc Bras Med Trop. 2010; 43: 217-223.
25. Bhattacharya D, Umbleja T, Carrat F, Chung RT, Peters MG, Torriani F,
et al. Women experience higher rates of adverse events during hepatitis C
virus therapy in HIV infection: a meta-analysis. J Acquir Immune Defic Syndr.
2010; 55: 170-175.
26. Villa E, Karampatou A, Cammà C, Di Leo A, Luongo M, Ferrari A, et al. Early
menopause is associated with lack of response to antiviral therapy in women
with chronic hepatitis C. Gastroenterology. 2011; 140: 818-829.
27. Mekky RY, Hamdi N, El-Akel W, Esmat G, Abdelaziz AI. Estrogen-related
MxA transcriptional variation in hepatitis C virus-infected patients. Transl Res.
2012; 159: 190-196.