This document discusses approaches to address health and wealth in society through innovation in the life sciences and health sector. The topsector vision is for a thriving Dutch life sciences sector that develops innovative health solutions based on scientific excellence to improve quality of life, increase productivity, support affordability of healthcare, and create business value. This will be achieved through roadmaps in areas like molecular diagnostics, regenerative medicine, and specialized nutrition. Efficient valorization requires bringing ideas to development and application, having a skilled workforce, access to capital, knowledge sharing infrastructure, and an integrated life sciences sector in the Netherlands.

1. Future proof Healthcare through innovation?
Approaches to address Health & Wealth in our society
Rob van Leen
Chief Innovation Officer, Royal DSM
Boegbeeld Life Science & Health
February 2014

2. Topsector Life Sciences & Health
1

3. Regiegroep Life Sciences & Health
Topsector vision: Health and wealth for society and economy
Vision
Society
QUALITY OF
LIFE
> improve QUALITY OF LIFE of patients
> increase PRODUCTIVITY within and beyond healthcare
Source: topsectorplan; cahier no. IV
PRODUCTIVITY
LIFE
SCIENCES
&
HEALTH
> support the AFFORDABILITY of healthcare
AFFORDABILITY
BUSINESS
Wealth
> create BUSINESS VALUE in the Netherlands
Economy
Health
The topsector envisions a thriving Dutch Life Sciences &
Health sector that develops innovative health solutions
based on scientific excellence that:
2

4. Regiegroep Life Sciences & Health
Three objectives which together contribute to affordable,
high-quality healthcare
PREVENTION
CURE
CARE
1. Maintain health,
prevent healthcare
2. Maximize effect,
minimize trauma
3. Manage disease
extramurally
3

5. Regiegroep Life Sciences & Health
LSH Roadmaps
•
Molecular Diagnostics
•
Imaging and image guided therapies
•
Home care and self-management
•
Regenerative medicine
•
Pharmacotherapy
•
One health
•
Specialized nutrition, health and disease
•
Health technology assessment & quality of life
•
Enabling technologies & infrastructure
•
Solutions to neglected diseases
4

6. Regiegroep Life Sciences & Health
Efficient valorization requires 7 critical success factors
IDEA GENERATION
DEVELOPMENT
Increase the number of
promising ideas
Accelerate the development
process and heighten the
chance of success
1
2
APPLICATION
Accelerate and broaden
effective application (nationally
and internationally)
Demanding Dutch market and patients,
a portal into Europe/ the rest of the World
Optimized legal and regulatory landscape
3Sufficient well educated, entrepreneurial people
4 Good accessibility to the right capital
5
Strong, accessible (fundamental) knowledge base
6
Shared public-private innovation infrastructure
The
7 Netherlands as one self-organized Life Sciences & Health sector
5

7. 6

8. Regiegroep Life Sciences & Health
Transition from TopInstitutes BMM, CTMM, TiP & NGI
• Transition period is necessary: Identify ‘pearls’ and continue
support, safeguard data infrastructure and valorization initiatives.
• Capitalize on built up PPS expertise and networks to attract EU
money (Horizon 2020, in e.g. IMI-2)
• Strenghten operational capacity of the Topsector (TKI-Office)
• Budget made available by EZ – efforts to include VWS and OCW
7

9. Meer informatie:
www.regiegroeplsh.nl
www.lshplaza.nl
www.zonmw.nl
8

10. @DSM > 23K People: Living our Passion
http://bit.ly/1jNawX9

11. People
Health
Food & Nutrition
Security
Sustainable Innovation Themes
 a Sustainable Company
Energy Security
Planet
Sustainable
Manufacturing/
Raw Materials
Profit

12. Building an intrinsically innovative company
20%
Innovation Sales 2015
@ ~5% higher Gross Margins
Top Quartile
McKinsey Innovation
Benchmark 2012
€1B
Disruptive Platforms, 2020

13. Accelerating and supporting innovation
DSM Innovation Center
New Business Development
Accelerators
EBA Biomedical
Excellence in Innovation
EBA Bio-based
Products & Services
CTO Office
EBA Advanced
Surfaces
Licensing
Business Incubator
Venturing

14. Why do we need Open Innovation?
DSM
99.999996% of world population outside DSM!
Networks needed!

15. Open Innovation in biomedical materials
Joint
R&D
Licensing
In
Joint
Business
Developments
Actamax
Joint-venture
Venturing
Spin in
Acquisitions
Divestments
R&D services
Licensing
Out
Spin out/off
Device design;
Exclusive material developments
Scientific Advisory Board
& other Consultants

16. DSM Biomedical
materials improve
over 4.4 million
people’s lives,
every day.

17. A world class portfolio of biomedical
materials
Silicone
hydrogels
Natural Materials
Biomedical
polyurethanes
Mechanical Devices
UHMWPE
biomaterials
Drug delivery
Coatings
ECMs
Polymers &
Metals
Bio
Commercialization

18. Escalation of healthcare costs
Cost per intervention
Healthy Life style
Food
&
Sport
Medication
& non-invasive
treatment
Surgery
Restore
Repair
Maintain
Health
Total disease cost
Nurture
Health
curative
preventive
Severity / Invasiveness of intervention
Page

19. Micronutrient intake in Western countries
Germany
United States
United Kingdom
The Netherlands
Source: Troesch et al BJN 2012

20. Example vitamin D: the inadequate status
impacts a number of body functions
Classical role of vitamin D: bone health
normal
• Improves bone mineral density through
calcium absorption and deposition
• Necessary to prevent rickets & osteomalacia
Emerging health benefits of vitamin D
• Muscle
- Reduces risk of falling by
improving muscle strength
• Immunity
- Strengthens the immune system
- Reduces risk of multiple sclerosis
and diabetes type I and II
• Cardiovascular - Lowers blood pressure
• Cancer
- Inhibits cell proliferation
osteoporotic

21. The health continuum : example of the knee
HALS-UH
Restore
Repair
Maintain
Health
Nurture
Health
Page 20

22. To conclude
Prevention, Cure and Care, together with Diagnostics all need integrated
attention to improve peoples lives and get a hold on healthcare costs
Open Innovation and Collaboration between all parts of the
“health value chain” is essential to accomplish breakthrough solutions
Topsector LSH increasingly integrates, facilitates and stimulates the complete
public private innovation infrastructure with all parties involved
DSM has competences in both Life Sciences and Materials Sciences which
contribute to a brighter life for people today and generations to come