HISTORY OF IVF ( IN-VITRO FERTILIZATION)

1. HISTORY OF IVF

2. HISTORY OF IVF (IN VITRO FERTILIZTION)
Introduction
what is IVF(In vitro fertilization)
Historical Background
1800(19th centuary)
1900 (20th centuary)
2000 (21th centuary)
IVF birth in world : 1978 to 2019

3. INTRODUCTION
- The early attribution of infertility to women persisted for
centuries and was often considered a divine punishment
- the only solution to infertility was prayer - to egyptian Isis,
phoenician astarte, Greek aphrodite or Roman venus
- first written documentation on infertility may be found in the
kanhoun papyrus ( oldest Egyptian medical text ), dated to 2200-
1950BC

4. what is IVF ( In-vitro fertilization )
- IVF is a process by which an egg is fertilized by sperm outside the
body: in vitro
- The term in vitro, From the latin meaning in glass, is used .as early
biological experiments involving cultivation to tissues outside the living
organism were carried out in glass containers such as beaker, test
tubes, or petri dishes.
- A colloquial term babies conceived as the result of ivf, is testtube
babies.

5. HISTORY OF IVF
-1890 : ENGLAND ( walter heape) cambridge university : reported the first known case
of embryo transplantation in rabbit.
1900 : early 1900’s much reaserch was done on hormone and how they related to
fertility.
-1932:brave new world ( novel ) published by aldous huxley, hyxley restrically
described the techniques of ivf as we know it.
1934 : gregory pincus performed IVF- lie reaserch on rabbits but was fired from
Harvaed due to his controversial research.

6. HISTORY OF IVF
- 1935 pincus and enzmann have started onestep earlier with the rabbit, isolation an ovum,
fertilizing it in a doe other than the one which furnished the oocyte and have thus
successfully inaugurated pregnancy in the unmated animal.
-1948 : miriam menken and john rock retrieved more than 800 oocytes from woman during
operations for various conditions. 138 of these oocytes werer exposed to spermatozoa in-
vitro.
- 1959: m.c chang sucessfully conducated IVF in rabbits

7. HISTORY OF IVF
-- 1961 : palmer from france described the first retrieval of oocytes by laproscoopy.
- 1965 : robert edward toghether with georgeanna and howard jones at johns hopkins hospital in
the USA attempted to fetrilized human oocytes in vitro.
-1973 : The first ivf pregnancy was reported by the Monash research team of professor carl wood
and john leeton in melbourne, australia. unfortunately, this resulted in early miscarriage.
1975: steptoe and edward published a report on an ectopic pregnancy following transfer of a human
embryo at the late morulae and early balstocyst stage.
1976 : Y. Menezo developed the worlds first B2 culture medium, known as the french medium. this
speciefic medium reflected the follicular, tubal and uterine enviroments of the sheep, rabbits, and
humans.

8. world first test tube baby birth
- 25 JULY 1978 The first ever IVF birth ( louise Brown) occured in oldham, england . this
birth was the result of the collaborative work of patrick steptoe and robert edwards
-3 OCTOMBER 1978 : THE FIRST INDIAN TEST TUBE BABY and world second one is
KANUPRIYA AGRWAL.(DURGA , kolkatta WEST BENGAL) - Dr. Subash Mukhopadyaya
- however, state authorities prevented him from presenting his work at scientific
conferences and, in the absence of scientific evidence, his work is not recognised by the
international scientific community.

9. HISTORY OF IVF
1979 : The first published use of ultrasound to identify growing follicles
1981 : ELIZABETH CARR, FIRST IVF BABY IN U.S.
1982 : the first french ivf birth occured in clamart, france by the group of
frydman and testart.
1982 : Birth of the first Austrian “ test tube baby” ( Twin Pregnacy)
1983 : monash ivf team reported on the birth of the first frozen embryo baby.
1983: first pregnancy after oocyte donation
1983 : first successful delivery following egg donation

10. HISTORY OF IVF
-1983: the first report on human pregnancy following cryopreservation, thawing and
transfer of an eight- cell embryo.
1983 : world’s first IVF triplet rerported by christopher Chen.
1984 : first surrogacy embryo transfer baby born in california
1985 : first report of the use of abdominal ultrasound guidence for embryo transfer

11. IVF BIRTH IN WORLD:1987 TO 2019
- IVF is available as a successful treatment for infertility almost all over the world.
- over 8 Million ivf children have been born and over 2.5 million cycles are being
performed every year, resulting in over 500,000 deliveries annually.