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Infant of diabetic
mother
1810
insights
Introduction
Pathophysiology
Complications
Management
12/08/2021 Infant of diabetic mother 2
Introduction
An infant that was born to a mother who
persistently had high glucose blood levels
during pregnancy.
3
 abnormal glucose control of
pregnancy
 Mothers with preexisting diabetes
12/08/2021 4
pathophysiology
Fetus
exposed
to high
blood
glucose
from
mother
Beta cell
hyperplasi
a in fetus
Increased
insulin
Fetal
hypogl
ycemia
MACROSOMIA
Diabetic
mother
Vasculopa
thy in
placental
vessels
Decreased
circulation
and
nutrition to
fetus
IUGR
Complications
5
• Macrosomia
• Hypoglycemia
• Hypocalcemia
• Hypomagnesemia
• Respiratory distress syndrome
• Hypoxia → Polycythemia → Thrombotic episodes
• Jaundice
• Decreased Iron
Congenital anomalies
Cardiovascular
system (most commonly
affected)
Ventricular septal defects (most
common)
Hypertrophic obstructive
cardiomyopathy or asymmetrical
septal hypertrophy (more specific for
IDM)
Transposition of great vessels
Other anomalies
• Sacral agenesis → caudal agenesis
syndrome (most specific for IDM)
• Anencephaly
• Spina bifida
• Lazy left colon syndrome→Appears as
pseudo obstruction
• Neural tube defects
6
Management in neonate
Investigations
•Blood sugar level monitoring (first 48 hours)
•CBC
•CXR
•Serum bilirubin, calcium, magnesium
•Vertebral radiography
•Barium enema
12/08/2021 7
AIIMS NICU Protocol for management of
neonatal hypoglycemia
12/08/2021 8
Symptomatic Asymptomatic
10% dextrose bolus
2ml/kg
Blood glucose level
<20mg/dl
Blood glucose level
20-45mg/dl
Glucose drip
Glucose Infusion rate 6mg/kg/min
• Breast feeds
• Reassess after
one hour
If no response – increase glucose infusion rate to
12mg/kg/min
If still no response – IM glucagon or diazoxide
The way to get started is
to quit
talking and begin doing.
9
Walt Disney
Thank you

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Infant of diabetic mother