Dementia & Delirium
Jo James
Lead Nurse Dementia
Imperial College Healthcare NHS Trust
Objectives
• Define the differences between dementia
& delirium
• Top tips to identify delirium
• Explore Assessment and Management
How does dementia differ from
delirium?
• Dementia is a long term condition with slow
onset and decline
• Delirium is an acute, short term response to a
physical insult – comes on suddenly and can
resolve in days to months.
• Delirium is always acute onset and is
characterised by level of arousal
(awakeness)
Differentiating the three Ds
Depression Delirium Dementia
Onset Generally
insidious,
Precipitant?
Coincides with
life changes,
often abrupt
Acute Chronic
Course Typically worse
in the morning;
situational
fluctuations but
less than
delirium
Short, often
worse at night,
in the dark and
on waking
Long.
Symptoms
progressive but
stable over time
Duration At least two
weeks, can be
months to years
Hours to less
than one month,
rarely (but
sometimes)
longer
Months to years
Differentiating the three Ds (2)
Depression Delirium Dementia
Awareness Clear Reduced Clear
Arousal
/Alertness
Normal Fluctuates;
lethargic or
hyper-vigilant
Generally normal
Attention Minimal
impairment but
distractible
Impaired,
fluctuates
Generally normal
Thinking/
Perception
Intact; delusions
and
hallucinations
absent except in
severe cases
Disorganised,
fragmented
Distorted,
delusions
hallucinations,
difficulty
distinguishing
reality and
misperceptions.
Difficulty with
abstraction, poor
judgement,
difficulty finding
words
Misperceptions
often absent
Prevalence
(66% of cases go unrecognised in hospital)
• Prevalent (on admission) 14-24%
• Incident (in hospital) 6-56%
• Postoperative: 15-53%
• Intensive care unit: 70-87%
• Nursing home/post-acute care: 20-60%
• Palliative care (up to) 80%
( Inouye SK, NEJM 2006;354:1157-65)
Outcomes
• Increased length of stay.
• Increased mortality (Hospital mortality rates of
patients with delirium are twice as high)
Hospital mortality: 22-76%
One-year mortality: 35-40%
• Increased risk of institutional placement.
• Patients with delirium are also three times more
likely to develop dementia.
Delirium phenotypes
• Hyperactive (20%) “Confused”
– Agitated, hyper-alert, restless, sympathetic
overdrive
• Hypoactive (30%) “Not themselves”
– Drowsy, inattentive, poor oral intake
• Mixed (50%)
Hypoactive delirium carries higher mortality
and is more often unrecognised
(Kiely et al. J of Geront Series A: 2007; 62: 174-
179)
The first question….
Is it something else?
•Dysphasia
•Deaf
•Drunk
•Drugged
•Depressed
•Downright difficult
•Dementia
Is it acute?
Get a collateral history
•When did it start?
•What were they like yesterday, a week
ago?
•Has it happened before?
•What else have you noticed?
How delirium happens…
Who is at risk?
• Older people
• Poly pharmacy.
• Dementia.
• Dehydrated.
• Infection.
• Severely ill people.
• People who are nearing the end of their life.
• Older people with constipation or urinary retention
What can trigger delirium?
• Immobility
• Use of physical restraint
• Use of bladder catheter
• Pain
• Hypoxia
• Malnutrition
• Multiple medications
• Intercurrent illness (infection/cardiac event etc)
• Dehydration or Constipation
• Sensory Impairment
• Sleep Disturbance
Early Signs of Delirium
1 Acute onset &
Fluctuating Course
Does abnormal behaviour come & go?
Fluctuate during day?
Increase/decrease in severity?
2 Inattention
Does Pt
Has difficulty focussing attention?
Become easily distracted?
Have difficulty keeping track of what’s being said?
3 Disorganized
thinking
Is pt’s thinking disorganised?
Incoherent?
i.e. rambling/incoherent
Unpredictable switching of subjects?
Unclear/illogical flow of ideas?
4
Altered LOC
Alert or vigilant?
Lethargic or stuporous
Comatose ?
Delirium requires presence of (1 & 2 )+(either 3 or 4)
Confusion Assessment Method (CAM)
4AT
Assessment t est
for delirium &
cognitive impairment
(label)
Patient name:
Date of birth:
Patient number:
_________________________________________________________
Date: Time:
Tester:
CIRCLE
[1] ALERTNESS
This includes patients who may be markedly drowsy (eg. difficult to rouse and/or obviously sleepy
during assessment) or agitated/hyperactive. Observe the patient. If asleep, attempt to wake with
speech or gentle touch on shoulder. Ask the patient to state their name and address to assist rating.
Normal (fully alert, but not agitated, throughout assessment) 0
Mild sleepiness for <10 seconds after waking, then normal 0
Clearly abnormal 4
[2] AMT4
Age, date of birth, place (name of the hospital or building), current year.
No mistakes 0
1 mistake 1
2 or more mistakes/untestable 2
[3] ATTENTION
Ask the patient: “Please tell me the months of the year in backwards order, starting at December.”
To assist initial understanding one prompt of “what is the month before December?” is permitted.
Months of the year backwards Achieves 7 months or more correctly 0
Starts but scores <7 months / refuses to start 1
Untestable (cannot start because unwell, drowsy, inattentive) 2
[4] ACUTE CHANGE OR FLUCTUATING COURSE
Evidence of significant change or fluctuation in: alertness, cognition, other mental function
(eg. paranoia, hallucinations) arising over the last 2 weeks and still evident in last 24hrs
No 0
Yes 4
4 or above: possible delirium +/- cognitive impairment
1-3: possible cognitive impairment
0: delirium or severe cognitive impairment unlikely (but
delirium still possible if [4] information incomplete)
4AT SCORE
GUIDANCE NOTES Version 1.2. Information and download: www.the4AT.com
The 4AT is a screening instrument designed for rapid initial assessment of delirium and cognitive impairment. A score of 4 or more
suggests delirium but is not diagnostic: more detailed assessment of mental status may be required to reach a diagnosis. A score of 1-3
What about Sedation?
• Should be a last resort
• Follow NICE Guidance
• Low doses are usually effective in Delirium
• Should be a short term solution
Management
• Try and identify the cause
• Out of ED as soon as possible – prioritise with
bed managers
• Safety – might abscond - positioning in clinical
area
• Inform family ASAP
• Do not catheterise unless absolutely necessary
• Orientate
• Maintain optimal hydration, mobility & nutrition-
prevent/treat constipation/pain
Key Points
• Delirium is an emergency (ED staff are good at
spotting emergencies….)
• We can improve outcomes if it is identified and
flagged up early
• Untreated, it can have disastrous effects on the
patient – including death
• It often goes unrecognised in hospitals –
(remember a false positive/suspicion is better
than missing it completely)
Jo james  demetia vs delerium
Jo james  demetia vs delerium

Jo james demetia vs delerium

  • 1.
    Dementia & Delirium JoJames Lead Nurse Dementia Imperial College Healthcare NHS Trust
  • 2.
    Objectives • Define thedifferences between dementia & delirium • Top tips to identify delirium • Explore Assessment and Management
  • 3.
    How does dementiadiffer from delirium? • Dementia is a long term condition with slow onset and decline • Delirium is an acute, short term response to a physical insult – comes on suddenly and can resolve in days to months. • Delirium is always acute onset and is characterised by level of arousal (awakeness)
  • 4.
    Differentiating the threeDs Depression Delirium Dementia Onset Generally insidious, Precipitant? Coincides with life changes, often abrupt Acute Chronic Course Typically worse in the morning; situational fluctuations but less than delirium Short, often worse at night, in the dark and on waking Long. Symptoms progressive but stable over time Duration At least two weeks, can be months to years Hours to less than one month, rarely (but sometimes) longer Months to years
  • 5.
    Differentiating the threeDs (2) Depression Delirium Dementia Awareness Clear Reduced Clear Arousal /Alertness Normal Fluctuates; lethargic or hyper-vigilant Generally normal Attention Minimal impairment but distractible Impaired, fluctuates Generally normal Thinking/ Perception Intact; delusions and hallucinations absent except in severe cases Disorganised, fragmented Distorted, delusions hallucinations, difficulty distinguishing reality and misperceptions. Difficulty with abstraction, poor judgement, difficulty finding words Misperceptions often absent
  • 6.
    Prevalence (66% of casesgo unrecognised in hospital) • Prevalent (on admission) 14-24% • Incident (in hospital) 6-56% • Postoperative: 15-53% • Intensive care unit: 70-87% • Nursing home/post-acute care: 20-60% • Palliative care (up to) 80% ( Inouye SK, NEJM 2006;354:1157-65)
  • 7.
    Outcomes • Increased lengthof stay. • Increased mortality (Hospital mortality rates of patients with delirium are twice as high) Hospital mortality: 22-76% One-year mortality: 35-40% • Increased risk of institutional placement. • Patients with delirium are also three times more likely to develop dementia.
  • 8.
    Delirium phenotypes • Hyperactive(20%) “Confused” – Agitated, hyper-alert, restless, sympathetic overdrive • Hypoactive (30%) “Not themselves” – Drowsy, inattentive, poor oral intake • Mixed (50%) Hypoactive delirium carries higher mortality and is more often unrecognised (Kiely et al. J of Geront Series A: 2007; 62: 174- 179)
  • 9.
  • 10.
    Is it somethingelse? •Dysphasia •Deaf •Drunk •Drugged •Depressed •Downright difficult •Dementia
  • 11.
    Is it acute? Geta collateral history •When did it start? •What were they like yesterday, a week ago? •Has it happened before? •What else have you noticed?
  • 12.
  • 13.
    Who is atrisk? • Older people • Poly pharmacy. • Dementia. • Dehydrated. • Infection. • Severely ill people. • People who are nearing the end of their life. • Older people with constipation or urinary retention
  • 14.
    What can triggerdelirium? • Immobility • Use of physical restraint • Use of bladder catheter • Pain • Hypoxia • Malnutrition • Multiple medications • Intercurrent illness (infection/cardiac event etc) • Dehydration or Constipation • Sensory Impairment • Sleep Disturbance
  • 15.
  • 16.
    1 Acute onset& Fluctuating Course Does abnormal behaviour come & go? Fluctuate during day? Increase/decrease in severity? 2 Inattention Does Pt Has difficulty focussing attention? Become easily distracted? Have difficulty keeping track of what’s being said? 3 Disorganized thinking Is pt’s thinking disorganised? Incoherent? i.e. rambling/incoherent Unpredictable switching of subjects? Unclear/illogical flow of ideas? 4 Altered LOC Alert or vigilant? Lethargic or stuporous Comatose ? Delirium requires presence of (1 & 2 )+(either 3 or 4) Confusion Assessment Method (CAM)
  • 17.
    4AT Assessment t est fordelirium & cognitive impairment (label) Patient name: Date of birth: Patient number: _________________________________________________________ Date: Time: Tester: CIRCLE [1] ALERTNESS This includes patients who may be markedly drowsy (eg. difficult to rouse and/or obviously sleepy during assessment) or agitated/hyperactive. Observe the patient. If asleep, attempt to wake with speech or gentle touch on shoulder. Ask the patient to state their name and address to assist rating. Normal (fully alert, but not agitated, throughout assessment) 0 Mild sleepiness for <10 seconds after waking, then normal 0 Clearly abnormal 4 [2] AMT4 Age, date of birth, place (name of the hospital or building), current year. No mistakes 0 1 mistake 1 2 or more mistakes/untestable 2 [3] ATTENTION Ask the patient: “Please tell me the months of the year in backwards order, starting at December.” To assist initial understanding one prompt of “what is the month before December?” is permitted. Months of the year backwards Achieves 7 months or more correctly 0 Starts but scores <7 months / refuses to start 1 Untestable (cannot start because unwell, drowsy, inattentive) 2 [4] ACUTE CHANGE OR FLUCTUATING COURSE Evidence of significant change or fluctuation in: alertness, cognition, other mental function (eg. paranoia, hallucinations) arising over the last 2 weeks and still evident in last 24hrs No 0 Yes 4 4 or above: possible delirium +/- cognitive impairment 1-3: possible cognitive impairment 0: delirium or severe cognitive impairment unlikely (but delirium still possible if [4] information incomplete) 4AT SCORE GUIDANCE NOTES Version 1.2. Information and download: www.the4AT.com The 4AT is a screening instrument designed for rapid initial assessment of delirium and cognitive impairment. A score of 4 or more suggests delirium but is not diagnostic: more detailed assessment of mental status may be required to reach a diagnosis. A score of 1-3
  • 18.
    What about Sedation? •Should be a last resort • Follow NICE Guidance • Low doses are usually effective in Delirium • Should be a short term solution
  • 19.
    Management • Try andidentify the cause • Out of ED as soon as possible – prioritise with bed managers • Safety – might abscond - positioning in clinical area • Inform family ASAP • Do not catheterise unless absolutely necessary • Orientate • Maintain optimal hydration, mobility & nutrition- prevent/treat constipation/pain
  • 20.
    Key Points • Deliriumis an emergency (ED staff are good at spotting emergencies….) • We can improve outcomes if it is identified and flagged up early • Untreated, it can have disastrous effects on the patient – including death • It often goes unrecognised in hospitals – (remember a false positive/suspicion is better than missing it completely)