Tool Box - Preclinical To Clinical Translation More details can be found on: http://www.clinical-translation.de/web Innovative methods and technologies for enhanced imaging, modelling and predictive toxicology Preclinical to Clinical Translation - New findings on effective and safe transition from the preclinical to the clinical phase! New efforts are needed to improve the ensemble of methods for ensuring safety and efficacy and increasing the chances of R & D to culminate in a marketable drug. And performing quality preclinical investigation is a prerequisite for reaching a decision whether to move forward towards the first-in-man study and enter phase ‘0’ of the clinical trial or not. Der Übergang von der präklinischen zur klinischen Phase ist der entscheidende Zeitpunkt im Verlauf der Drug-Discovery. Denn noch immer scheitern 80 % der Versuche, ein Medikament zu first-in-man-studies voranzubringen. Daher wird sich die Konferenz sowohl auf diese Problematik als auch auf die vorhandenen Lösungenen im Markt konzentrieren. So wird den Teilnehmern ein breites Spektrum von Voträgen geboten, ausgehend von Einsatz innovativer Technologien im Bereich Imaging und Modelling bis hin zum intelligenten Daten Management. Entdecken Sie gemeinsam mit marktführenden Pharmaunternehmen das ideale „Werkzeug“ für erfolgsversprechende Translation! Weiteres finden Sie auf: http://www.clinical-translation.de/web Keywords: drug discovery, clinical trial, PBPK, PK/PD, toxicology, preclinical, clinical, translation, research, trial

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Translational Research
Reaching Accurate Stop/Go Decisions – Imaging Biomarkers –
Successfully Applying Predictive Tools
28 – 30 November 2011 | Dorint Hotel, Potsdam, Germany
• Better plan your proof-of-concept for a successful translation by learning more
Meet the following specialists:
on the latest and most innovative methods of imaging biomarkers
• Dr. Richard Luke, Principal Scientist,
Astrazeneca • Learn more about the latest imaging techniques for monitoring disease
• Dr. Michael Merz, Director Clinical progression by strategically applying and combining FLT/FDG-PET and MRI
Research,
Novartis International AG • Optimize your ROI by designing an adaptive clinical trial and by performing an
• Dr. Heiko G. Niessen, Clinical attrition analysis in the early stages
Imaging, Global Department of
Translational Medicine,
• Improve the integration of predictive measures into your trial design by
Boehringer Ingelheim Pharma identifying and avoiding toxicological risks
GmbH & Co. KG
• Gain new ideas about how to standardize translational methods and develop
• Prof. Stephen Williams, Imaging
your own translational “tool box”
Science and Biomedical Engineering
University of Manchester
• Prof. Martin Wehling, Managing Highlight Speakers:
Director,
Institute for Experimental & Clinical Professor Martin Wehling, Dr. Detlef Stiller, Head of
Pharmacology University of Managing Director, Institute for in-vivo Imaging lab, Target
Heidelberg experimental & Clinical Phar- Discovery Research,
• Dr. Jörg König, Laboratory Head, macology, Boehringer Ingelheim
Institute of Experimental and University of Heidelberg Pharma, GmbH & CO.KG
Clinical Pharmacology and Clinical
Toxicology,
Friedrich-Alexander-University Join our informative evening workshops:
Erlangen-Nürnberg
• Dr. Kaye Williams, Group A | Magnetic resonance neuro-imaging as a translational tool in
Leader Hypoxia and Therapeutics, drug discovery
University of Manchester
• Dr. Detlef Stiller, Head of In-Vivo-
B | Preclinical-to-clinical and in vitro-to-in vivo translation of trans-
Imaging, Target Discovery Research, port-mediated/limited drug absorption, distribution and excretion
Boehringer Ingelheim Pharma, C | Single and multiple-transfected cell lines for the analysis
GmbH & CO.KG of transporter-mediated drug-drug interactions
• Dr. Stefanie Reif, Modelling & D | Interactive graphical exploration of safety data –
Simulation Senior Expert,
enhancing signal detection and understanding
Bayer Pharma AG
• Dr. Clemens Günther, Director,
Researched and Supported by
Head of Global Preclinical developed by
Development,
Intendis GmbH
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• Dr. Maciej J. Zamek-Gliszczynski, Media Partners
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To Register | T +49 (0)30 20 91 33 30 | F +49 (0)30 20 91 32 10 | E info@iqpc.de | www.clinical-translation.de/web

2. Imaging & Modelling Sponsorship
for Optimized We have a variety of packages available to suit your requirements.
For all Sponsorship and Exhibition opportunities call Florian Wallner:
Translational Research +49 (0)30 20 91 32 75 or email florian.wallner@iqpc.de.
28 – 30 November 2011 | Dorint Hotel, Potsdam, Germany
Who will you meet?
By joining the conference you will learn how to ...
International pharmaceutical
• Strategically apply the latest imaging techniques for monitoring disease progression and biotech companies
and combining such as FLT/FDG-PET and MRI Job function:
• Directors
• Improve the integration of predictive measures into your trial design by identi- • Managers
• Global Heads
fying and avoiding toxicological risks according to lessons-learnt in AstraZeneca • Senior scientists
• Researchers
• Optimize your ROI, save time and money and avoid high attrition rates by better
Departments:
designing your preclinical studies • Translational Research
• DMPK
• Improve your proof-of-concept by learning more about the latest and most • PKPD
innovative methods of imaging biomarkers • ADME
• Biomarker Research
• Toxicity
• Successfully plan physiologically-based PK models and technologies, considerably • Safety
enhancing your prediction, by understanding better the pros and cons of different • Modelling
• Imaging
modelling techniques
Industries:
Do not miss the opportunity to network, brainstorm and learn more! Pharma
Biotech
“Translational medicine is still in its infancy, and needs careful development both as a CRO's
generic science and in concrete projects. Professional conferences are a great way to spur a
constructive discussion on the way to finding a sustainable translational tool box” Translational Research Tool
Conference Chairman: Prof. Martin Wehling, Managing Director, Manufacturer
Institute for Experimental & Clinical Pharmacology, University of Heidelberg
Solution Provider for Screening
Systems, Imaging Systems,
Modelling Technologies, Testing
Others
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We encourage your feedback and participation, for all comments or enquiries please contact us on For further information
+49 (0)30 20 91 32 74 or eq@iqpc.de.
please visit our website
www.clinical-translation.de/
Get free white papers, articles and much more! web or contact us on
www.clinical-translation.de/web +49 (0)30 20 91 32 74 or email
eq@iqpc.de.
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To Register | T +49 (0)30 20 91 33 30 | F +49 (0)30 20 91 32 10 | E info@iqpc.de | www.clinical-translation.de/web