Introduction about hydrogel durg delivery system, with design criteria and techniques, mechanism, application, current tends. How it's mechanism work in controlled drug delivery system.

1. By Bushra Siddiqui
M.pharm 1st year
IIMT COLLEGE OF PHARMACY
Hydrogel-Based
Controlled Drug
Delivery system

2. Contents
Introduction
1.
Hydrogel design criteria
2.
techniques for Crosslinking in hydrogel design
3.
Process of Physical Crosslinking
4.
Process of Crosslinking via hydrogen bonds
5.
Mechanism of drug release from hydrogel matrix
6.
Controlled diffusion
7.
Controlled swelling
8.
Hydrogel application
9.
Hydrogel uses in Gynecology
10.
Current trends of hydrogel
11.
Conclusion
12.

3. Introduction
Hydrogels are 3-dimensional polymer matrices which are crosslinked
and have a strong propensity to absorb water.
They do not dissolve in water and under physiological circumstances,
they swell without deforming their Hydrophilic network.
It must be supplied as films, beads, microparticles, nanoparticlesand
among other forms.
Used in experimental medicine and clinical practice, separation of
biomolecules, cellular immobilization, tissue engineering,
regeneration and diagnostic.

4. Hydrogel design criteria
Hydrogel production and
drug loading design
requirement must be
assessed, by formation of
network and choice of
material.
Choosing right material
and procedure is
essential.
Diffusion of drug is
controlled by
Molecular size
crosslinking density
kind of polymer network

5. Techniques for
crosslinking in
hydrogel
design
Used to create hydrogel in categories
such as:
1. Physical
2. Chemical
3. Via hydrogen bonding

6. Process of Physical Crosslinking
Heating/ Cooling polymeric
mixture
Through Iconic contact
Crosslinking
Intricate aggravation /
Complex coacervation
1.
2.
3.

7. Process of Crosslinking via hydrogen bonds
Crosslinking using graft and
block Copolymers
Freeze-thaw technique
Via electrostatic absorption
and chelation
1.
2.
3.

8. Mechanism of drug
release from
hydrogel matrix
When hydrophillic polymer is used in the
system the release pattern is quit different
then, when when hydrophobic polymer
used.
Have three fundamental process:-
1. Controlled diffusion
2. Controlled swelling
3. Martix drug release

9. Process where molecules move from high
concentration to low concentration through
hydrogel as medium.
Controlled
diffusion
Often exhibits in sustained and
controlled profile.
Used for designing drug delivery for
optimal therapeutic outcome.
Mechanism

10. Controlled
swelling
Involves the absorption of water by hydrogel
matrices, influencing drug release by modulating
matrix structure.
Mechanism
It results in sustained drug release.
It is utilized in pharmaceutical research.

11. Hydrogel
application
Hydrogels in treatment of cancer.
Hydrogels for distribution to the
eyes.
Hydrogels for long term protein
and DNA delivery.
Colic medication delivery using
hydrogels.
Hydrogels for topical medication
administration.

12. FOR
CONTRACEPTION
FOR ENGINEERING
OF VAGINAL
TISSUE
BREAST IMPLANT
HYDROGELS
FOR TREATMENT
OF WOUNDS
FOR REGULATED
ADMINISTRATION
FOR ORAL
ADMINISTRATION
Hydrogel uses
Hydrogel uses
in Gynecology
in Gynecology

13. HYDROGEL BASED
FLEXIBLE
ELECTRONICS
DEVELOPMENT OF
THERMOSENSITIVE HYDROGEL
BASED ON POLAXAMER 407
AND GELLAN GUM WITH
INCLUSION COMPLEXES
INJECTABLE HYDROGEL BASED
ON HYALURONIC ACID
PREPARED BY SCHIFF BASE
FOR LONG TERM CONTROLLED
DRUG RELEASE
PH-SENSITIVE HYDROGEL
BASED ON
CARBOXYMETHYLATED
KONJACGLUCOMANNAN

14. Conclusion
It made in understanding hydrogel matrices for the encapsulation
and targeted delivery of various therapeutic agents.
acids, hydrogel offers a versatile platform which enables protection
against degradation and controlled release kinetics.
Exploration of nanotechnology and smart polymer in conjunction
with hydrogel.
Demonstrating synergistic effect.
1.
Facilitation enhanced drug loading capacity
2.

15. Thank you!