The document summarizes research on the artificial urinary sphincter (AS) for treating urinary incontinence following prostatectomy. It finds that while AS has success rates of around 79% and patient satisfaction, the evidence is limited as only one randomized controlled trial exists. Systematic reviews call for more studies directly comparing AS to other surgical therapies. Health technology assessments in Brazil did not recommend AS for public insurance due to low evidence, but private insurance does cover it. More high-quality research is needed to determine the effectiveness and costs of AS versus other options.
IMPACT OF HEALTH INFORMATICS TECHNOLOGY ON THE IMPLEMENTATION OF A MODIFIED E...hiij
The Modified Early Warning System (MEWS) is based on a patient score that helps the medical team monitor patients to identify a patient that may be experiencing a sudden decline in care. This study consists of a detailed review of clinical data and patient outcomes to assess impact of technology and patient care.There are a total of thirteen hospitals included in this review. These facilities have implemented vitals capture and the MEWS scoring system.
s it all in the Wrist? The Potential of Activity Trackers to Rise Physical Ac...CrimsonpublishersCancer
A growing body of evidence suggests that higher levels of physical activity are inversely associated with treatment side-effects and mortality in cancer survivors. Conversely, a limited percentage of cancer patients achieve physical activity goals and fitness compared with age-matched peers or other chronic medical conditions. In the last years, the next generation of activity trackers has integrated several parameters of physical fitness and mobility measurements. These multi-task devices go beyond objective physical activity measurements. Due to its functioning based on integrated platforms, clinicians may experience a unique opportunity to incorporate more active behaviors into their patients’ lives. This mini-review will discuss the advantages, challenges and future directions of most recent activity trackers in oncology.
IMPACT OF HEALTH INFORMATICS TECHNOLOGY ON THE IMPLEMENTATION OF A MODIFIED E...hiij
The Modified Early Warning System (MEWS) is based on a patient score that helps the medical team monitor patients to identify a patient that may be experiencing a sudden decline in care. This study consists of a detailed review of clinical data and patient outcomes to assess impact of technology and patient care.There are a total of thirteen hospitals included in this review. These facilities have implemented vitals capture and the MEWS scoring system.
s it all in the Wrist? The Potential of Activity Trackers to Rise Physical Ac...CrimsonpublishersCancer
A growing body of evidence suggests that higher levels of physical activity are inversely associated with treatment side-effects and mortality in cancer survivors. Conversely, a limited percentage of cancer patients achieve physical activity goals and fitness compared with age-matched peers or other chronic medical conditions. In the last years, the next generation of activity trackers has integrated several parameters of physical fitness and mobility measurements. These multi-task devices go beyond objective physical activity measurements. Due to its functioning based on integrated platforms, clinicians may experience a unique opportunity to incorporate more active behaviors into their patients’ lives. This mini-review will discuss the advantages, challenges and future directions of most recent activity trackers in oncology.
Outcome Measures in Cancer: Do disease specific instruments offer greater sen...Office of Health Economics
Paula's slides for her presentation on Outcomes Measures in Cancer given at the C2E2 Rounds Conference at the University of British Columbia on July 5th, 2017.
The Paperless partograph – The new user-friendly and simpler tool for monitor...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Eligibility for national screening programmes can be personalised according to individual risk in order to improve outcomes and reduce costs. Existing methods of economic evaluation can be adapted to identify risk thresholds and help optimise services. We describe the development of a decision model used to evaluate the cost-effectiveness of risk-based screening for diabetic retinopathy.
Author(s) and affiliation(s): Chris Sampson, Office of Health Economics Marilyn James, University of Nottingham David Whynes, University of Nottingham Antonio Eleuteri, University of Liverpool Simon Harding, University of Liverpool.
Conference/meeting: Health Technology Assessment International (HTAi) 2018
Location: Vancouver, Canada
Date: 03/06/2018
Do EQ-5D-3L and EQ-5D-5L Capture the Same Changes in Quality of Life Over Tim...Office of Health Economics
The existence of important dissimilarities between EQ-5D-3L and EQ-5D-5L, both in terms of the health profiles and preference-based values, is a key topic in current research. This study compares the performance of the 3L and 5L versions of the EQ-5D in capturing changes in quality of life and the resulting impact on estimates of QALYs for a large cohort of cancer patients. Data were obtained from Cancer2015, a large-scale longitudinal cancer cohort study in Australia. Cancer 2015 enrols newly diagnosed, treatment-naïve cancer patients, who complete quality of life questionnaires at baseline, and at various follow-up points (approximately 3 and/or 6 months continuously). Genetic Matching techniques are used to construct a match comparison group of patients. Post-matching regression adjustment is also implemented to control for any remaining imbalances. For matched QLQ-C30 profiles, we compare 3L and 5L tariffs, as well as the magnitude of changes in quality of life at different points along the treatment trajectory of individuals. We pay special attention to the sensitivity of the measures, by exploring the impact of 3L vs 5L on larger changes in quality of life compared to smaller changes. Our analysis finds that improvements in HRQoL as measured by the QLU-C10D (which is derived from the condition specific EORTC QLQ-C30 instrument) appear to be associated with smaller changes in utility quantified by the 5L compared to the 3L. When HRQoL is deteriorating between observations then the 5L tariff is found to produce bigger utility losses. While the crosswalk (a) loses the increased sensitivity of the 5L (if it detects more change) but (b) it stretches out utility values across a larger range (the 3L range), and hence gains or losses are larger and more in line with the 3L tariffs.
Author(s) and affiliation(s): Paula Lorgelly (OHE), Patricia Cubi-Molla (OHE), Mark Pennington (King's College London), Richard Norman (Curtin)
Conference/meeting: EuHea 2018
Location: Maastricht, Netherlands
Date: 13/07/2018
Academic doctors' views of complementary and alternative medicine (CAM) and i...home
There has been a marked increase in the use of complementary and alternative medicine (CAM)
in the UK population in recent years. Surveys of doctors' perspectives on CAM have identified a variety of views
and potential information needs. While these are useful for describing the proportions of doctors who hold
particular attitudes towards CAM, they are less helpful for understanding why. In addition, while the views of nonacademic
doctors have begun to be studied, the perspective and rationales of academic doctors remains underresearched.
It seems important to investigate the views of those with a research-orientation, given the emphasis
on the need for more scientific evidence in recent debates on CAM.
Personalised medicine holds great promised for both improving patients’ outcomes and enhancing the efficiency of treatment. Medicines paired with diagnostics are the backbone of personalised medicine, presenting new challenges in for health technology assessment. The situation in England, particularly how NICE might respond to this challenge, was the focus of the third networking event co-sponsored by the Association of the British Pharmaceutical Industry association (ABPI) and the British In Vitro Diagnostics Association. At this one-day event, speakers set the stage for discussion by presenting defining the context of this challenge for England.
OHE’s Adrian Towse presented on the economics. He discussed the elements of value of a diagnostics test (see our earlier blog post) and described the context necessary to produce useful assessments and to ensure subsequent use in the marketplace. His topics included issues of evidence generation, incentives for innovation, flexible approaches to access coincident with evidence development, and encouraging uptake and use.
The Adapted ADAPTE approach to CPG adaptation proposed by the Alexandria Center for Evidence-Based Clinical Practice Guidelines, Alexandria University, Egypt.
An oral presentation conducted by Prof. Tarek Omar during the national initiative of the Pediatrics Department, Armed Forces College of Medicine, themed; 'Towards National Guidelines' that was launched in 2018 and started by Pediatrics CPGs
Introductory lecture to Wikipedia for the students (bachelor/master) in Journalism / Public Relations in New Bulgarian University, summer semester 2015/2016
Встъпителна лекция за Уикипедия за студентите (бакалаври/магистри) по Журналистика/Връзки с обществеността в Нов български университет, летен семестър 2015/2016.
Outcome Measures in Cancer: Do disease specific instruments offer greater sen...Office of Health Economics
Paula's slides for her presentation on Outcomes Measures in Cancer given at the C2E2 Rounds Conference at the University of British Columbia on July 5th, 2017.
The Paperless partograph – The new user-friendly and simpler tool for monitor...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Eligibility for national screening programmes can be personalised according to individual risk in order to improve outcomes and reduce costs. Existing methods of economic evaluation can be adapted to identify risk thresholds and help optimise services. We describe the development of a decision model used to evaluate the cost-effectiveness of risk-based screening for diabetic retinopathy.
Author(s) and affiliation(s): Chris Sampson, Office of Health Economics Marilyn James, University of Nottingham David Whynes, University of Nottingham Antonio Eleuteri, University of Liverpool Simon Harding, University of Liverpool.
Conference/meeting: Health Technology Assessment International (HTAi) 2018
Location: Vancouver, Canada
Date: 03/06/2018
Do EQ-5D-3L and EQ-5D-5L Capture the Same Changes in Quality of Life Over Tim...Office of Health Economics
The existence of important dissimilarities between EQ-5D-3L and EQ-5D-5L, both in terms of the health profiles and preference-based values, is a key topic in current research. This study compares the performance of the 3L and 5L versions of the EQ-5D in capturing changes in quality of life and the resulting impact on estimates of QALYs for a large cohort of cancer patients. Data were obtained from Cancer2015, a large-scale longitudinal cancer cohort study in Australia. Cancer 2015 enrols newly diagnosed, treatment-naïve cancer patients, who complete quality of life questionnaires at baseline, and at various follow-up points (approximately 3 and/or 6 months continuously). Genetic Matching techniques are used to construct a match comparison group of patients. Post-matching regression adjustment is also implemented to control for any remaining imbalances. For matched QLQ-C30 profiles, we compare 3L and 5L tariffs, as well as the magnitude of changes in quality of life at different points along the treatment trajectory of individuals. We pay special attention to the sensitivity of the measures, by exploring the impact of 3L vs 5L on larger changes in quality of life compared to smaller changes. Our analysis finds that improvements in HRQoL as measured by the QLU-C10D (which is derived from the condition specific EORTC QLQ-C30 instrument) appear to be associated with smaller changes in utility quantified by the 5L compared to the 3L. When HRQoL is deteriorating between observations then the 5L tariff is found to produce bigger utility losses. While the crosswalk (a) loses the increased sensitivity of the 5L (if it detects more change) but (b) it stretches out utility values across a larger range (the 3L range), and hence gains or losses are larger and more in line with the 3L tariffs.
Author(s) and affiliation(s): Paula Lorgelly (OHE), Patricia Cubi-Molla (OHE), Mark Pennington (King's College London), Richard Norman (Curtin)
Conference/meeting: EuHea 2018
Location: Maastricht, Netherlands
Date: 13/07/2018
Academic doctors' views of complementary and alternative medicine (CAM) and i...home
There has been a marked increase in the use of complementary and alternative medicine (CAM)
in the UK population in recent years. Surveys of doctors' perspectives on CAM have identified a variety of views
and potential information needs. While these are useful for describing the proportions of doctors who hold
particular attitudes towards CAM, they are less helpful for understanding why. In addition, while the views of nonacademic
doctors have begun to be studied, the perspective and rationales of academic doctors remains underresearched.
It seems important to investigate the views of those with a research-orientation, given the emphasis
on the need for more scientific evidence in recent debates on CAM.
Personalised medicine holds great promised for both improving patients’ outcomes and enhancing the efficiency of treatment. Medicines paired with diagnostics are the backbone of personalised medicine, presenting new challenges in for health technology assessment. The situation in England, particularly how NICE might respond to this challenge, was the focus of the third networking event co-sponsored by the Association of the British Pharmaceutical Industry association (ABPI) and the British In Vitro Diagnostics Association. At this one-day event, speakers set the stage for discussion by presenting defining the context of this challenge for England.
OHE’s Adrian Towse presented on the economics. He discussed the elements of value of a diagnostics test (see our earlier blog post) and described the context necessary to produce useful assessments and to ensure subsequent use in the marketplace. His topics included issues of evidence generation, incentives for innovation, flexible approaches to access coincident with evidence development, and encouraging uptake and use.
The Adapted ADAPTE approach to CPG adaptation proposed by the Alexandria Center for Evidence-Based Clinical Practice Guidelines, Alexandria University, Egypt.
An oral presentation conducted by Prof. Tarek Omar during the national initiative of the Pediatrics Department, Armed Forces College of Medicine, themed; 'Towards National Guidelines' that was launched in 2018 and started by Pediatrics CPGs
Introductory lecture to Wikipedia for the students (bachelor/master) in Journalism / Public Relations in New Bulgarian University, summer semester 2015/2016
Встъпителна лекция за Уикипедия за студентите (бакалаври/магистри) по Журналистика/Връзки с обществеността в Нов български университет, летен семестър 2015/2016.
RESEARCH-BASED LITERATURE SUPPORT FOR CAUTI 2.docxaudeleypearl
RESEARCH-BASED LITERATURE SUPPORT FOR CAUTI 2
Research-Based Literature Support for CAUTI
Kamila Julian
Chamberlain College of Nursing
NR 505: Advanced Research Methods: Evidenced Based Practice
July 2019
Running head: RESEARCH-BASED LITERATURE SUPPORT FOR CAUTI 1
RESEARCH-BASED LITERATURE SUPPORT FOR CAUTI 8
Research-Based Literature Support for CAUTI
Preventing inappropriate use of a urinary catheter and the risk of patient harm associated with the use of indwelling catheters remains a significant challenge for healthcare facilities. The purpose of this paper is to provide research-based literature support from 10 (ten) different research-based references, on the prevention of CAUTI, evaluating interventions that support the use of nurse-driven protocols to reduce the incidence of CAUTI.
The following is the proposed PICO question: “How does the use nurse-driven protocol for evaluating the appropriateness and prevalence of catheter use or removal, compared with no protocol affect the CAUTI rates?”
The literature review from Fakih, Krein, Edson, Watson, Battles, and Saint (2014) aimed to engage healthcare workers to prevent CAUTI and prevent patient harm. A quantitative approach and a quasi-experimental design were used to assess the impact of guidelines for CAUTI prevention and reduce CAUTI rates in the state of Michigan through the use of a bladder bundle, promoting a daily evaluation of catheter indication (Fakih et al., 2014). The ability of the selected design to generate a cause and effect relationship collaborated in spreading educational insights and guidance to various stakeholders. A disadvantage of such design is the lack of control group, as internal validity is not easy to control once a probability of a stakeholder not following all the necessary steps of the protocol to generate true findings, for example nurses not consistent with their rounds to evaluate daily necessity of indwelling catheter, which are important in order to identify gaps and make appropriate and necessary modifications based on new evidence. Target population here are hospitalized patients from 163 units including ER, ICU, Surgical, and operating room from 71 acute care hospitals in the state of Michigan, with an equal probability of being selected resulting in random sampling and confidentiality (Fakih et al., 2014).
The aim of the study by Shehab (2017) is to analyze the impact of the protocol of care, from nurse’s knowledge, of patients that requires a urinary catheter. A quasi-experiment design was used to test assumptions of effective changes in nurse’s knowledge after caring out the protocol of care on patients with the urinary catheter by using a structured interview questionnaire and a nurse’s knowledge assessment tool (Shehab, 2017). An advantage of this study is to evaluate nurse’s readiness to follow protocols and to update their knowledge on how to provide the best EBP care for patients with a Foley catheter. ...
class GERONTOLOGICAL NURSINGJournal Article Summary AssignmentT.pdflanuszickefoosebr429
class GERONTOLOGICAL NURSING
Journal Article Summary Assignment:
The purpose of the journal article summary assignment is for students to improve their
knowledge of evidence-based geriatric nursing practice and evidence-based protocols.
Students will review evidence-based literature and reflect on how the literature impacts
their professional nursing practice. Students will summarize two articles published in a
peer-reviewed journal within the last 10 years. The journal articles must address the
geriatric population. Topics will be chosen from the provided list (unless prior approval is
given), and the topic may not be repeated on the two journal article summaries. The
student should summarize each article and discuss how the findings are significant to
clinical practice. Article summaries should use APA format (double spaced, but no cover
page) and should be no more than 3 pages. The two article summaries are 10% of the total
class grade (2 x 5%).
Journal summaries should use the following format:
• Purpose: Describe the purpose of the article/study.
• Strength of Evidence: Identify the type of evidence used to support the findings, and
the strength of the evidence. If the article is based on research, describe the study
design, setting, subjects, and sample size.
• Results: Summarize the findings of the study.
• Limitations: Identify study limitations that may weaken evidence or limit
generalizability.
• Significance: Describe how the findings are significant to geriatric nursing practice.
Do the findings represent a change in practice and how do the findings inform your
nursing practice (what did you learn)?
Topics for journal article summaries and class presentations choose one of those topic and APA
styles
• Pain
• Heart Failure
• Stroke
• Substance/Alcohol Abuse
• Urinary Incontinence
• Sexuality Issues
• Frailty/Fall Risk
• Iatrogenesis
• Sleep Disturbances
• Nutrition
• Hydration
• Orthostatic Hypotension
• Dementia
• Vision
• Hearing
• Polypharmacy
• Cultural Considerations
• Elder Communities
Solution
Ques-1: Purpose:
The purpose of the article is to examine the evidence-based practice of geriatric patients who
have been suffering from “urinary tract infection induced- urinary incontinence”. So that
catheterization of urinary tract have reduce urinary incontinence in geriatric patients thereby it is
essential implement to procedures to reduce urinary infection induced incontinence using
catheters for overflow incontinence
Ques-2:
Catheterization regimen:
\"RCT\" (simple randomized control design) and randomized trial: These two methods used
synonymously. However, it has illustrated that RCT is pertaining to trail design that include
control groups. In this design, patient groups who are receiving experimental treatment compared
with control groups (placebo groups).
In the above design it has clearly can be seen a randomized RCT was performed in two intensive
units of respiratory care of total 2990 bedded tertiary referral medical ce.
APRIL 2018, VOL. 22 NO. 2 CLINICAL JOURNAL OF ONCOLOGY NURSING.docxfestockton
APRIL 2018, VOL. 22 NO. 2 CLINICAL JOURNAL OF ONCOLOGY NURSING 175CJON.ONS.ORG
C
Nephrotoxicity
Evidence in patients receiving cisplatin therapy
Elizabeth A. Duffy, DNP, RN, CPNP, Wendy Fitzgerald, RN, MSN, PPCNP-BC, CPON®, Kelley Boyle, MSN, RN, PCNS-BC, and Radha Rohatgi, PharmD, BCOP
CISPLATIN IS A PLATINUM COMPOUND THAT HAS BEEN USED as a chemotherapeutic
agent for many different cancers, including ovarian, testicular, lung, cervical,
and bladder cancers (Ruggiero, Rizzo, Trombatore, Maurizi, & Riccardi, 2016;
Santoso, Lucci, Coleman, Shafer, & Hannigan, 2003). The primary dose-
limiting toxicity of cisplatin is nephrotoxicity, a well-known side effect
(Jones, Spunt, Green, & Springate, 2008; Miller, Tadagavadi, Ramesh, &
Reeves, 2010). Nephrotoxicity involves glomerular or tubular dysfunction
of the kidneys after exposure to medications, other treatments, or toxins
(Skinner, 2011). Nephrotoxicity associated with cisplatin is related to accu-
mulation of metabolites in the renal proximal tubule cells of the kidneys,
where about 90% of cisplatin undergoes urinary excretion (Ruggiero et al.,
2016). Accumulation of these metabolites causes direct inflammation; the
production of reactive oxygen species, which leads to oxidative cell damage;
and cell death (Miller et al., 2010; Ruggiero et al., 2016). Many methods are
available to measure kidney function and define nephrotoxicity or acute
kidney injury (see Table 1).
Most patients receiving cisplatin experience acute impairment of glo-
merular and tubular function in varying degrees. Toxicity is dependent on
individual cisplatin pharmacokinetics and is usually more severe with high
total cisplatin doses and when other potential nephrotoxic medications are
given concurrently (Skinner, 2011; Womer, Pritchard, & Barratt, 1985). In one
study, children aged 10 years or older at treatment had a lower glomerular
filtration rate 10 years after therapy compared to children aged younger than
10 years at treatment (Skinner et al., 2009).
Nephrotoxicity can be reversible, but for some individuals, it can result
in permanent kidney injury, chronic progressive renal failure, or renal tubule
function impairment (Skinner et al., 2009). Chronic and severe reductions
of renal function have several sequelae. The immediate impact may be dose
reduction or cessation of potentially lifesaving nephrotoxic chemotherapy,
thereby increasing the risk of relapse or progression of the cancer. In the
event of a disease relapse or progression, changes to renal function may limit
enrollment in phase 1 or 2 clinical trials because of inclusion parameters
related to baseline renal function.
Hydration and diuretics have been used in conjunction with cisplatin
administration for decades to improve the excretion of cisplatin and reduce
the incidence of nephrotoxicity. One method of promoting this excretion is
through osmotic diuresis with mannitol (Morgan et al., 2014). However, the
amount ...
A fuzzy inference system for assessment of the severity of the peptic ulcerscsandit
Peptic ulcer disease is the most common ulcer of an
area of the gastro- intestinal tract. The aim
of this study is to utilize soft computing techniqu
es to manage uncertainty and imprecision in
measurements related to the size, shape of the abno
rmality. For this, we designed a
fuzzy
inference system (FIS) which emulates the process o
f human experts in detection and analysis of
the
peptic ulcer
.
The proposed approach models the vagueness and unce
rtainty associated to
measurements of small objects in low resolution ima
ges In this study, for the first time, we
applied soft computing technique based upon fuzzy i
nference system (FIS) for assessment of the
severity of the peptic ulcer. Performance results r
eveal the FIS with maximum accuracy of
98.1%, which reveals superiority of the approach. T
he intelligent FIS system can help medical
experts as a second reader for detection of the pep
tic ulcer in the decision making process and
consequently, improves the treatment process
A fuzzy inference system for assessment of the severity of the peptic ulcerscsandit
Peptic ulcer disease is the most common ulcer of an area of the gastro- intestinal tract. The aim
of this study is to utilize soft computing techniques to manage uncertainty and imprecision in
measurements related to the size, shape of the abnormality. For this, we designed a fuzzy
inference system (FIS) which emulates the process of human experts in detection and analysis of
the peptic ulcer. The proposed approach models the vagueness and uncertainty associated to
measurements of small objects in low resolution images In this study, for the first time, we
applied soft computing technique based upon fuzzy inference system (FIS) for assessment of the
severity of the peptic ulcer. Performance results reveal the FIS with maximum accuracy of
98.1%, which reveals superiority of the approach. The intelligent FIS system can help medical
experts as a second reader for detection of the peptic ulcer in the decision making process and
consequently, improves the treatment process.
Prospective Study of Acute Appendicitis with its Clinical, Radiological Profi...semualkaira
Acute appendicitis is the most common condition encountered in general surgical practice. Alvarado and Modified Alvarado Scores (MASS) are the commonly used scoring
systems for its diagnosis, but its performance has been found to
be poor in certain populations. Hence, we compared the RIPASA
score with MASS, to find out which is a better diagnostic tool for
acute appendicitis in the Indian population.
Comparative efficacy of interventions to promote hand hygiene
in hospital: systematic review and network meta-analysis
Nantasit Luangasanatip,1, 2 Maliwan Hongsuwan,1 Direk Limmathurotsakul,1, 3 Yoel Lubell,1, 4
Andie S Lee,5, 6 Stephan Harbarth,5 Nicholas P J Day,1, 4 Nicholas Graves,2, 7 Ben S Cooper1, 4
Frequency of Anastomotic Leak in Early Versus Dealyed Oral Feeding after Elec...semualkaira
Intestinal stoma is usually performed as component of other surgical intervention for small and large bowel
pathologies. Of these temporary colostomy are commonest stomas
created for de-functioning of the distal anastomotic site to minimise the chances of leak. Colostomy is usually reversed at 8 to 12
weeks and Ileostomy closure is often considered a minor procedure but it is associated with significant morbidity and mortality
Frequency of Anastomotic Leak in Early Versus Dealyed Oral Feeding after Elec...semualkaira
Intestinal stoma is usually performed as component of other surgical intervention for small and large bowel
pathologies. Of these temporary colostomy are commonest stomas
created for de-functioning of the distal anastomotic site to minimise the chances of leak. Colostomy is usually reversed at 8 to 12
weeks and Ileostomy closure is often considered a minor procedure but it is associated with significant morbidity and mortality
ISSN 2347-2251
It appears that you're describing the scope of a scientific journal. This journal covers a wide range of topics related to both Pharmaceutical Sciences and Biological Sciences of the scopus database journal.
Indo-American Journal of Pharma and Bio Sciences is an international, online, English-language journal that publishes articles on pharmaceutical and biological sciences of the ugc carelist journals.
ISSN 2347-2251
Manuscripts should be carefully checked for grammatical and punctuation errors. All papers undergo peer review. Please note that all articles published in this journal represent the opinions of the authors and do not necessarily reflect the official policy of the Journal of Indo-American Journal of Pharma and Bio Sciences of the journals to publish paper.
Similar to Ht ai 2015 poster 238 - Efficiency of the Artificial Urinary Sphincter (20)
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
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263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ht ai 2015 poster 238 - Efficiency of the Artificial Urinary Sphincter
1. ABSTRACT
An artificial urinary sphincter (AS) is an implantable device used to treat patients with urinary
incontinence associated with radical prostatectomy (Fig. 1). Although apparently effective, this
technology has a very high cost and it is not reimbursed by the Public Health System. Aim: To analyze
the efficiency of the use of AS in the treatment of post prostatectomy urinary incontinence when
compared to other treatment strategies. Methods: Systematic literature survey including data from
Pubmed, Embase, Cochrane library and International Health Technology Assessment (HTA) sites
published since 2012. Search terms used were artificial urinary sphincter and urinary incontinence.
Results: The survey was able to identify 129 publications related to this subject. Careful title screening
and thorough abstract reading limited the number of included articles to 10 (4 systematic reviews, 2
health technology assessments, 2 observational studies, 1 economic evaluation and one clinical
guideline). No controlled randomized clinical trials were found comparing the use of this technology
with other strategies. Data from the available studies indicate that the AS is currently indicated in
cases of moderate to severe urinary incontinence, with high success rates and high patient satisfaction
scores, in spite of the eventual need for late revision and even removal of the device along the years.
Conclusion: Due to the low evidence score of the available literature, great care is to be use in the
eventual incorporation of this technology. Careful economic evaluations and the development of
clinical guidelines are deemed necessary to assure an informed decision on this subject.
METHODS
The question that guided the search for evidence is based in the PICO strategy, with Population (P) the
patients undergoing radical prostatectomy with moderate or severe urinary incontinence, Intervention
(I) the artificial urinary sphincter (AS), Comparator (C ) other surgical therapies and Outcomes (O) the
resolution of incontinence, complications and costs. The question was "Which is the efficiency for
treatment of moderate or severe urinary incontinence after radical prostatectomy compared to other
surgical therapies?". The search of studies was conducted in the PubMed, EMBASE, Cochrane, HTA
agencies linked to INATHA and Ministry of Health of Brazil. The terms Mesh used were "artificial urinary
sphincter" and "urinary incontinence", adapted to the search in the different base systems. The criteria
for selecting studies were agree with the question of research, published from 2012 and study design
(systematic reviews, technology assessment and recent clinical studies have not assessed by the
secondary studies). The studies were evaluated for quality of evidence according the Guidelines of the
Brazilian Network Technology Assessment – REBRATS.
RESULTS
EFFICIENCY OF THE ARTIFICIAL URINARY SPHINCTER IN THE TREATMENT OF
POST PROSTATECTOMY URINARY INCONTINENCE
Eliane Molina Psaltikidis - MSc. RN. HTA center; Joaquim Murray Bustorff-Silva - MD. Ph.D. pediatric surgeon;
Mariângela Ribeiro Resende - MD. Ph.D. infectious diseases
Clinical Hospital of State University of Campinas - UNICAMP
Ten studies were selected for analysis as shown in Figure 1.
The systematic reviews analyzed1,2,3,4 identified only one randomized
controlled trial5, with small sample (45 patients), comparing AS and
injection of Macroplastique® with favorable outcome for the use of the
AS in the group with severe incontinence (OR 8.89, 95% CI 1.40-56.57).
Stands out a systematic review of high methodological rigor2 using
GRADE system, which presented the main results of using the AS:
Social Continence (≥1 diaper/day) - on average 79% (ranging from
61 to 100%).
AS revision rate of 26% (14-44%) due to mechanical failure (6%),
erosion / infection (8.5%) and urethral atrophy (7.9%).
After 2 years follow-up, 84 to 98% of patients have functioning with
or without revision.
Four studies evaluated patient satisfaction, by various methods, but
all with results favorable to the use of AS.
Figure 1. Artificial
urinary sphincter (AS)
Overall, the reviews agree on the need for further studies comparing AS with surgical alternatives, with
greater methodological rigor, about the effectiveness, occurrence of mechanical failure, complications
and patient satisfaction.
Two clinical trials not covered by the systematic reviews were analyzed:
Cohort of 77 patients with AS6 assessed the outcomes related them to the previous radiotherapy. The
overall rate of continence (no diaper or 1 daily) was similar in both groups (87%). The surgical revision
rate of AS was 10% and 12% between irradiated and non-irradiated, though the incidence of urethral
stricture was higher among irradiated (62% vs 10%).
A retrospective observational study of 57 patients with AS7, overall rate of AS of stay was 80% after 15
and 20 years. Continence (no use of diaper) of 77% and 89% patient satisfaction.
2. RESULTS CONTINUED
Two technology assessments were included in the analysis, both from the Ministry of Health of Brazil:
One HTA8 analyzed 23 studies on AS and urethral sling, all non-comparative, uncontrolled and potential
selection bias. The results suggest that for moderate to severe incontinence AS has a similar effect to
the slings (79% and 75%), while for severe incontinence AS reporting had higher cure rate and/or
improvement (90%) to the slings (71 %).
Recommendation Report9 of the AS for severe urinary incontinence after prostatectomy for the public
health system was analysed. It concluded that the quality of the evidence in studies about AS is low,
with only one randomized study, and there isn´t observational studies comparing use of sling versus AS.
Several studies have analyzed global cases of urinary incontinence without stratification in severity and
differences in inclusion criteria and measurement of outcomes. The recommendation decided to no
incorporation of AS as isolated technology. Suggested the elaboration of Clinical Protocol for national
determination about the options of care for patients with urinary incontinence in the public health
system.
An economic evaluation10, prepared by the Ministry of Health of Brazil, used decision model (Markov)
and considered life expectancy, complications, life quality, short and long-term costs of three strategies
(AS, Sling and treatment conservative). The result of the strategies was:
For conservative treatment no has extra-charge, but was less effective therapy;
For AS was average cost of R$ 29,212 per patient (about U$ 9,700);
For the Sling was average cost of R$ 7,704 (about U$ 2,600);
Demonstrated incremental cost-effectiveness Sling and AS with conservative treatment,
demonstrating cost-effectiveness of Sling for moderate cases and AS for severe cases of urinary
incontinence.
Despite the AS and slings not be incorporated in the public health system, the National Health Agency
(ANS), which governs the private health system in Brazil, developed a clinical protocol11 for the use of
these materials for urinary incontinence post-prostatectomy subsidizing its introduction in the list of
procedures covered by private health insurance providers.
CONCLUSIONS
REFERENCES
1. Silva L, Andriolo R, Atallah A, da Silva E. Surgery for stress urinary incontinence due to presumed sphincter deficiency after prostate. Cochrane Database Syst Rev [Internet]. 2014;(6):1–
13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21491408
2. Van der Aa F, Drake MJ, Kasyan GR, Petrolekas A, Cornu J-N. The artificial urinary sphincter after a quarter of a century: a critical systematic review of its use in male non-neurogenic
incontinence. Eur Urol [Internet]. 2013 Apr;63(4):681–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23219375
3. Montague DK. Artificial urinary sphincter: long-term results and patient satisfaction. Adv Urol [Internet]. 2012 Jan [cited 2014 Aug 2];2012:835290. Available from:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3318201&tool=pmcentrez&rendertype=abstract
4. Brasil. Agência Nacional de Saúde Suplementar - ANS., Brasileira AM. Diretrizes Clínicas na Saúde Suplementar [Internet]. 2012. Available from: http://apsredes.org/site2012/wp-
content/uploads/2012/09/DIRETRIZES_SAUDE-SUPLEMENTAR2.pdf
5. Imamoglu MA, Tuygun C, Bakirtas H, Yigitbasi O, Kiper A. The comparison of artificial urinary sphincter implantation and endourethral macroplastique injection for the treatment of
postprostatectomy incontinence. Eur Urol 2005;47:209-13.
6. Sathianathen NJ, McGuigan SM, Moon D a. Outcomes of artificial urinary sphincter implantation in the irradiated patient. BJU Int [Internet]. 2014 Apr [cited 2014 Aug 2];113(4):636–41.
Available from: http://www.ncbi.nlm.nih.gov/pubmed/24131859
7. Léon P, Chartier-Kastler E, Rouprêt M, Ambrogi V, Mozer P, Phé V. Long-term functional outcomes after artificial urinary sphincter (AMS 800®) implantation in men with stress urinary
incontinence. BJU Int [Internet]. 2014 Jun 23 [cited 2014 Aug 2];1–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24958004
8. Brasil, Ministério da Saúde. Secretaria de Ciência T e IED de C e T. PTC 05/2012. Eficácia e segurança de esfíncter urinário artificial no tratamento da incontinência urinária [Internet].
Brasília; 2012. Available from: http://portal2.saude.gov.br/rebrats/visao/estudo/detEstudo.cfm?codigo=388&evento=6&v=true
9. Brasil M da SCN de I de T no S-C. Esfíncter urinário artificial na incontinência urinária masculina grave pós - prostatectomia - Relatório de Recomendação [Internet]. 2013. Available
from: http://portalsaude.saude.gov.br/images/pdf/2014/janeiro/28/EsfincterUrinario-final.pdf
10. Brasil, Ministério da Saúde. Secretaria de Ciência T e IED de C e T. Custo-efetividade do Esfíncter Urinário Artificial e Sling Urinário no tratamento de incontinência urinária no
tratamento de incontinência urinária pós-prostatectomia [Internet]. Brasília; 2012 p. 1–32. Available from:
http://portal2.saude.gov.br/rebrats/visao/estudo/detEstudo.cfm?codigo=412&evento=6&v=tru
11. Brasil. Agência Nacional de Saúde Suplementar - ANS., Brasileira AM. Diretrizes Clínicas na Saúde Suplementar [Internet]. 2012. Available from: http://apsredes.org/site2012/wp-
content/uploads/2012/09/DIRETRIZES_SAUDE-SUPLEMENTAR2.pdf
EFFICIENCY OF THE ARTIFICIAL URINARY SPHINCTER IN THE TREATMENT OF
POST PROSTATECTOMY URINARY INCONTINENCE
Eliane Molina Psaltikidis - MSc. RN. HTA center; Joaquim Murray Bustorff-Silva - MD. Ph.D. pediatric surgeon;
Mariângela Ribeiro Resende - MD. Ph.D. infectious diseases
Clinical Hospital of State University of Campinas - UNICAMP
The AS has been used for decades in the treatment of moderate to severe urinary incontinence, having
the support only several observational studies with continence results or significant improvement of
incontinence. The literature also reports complications requiring surgical revision of the device over the
years and possible replacement or withdrawal.
In the search for evidence, we met several systematic reviews and recent technology assessments that
highlight the lack of randomized controlled trials comparing the AS to other surgical treatments for
urinary incontinence.
The Brazilian public health system did not incorporate the AS, considering the lack of solid evidence
about its benefits, costs and the absence of a clinical protocol nationwide to assist patients with urinary
incontinence. In contrast, the use of AS has been financed by the private health system, pressing public
health services and professionals for the widespread introduction of technology. It is therefore essential
and necessary to perform new studies comparing surgical alternative treatment of urinary incontinence,
especially moderate and severe, with greater methodological rigor.