An infectious disease is caused by pathogenic microorganisms entering the body and reproducing, potentially leading to infection and disease. Microbes cause disease via production of toxins, direct invasion, or triggering immune responses. Infections progress through incubation, prodromal, clinical, and decline phases. Diseases are classified as acute, chronic, or latent based on duration and as local or systemic based on location. Primary infections occur in healthy individuals, while secondary infections impact weakened individuals already suffering from a primary infection. Infectious diseases spread through air, water, body fluids, contaminated objects, and vectors.