Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
Background and Aims: Laryngoscopy for tracheal intubation produces a hemodynamic stress response like changes in heart rate and blood pressure, intracranial pressure, intra ocular pressure (IOP). Many pharmacological and non-pharmacological methods have been employed to limit these pressor responses. We hypothesize that as lower lifting forces are required to visualize the glottis while using videolaryngoscopes, hence they should have a beneficial influence on hemodynamics and in turn IOP.
Methods: After taking written and informed consent, the patients were allocated by computer generated randomization in 2 groups of 40 patients each.
Grp VL- patients were intubated using Kings Vision videolaryngoscope Grp DL – patients were intubated using Macintosh laryngoscope.
Heart rate, blood pressure and IOP were recorded just before laryngoscopy,(either by Macintosh or Kings Vision videolaryngoscope) and 1 , 3 and 5 minutes after intubation, by independent anaesthesiologists
Results: There was a significant difference in IOP, both in left and right eye from the baseline in direct laryngoscopy group at 1 3 and 5 minutes. No significant difference in IOP from baseline levels was noted in videolaryngoscopy (VL) group .In fact a decrease in IOP was noted at 5 min in VL group in the left eye and no significant change happened in IOP of right eye anytime that we measured (1,3 and 5 min) post intubation.
Conclusion: With the use of KVVL, lesser hemodynamic changes and lesser variations in IOP were noted, so the above can be better than DL for use in surgeries where sudden increase in IOP can be deleterious.
Key Words: Intraocular pressure, video laryngoscope, King Vision, Mcintosh, hemodynamic
Evaluation of Effect of Low Dose Fentanyl, Dexmedetomidine and Clonidine in S...iosrjce
In the present study effect of intrathecal hyperbaric Bupivacaine 0.5% with low doses of Clonidine
or Fentanyl or Dexmedetomidine were compared in elective lower abdominal surgeries. This was a prospective
randomized control trial. 90 patients belonging to ASA 1 &II, aged between 20-50 years were allocated into
three groups. Group-C: Clonidine 30µg, Group-D: Dexmedetomidine 5 µg, Group-F: Fentanyl 25 µg. The
onset of sensory blockade was comparable in all the three groups. The onset of motor blockade was earlier by
about 1.3 mins in Dexmedetomidine group when compared to Clonidine and Fentanyl group. Duration of
sensory blockade was prolonged in Dexmedetomidine group (346mins) when compared to Clonidine (300mins)
and Fentanyl (302mins) group. Time duration of motor blockade was prolonged in Dexmedetomidine group
(269mins) when compared to Clonidine (223mins) and Fentanyl (220mins) group. The haemodynamic
parameters were clinically and statistically insignificant The time of first request for analgesics by the patients
was more in Dexmedetomidine group (250mins) when compared to Clonidine (194mins) and Fentanyl
(189mins) group. The use of intrathecal Dexmedetomidine as an adjuvant to Bupivacaine is an attractive
alternative to Fentanyl or Clonidine for long duration surgical procedures due to its profound intrathecal
anesthetic and analgesic properties combined with minimal side effects.
Evaluation of Effect of Low Dose Fentanyl, Dexmedetomidine and Clonidine in S...iosrjce
In the present study effect of intrathecal hyperbaric Bupivacaine 0.5% with low doses of Clonidine
or Fentanyl or Dexmedetomidine were compared in elective lower abdominal surgeries. This was a prospective
randomized control trial. 90 patients belonging to ASA 1 &II, aged between 20-50 years were allocated into
three groups. Group-C: Clonidine 30µg, Group-D: Dexmedetomidine 5 µg, Group-F: Fentanyl 25 µg. The
onset of sensory blockade was comparable in all the three groups. The onset of motor blockade was earlier by
about 1.3 mins in Dexmedetomidine group when compared to Clonidine and Fentanyl group. Duration of
sensory blockade was prolonged in Dexmedetomidine group (346mins) when compared to Clonidine (300mins)
and Fentanyl (302mins) group. Time duration of motor blockade was prolonged in Dexmedetomidine group
(269mins) when compared to Clonidine (223mins) and Fentanyl (220mins) group. The haemodynamic
parameters were clinically and statistically insignificant The time of first request for analgesics by the patients
was more in Dexmedetomidine group (250mins) when compared to Clonidine (194mins) and Fentanyl
(189mins) group. The use of intrathecal Dexmedetomidine as an adjuvant to Bupivacaine is an attractive
alternative to Fentanyl or Clonidine for long duration surgical procedures due to its profound intrathecal
anesthetic and analgesic properties combined with minimal side effects.
Awake Fiberoptic Intubation with Sedation in Cardiac (High-Risk) Patients – O...info622939
Embark on a compelling exploration of anesthesia innovation with our presentation on 'Awake Fiberoptic Intubation with Sedation in Cardiac (High-Risk) Patients – Our Experience.' Delve into the intricacies of this specialized technique, tailored for high-risk cardiac patients, as we share our unique insights and experiences.
Comparison of Ondansetron and Granisetron for Prevention of Nausea and Vomiti...Apollo Hospitals
The most common and distressing symptoms, which follow anaesthesia and surgery, are pain and emesis. The consequences of PONV are physical, surgical and anesthetic complications for patients as well as financial implications for the hospitals or institutions. Sometimes nausea and vomiting may be more distressing especially after minor and ambulatory surgery, delaying the hospital discharge. Laparoscopic surgery is one condition, where risk of PONV is particularly pronounced due to pneumo-peritoneum causing stimulation of mechanoreceptors in the gut. In spite of plenty of anti-emetic drugs available no single drug is 100% effective in prevention of PNV and combination therapy has got a lot of side effects.
Comparison of Efficacy of Various Doses of Esmolol In Attenuating Presssor Re...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Echocardiography was performed using contrast for all studies. The contrast agent used was a commercially available sulfur hexafluoride microbubble preparation, SonoVue (Bracco Imaging SpA). This agent was administered in 0.3-mL bolus doses intravenously for each image acquisition followed by 1 to 2 mL of saline flush. After acquisition of resting images to exclude significant valvular disease, intravenous dobutamine was infused at a starting dose of 10 µg·kg–1·min–1 followed by increasing doses of 20 µg·kg–1·min–1, 30 µg·kg–1·min–1, up to a maximum of 40 µg·kg–1·min–1 in 3-minute stages. Intravenous atropine was administered in 300-μg boluses up to a maximum of 1200 μg for those patients not achieving 85% of the predicted maximal heart rate. Images were taken in the apical 2-chamber, 3-chamber, 4-chamber, and parasternal short-axis views at baseline, low-dose stress, high-dose stress, and recovery
Le degré de relâchement musculaire en chirurgie coelioscopique de la vésicule biliaire fait partie du quotidien des discussions entre anesthésistes et chirurgiens au bloc opératoire. Au fond tous sont convaincus de l'efficacité du curare : le chirurgien qui le demande et l'anesthésiste qui pense lui à sa décurarisation.
Cette étude teste curarisation profonde versus curarisation de routine dans la chirurgie coelioscopique de la vésicule biliaire. Avec comme première question "est-ce qu'une curarisation profonde permet de travaillert avec une pression abdominable moindre?", pression dont on sait qu'elle est pourvoyeuse de douleur post-opératoire.
La réponse est que le degré de curarisation participe de façon marginale au confort du chirurgien... et ne permet pas plus fréquemment de travailler à pression abdominale basse.
Similar to Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
Awake Fiberoptic Intubation with Sedation in Cardiac (High-Risk) Patients – O...info622939
Embark on a compelling exploration of anesthesia innovation with our presentation on 'Awake Fiberoptic Intubation with Sedation in Cardiac (High-Risk) Patients – Our Experience.' Delve into the intricacies of this specialized technique, tailored for high-risk cardiac patients, as we share our unique insights and experiences.
Comparison of Ondansetron and Granisetron for Prevention of Nausea and Vomiti...Apollo Hospitals
The most common and distressing symptoms, which follow anaesthesia and surgery, are pain and emesis. The consequences of PONV are physical, surgical and anesthetic complications for patients as well as financial implications for the hospitals or institutions. Sometimes nausea and vomiting may be more distressing especially after minor and ambulatory surgery, delaying the hospital discharge. Laparoscopic surgery is one condition, where risk of PONV is particularly pronounced due to pneumo-peritoneum causing stimulation of mechanoreceptors in the gut. In spite of plenty of anti-emetic drugs available no single drug is 100% effective in prevention of PNV and combination therapy has got a lot of side effects.
Comparison of Efficacy of Various Doses of Esmolol In Attenuating Presssor Re...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Echocardiography was performed using contrast for all studies. The contrast agent used was a commercially available sulfur hexafluoride microbubble preparation, SonoVue (Bracco Imaging SpA). This agent was administered in 0.3-mL bolus doses intravenously for each image acquisition followed by 1 to 2 mL of saline flush. After acquisition of resting images to exclude significant valvular disease, intravenous dobutamine was infused at a starting dose of 10 µg·kg–1·min–1 followed by increasing doses of 20 µg·kg–1·min–1, 30 µg·kg–1·min–1, up to a maximum of 40 µg·kg–1·min–1 in 3-minute stages. Intravenous atropine was administered in 300-μg boluses up to a maximum of 1200 μg for those patients not achieving 85% of the predicted maximal heart rate. Images were taken in the apical 2-chamber, 3-chamber, 4-chamber, and parasternal short-axis views at baseline, low-dose stress, high-dose stress, and recovery
Le degré de relâchement musculaire en chirurgie coelioscopique de la vésicule biliaire fait partie du quotidien des discussions entre anesthésistes et chirurgiens au bloc opératoire. Au fond tous sont convaincus de l'efficacité du curare : le chirurgien qui le demande et l'anesthésiste qui pense lui à sa décurarisation.
Cette étude teste curarisation profonde versus curarisation de routine dans la chirurgie coelioscopique de la vésicule biliaire. Avec comme première question "est-ce qu'une curarisation profonde permet de travaillert avec une pression abdominable moindre?", pression dont on sait qu'elle est pourvoyeuse de douleur post-opératoire.
La réponse est que le degré de curarisation participe de façon marginale au confort du chirurgien... et ne permet pas plus fréquemment de travailler à pression abdominale basse.
Effect Of Remote Ischemic Preconditioning On AKI Among.pptxNayyarSaleem2
Remote ischemic pre conditioning in prevention of AKI
Similar to Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study (20)
Introduction: Depression in the elderly has disastrous implications that not only lowers quality of life, but it also has an impact on the prognosis of other chronic conditions, exacerbating disability. As estimated by WHO, depression occurs in 7% of the general elderly population and the same in India is 9.3%. This study was undertaken to know the prevalence of depression among the geriatric age group with Dependency as risk factor in villages of our field practice area.
Methodology: It’s a Cross sectional study of 251 geriatric population. The selection of villages was done through Simple random sampling and all the villagers of age above 60 years were included in the study. The identification of depression was carried out using the Geriatric Depression Scale (GDS). The dependency was calculated using the Barthel Index
Results: From our study it is found that the prevalence of depression and dependency among the geriatric population in our study area is 43% and 29% respectively. The Barthel score among depressed were also less(median (IQR) Barthel score: depressed - 65(50,85) ; not depressed -70(60,89); p value - <0.001 ). Nearly 80% of the females who were categorized as dependent were depressed (p value – 0.006). Multivariate logistic regression for depression upon Barthel score, age and gender shown significance OR for Barthel score but later after adjusting for other two factors, the AOR was not significant.
Conclusion: The study makes us understand the importance of analysing the dependency status while screening for the mental health status of the elderly person. This also gives us the idea to include the same in the interventions those are carried for improving the quality of life of elderly
Key Words: Geriatric, depression, dependency, GDS, Barthel index
32-year-oldprimigravida, CATB2, Covid positive patient with acute onset of facial palsy, fever, sore throat and productive cough referred from a peripheral hospital came for caesarian section. Past history revealed occurrence of juvenile dermatomyositis for which she took steroids for one and a half year which was slowly weaned off. Prevalence of dermatomyositis is 1to 8 in 100,000. She was started on steroids which was to be continued for a week after caesarian section. She was on paracetamol and cefuroxime on admission. Basic investigations were normal. Caesarian section was done in covid theater following covid protocols under subarachnoid anesthesia Baby had an APGAR score of 9 and was covid negative. Mothers’ recovery was slow. Facial deviation got corrected in 4to 5 months. Ptosis persisted even after 9months and is on treatment. Dermatomyositis is an uncommon inflammatory disease that affects mainly proximal muscle limiting day to day activities. But it can affect respiratory, cardiac and gastrointestinal systems, eyes and joints. Diagnosis is by muscle biopsy and an increase in muscle enzymes. Pregnancy during remission period is safe. But pregnancy can provoke the disease. Skin changes usually precedes muscle symptoms, though we could not notify any lesions. Lung involvement is prominent, and covid also carries the same amount of risk with respiratory system. Systemic glucocorticoids are the first line of treatment. Immunosuppressant drugs Azathioprine and methotrexate are added as second line of therapy, though these drugs are unsafe during pregnancy. Intravenous immunoglobulin, give good outcome during pregnancy. Plasmapheresis is also beneficial. Most of the pregnant patients end up in caesariansection. Regionalanesthesia is the choice of anesthesia. Covid patients with respiratory infections, maintaining saturation above90%, choice of anesthesia is usually regional anesthesia.
Key Words: Juvenile Dermatomyositis, COVID, Cesarian Section
Cutthroat often poses a challenge to the autopsy surgeon in determining the manner of death. An incised wound or ‘slash wound’, results when an object with a sharp tip or edge makes tangential contact with skin. Cutthroat may be homicidal, suicidal, or accidental.
Suicidal cutthroat injuries are usually oblique, starting from higher up and tapering lower down, and associated with hesitation cuts unless it is a determined suicide. It is more commonly seen in anatomical zone II of the neck.
Homicidal cutthroat injuries can be seen in any zone of the neck, even in the back of the neck, and are usually associated with an “overkill” phenomenon.
This case series discuss the two homicidal cutthroat injuries and their difference from suicidal cutthroat.
Key Words: Cutthroat, hesitation cuts, overkill, slash wound
A friction burn occurs when the skin is scraped off by contact with some hard object, such as the road, the floor, etc., or by prolonged contact with a smooth surface. It is usually confused with burns but it is both an abrasion and a heat burn.
A friction burn can occur in any part of the body but these usually affect bony prominences, such as the hands, forearms, elbows, knees, heels, head, or chin. It can per se be a cause of death.
This case series highlights the characteristics of friction burns and their medico-legal significance.
Key Words: Friction burn, road traffic accident, abrasion, heat burn
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Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
1. Samiksha Khanuja et al.: Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with
Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
489
International Journal of Medical and Pharmaceutical Research
Website: https://ijmpr.in/ | Print ISSN: 2958-3675 | Online ISSN: 2958-3683 Original Article
NLM ID: 9918523075206676
Volume: 4 Issue:3 (May-June 2023); Page No: 489-495
IJMPR
Copyright@IJMPR
Intraocular Pressure Changes Following Laryngoscopy and
Tracheal Inubation with Macintosh Laryngoscope and
Videolaryngoscope (King Vision) In Non-Ophthalmic
Surgeries: A Randomized Study
Samiksha Khanuja*1
, Pratibha Panjiar1
, Vertika Sachhan2
, Sana Hussain2
, Neha Sinha3
,
Taskin Khan4
, Khairat Mohammad Butt5
1
MBBS, MD, Anaesthesia, Associate Professor, Hamdard Institute of Medical Sciences, New Delhi
2
MBBS, MD, Anaesthesia, Assistant Professor, Hamdard Institute of Medical Sciences, New Delhi
3
MBBS, post graduate student, Hamdard Institute of Medical Sciences, New Delhi
4
MBBS, MS, Ophthalmology, Associate Professor, Hamdard Institute of Medical Sciences, New Delhi
5
MBBS, MD, Anaesthesia, Professor, Hamdard Institute of Medical Sciences, New Delhi
ABSTRACT
Background and Aims: Laryngoscopy for tracheal intubation produces a hemodynamic stress response like changes in
heart rate and blood pressure, intracranial pressure, intra ocular pressure (IOP). Many pharmacological and non-
pharmacological methods have been employed to limit these pressor responses. We hypothesize that as lower lifting
forces are required to visualize the glottis while using videolaryngoscopes, hence they should have a beneficial influence
on hemodynamics and in turn IOP.
Methods: After taking written and informed consent, the patients were allocated by computer generated randomization in
2 groups of 40 patients each.
Grp VL- patients were intubated using Kings Vision videolaryngoscope Grp DL – patients were intubated using
Macintosh laryngoscope.
Heart rate, blood pressure and IOP were recorded just before laryngoscopy,(either by Macintosh or Kings Vision
videolaryngoscope) and 1 , 3 and 5 minutes after intubation, by independent anaesthesiologists
Results: There was a significant difference in IOP, both in left and right eye from the baseline in direct laryngoscopy
group at 1 3 and 5 minutes. No significant difference in IOP from baseline levels was noted in videolaryngoscopy (VL)
group .In fact a decrease in IOP was noted at 5 min in VL group in the left eye and no significant change happened in
IOP of right eye anytime that we measured (1,3 and 5 min) post intubation.
Conclusion: With the use of KVVL, lesser hemodynamic changes and lesser variations in IOP were noted, so the above
can be better than DL for use in surgeries where sudden increase in IOP can be deleterious.
Key Words: Intraocular pressure, video laryngoscope, King Vision, Mcintosh, hemodynamic
*Corresponding Author
Samiksha Khanuja
MBBS, MD, Anaesthesia, Associate Professor, Hamdard Institute of Medical Sciences, New Delhi
INTRODUCTION
Laryngoscopy for tracheal intubation has been known to produce a hemodynamic stress response like changes in
heart rate and blood pressure, intracranial pressure, intra ocular pressure (IOP) etc [1, 2]. This has been further confirmed
by the rise inplasma nor adrenaline levels, hence increased sympathetic activity [3].
Though brief stress response is tolerated well with no long term complications in healthy individuals, it can have
deleterious effects on patients with uncompensatedsympathetic responses like in hypertension, myocardial insufficiency
and cerebrovascular disease. Rise in IOP can be a reliable indicator of this stress response [4].
Many pharmacological and non-pharmacological methods have been employed to limit these pressor responses.
Premedication with various drugs have been studied extensively for the same. Simultaneously use of airway establishing
methods have been studied. For example use of supraglottic devices like laryngeal mask airway (conventional, proseal,
intubating) have been compared for its effect on IOP [5, 6]. Videolaryngoscope functions independently of the line of
sight, reduces upward lifting forces to expose the glottis and requires less cervical neck movement for intubation.
Videolaryngoscopy has been a part of AIDAA algorithm for unanticipated difficultairway for its use in first attempt
alongside direct laryngoscopy. There is also a significant increase in the percentage of glottic opening visibility when
using the video laryngoscope with cervical spine immobilization [8, 9].
2. Samiksha Khanuja et al.: Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with
Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
490
Practically it has gained widespread popularity during the COVID pandemic [7]. Conventional laryngoscopy has
been compared to video laryngoscopy as well for its effect on IOP. Even the different video laryngoscopes have been
compared for IOP changes associated with intubation via them.
We in this study compared the hemodynamics and pressor response in patients intubated using Macintosh direct
laryngoscope and Kings Vision video laryngoscope.We hypothesize that as lower lifting forces are required to visualize
the glottis while using videolaryngoscopes, hence they should have a beneficial influence on hemodynamics and in turn
IOP. To the best of our knowledge no study has as of now been done to compare the pressor response by use of
Macintosh direct laryngoscopy and Kings vision video laryngoscopy in non-ophthalmic procedures.
MATERIALS AND METHODS
This prospective randomized study was conducted in the operating room of HamdardInstitute of Medical Sciences &
HAHC Hospital after institutional ethical committee approval .The CTRI registration number of the trial is
CTRI/2020/10/028415.
Eighty patients who were ASA grade 1, either sex, 18 - 65 years of age, scheduled for any non-ophthalmic surgery
under general anaesthesia and requiring endotracheal intubation were included in this study. Patients of ASA grade 2 or
more, patients with any preexisting raised IOP, anticipated difficult airway and history of relevant drug allergy was
excluded from the study. In cases where laryngoscopy time exceeded 20 seconds, those patients were also excluded.
After taking written and informed consent, the patients were allocated bycomputer generated randomization in two
groups of forty patients each.
Grp VL- patients were intubated using Kings Vision videolaryngoscope Grp DL – patients were intubated using
Macintosh laryngoscope.
Intraoperative monitoring included electrocardiograph, heart rate oxygen saturation s(sPo2), end tidal carbon dioxide
and non invasive blood pressure, through a multi- channel cardiac monitor. Baseline vitals were recorded. The intraocular
pressure of both eyes was recorded by an experienced ophthalmologist with the help of Schiotz tonometer. General
anaestheia was induced with the predefined protocol. Injection Fentanyl 2ug/kg IV was used for premedication. Induction
was done by Injection propofol 2 mg/kg IV and Injection Vecuronium 0.1 mg/kg IV. Laryngoscopies, both direct and
video assisted was performed by the experienced anaesthesiologists. Heart rate, blood pressure and IOP were recorded
just before laryngoscopy, (either by Macintosh or Kings Vision video laryngoscope) and 1, 3 and 5 minutes after
intubation, by independent anaesthesiologists.
Statistical evaluation
The data has been presented as mean ± SD. Student’s t-test was used to compare demographic data and
intra-ocular pressure and haemodynamic parameters at each point of time. The trends of heart rate, blood pressure and
IOP within the group were analysed using two-way analysis of variance with post-hoc analysis. Postoperative adverse
effects were compared using the chi square test. P
<0.05 was considered significant.
RESULTS
The patients characteristics showed no difference between the two groups (Table 1)
Table 1: Patients Characteristics
DL VL P-value
Age (in years) 36.08± 11.08 37.83 ±10.74 0.476*
Sex
Male 18(45.0) 20(50.0) 0.654**
Female 22(55.0) 20(50.0)
Weight (in Kgs) 57.3±7.7 58.35±8.5 0.565*
Height 155.95±4.63 156.12±4.64 0.867*
BMI (Kgs/m2)
23.53±2.86 23.89±2.99 0.589*
*Independent t-test, **Chi-square test
All vitals parameters, heart rate , pulse oximetry, systolic(SBP), diastolic(DBP) and mean arterial pressure(MAP)
were recorded before induction, after induction but before intubation, after intubation at 1, 3 and 5 minutes. There was no
significant difference found in heart rate and oxygen saturation between the two groups. The intergroup comparison of
SBP, DBP and MAP showed a significant difference at 3 mins after intubation in the DL and VL groups (p value 0.01,
0.003 and 0.001 respectively at 1, 3 and 5 min).
3. Samiksha Khanuja et al.: Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with
Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
491
Table 2: Changes in physiological parameters
PhysiologicalParameters DL VL P-value*
Systolic Blood Pressure
BI 131.50±13.741 131.03±14.165 0.879
PI 121.58±18.31 122.25±17.95 0.868
1min 122.90±18.37 125.83 14.97 0.437
3min 121.05±13.12 113.13 ±13.64 0.01**
5min 113.50 ±13.90 112.93±14.83 0.859
Diastolic Blood Pressure ( in mm Hg)
BI 76.20± 8.34 74.13 ±8.13 0.263
PI 71.18± 11.56 72.73 ±12.34 0.554
1min 75.68 ±10.61 74.98 ±10.35 0.766
3min 74.83± 10.26 67.63 ±10.30 0.003**
5min 68.78 ±10.0 68.03 ±9.43 0.731
MAP (in mm Hg)
BI 93.75± 8.71 92.13± 8.54 0.402
PI 87.68± 11.98 88.30 ±13.14 0.825
1min 90.90 ±10.35 90.78 ±10.34 0.957
3min 88.95 ±8.36 81.93 ±10.13 0.001**
5min 82.85 ±9.2 82.25 ±9.9 0.781
Pulse Rate (per minute )
BI 86.65 ±15.52 85.23± 13.47 0.662
PI 79.98 ±11.06 80.63 ±10.60 0.789
1min 85.35 ±11.65 84.65 ±9.69 0.771
3min 77.43 ±9.95 80.33 ±7.08 0.137
5min 73.3 ±14.34 76.93 ±6.97 0.155
SPO2 (%)
BI 99.93± 0.27 99.93± 0.27 1.0
PI 99.80 ±0.52 99.75± 0.63 0.699
1min 99.75± 0.53 99.93± 0.27 0.07
3min 99.90 ±0.30 99.93± 0.27 0.697
5min 99.85 ±0.36 99.88± 0.34 0.747
*Independent t-test, ** statistically significant
Figure 1: Changes in MAP in two groups
Intergroup analysis of difference of left eye IOP from baseline at 1, 3 and 5 minutes post intubation was significantly
higher in the DL group compared to VL group withp values 0.00. 0.004 and 0.00 respectively. In addition, intragroup
analysis of left eyeIOP showed significant increase in value from baseline (before intubation) and at 1 and 3 mins after
intubation in DL group (p value 0.00 and 0.016). Whereas in the VLgroup a significant decrease in IOP was observed at
5 mins post intubation compared to baseline (p value 0.00). No significant increase in IOP was observed at 1 and 3
minutes in VL group.
95
90
85
80
75
BI PI 1min 3min 5min
DL VL
4. Samiksha Khanuja et al.: Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with
Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
492
Table 3: Changes in Intraocular Pressure
*Independent t-test, ** statistically significant
Intergroup analysis of difference in IOP measures at 1 min, 3 min and 5 min frombaseline values (Pi) – Left Eye
Group Statistics
DL_VL N Mean Std. Deviation Std. Error Mean P value
LeftBL-1min 1.0 40 -2.2650 3.41194 .53947 0.000
2.0 40 .6325 2.58758 .40913
LeftBL-3min 1.0 40 -1.1575 2.89623 .45793 0.004
2.0 40 .6200 2.37748 .37591
LeftBL-5min 1.0 40 -.8725 2.82607 .44684 0.000
2.0 40 1.4975 2.38602 .37726
Intergroup analysis of difference of right eye IOP from baseline at 1, 3 and 5 mins postintubation was significantly
higher in the DL group compared to VL group with p values 0.00. 0.001 and 0.004 respectively. Intragroup analysis of
right eye IOP showed significant increase in value from baseline (before intubation) and at 1 3 and 5mins after intubation
in DL group (p value 0.00, 0.002 and 0.003). Whereas in the VLgroup no significant change in IOP was observed post
intubation compared to baseline.
Intergroup analysis of difference in IOP measures at 1 min, 3 min and 5 min frombaseline values (Pi) - Right eye
Group Statistics
DL_VL N Mean Std. Deviation Std. Error Mean P value
RightBL-1min 1.0 40 -1.9075 2.35757 .37276 0.000
2.0 40 .1700 1.83068 .28946
RightBL-3min 1.0 40 -1.5025 2.88155 .45561 0.001
2.0 40 .4425 2.09614 .33143
RightBL-5min 1.0 40 -1.3700 2.69284 .42578 0.004
2.0 40 .3000 2.32875 .36821
2
1.5
1
0.5
0
-
0.5
-1
-
1.5
-2
-
2.5
Mean difference in IOP pressure in left
eye
1mi
n
3mi
n
5mi
n
Direct
Laryngoscopy
Video-assisted
Laryngoscopy
5. Samiksha Khanuja et al.: Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with
Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
493
DL Left and Right Intragroup analysis
Paired Samples Statistics
Mean N Std. Deviation Std. Error Mean P value
Pair 1 AIOPleftpi 12.3400 40 2.68527 .42458 .000
AIOPLeft1min 14.6050 40 2.31992 .36681
Pair 2 AIOPleftpi 12.3400 40 2.68527 .42458 .016
AIOPleft3min 13.4975 40 1.58024 .24986
Pair 3 AIOPleftpi 12.3400 40 2.68527 .42458 0.58
AIOPleft5min 13.2125 40 2.12858 .33656
Pair 4 AIOPrightPi 12.0850 40 2.21412 .35008 .000
AIOPright1min 13.9925 40 2.38278 .37675
Pair 5 AIOPrightPi 12.0850 40 2.21412 .35008 .002
AIOPright3min 13.5875 40 2.44385 .38641
Pair 6 AIOPrightPi 12.0850 40 2.21412 .35008 .003
AIOPright5min 13.4550 40 2.22399 .35164
VL Left and Right eyeIntragroup analysis
Paired Samples Statistics
Mean N Std. Deviation Std. Error Mean P value
Pair1 AIOPleftpi 14.0975 40 2.63093 .41599 .130
AIOPLeft1min 13.4650 40 2.01056 .31790
Pair2 AIOPleftpi 14.0975 40 2.63093 .41599 .107
AIOPleft3min 13.4775 40 1.43160 .22636
Pair3 AIOPleftpi 14.0975 40 2.63093 .41599 .000
AIOPleft5min 12.6000 40 1.75412 .27735
Pair4 AIOPrightPi 14.3375 40 1.52999 .24191 .560
AIOPright1min 14.1675 40 1.69227 .26757
Pair5 AIOPrightPi 14.3375 40 1.52999 .24191 .190
AIOPright3min 13.8950 40 1.38988 .21976
Pair6 AIOPrightPi 14.3375 40 1.52999 .24191 .420
AIOPright5min 14.0375 40 1.68092 .26578
DISCUSSION
There was a significant difference in IOP, both in left and right eye from the baselinein direct laryngoscopy group at
1 3 and 5 minutes. No significant difference in IOP from baseline levels was noted in videolaryngoscopy (VL) group .In
fact a decrease in IOP was noted at 5 min in VL group in the left eye and no significant change happened in IOP of right
eye anytime that we measured (1, 3 and 5 min) post intubation. Systolic blood pressure, diastolic blood pressure and
Mean arterial pressure were the significant predictors that corelated with the changes in IOP. There was a significant
increase in all at 3 minutes in VL group.
Various studies associate the tracheal intubation with the rise in IOP [10, 11]. These were probably due to the
Mean difference in IOP in Right eye
1
0.5
0
-0.5
-1
-1.5
-2
-2.5
1min 3 min 5min
Direct Laryngoscopy Video-assisted Laryngoscopy
6. Samiksha Khanuja et al.: Intraocular Pressure Changes Following Laryngoscopy and Tracheal Inubation with
Macintosh Laryngoscope and Videolaryngoscope (King Vision) In Non-Ophthalmic Surgeries: A Randomized Study
494
changes in ocular blood flow and alterations in arterial blood pressure and due to increase in central venous pressure
during tracheal intubation dueto vasoconstriction [12].
The resistance to the outflow of aqueous humor between anterior chamber and canalof Schlemm can also contribute
to the sudden rise in IOP during tracheal intubation. Various studies have compared conventional laryngoscopy to
videolaryngoscopy in terms of the stress response, various videolaryngoscopes have also been compared among
themselves for the same. But to the best of our knowledge no study has previously compared the conventional Mcintosh
larygoscopy and King s Visionlaryngoscopy.
Malik et al [13] and Xue et al [14] almost had similar reports that the Macintosh, Tru- view EVO2, Glide Scope,
and Airwayscope had no advantages on attenuating hemodynamic responses to intubation and the Glide Scope video
laryngoscope and theMacintosh laryngoscope caused similar hemodynamic changes to intubation respectively. Jeon et al
[15] supported the above two by reporting no difference in the hemodynamic parameters during intubation with the
McGrath Series 5 and the GlideScope video laryngoscope.The present study showed that the MAP values in DLgroup
had significant difference post intubation while in VL group showed no such difference. This is in slight variance to the
above studies.
On comparing Mccoy and Macintosh blades lesser stress response was reported in theformer by McCoy et al [16]
and Singhal et al [17]. This was probably due to lower lifting force required by the Mccoy blade. Russell etal [18]
conclusively measured the lifting forces required by Video and Mcintosh laryngoscopes and reported it to be less with
videolaryngoscopes.
A few studies which compared the Kings Vision and Macintosh laryngoscope postulated that KVVL offers faster
intubating conditions for tracheal intubation requiring armored ETTs in comparison to DL using Macintosh blade but
requireslonger times to visualize the glottis and to intubate the trachea, but does not causeadditional desaturation [19].
With regards to the above mentioned studies, the present study showed that the changes in MAP, SBP and DBP
varied proportionately with the changes in IOP fromthe baseline, showing statistically significant increase of MAP at 3
minutes in DL group. The changes in IOP from baseline in both left and right eye were more in DL group. VL showed
statistically non significant changes.
The above findings can be due to the assumption that Kings vision probably requires alesser lifting force and hence
lesser release of catecholamines, hence decreased sympathetic activity and less rise or in fact stable IOP.
CONCLUSION
Hence the conclusion of the study was that with the use of KVVL, lesser hemodynamic changes and lesser variations
in IOP were noted, so the above can be better than DL for use in surgeries where sudden increase in IOP can be
deleterious.
Limitation
One limitation of the study is that as ASA 1 patients were only included, the mean ageof the study groups was under
40, which is less than the patients usually encountered for ophthalmic surgeries. Also the patients with altered stress
response like hypertensives were excluded from the study,so there response to KVVL cant be definitely made out.
Further studies are needed in higher ASA grade patients with catecholamine measurements during laryngoscopy to
definitely establish the use of KVVL overMcintosh DL.
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