The document describes a medical device company called Flux Medical that is developing an innovative solution for treating atrial fibrillation using a stent-like implant. The implant uses magnetic induction heating of a coil to ablate the tissue and block abnormal electrical signals in the pulmonary veins. The summary is as follows:
1) Flux Medical is developing a stent-like implant that uses magnetic induction heating to ablate tissue and treat atrial fibrillation by blocking abnormal electrical signals in the pulmonary veins.
2) The implant aims to simplify the treatment procedure compared to current ablation treatments and reduce risks, costs, and need for follow-up treatments.
3) Flux Medical's research and development process involves engineering
The Future of Personalized Implants in Joint Replacement: Additive, Robotics,...April Bright
Orthopedics is primed for mass customization of implants thanks to advancements in additive, AI and robotics. Fully leveraged, the technologies can produce patient-specific implants that achieve clinical benefit, decrease cost and maintain O.R. workflow. Founder and Chief Medical Officer of Monogram Orthopaedics, Douglas Unis, M.D., shares his reimagined vision of personalized joint replacement implants and just-in-time inventory solutions.
Apresentação digital do Saens Peña Offices. Um lançamento comercial com salas e lojas comerciais na Rua Almirante Cochrane, esquina com a Santo Afonso.
O empreendimento está sendo construído ao lado do Metrô da Praça Saens Peña, no bairro da Tijuca, Zona Norte do Rio de Janeiro
The Future of Personalized Implants in Joint Replacement: Additive, Robotics,...April Bright
Orthopedics is primed for mass customization of implants thanks to advancements in additive, AI and robotics. Fully leveraged, the technologies can produce patient-specific implants that achieve clinical benefit, decrease cost and maintain O.R. workflow. Founder and Chief Medical Officer of Monogram Orthopaedics, Douglas Unis, M.D., shares his reimagined vision of personalized joint replacement implants and just-in-time inventory solutions.
Apresentação digital do Saens Peña Offices. Um lançamento comercial com salas e lojas comerciais na Rua Almirante Cochrane, esquina com a Santo Afonso.
O empreendimento está sendo construído ao lado do Metrô da Praça Saens Peña, no bairro da Tijuca, Zona Norte do Rio de Janeiro
HePIS has conducted a survey in order to measure IT Managers’ awareness regarding Green ICT.
The sample consists of 44 respondents working in companies that operate both in the Greek private and public sector, as well as NGOs, all of which have big IT departments.
Áteresztő Bél Szindróma (ÁBSZ)
2013-ban, a Szegedi Tudományegyetem Családorvosi Tanszékének szervezésében, a háziorvos továbbképzés keretében tartott előadás.
Введение - круглый стол "Технологии конструирования будущего для библиотек, м...Ekaterina Shibaeva
Круглый стол "Технологии конструирования будущего для библиотек, музеев, архивов" состоялся 20 ноября 2013 года в рамках Объединенной международной научно-практической конференции "Электронный век культуры" и "EVA 2013 Москва".
Он стал третьим в серии мероприятий о будущем библиотек, организованным журналом "Библиотековедение".
Представляя библиотеку будущего - об английском библиотечном форсайт исследов...Ekaterina Shibaeva
Презентация подготовлена для круглого стола "Технологии конструирования будущего для библиотек, музеев, архивов", который состоялся 20 ноября 2013 года в рамках Объединенной международной научно-практической конференции "Электронный век культуры" и "EVA 2013 Москва".
There comes a time in every business when start-up mode has to change. Using data and relying on information from others is imperative in taking a business to the next level. Everything should be about evidence marketing.
SPANISH EXPLORER. 1. LOS SALUDOS Y LAS PRESENTACIONES.Martha Lino
Material used at the Spanish Explorer course. This course is taught in my project Spanish with Eugenia. In this class we´ll learn how to say hello and introduce ourselves in Spanish.
Заставка круглого стола "Технологии конструирования будущего для библиотек, м...Ekaterina Shibaeva
Круглый стол "Технологии конструирования будущего для библиотек, музеев, архивов" состоялся 20 ноября 2013 года в рамках Объединенной международной научно-практической конференции "Электронный век культуры" и "EVA 2013 Москва".
Conferencia: "Superando la brecha entre Investigación y Aplicación", a cargo del Dr. Ander Ramos, investigador de TECNALIA.
TECNALIA Perspectives 2015. “Industria y Tecnología: Investigación traslacional, de la ciencia al mercado” es el título del evento que contó con la participación del Dr. Niels Birbaumer, experto mundial en el desarrollo de interfaces cerebro-computador y del investigador Dr. Ander Ramos, Premio al Mejor Investigador Joven de Alemania en 2014 por la Academia Alemana para las Ciencias y las Letras.
También presentamos dos novedosas iniciativas de TECNALIA como son un dispositivo de estimulación eléctrica funcional para rehabilitación de pacientes de ictus y el robot quirúrgico con visión 3D y sensaciones táctiles.
Más información en http://www.tecnalia.com
The SuperArgus state-of-the-art preclinical PET/CT system: An overview of the...Scintica Instrumentation
These systems are ideally suited for pre-clinical imaging of small animals such as mice and rats, all the way up to medium sized animals such as rabbits, non-human primates and other similarly sized animals. Some of the unique imaging capabilities include real-time imaging of awake animals, as well as multiplexed PET imaging of standard and non-standard isotopes. Key research applications and example images were reviewed.
Positron Emission Tomography (PET) is the gold standard in metabolic imaging, providing high sensitivity to specific radiotracer used to detect specific metabolic activity or biomarkers in vivo. The most common uses for PET imaging in pre-clinical research include oncology, neurobiology, cardiology, as well as dynamic imaging.
These systems are considered to be best in class imaging system with state of the art detectors and electronics. The systems have been designed to be self-shielded, requiring no additional shielding at the location selected for installation. The systems come in a three different bore sizes allowing for imaging of animals such as mice all the way up to rabbits and even non-human primates. The CT component of these systems has been optimized for reduced radiation exposure, rapid acquisition times, and high resolution images; all ideal for the longitudinal studies so commonly performed in pre-clinical research.
The SuperArgus system is uniquely designed to provide consistent resolution across the entire field of view, while maintaining sensitivity and system performance. Reconstruction algorithms have also been implemented to rapidly process and display the acquired images. The system performs very well for standard imaging applications such as oncology, cardiology, etc. Additionally, the system has some unique features which allow for some unique imaging capabilities such as real-time awake animal imaging, self-gated cardiac imaging, as well as multiplex imaging of standard and non-standard isotopes.
HePIS has conducted a survey in order to measure IT Managers’ awareness regarding Green ICT.
The sample consists of 44 respondents working in companies that operate both in the Greek private and public sector, as well as NGOs, all of which have big IT departments.
Áteresztő Bél Szindróma (ÁBSZ)
2013-ban, a Szegedi Tudományegyetem Családorvosi Tanszékének szervezésében, a háziorvos továbbképzés keretében tartott előadás.
Введение - круглый стол "Технологии конструирования будущего для библиотек, м...Ekaterina Shibaeva
Круглый стол "Технологии конструирования будущего для библиотек, музеев, архивов" состоялся 20 ноября 2013 года в рамках Объединенной международной научно-практической конференции "Электронный век культуры" и "EVA 2013 Москва".
Он стал третьим в серии мероприятий о будущем библиотек, организованным журналом "Библиотековедение".
Представляя библиотеку будущего - об английском библиотечном форсайт исследов...Ekaterina Shibaeva
Презентация подготовлена для круглого стола "Технологии конструирования будущего для библиотек, музеев, архивов", который состоялся 20 ноября 2013 года в рамках Объединенной международной научно-практической конференции "Электронный век культуры" и "EVA 2013 Москва".
There comes a time in every business when start-up mode has to change. Using data and relying on information from others is imperative in taking a business to the next level. Everything should be about evidence marketing.
SPANISH EXPLORER. 1. LOS SALUDOS Y LAS PRESENTACIONES.Martha Lino
Material used at the Spanish Explorer course. This course is taught in my project Spanish with Eugenia. In this class we´ll learn how to say hello and introduce ourselves in Spanish.
Заставка круглого стола "Технологии конструирования будущего для библиотек, м...Ekaterina Shibaeva
Круглый стол "Технологии конструирования будущего для библиотек, музеев, архивов" состоялся 20 ноября 2013 года в рамках Объединенной международной научно-практической конференции "Электронный век культуры" и "EVA 2013 Москва".
Conferencia: "Superando la brecha entre Investigación y Aplicación", a cargo del Dr. Ander Ramos, investigador de TECNALIA.
TECNALIA Perspectives 2015. “Industria y Tecnología: Investigación traslacional, de la ciencia al mercado” es el título del evento que contó con la participación del Dr. Niels Birbaumer, experto mundial en el desarrollo de interfaces cerebro-computador y del investigador Dr. Ander Ramos, Premio al Mejor Investigador Joven de Alemania en 2014 por la Academia Alemana para las Ciencias y las Letras.
También presentamos dos novedosas iniciativas de TECNALIA como son un dispositivo de estimulación eléctrica funcional para rehabilitación de pacientes de ictus y el robot quirúrgico con visión 3D y sensaciones táctiles.
Más información en http://www.tecnalia.com
The SuperArgus state-of-the-art preclinical PET/CT system: An overview of the...Scintica Instrumentation
These systems are ideally suited for pre-clinical imaging of small animals such as mice and rats, all the way up to medium sized animals such as rabbits, non-human primates and other similarly sized animals. Some of the unique imaging capabilities include real-time imaging of awake animals, as well as multiplexed PET imaging of standard and non-standard isotopes. Key research applications and example images were reviewed.
Positron Emission Tomography (PET) is the gold standard in metabolic imaging, providing high sensitivity to specific radiotracer used to detect specific metabolic activity or biomarkers in vivo. The most common uses for PET imaging in pre-clinical research include oncology, neurobiology, cardiology, as well as dynamic imaging.
These systems are considered to be best in class imaging system with state of the art detectors and electronics. The systems have been designed to be self-shielded, requiring no additional shielding at the location selected for installation. The systems come in a three different bore sizes allowing for imaging of animals such as mice all the way up to rabbits and even non-human primates. The CT component of these systems has been optimized for reduced radiation exposure, rapid acquisition times, and high resolution images; all ideal for the longitudinal studies so commonly performed in pre-clinical research.
The SuperArgus system is uniquely designed to provide consistent resolution across the entire field of view, while maintaining sensitivity and system performance. Reconstruction algorithms have also been implemented to rapidly process and display the acquired images. The system performs very well for standard imaging applications such as oncology, cardiology, etc. Additionally, the system has some unique features which allow for some unique imaging capabilities such as real-time awake animal imaging, self-gated cardiac imaging, as well as multiplex imaging of standard and non-standard isotopes.
This webinar was hosted in partnership with Quantum Computing & Simulation Hub, by the Quantum Technologies Innovation Network https://ktn-uk.org/quantum/.
Learn of the potential of cryo-electronics in quantum computing and other disciplines.
Cryogenic electronics is of critical importance in many fields including quantum technologies, astronomy and particle physics. This event was designed to bring scientists, engineers and industry across all relevant disciplines to advance the integration of electronics at cryogenic temperatures and combine resources to solve common challenges.
With this meeting, we hope to progress towards demonstrating the relevance and market size of cryogenic electronics. We welcome foundries and industry stakeholders in considering further engagement with this technology and present a state-of-the-art picture for all relevant stakeholders.
Custom IMD is an European research and development project formed by 13 partners. Partially funded by the European Union within the 6th Framework Programme, it will develop new biomaterials for customised medical implants. The main technology involved in the project is the Rapid Manufacturing, allowing the final product to be ready to surgery in 48 hours after medical request.
KTH SmarTS Lab - An Introduction to our Research Group and ActivitiesLuigi Vanfretti
This presentation gives a very general overview of the activities and the approach adopted at KTH SmarTS Lab for research and development of cyber-physical power systems applications, i.e. smart grids.
During the research phase, it’s important that engineers have access to resources that inspire innovative thinking, and IEEE Xplore has been an invaluable starting point for those looking for the next big breakthrough.
Freedom: The Promise of Telemetry Revisited - Stellar Telemetry Webinar (TSE ...InsideScientific
The innovative Stellar Telemetry System allows individual recording of key physiological parameters in freely roaming and socially active animals. In this webinar we will discuss added capabilities of such a system, in particular flexibility and freedom for both scientist and subject. In one 'subtropical' setting we will learn how such a system can be used in a colony of primates that are free to roam, without traditional geographical or data management limitations. In the other setting we return to the lab and see how a system like this can enhance measurement capabilities in a traditional rodent model.
To explain the tremendous evolution in ICT the last decades, one typically refers to the Law of Moore. Today we’re facing with new languages and methodologies popping up like buzz words. Understanding the evolution of programming and cornerstone concepts will help you to position and value future programming languages and trends.
Although GPS developments started in 1967, it’s only in the early 70’s that NASA launched its first Earth Observation satellite. Contemporary technologies like satellite navigation and remote sensing are key in our daily life. Still, we ain’t seen nothing yet. Explore the potential of these technologies in your future products or services, and find a way to get things done.
Based on demonstrations and cases you’ll explore the future impact on new interface technologies like gesture, augmented and virtual reality. Douglas Engelbart developed the computer mouse in the ’60s. It was the first in a list of human interface technologies that revolutionized the way we interact with ICT. What’s the next big thing?
At the end of the ’60s, the first research programs started on humanoid robots. Although this technology inspired many of us, it’s only now that we see first applications arise. What’s the status of the robotics technology? How is it impacted by other technologies like AI, RF and energy storage? Let’s discuss the evolution and potential for your business based on recent projects and technologies available at our partners and alumni start-ups.
Let’s discuss the boundary conditions to innovate successfully based on some cases in Flanders and the Netherlands. Most governments are taking about half of their gross national product for their account. They can be better off by being open to innovation in the public purchase process and act as a launching customer for their industry and start-ups.
What’s the impact of public moonshot projects on innovation if they’re set up the right way? Armstrong saw his first footstep on the moon as one small step for man, one giant leap for mankind. And he was right.
The human aspect in driving innovation is not to be underestimated. Driving innovation is done by implementing the necessary tools and structures. However driving desired behavior on individual and team level is at least equally important. Möbius will share insights in how to build an innovation and continuous improvement culture.
The key concept in any start-up? The freedom to experiment as basis for accelerated learning. Or like Pink Floyd sang in the 70’s: “We don’t need no education.” Is your FabLab ready for it?
How do you set up your venture and accelerate growth? Start-ups are in a fundamental different position than corporates. As a consequence they play a different ball game. What can the start-up culture learn from the ’60s?
What are the differences between popular innovation project management methodologies? Why does project management often fail? Learn how risk assessment should define your methodology in order to become a real innovation factory. The waterfall methodology has been promoted for years as the best practice for IR&D management. These days agile and scrum are increasingly popular as alternative. Hater or believer? Good or bad? Get guided through our body of knowledge as published in the Inspire Toolbox.
Project management in innovation can only be successful if it’s driven by a robust methodology integrating a clear quality assurance concept. What can trendy methodologies learn from the house of quality?
50 years ago, innovation centers like Xerox or Philips’ Natlab set the benchmark with their methodologies on organizing innovation. Today, innovation is influenced by rapid-moving triggers and companies have to organize accordingly. Discover current best practices on organizing your innovation ecosystem.
How do you reinvent a mature business with the right cocktail of user insights and technologies? The message is clear: choose for differentiation or servitization, or loose.
AI has an inevitable impact on your next generation products and services. Things evolved relatively slow since the first AI experiments in the ’60s. Today, AI is accelerating as no other technology has done before. How will the 4th wave of Artificial Intelligence transform your future business?
Discover the newest insights in understanding value drivers and their impact on new products and services. From technology improvement towards platform economy with the value pyramid. How to use new design skills and service design to create experience economy?
The adoption of innovative IoT technology in smart cities seems to go slower than the utopian predictions of the last decade. This might be because the traditional business-to-government model is no longer sufficient to bear the investment cost and get these systems operational. Multi-sided business models can offer
a possible solution, but require a different approach from governments as well as suppliers, as illustrated by recent Verhaert cases.
AI can be weaved together with space technologies to provide exciting new solutions to a wide array of industries. Get a glimpse of how space data can enhance businesses, and how ESA Space Solutions Belgium can offer you the tools and funding to develop your ideas.
New space in the Belgian and European start-up technology ecosystem. Presentation at the launch event of ESA Space Solutions Belgium on Wednesday the 7th of November in Brussels.
Implicitly or explicitly all competing businesses employ a strategy to select a mix
of marketing resources. Formulating such competitive strategies fundamentally
involves recognizing relationships between elements of the marketing mix (e.g.,
price and product quality), as well as assessing competitive and market conditions
(i.e., industry structure in the language of economics).
Cracking the Workplace Discipline Code Main.pptxWorkforce Group
Cultivating and maintaining discipline within teams is a critical differentiator for successful organisations.
Forward-thinking leaders and business managers understand the impact that discipline has on organisational success. A disciplined workforce operates with clarity, focus, and a shared understanding of expectations, ultimately driving better results, optimising productivity, and facilitating seamless collaboration.
Although discipline is not a one-size-fits-all approach, it can help create a work environment that encourages personal growth and accountability rather than solely relying on punitive measures.
In this deck, you will learn the significance of workplace discipline for organisational success. You’ll also learn
• Four (4) workplace discipline methods you should consider
• The best and most practical approach to implementing workplace discipline.
• Three (3) key tips to maintain a disciplined workplace.
Enterprise Excellence is Inclusive Excellence.pdfKaiNexus
Enterprise excellence and inclusive excellence are closely linked, and real-world challenges have shown that both are essential to the success of any organization. To achieve enterprise excellence, organizations must focus on improving their operations and processes while creating an inclusive environment that engages everyone. In this interactive session, the facilitator will highlight commonly established business practices and how they limit our ability to engage everyone every day. More importantly, though, participants will likely gain increased awareness of what we can do differently to maximize enterprise excellence through deliberate inclusion.
What is Enterprise Excellence?
Enterprise Excellence is a holistic approach that's aimed at achieving world-class performance across all aspects of the organization.
What might I learn?
A way to engage all in creating Inclusive Excellence. Lessons from the US military and their parallels to the story of Harry Potter. How belt systems and CI teams can destroy inclusive practices. How leadership language invites people to the party. There are three things leaders can do to engage everyone every day: maximizing psychological safety to create environments where folks learn, contribute, and challenge the status quo.
Who might benefit? Anyone and everyone leading folks from the shop floor to top floor.
Dr. William Harvey is a seasoned Operations Leader with extensive experience in chemical processing, manufacturing, and operations management. At Michelman, he currently oversees multiple sites, leading teams in strategic planning and coaching/practicing continuous improvement. William is set to start his eighth year of teaching at the University of Cincinnati where he teaches marketing, finance, and management. William holds various certifications in change management, quality, leadership, operational excellence, team building, and DiSC, among others.
Buy Verified PayPal Account | Buy Google 5 Star Reviewsusawebmarket
Buy Verified PayPal Account
Looking to buy verified PayPal accounts? Discover 7 expert tips for safely purchasing a verified PayPal account in 2024. Ensure security and reliability for your transactions.
PayPal Services Features-
🟢 Email Access
🟢 Bank Added
🟢 Card Verified
🟢 Full SSN Provided
🟢 Phone Number Access
🟢 Driving License Copy
🟢 Fasted Delivery
Client Satisfaction is Our First priority. Our services is very appropriate to buy. We assume that the first-rate way to purchase our offerings is to order on the website. If you have any worry in our cooperation usually You can order us on Skype or Telegram.
24/7 Hours Reply/Please Contact
usawebmarketEmail: support@usawebmarket.com
Skype: usawebmarket
Telegram: @usawebmarket
WhatsApp: +1(218) 203-5951
USA WEB MARKET is the Best Verified PayPal, Payoneer, Cash App, Skrill, Neteller, Stripe Account and SEO, SMM Service provider.100%Satisfection granted.100% replacement Granted.
What are the main advantages of using HR recruiter services.pdfHumanResourceDimensi1
HR recruiter services offer top talents to companies according to their specific needs. They handle all recruitment tasks from job posting to onboarding and help companies concentrate on their business growth. With their expertise and years of experience, they streamline the hiring process and save time and resources for the company.
RMD24 | Debunking the non-endemic revenue myth Marvin Vacquier Droop | First ...BBPMedia1
Marvin neemt je in deze presentatie mee in de voordelen van non-endemic advertising op retail media netwerken. Hij brengt ook de uitdagingen in beeld die de markt op dit moment heeft op het gebied van retail media voor niet-leveranciers.
Retail media wordt gezien als het nieuwe advertising-medium en ook mediabureaus richten massaal retail media-afdelingen op. Merken die niet in de betreffende winkel liggen staan ook nog niet in de rij om op de retail media netwerken te adverteren. Marvin belicht de uitdagingen die er zijn om echt aansluiting te vinden op die markt van non-endemic advertising.
Attending a job Interview for B1 and B2 Englsih learnersErika906060
It is a sample of an interview for a business english class for pre-intermediate and intermediate english students with emphasis on the speking ability.
Improving profitability for small businessBen Wann
In this comprehensive presentation, we will explore strategies and practical tips for enhancing profitability in small businesses. Tailored to meet the unique challenges faced by small enterprises, this session covers various aspects that directly impact the bottom line. Attendees will learn how to optimize operational efficiency, manage expenses, and increase revenue through innovative marketing and customer engagement techniques.
Affordable Stationery Printing Services in Jaipur | Navpack n PrintNavpack & Print
Looking for professional printing services in Jaipur? Navpack n Print offers high-quality and affordable stationery printing for all your business needs. Stand out with custom stationery designs and fast turnaround times. Contact us today for a quote!
Premium MEAN Stack Development Solutions for Modern BusinessesSynapseIndia
Stay ahead of the curve with our premium MEAN Stack Development Solutions. Our expert developers utilize MongoDB, Express.js, AngularJS, and Node.js to create modern and responsive web applications. Trust us for cutting-edge solutions that drive your business growth and success.
Know more: https://www.synapseindia.com/technology/mean-stack-development-company.html
"𝑩𝑬𝑮𝑼𝑵 𝑾𝑰𝑻𝑯 𝑻𝑱 𝑰𝑺 𝑯𝑨𝑳𝑭 𝑫𝑶𝑵𝑬"
𝐓𝐉 𝐂𝐨𝐦𝐬 (𝐓𝐉 𝐂𝐨𝐦𝐦𝐮𝐧𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬) is a professional event agency that includes experts in the event-organizing market in Vietnam, Korea, and ASEAN countries. We provide unlimited types of events from Music concerts, Fan meetings, and Culture festivals to Corporate events, Internal company events, Golf tournaments, MICE events, and Exhibitions.
𝐓𝐉 𝐂𝐨𝐦𝐬 provides unlimited package services including such as Event organizing, Event planning, Event production, Manpower, PR marketing, Design 2D/3D, VIP protocols, Interpreter agency, etc.
Sports events - Golf competitions/billiards competitions/company sports events: dynamic and challenging
⭐ 𝐅𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐬:
➢ 2024 BAEKHYUN [Lonsdaleite] IN HO CHI MINH
➢ SUPER JUNIOR-L.S.S. THE SHOW : Th3ee Guys in HO CHI MINH
➢FreenBecky 1st Fan Meeting in Vietnam
➢CHILDREN ART EXHIBITION 2024: BEYOND BARRIERS
➢ WOW K-Music Festival 2023
➢ Winner [CROSS] Tour in HCM
➢ Super Show 9 in HCM with Super Junior
➢ HCMC - Gyeongsangbuk-do Culture and Tourism Festival
➢ Korean Vietnam Partnership - Fair with LG
➢ Korean President visits Samsung Electronics R&D Center
➢ Vietnam Food Expo with Lotte Wellfood
"𝐄𝐯𝐞𝐫𝐲 𝐞𝐯𝐞𝐧𝐭 𝐢𝐬 𝐚 𝐬𝐭𝐨𝐫𝐲, 𝐚 𝐬𝐩𝐞𝐜𝐢𝐚𝐥 𝐣𝐨𝐮𝐫𝐧𝐞𝐲. 𝐖𝐞 𝐚𝐥𝐰𝐚𝐲𝐬 𝐛𝐞𝐥𝐢𝐞𝐯𝐞 𝐭𝐡𝐚𝐭 𝐬𝐡𝐨𝐫𝐭𝐥𝐲 𝐲𝐨𝐮 𝐰𝐢𝐥𝐥 𝐛𝐞 𝐚 𝐩𝐚𝐫𝐭 𝐨𝐟 𝐨𝐮𝐫 𝐬𝐭𝐨𝐫𝐢𝐞𝐬."
Digital Transformation and IT Strategy Toolkit and TemplatesAurelien Domont, MBA
This Digital Transformation and IT Strategy Toolkit was created by ex-McKinsey, Deloitte and BCG Management Consultants, after more than 5,000 hours of work. It is considered the world's best & most comprehensive Digital Transformation and IT Strategy Toolkit. It includes all the Frameworks, Best Practices & Templates required to successfully undertake the Digital Transformation of your organization and define a robust IT Strategy.
Editable Toolkit to help you reuse our content: 700 Powerpoint slides | 35 Excel sheets | 84 minutes of Video training
This PowerPoint presentation is only a small preview of our Toolkits. For more details, visit www.domontconsulting.com
Digital Transformation and IT Strategy Toolkit and Templates
Innovation day 2013 3.1 ann-rose gustin (flux medical) - when nature fails, technology takes over
1. 2
When nature fails, technology takes over:
Innovative Solutions by Flux Medical
CONFIDENTIAL
Ann-Rose Gustin
Chief Operation Officer Flux Medical
annerose.gustin@pandora.be
THEME 3 : HOW TO ORGANIZE FOR INNOVATION – BASED ON CASES
2. When nature fails, technology takes over:
Innovative Solutions by Flux Medical
in cooperation with Verhaert
3.3 3.4 3.5 3.5 3.6 3.6 3.73.4
3.4 3.5 3.6 3.9 4.2 4.6
2.9
5.0
2.4 2.3 2.4 2.7
3.0
3.3
3.6
2.1
1.2 1.4
1.6
1.8
2.1
2.4
0.8
1.0
3
3. Glenn Van Langenhove, Chief Executive Officer and founder
MD, PhD, MBA
Interventional cardiologist, Middelheim Hospital
Medical Director Thermocore (2000-2009), technology successfully
licensed to Bristol Myers Squibb
President Belgian society of Interventional Cardiology
Expert in stenting business
Bruno Schwagten, Chief Scientific Officer and founder
MD, PhD
Cardiologist - Electrophysiologist, Middelheim Hospital
Entrepreneur in residence,
EP training Erasmus University, Rotterdam, The Netherlands
Co-founder of the Society of Cardiac Robotic Navigation
Expert in cardiac arrhythmias
Anne-Rose Gustin, Chief operations Officer
Manager of Safety & Prevention, Quality and Environment, Carestel
NV and Thermocore Medical Systems,
Managing partner Incubate Cardiac Solutions
Master degree in Eastern Languages/Sinology/Japanology
Special degree in Business Communication
Team
4
4. Atrial fibrillation
Caused by abnormal electrical impulses originating in the pulmonary veins
Symptoms: palpitations, fainting, chest pain, decreased quality of life
Outcome: severe stroke and congestive heart failure leading to death
1 in 4 above 40 and increasing - currently 2.5 million patients treated in US
alone
High cost to society: 6.5 billion USD in US annually (Source: CDC)
5
6. Single invasive treatment
not requiring follow-up
medication
Successrate: 50 – 60%
10,000 EUR per procedure
(reimbursement in place in
Europe and US)
Complex:
- requires highly skilled
team
- dedicated electrophys lab
Recognised first line
treatment in new guidelines
in Europe and US
Chronic treatment with
medication
Successrate: 30-40%,
with frequent side effects
4,000 EUR per year per
person medication cost
1 in 3 patients do not
tolerate medication
Medication can induce
life threatening
arrhythmias
Ablation Medication
* ESC = European Society of Cardiology
ACC= American College of Cardiology
AHA= American Heart Association
AF treatments as per current ESC, ACC, AHA Guidelines
7
7. Aberrant signals are blocked by creating a line of scar tissue between
the pulmonary source of the signal and the muscles of the left atrium
• Difficult lenghty procedures special team required 10,000 EUR per patient
• Possible perforation of the vessel wall , damage to surrounding tissues / nerves, collateral
damage to the left atrium due to imprecise ablation
• Reconnection leads to invasive redo and is required in 50% of cases within 2-5 years
• Radiation exposure to patient and operator
Point by point treatment Single shot devices
Disadvantages adressed by the Flux system
Treatment principle
Treatment options
Current ablation treatments
8
8. Procedure
• One stent-like device per pulmonary vein
• A circular heating coil in the stent touches the full circumference of the vein
• Externally applied magnetic energy heats the coil until the electrical
currents from vein to atrium are fully interrupted
• The stent includes a full set of safety features
Competitive edge over currently used ablation procedures
• A simple, low-risk, standard procedure compared to current ablation
treatments
• Reduced procedure time: increasing capacity of the cathlab
• Reduced collateral damage to surrounding tissues and atrium
• Reduced radiation damage to the operator and patient
• Repeat procedures are possible, non-invasive, quick and simple
• This procedure does not compromise future surgical intervention if needed
• Significant cost advantage to society
• High profit margins on the device and procedures
Medical device developed by Flux
9
11. IP protection
Search for investors
R&D:
• Engineering subcontractors
• Scientific path from modelling to first in man
• From concept to proof of concept
From Concept to Realisation:
12
12. Verhaert NV - Belgium
Experience:
Leading engineering company with a track record in design of
satellite components, medical devices (orthopaedic), products
combining electronics with advanced material sciences
Provide to Flux:
Stent engineering - Magnet design development - CE certification
Feops NV - Belgium
Experience
Biophysics, modelling of physiological processes, prototyping
of virtual medical devices
Provide to Flux:
Prediction of the physical parameters and behaviour of the human pulmonary
veins
Anatomic and physhiological feasability analysis & definition of stent parameters
Contract Medical International (CMI) – Dresden Germany
Experience
Leading stent manufacturer
Provide to Flux:
Development and manufacturing of stent prototypes for animal
and human trials. Candidate for future stent production
Engineering Subcontractors
13
13. Research phase Development phase Human trials
Animal model Animal trials First In Man
In vitro/in vivo In vivo In vivo
University of Ghent
Merelbeke
Paris
Singapore
Affiliated
Electrophysiology Centers
across Europe and VS
Efficient, nearby, low cost High quality, complete file Reliable and fast
Scientific path from modelling to first in man
14
14. Question Workpackage Subcontractor Outcome
Anatomical variability
of pulmonary veins
• Literature
• FEA: CT scan of 100
pts
• PyFormex
• Slicer 3D
• >90% pts eligible for
implant
• custom made
implants
• presented at
Cardiostim 2012
• submitted JACC
From concept to ex vivo proof of concept
15
15. Question Workpackage Subcontractor Outcome
Stretchability of
pulmonary veins
• Ex-vivo animal trial
•Prelevated specimens
of weight matched
sow hearts
• safe stretching x1.8
times
• huge safety margin
for implants
+ 120%+ 80%
From concept to ex vivo proof of concept
16
16. Question Workpackage Subcontractor Outcome
Radial forces
required for vein
scaffolding and
implant fixation
• FEA: software
model used for
coronary artery
stenting, including
variables of vein
thickness and size,
strut size, implant
diameter and length
• feasible for self-
expanding device
• definition of device
design parameters
From concept to ex vivo proof of concept
17
17. Question Workpackage Subcontractor Outcome
Selection of optimal
energy used by
implant
• Engineering study
on energy sources
• Iterative material
bench testing
• Multiple in vitro
trials
• Induction heating
by magnetic field
• Selecting optimal
alloy
• Magnet properties
and design
• Coil properties and
design
From concept to ex vivo proof of concept
18
18. Question Workpackage Subcontractor Outcome
Device prototyping • Breadboarding
• Bench testing
• In vitro and ex vivo
testing
• Prototype ready for
in vivo animal trials
From concept to ex vivo proof of concept
19
19. Question Workpackage Subcontractor Outcome
Controlled heating
of the implant
• Breadboarding of
control mechanisms
• Bench testing
• Incorporation in the
implants
• In vitro and ex vivo
testing
• Controlled heating
within range of 1
degree Celcius is
feasible
• Homogenous
lesion formation in
ablated tissue
From concept to ex vivo proof of concept
20
20. •Long procedure
•Chance of repeat procedures due to incomplete conduction
block
•Surgeon exposure to X-Rays for visualisation of catheter
position
Current state-
of-the-art
•Single incision for placing implant
•Entire circumference of vein is treated at once
reducing procedure time
•Multiple veins can be treated simultaneously
reducing procedure time
•Repeat procedures are possible, quick and simple
•Ablation procedure can be performed without
the direct attention of a surgeon
Proposal
Goals:
•Technology investigation
•Initial feasibility of
technology
•Application ideation
Actions:
•Desk research
•Brainstorm sessions
•Initial patent screening
•Initial modelling
•Criteria exploration (regular
interaction with Flux Team)
Results:
•Morphological chart of
solution options
•First trade-off
•Hysteresis heating shows
potential for safe, controlled
heating – Further testing
required
•Joule heating and eddy
current heating as alternative
options
Phase 1 -
Feasibility
Goals:
•Practical verification of
hysteresis heating
•Material selection
•Parameter investigation
Actions:
•Breadboard testing of
various materials (Fe3O4 and
ZnFe2O4, 2x Ferrofluids)
•Testing parameter influences
(Frequency, field strength,
material mass)
•Initial thermal modelling
•Initial magnetic modelling
Effect of insulation (thermal &
electrical)
Results:
•First characterisation of
frequency, field strength and
mass effects
•Steady Sate and Transient
Thermal model
•Magnetic model
•Hysteresis heating achieved
(Fe3O4 and Ferrofluid show
potential, but efficiencies are
too low
• Refocus on Joule heating
with temperature sensing
Phase 2 –
Technology
breadboarding
Goals: (Current Phase)
•Ablation of tissue
•Temperature control
•Initial implant design
•Initial applicator design
•Formal risk assessment
Actions:
•Breadboard testing of
various implant designs and
temperature sensing
technologies (Bi-Metal switch,
PTC, Polyswitch, Digital
Thermostat...)
Results:
•Heating efficiency of Joule
heating is much higher
•Ablation of tissue samples
(pig heart vessels) achieved
•Temperature control
achieved in lab environment
• Implant design iterated
• Applicator concepts created
• Risk File
Phase 3 –
System
Breadboarding
Goals:
• Use all data and information
to build a demonstrator
• “Looks like real” – A
dimensionally correct model
to get the look and feel of the
final product
• “Works like real” – A fully
functional system model for
performing tests
Actions:
• Detailed system design of
equipment and implant
• Assembly of demonstrator
• Test campaign with
demonstrator
• Quality assurance
options
Phase 4 –
Demonstrator
Go/no-go
Goals:
• Use all data and information
to build a prototype
• Prototype to perform
ablations during clinical trials
•Application ideation
Actions:
• Detailed design of
equipment and implant
• Manufacture and assembly
of prototype
• Clinical trials with prototype
• Quality assurance
Phase 5 –
Detailed Design,
Prototype &
Clinical Trials
Go/no-go
Goals:
• Final design for production
• Production of first series
• Batch production
Actions:
•Detailed design of equipment
and implant taking into
account manufacturing
methods, materials and costs
• Manufacture and assembly of
product
• Quality assurance
Phase 6 –
Production
Go/no-go
Go/no-go
Proposal
Achieved
Confidential
21. BrainstormonImplantApplication Material on Implant
•How do we get the
active material in/on the
implant
Reduce Blood Cooling
Effect
•Difficult to control factor
is blood cooling of the
implant and active zone,
how can this be reduced
Other Foldable or
Flexible Mechanisms
•Are there other ways to
place the material apart
from or connected to a
stent
Out There
•Parking area for
miscellaneous and far
out of the box ideas
Confidential
23