The economic crisis may negatively impact HIV in developing countries in three main ways: 1) Donor countries may find it difficult to meet ODA commitments due to increased fiscal deficits from economic recovery packages and decreased tax revenues. 2) Developing countries will face more challenging economic conditions with weak social protections and inability to finance countercyclical spending. 3) Vulnerable populations are most at risk, with potential risks including interruption of HIV treatment, increased high-risk behaviors, and pressure on health systems.