The document discusses reimagining scientific communication by making all components of data-intensive projects like genomic analysis openly accessible on the web through RESTful APIs. This would allow others to reproduce an entire analytical environment by accessing the underlying code, data, software and hardware from a narrative that interweaves scientific assertions with the executable evidence. The goal is to create "clear Science" that transparently shows the support behind scientific claims.
Designing a Mobile Experience for Breast Cancer SurvivorsDerekOlson
This presentation was originally given at UPA 2012.
Description:
A case study detailing mobile usability testing methods, development of a controlled vocabulary, and delivery of personalized medical content
This 3-year project for Breastcancer.org set out to deliver personalized web content to breast cancer patients on their mobile devices. User research highlighted a critical challenge associated with capturing accurate diagnosis information from patients. The case study will include two unexpected but effective solutions to this problem.
Breast cancer what type are you at risk forBruce L Bair
Breast cancer comes in types, receptor positive or negative and genetic associated or not. Learn how to talk about it and then use your knowledge to have a great discussion with your doctor.
- Were you diagnosed with colon or rectal cancer before the age of 50?
- Was anyone in your family diagnosed with colon cancer before the age of 50?
- Was anyone in your family diagnosed with uterine (endometrial) cancer before the age of 50?
- Are there cancers across several generations on one side of your family?
If you answered YES to just one of these questions, it's time to talk turkey about Lynch syndrome.
Lynch syndrome is an inherited genetic mutation, and having it increases your chance of getting colorectal cancer to 80%. Unfortunately, nearly every person living with Lynch syndrome is completely unaware of it.
Lynch syndrome also puts you at higher risk for brain, breast, kidney, melanoma, ovarian, pancreas, small bowel, stomach, or uterine/endometrial cancers. Knowledge is power and will help your medical team act more aggressively with their screening measures.
Brian Mansfield, a music critic for USA Today, didn't know he had Lynch syndrome until he was diagnosed with colorectal cancer earlier this year at the age of 48. After his diagnosis, he began talking with his family about their health history, "then the family tree lit up like a Christmas tree." Brian is chronicling his journey through a weekly USA Today online column, "My Semicolon Life."
Join national patient advocacy group Fight Colorectal Cancer as we host Brian and his doctor, Dr. Bill Harb, a colorectal surgeon at Cumberland Surgical Associates, along with Associate Director of Human Genetics at Ohio State University Heather Hampel as they tell you more about Lynch syndrome and how to dig into the medical mystery that may be lurking within your family tree. With the holidays coming up, never has there been a more appropriate time to talk turkey...and Lynch syndrome.
**Fight Colorectal Cancer thanks Can't Stomach Cancer, the Colon Club, Kidney Cancer Association, Myriad Genetics, and Ovarian Cancer National Alliance for their assistance with this webinar.**
#pinktober-#breast cancer awarness campaign #NBCAMDrDarshna Pandya
breast cancer awarness campaign from basics of breast cancer-right from ZERO TO SHE-RO
our social philanthropic activity for betterment of women,to make them aware against deadly diseases-------BREASTCANCER. We teach them when and how to do self examination of breast.we try to allviate fear of chemotherapy and radiotherapy and precautions to be taken during tretment.
Designing a Mobile Experience for Breast Cancer SurvivorsDerekOlson
This presentation was originally given at UPA 2012.
Description:
A case study detailing mobile usability testing methods, development of a controlled vocabulary, and delivery of personalized medical content
This 3-year project for Breastcancer.org set out to deliver personalized web content to breast cancer patients on their mobile devices. User research highlighted a critical challenge associated with capturing accurate diagnosis information from patients. The case study will include two unexpected but effective solutions to this problem.
Breast cancer what type are you at risk forBruce L Bair
Breast cancer comes in types, receptor positive or negative and genetic associated or not. Learn how to talk about it and then use your knowledge to have a great discussion with your doctor.
- Were you diagnosed with colon or rectal cancer before the age of 50?
- Was anyone in your family diagnosed with colon cancer before the age of 50?
- Was anyone in your family diagnosed with uterine (endometrial) cancer before the age of 50?
- Are there cancers across several generations on one side of your family?
If you answered YES to just one of these questions, it's time to talk turkey about Lynch syndrome.
Lynch syndrome is an inherited genetic mutation, and having it increases your chance of getting colorectal cancer to 80%. Unfortunately, nearly every person living with Lynch syndrome is completely unaware of it.
Lynch syndrome also puts you at higher risk for brain, breast, kidney, melanoma, ovarian, pancreas, small bowel, stomach, or uterine/endometrial cancers. Knowledge is power and will help your medical team act more aggressively with their screening measures.
Brian Mansfield, a music critic for USA Today, didn't know he had Lynch syndrome until he was diagnosed with colorectal cancer earlier this year at the age of 48. After his diagnosis, he began talking with his family about their health history, "then the family tree lit up like a Christmas tree." Brian is chronicling his journey through a weekly USA Today online column, "My Semicolon Life."
Join national patient advocacy group Fight Colorectal Cancer as we host Brian and his doctor, Dr. Bill Harb, a colorectal surgeon at Cumberland Surgical Associates, along with Associate Director of Human Genetics at Ohio State University Heather Hampel as they tell you more about Lynch syndrome and how to dig into the medical mystery that may be lurking within your family tree. With the holidays coming up, never has there been a more appropriate time to talk turkey...and Lynch syndrome.
**Fight Colorectal Cancer thanks Can't Stomach Cancer, the Colon Club, Kidney Cancer Association, Myriad Genetics, and Ovarian Cancer National Alliance for their assistance with this webinar.**
#pinktober-#breast cancer awarness campaign #NBCAMDrDarshna Pandya
breast cancer awarness campaign from basics of breast cancer-right from ZERO TO SHE-RO
our social philanthropic activity for betterment of women,to make them aware against deadly diseases-------BREASTCANCER. We teach them when and how to do self examination of breast.we try to allviate fear of chemotherapy and radiotherapy and precautions to be taken during tretment.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
1. clear Science
dragging scientific communication into
the information age
erich s. huang, md/phd
director, cancer research
sage bionetworks
erich.huang@sagebase.org
@erichhuang
3. Betty Jones
“I have a lump near my mastectomy scar”
4. Betty Jones
menopause
~50 years
“high risk” breast cancer “normal risk” breast cancer
5. Betty Jones
menopause
36 years ~50 years
“high risk” breast cancer “normal risk” breast cancer
6. Betty Jones
African American Population Non-African American Population
16%
39%
61%
84%
Triple Negative Breast Cancer Triple Negative Breast Cancer
All Other Types All Other Types
http://jama.jamanetwork.com/article.aspx?articleid=202952
7. her2
receptor
progesterone
receptor
estrogen
receptor
breast cancer cell
depends on receptor-driven
growth signals
8. her2
receptor
progesterone
receptor
estrogen
receptor
breast cancer cell
depends on receptor-driven
growth signals
9. her2
receptor
progesterone
receptor
LS
estrogen
NA
receptor
S IG
T H
OW
G R
breast cancer cell
depends on receptor-driven
growth signals
11. “triple negative” breast cancer
breast cancer cell
growth signals become
independent of receptors
12. “triple negative” breast cancer
the receptors are no longer present on the
cell surface...
breast cancer cell
growth signals become
independent of receptors
13. “triple negative” breast cancer
the receptors are no longer present on the
cell surface...
but the intracellular signals persist
breast cancer cell
growth signals become
independent of receptors
14. “triple negative” breast cancer
the receptors are no longer present on the
cell surface...
but the intracellular signals persist
T
N S
E L
D A
N N
E IG
EP S
D H
IN T
OW
G R
breast cancer cell
growth signals become
independent of receptors
21. radiotherapy 3d planning
http://radonc.ucsf.edu/patient_information/breast/images/Radiation_Oncology_breast_img_2.jpg
22. Betty Jones
“I have a lump near my mastectomy scar”
23. Betty Jones
Triple negative breast cancer.
What are the options?
24. Betty Jones
Triple negative breast cancer.
What are the options?
Standard Stuff (Old Fashioned Targets)
Anthracyclines
Taxanes
Anti-Metabolites
25. Betty Jones
Triple negative breast cancer.
What are the options?
Standard Stuff (Old Fashioned Targets)
Anthracyclines
Taxanes
Anti-Metabolites
Platinum Agents
26. Betty Jones
Triple negative breast cancer.
What are the options?
{
Standard Stuff (Old Fashioned Targets)
Anthracyclines
conventional Taxanes
chemotherapy Anti-Metabolites
Platinum Agents
27. Betty Jones
Triple negative breast cancer.
What are the options?
{
Standard Stuff (Old Fashioned Targets)
Anthracyclines
conventional Taxanes
chemotherapy Anti-Metabolites
Platinum Agents
Targeted Agents
Cetuximab + Platinum (BALI-1)
Bevacizumab (GeparQuinto)
PARP Inhibitors
SRC Inhibitors
HDAC Inhibitors (ER-alpha)
28. Betty Jones
Triple negative breast cancer.
What are the options?
{
Standard Stuff (Old Fashioned Targets)
Anthracyclines
conventional Taxanes
chemotherapy Anti-Metabolites
Platinum Agents
{
Targeted Agents
Cetuximab + Platinum (BALI-1)
Bevacizumab (GeparQuinto)
new therapies PARP Inhibitors
SRC Inhibitors
HDAC Inhibitors (ER-alpha)
29. Betty Jones
Triple negative breast cancer.
What are the options?
{
Standard Stuff (Old Fashioned Targets)
Anthracyclines
conventional Taxanes
chemotherapy Anti-Metabolites
CURRENT KNOWLEDGE:
Platinum Agents
ALL THESE THERAPIES
{
Targeted Agents
ARE A Platinum (BALI-1)
Cetuximab + WASH
Bevacizumab (GeparQuinto)
new therapies PARP Inhibitors
SRC Inhibitors
HDAC Inhibitors (ER-alpha)
63. the status quo can reproduce
tolerates poor partially
communication
of findings
6%
can reproduce
from processed
data w/ 21%
discrepancies
54%
can reproduce w/ 8% cannot
discrepancies reproduce
11%
can reproduce in
principle
65. so what’s in
principle
208,294,724
reproducible, is not
datapoints practically
reproducible
124 pages
supplemental material
? lines
unobtainable source
code
? version or
architecture of R
? R packages
key R package
“ClaNC”
no longer
available
442 citations
69. THE SCIENTIFIC PROCESS:
it’s not one and done...
define a question form a hypothesis
gather information experimentally test
your hypothesis
70. THE SCIENTIFIC PROCESS:
it’s not one and done...
analyze
define a question form a hypothesis experimental data
gather information experimentally test
your hypothesis
71. THE SCIENTIFIC PROCESS:
it’s not one and done...
analyze
define a question form a hypothesis experimental data
gather information experimentally test draw conclusions
your hypothesis
72. THE SCIENTIFIC PROCESS:
it’s not one and done...
analyze
define a question form a hypothesis experimental data report, i.e. “publish”
gather information experimentally test draw conclusions
your hypothesis
73. THE SCIENTIFIC PROCESS:
it’s not one and done...
analyze
define a question form a hypothesis experimental data report, i.e. “publish”
gather information experimentally test draw conclusions
your hypothesis
validation by the scientific community
validation by clinical trials
79. store on local
generate data server
@ the bench or
from a clinical cohort
analyze on local
machine
80. store on local
generate data server
@ the bench or
from a clinical cohort
analyze on local
machine
81. store on local
generate data server
@ the bench or
from a clinical cohort
analyze on local
machine
write a
document
82. store on local
generate data server
@ the bench or
from a clinical cohort
analyze on local
machine
write a
document
al
to journ
su bmit
83. store on local
generate data server
@ the bench or
from a clinical cohort
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
84. store on local
generate data server
@ the bench or
from a clinical cohort
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
85. store on local
generate data server
@ the bench or
from a clinical cohort
accepted
& digitally
typeset
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
86. printed
on paper
store on local
generate data server
@ the bench or
from a clinical cohort
accepted
& digitally
typeset
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
87. printed
on paper
store on local
generate data server
@ the bench or
from a clinical cohort static html
representation
accepted
& digitally
typeset
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
88. printed
on paper
store on local
generate data server
@ the bench or
from a clinical cohort static html
representation
accepted
& digitally
typeset
static pdf
representation
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
89. printed
on paper
store on local
generate data server
@ the bench or
from a clinical cohort static html
representation
accepted
& digitally
typeset
static pdf
representation
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
90. printed
on paper
store on local
generate data server
@ the bench or
from a clinical cohort static html
representation
THE ACTUAL SCIENCE accepted
& digitally
typeset
static pdf
representation
analyze on local
machine
sent to
write a reviewers
document as pdf
al
to journ
su bmit
91. printed
on paper
store on local
generate data server
@ the bench or
from a clinical cohort static html
representation
THE ACTUAL SCIENCE accepted
& digitally
typeset
static pdf
representation
analyze on local
machine
SCIENTIFIC CLAIMS
sent to
write a reviewers
document as pdf
al
to journ
su bmit
92. store on local
generate data server
@ the bench or
from a clinical cohort
THE ACTUAL SCIENCE
analyze on local
machine
93. store on local
generate data server
@ the bench or
from a clinical cohort
THE ACTUAL SCIENCE
analyze on local
machine
99. clear Science
1. re-imagine scientific communication
2. make every component of a data-intensive project
(e.g. genomic analysis) web accessible
100. clear Science
1. re-imagine scientific communication
2. make every component of a data-intensive project
(e.g. genomic analysis) web accessible
3. allow consumption of content at a variety of levels
of complexity and abstraction
4. leverage open, RESTful APIs
109. code
data
software
hardware
clear Science
a narrative that coherently interweaves
scientific assertions with the executable data,
code, software & hardware that support them
113. “ If I have seen further it is by standing on the shoulders
of giants. ”
114. Betty Jones
“I have a lump near my mastectomy scar”
115.
116. brian bot
stephen friend
josh greenberg david burdick
mike kellen
external partners
myles axton ian mulvaney kelly lamarco
editor head of technology senior editor
nature genetics •
science trans. medicine
mark patterson
managing exec. editor
phil bourne eLife sciences eric schadt
founding editor-in-chief dir. inst. for genomics &
plos comp. biology multiscale biology
mt. sinai school of med.
117. brian bot
stephen friend
josh greenberg david burdick
mike kellen
our patients
external partners
myles axton ian mulvaney kelly lamarco
editor head of technology senior editor
nature genetics •
science trans. medicine
mark patterson
managing exec. editor
phil bourne eLife sciences eric schadt
founding editor-in-chief dir. inst. for genomics &
plos comp. biology multiscale biology
mt. sinai school of med.