R can be used for large scale data analysis on Hadoop through tools like Rhadoop, R + Hadoop Streaming, and Rhipe. The document demonstrates using Rhadoop to analyze a large mortality dataset on Hadoop. It shows how to install Rhadoop, run a word count example, and analyze causes of death from the dataset using MapReduce jobs with R scripts. While Rhadoop allows scaling R to big data on Hadoop, its development is ongoing so backward compatibility must be considered. Other options like Pig with R may provide better integration than Rhadoop alone.