1) Computers have become increasingly powerful tools for biology and medicine since the 1960s. 2) The human genome project, which took over 10 years and billions of dollars to complete, was completed in the early 2000s and the cost of genome sequencing has dropped dramatically to $1000. 3) Big data from various 'omic fields like genomics, along with clinical, imaging, and exposure data is driving major changes in biology as more data becomes available for analysis.

1. The Future of Biology &
Medicine is All About Computers
Philip E. Bourne PhD
philip.bourne@nih.gov

2. Computers an Ever Powerful
Tool
1974
1960’s
1981
Today

3. The Human Genome
• Took at least 10 years
and several $bn
• Biology’s equivalent of
landing on the moon
• Genome now costs
$1000

4. Proteins and You
HIV Protease
Hemoglobin
Common Cold
Virus
Ribosome
Prion

5. Studying Iron Metabolism

6. Some Things Stay with You Your
Whole Life

7. Numberofreleasedentries
Year
The Growth of Data is A Major
Driver in Biology

8. Why are there so many different shapes?

9. Big Data
Other ‘Omic
Imaging Phenotypic
Clinical
Genomic
Exposure

10. An Example of That Potential:
The Story of Meredith
http://fora.tv/2012/04/20/Congress_Unplugged_Phil_Bourne

11. Josh Sommer – A Remarkable Young Man
Co-founder & Executive Director the Chordoma Foundation
http://sagecongress.org/Presentations/Sommer.pdf

12. “And that’s why we’re here today. Because something called precision
medicine … gives us one of the greatest opportunities for new medical
breakthroughs that we have ever seen.”
President Barack Obama
January 30, 2015
Precision Medicine

14. Being a Scientist is a Great Life