This document discusses fail-safe designs, fall-back systems, and intrinsically safe designs for process safety. It provides 5 case studies of process safety failures and their root causes. These include a reformer reactor failure due to a shut-off logic design error, a steam turbine rotor failure from corrosion and lack of steam sampling, an FCC air blower trip caused by a level instrument failure, a furnace transfer line failure from introducing steam with water, and an air cooler leak from lack of protection during freezing. The document emphasizes the importance of accurate data, clarity on design basis, robust designs, expertise, standards, and over-estimating risk to build intrinsically safe designs with inherent protections against failures.