This document provides an overview and agenda for the iHT2 2013 Health IT Summit opening keynote. The keynote covers the impact of meaningful use on health IT and driving better healthcare, better health, and reduced costs. It also discusses innovation and transformation in health IT, including increasing venture capital funding and the growing size of the health IT industry. The keynote then focuses on the Sharp health system's journey in developing population health strategies and using technologies like their patient portal and health information exchange. It closes by emphasizing that health reform has catalyzed the need for care models that demand health IT and technology.