Infectious Diseases visual_po_transition_122123.pptx

1. Transitioning patients from
IV to PO by day 7 was
highly variable by hospital
(25.8 - 65.9%)
Severity of illness
Comorbidities
Immunosuppression
ICU admission
Fever/hypotension as of day 5
SUMMARY:
Opportunities exist for earlier and more frequent transition to oral antibiotic therapy.
Source control w/i 7 days
Maintained on IV
therapy:
JAMA Netw Open. Published January 02, 2024.
doi:10.1001/jamanetworkopen.2023.49864
Most Commonly Prescribed Oral Antibiotic (%)
Transition to Oral Antibiotic Therapy for Gram-Negative Bloodstream
Infections
STUDY DESIGN:
Retrospective cohort study of 4581 gram-negative bloodstream infection (GN-BSI) episodes from hospitalized adults collected from 1/1/2019 to
12/31/2019.
Day 2 Day 5 Day 7
Median day of source
control in patients with
successful source control
by day 7
43% transitioned to
oral antibiotics
89.7% of patients
clinically stable
Median day of oral
transition
*Few patients received ≥1
antibiotic
62.2
28.3
11.5
0.9
Fluoroquinolones
Beta-lactams
TMP-SMX
Other