Hsc quiescence online
•Download as PPT, PDF•
2 likes•3,010 views
This document summarizes a journal club discussion on cell cycle kinetics of hematopoietic stem cells. It discusses the concepts of quiescence and dormancy in stem cells and compares the conventional and dormancy models of hematopoiesis. It reviews different methods for studying stem cell quiescence like BrdU, H2B, and CFSE labeling and their advantages and disadvantages. It highlights a recent study using CFSE labeling that challenges the notion that stem cell function is directly associated with quiescence and that long-term repopulating stem cells are permanently split into cycling and dormant populations. It proposes hypothetical dynamic models of steady state hematopoiesis where the quiescent and cycling fractions of stem cells fluctu
Report
Share
Report
Share
![Definitions ,[object Object],[object Object],Cell cycle kinetics: turnover rate – one division per ... days # of divisions during lifetime](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommended
HEMATOPOIETIC STEM CELL TRANSPLANTS IN PEDIATRIC by DR ABHIJEET MANOHAR WANKHEDE
Hematopoietic stem cell transplantation involves infusing stem cells collected from bone marrow, peripheral blood, or umbilical cord blood into a patient to reestablish their bone marrow and immune system function after it is damaged by disease. The first successful bone marrow transplant was performed in 1956. Stem cell transplants can be autologous using the patient's own cells or allogenic using cells from a donor. Allogenic transplants carry risks of graft-versus-host disease. Pediatric indications for transplantation include leukemia, myelodysplastic syndromes, lymphoma, inherited blood disorders, and solid tumors. The preparative regimen aims to eliminate the disease while immunosuppressing the patient to prevent graft
Hematopoietic stem cell transplantation for patients with AML
Allogeneic hematopoietic stem cell transplantation (allo HSCT) from an HLA-matched related donor provides the most potent anti-leukemic effect of any post-remission therapy in AML, as demonstrated by the lowest rates of relapse.
Graft vs leukemia plays and important role here.
Provides the best chance of long-term survival
HEMATOPOIETIC STEM CELL TRANSPLANTATION
This document provides an overview of hematopoietic stem cell transplantation (HSCT). It defines hematopoietic stem cells and HSCT, and describes the types of transplants including autologous and allogenic. The key indications for each type are outlined. The process of HSCT is summarized, including donor selection, stem cell collection, cryopreservation, conditioning chemotherapy, stem cell infusion, and engraftment recovery. Post-transplant complications and supportive care measures are briefly discussed.
Hematopoetic stem cell transplantation by Dr.Kumarbhargav Kaptan
The document reviews the current status of hematopoietic stem cell transplantation, describing the types of stem cells used including embryonic, adult, induced pluripotent, and umbilical cord stem cells. It discusses sources of hematopoietic stem cells, the process of transplantation including donor evaluation and conditioning regimens, and indications for transplantation in both malignant and non-malignant conditions such as sickle cell anemia, thalassemia major, and immunodeficiency diseases. Outcomes of transplantation for diseases like Hodgkin's lymphoma are also reviewed.
STEM CELL THERAPY
Peripheral blood stem cell transplantation (PBSCT) involves collecting stem cells from a patient's bloodstream and later infusing them back into the patient after chemotherapy or radiation therapy. PBSCT has replaced bone marrow as the most common stem cell transplantation procedure. Stem cells are collected from the bloodstream using growth factors alone or with chemotherapy, and the minimum number needed for a safe transplant is 2 million CD34+ cells per kilogram of body weight. PBSCT results in faster recovery time compared to bone marrow transplants due to higher numbers of stem cells and T cells collected.
Haematopoietic Stem Cell Mobilisation and Apheresis
The document provides an overview of autologous stem cell transplantation, including scientific background on blood cell formation and the bone marrow microenvironment. It describes the stem cell transplant process, including stem cell mobilization using agents like filgrastim and plerixafor, stem cell collection via apheresis, and patient evaluation and preparation for the collection procedure. The goal of the process is to collect enough CD34+ stem cells from the patient's peripheral blood to later be reinfused after high-dose chemotherapy or radiation to rescue the patient's bone marrow.
Stem cell transplantation
Stem cell transplantation replaces unhealthy cells with healthy ones. It has a history dating back to the mid-19th century when it was discovered that marrow was the source of blood cells. Modern stem cell transplantation uses stem cells from three sources: peripheral blood, marrow, or umbilical cord. The types of transplantation are syngeneic using identical twins, autologous using one's own stem cells, and allogeneic using donor stem cells which can cause graft-versus-host disease. Stem cell transplantation treats conditions like blood disorders and cancers.
Advances in stem cell transplantation
This document discusses hematopoietic stem cell transplantation (HSCT) and its current state and future opportunities. HSCT is an effective treatment for hematologic, immune, metabolic and cancerous diseases. It replaces defective cells and offers high-dose therapy and graft-versus-tumor effects. While HSCT faces challenges like toxicity and costs, advances in unrelated donor matching, cord blood use, and reduced intensity regimens have expanded its applications. Standards and accreditation are needed to ensure quality, and further growth depends on expanded donor availability and combining HSCT with new cellular immunotherapies.
Recommended
HEMATOPOIETIC STEM CELL TRANSPLANTS IN PEDIATRIC by DR ABHIJEET MANOHAR WANKHEDE
Hematopoietic stem cell transplantation involves infusing stem cells collected from bone marrow, peripheral blood, or umbilical cord blood into a patient to reestablish their bone marrow and immune system function after it is damaged by disease. The first successful bone marrow transplant was performed in 1956. Stem cell transplants can be autologous using the patient's own cells or allogenic using cells from a donor. Allogenic transplants carry risks of graft-versus-host disease. Pediatric indications for transplantation include leukemia, myelodysplastic syndromes, lymphoma, inherited blood disorders, and solid tumors. The preparative regimen aims to eliminate the disease while immunosuppressing the patient to prevent graft
Hematopoietic stem cell transplantation for patients with AML
Allogeneic hematopoietic stem cell transplantation (allo HSCT) from an HLA-matched related donor provides the most potent anti-leukemic effect of any post-remission therapy in AML, as demonstrated by the lowest rates of relapse.
Graft vs leukemia plays and important role here.
Provides the best chance of long-term survival
HEMATOPOIETIC STEM CELL TRANSPLANTATION
This document provides an overview of hematopoietic stem cell transplantation (HSCT). It defines hematopoietic stem cells and HSCT, and describes the types of transplants including autologous and allogenic. The key indications for each type are outlined. The process of HSCT is summarized, including donor selection, stem cell collection, cryopreservation, conditioning chemotherapy, stem cell infusion, and engraftment recovery. Post-transplant complications and supportive care measures are briefly discussed.
Hematopoetic stem cell transplantation by Dr.Kumarbhargav Kaptan
The document reviews the current status of hematopoietic stem cell transplantation, describing the types of stem cells used including embryonic, adult, induced pluripotent, and umbilical cord stem cells. It discusses sources of hematopoietic stem cells, the process of transplantation including donor evaluation and conditioning regimens, and indications for transplantation in both malignant and non-malignant conditions such as sickle cell anemia, thalassemia major, and immunodeficiency diseases. Outcomes of transplantation for diseases like Hodgkin's lymphoma are also reviewed.
STEM CELL THERAPY
Peripheral blood stem cell transplantation (PBSCT) involves collecting stem cells from a patient's bloodstream and later infusing them back into the patient after chemotherapy or radiation therapy. PBSCT has replaced bone marrow as the most common stem cell transplantation procedure. Stem cells are collected from the bloodstream using growth factors alone or with chemotherapy, and the minimum number needed for a safe transplant is 2 million CD34+ cells per kilogram of body weight. PBSCT results in faster recovery time compared to bone marrow transplants due to higher numbers of stem cells and T cells collected.
Haematopoietic Stem Cell Mobilisation and Apheresis
The document provides an overview of autologous stem cell transplantation, including scientific background on blood cell formation and the bone marrow microenvironment. It describes the stem cell transplant process, including stem cell mobilization using agents like filgrastim and plerixafor, stem cell collection via apheresis, and patient evaluation and preparation for the collection procedure. The goal of the process is to collect enough CD34+ stem cells from the patient's peripheral blood to later be reinfused after high-dose chemotherapy or radiation to rescue the patient's bone marrow.
Stem cell transplantation
Stem cell transplantation replaces unhealthy cells with healthy ones. It has a history dating back to the mid-19th century when it was discovered that marrow was the source of blood cells. Modern stem cell transplantation uses stem cells from three sources: peripheral blood, marrow, or umbilical cord. The types of transplantation are syngeneic using identical twins, autologous using one's own stem cells, and allogeneic using donor stem cells which can cause graft-versus-host disease. Stem cell transplantation treats conditions like blood disorders and cancers.
Advances in stem cell transplantation
This document discusses hematopoietic stem cell transplantation (HSCT) and its current state and future opportunities. HSCT is an effective treatment for hematologic, immune, metabolic and cancerous diseases. It replaces defective cells and offers high-dose therapy and graft-versus-tumor effects. While HSCT faces challenges like toxicity and costs, advances in unrelated donor matching, cord blood use, and reduced intensity regimens have expanded its applications. Standards and accreditation are needed to ensure quality, and further growth depends on expanded donor availability and combining HSCT with new cellular immunotherapies.
autologous bone marrow transplant
Autologous bone marrow transplant involves harvesting a patient's own bone marrow stem cells, storing them, and later re-infusing them after high-dose chemotherapy or radiation treatment to destroy cancerous cells. The stem cells help repopulate the bone marrow and restore the immune system. Complications can include infections during the neutropenic phase, graft-versus-host disease, and mucositis. Long term effects may include secondary cancers or sterility. Autologous transplants are commonly used to treat blood cancers like lymphoma or multiple myeloma.
Stem cell transplant
This document provides an overview of hematopoietic stem cell transplantation (HSCT). It discusses the history and development of HSCT, the types of transplants including autologous and allogeneic, stem cell sources, the transplant process from collection and storage to conditioning and infusion, complications, and management considerations. Key events in the history of HSCT are highlighted, such as the first successful transplant between identical twins in 1956 and advances that enabled unrelated donor transplants.
Hematopoietic stem cell transplantation in Pediatrics
This document discusses hematopoietic stem cell transplantation in pediatrics. It defines hematopoietic stem cell transplantation as any procedure where stem cells from any donor or source are given to a recipient with the intention of repopulating or replacing their hematopoietic system. The document then reviews the history of stem cell transplantation, different stem cell sources including bone marrow, peripheral blood, and umbilical cord blood, and types of transplantation including autologous, allogeneic, and syngeneic. It also discusses procedures, conditioning regimens, and applications of autologous transplantation.
Haematopoietic stem cell transplantation
Hematopoietic stem cell transplant (HSCT) involves transplanting hematopoietic stem cells to re-establish normal bone marrow function in patients with blood disorders or cancer. HSCT has become an established treatment for many malignant and non-malignant blood diseases. HSCT sources include bone marrow, peripheral blood, and umbilical cord blood. The transplant process involves stem cell collection, processing, conditioning chemotherapy, stem cell infusion, and recovery. Complications can include graft-versus-host disease. Matching HLA antigens between donor and recipient is important for transplant success, especially in allogeneic HSCT. Advances have improved outcomes, but further progress is still needed.
White Paper 2012
Machine pulsatile perfusion is a novel technique for isolating stem cells from the entire afterbirth, including placenta and umbilical cord, which results in a 2-5x higher yield of CD34+ stem cells compared to cord blood alone. The technique mimics the human heart and gently extracts stem cells using perfusate chemistry matched to normal body conditions. Studies show afterbirth-derived stem cells isolated using this method have similar performance to cord blood stem cells for blood and immune cell production and it is being explored as a new source of stem cells for transplantation therapies.
BONE MARROW TRANSPLANT
Bone marrow transplantation involves replacing damaged or destroyed bone marrow with healthy bone marrow stem cells. There are three types of bone marrow transplants: autologous using the patient's own stem cells collected before treatment, allogeneic using a donor's stem cells, and syngeneic using an identical twin's stem cells. Preparations for transplant include testing and treatments to suppress the immune system to prevent rejection of the donor cells. Risks include infection, graft failure or rejection, and complications from the immune suppression. Nurses monitor patients closely during transplant for issues like pain, fatigue, infection risk, and fluid imbalances.
Bone Marrow Transplant in Oncology
A brief presentation on Bone Marrow Transplant in Oncology by S K Rezaul, proudly presented by Biomedicz (www.biomedicz.com).
Bone marrow trans
Bone marrow transplantation replaces damaged or destroyed bone marrow with healthy stem cells. It is used to treat certain cancers, blood disorders, and chemotherapy side effects. There are three main types: autologous uses the patient's own stem cells; allogeneic uses a donor's stem cells; umbilical cord blood transplantation uses stem cells from umbilical cord blood. Preparations include testing and treatment for both the recipient and donor. Risks include infections, graft failure, and graft-versus-host disease. A multidisciplinary team oversees the transplant process.
Bone marrow transplantation
The bone marrow is the soft, fatty tissue inside bones that produces blood cells. It contains stem cells that give rise to red blood cells, white blood cells, and platelets. A bone marrow transplant replaces damaged or destroyed bone marrow with healthy stem cells from either the patient (autologous transplant) or a donor (allogenic transplant). Proper donor matching through HLA typing is important for success of an allogenic transplant to reduce graft-versus-host disease.
Nihms 356918
1) Hematopoietic stem cells (HSCs) emerge through distinct developmental stages in different anatomical sites as the embryo develops. Early in development, primitive hematopoiesis occurs in the yolk sac, followed by emergence of adult repopulating HSCs in the aorta-gonad-mesonephros region.
2) HSCs are thought to originate directly from hemogenic endothelial cells in the embryo, though their exact developmental origin is still debated.
3) HSC development is regulated by transcriptional factors and signaling molecules that direct HSCs to maintain a balance of self-renewal and differentiation throughout embryonic development and after birth.
Bone marrow transplant
Bone marrow is the soft tissue inside bones that produces blood cells. A bone marrow transplant replaces unhealthy blood-forming cells with healthy ones from a donor. This procedure treats life-threatening blood disorders like leukemia and bone marrow cancers. There are two main types of bone marrow transplants - autologous, using the patient's own cells, and allogeneic, using cells from a donor matched to the patient. Both aim to rescue the body's blood cell production after chemotherapy or cure a genetic disorder affecting blood cells.
Bone marrow transplantation
Bone marrow transplantation involves harvesting stem cells from either the patient (autologous) or a donor (allogeneic) and administering high-dose chemotherapy to eliminate malignant or damaged bone marrow cells. Allogeneic transplants can provide a graft-versus-tumor effect from donor immune cells attacking cancer cells, but also risk graft-versus-host disease as donor cells may attack patient tissues. The choice of donor, degree of tissue matching, and immuno-modulation of the graft influence efficacy and complications like relapse and GVHD. Further research aims to maximize the graft-versus-tumor effect while minimizing graft rejection and side effects.
Presentation of stem cell and bone marrow tranplan tation
The document discusses stem cell and bone marrow transplantation. It defines stem cells, embryonic stem cells, and adult stem cells. It also defines bone marrow transplantation and describes the different sources of bone marrow stem cells including peripheral blood, bone marrow harvest, and umbilical cord blood. The document outlines the indications for bone marrow stem cell transplantation and the types including autologous and allogeneic transplants. It provides details on the procedures for bone marrow transplantation and post-transplantation care and discusses common side effects.
Bone marrow transplant-some facts to know.
With many advances and techonological progress bone marrow transplants are a feasible option and provide much needed hope, comfort and relief to the families of patients.
The collection and processing of hematopoietic
BASICS OF HSC COLLECTION AND PROCESSING INCLUDING ALL THE THREE SOURCES, A BRIEF ABOUT STEM CELL MOBILIZATION, STEM CELL SELECTION CRYOPRESERVATION AND DMSO
Ubc's
In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologically and genetically part of the fetus and, (in humans), normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta. Conversely, the fetal heart pumps deoxygenated, nutrient-depleted blood through the umbilical arteries back to the placenta.
The blood within the umbilical cord, known as cord blood, is a rich and readily available source of primitive, undifferentiated stem cells (of type CD34-positive and CD38-negative). These cord blood cells can be used for bone marrow transplant.
Some parents choose to have this blood diverted from the baby's umbilical blood transfer through early cord clamping and cutting, to freeze for long-term storage at a cord blood bank should the child ever require the cord blood stem cells (for example, to replace bone marrow destroyed when treating leukemia).
In the future, cord blood-derived embryonic-like stem cells (CBEs) may be banked and matched with other patients, much like blood and transplanted tissues. The use of CBEs could potentially eliminate the ethical difficulties associated with embryonic stem cells (ESCs).
All about cord blood banking
Cord blood banking involves collecting and storing the blood from the umbilical cord and placenta after a baby is born. This blood contains stem cells that can be used for transplants to treat diseases like leukemia. While there are debates around cord blood banking, it has been used in thousands of successful transplants worldwide to treat over 70 diseases. The process of cord blood collection is simple and poses no risks to mother or baby. Banking cord blood provides a stem cell source for transplants and may help treat more diseases as research continues.
Hepatocyte transplant.dr quiyum
Hepatocyte transplantation is an alternative to liver transplantation that aims to restore hepatic function without replacing the entire organ. It involves transplanting isolated hepatocytes from donor livers into patients with liver-based metabolic disorders or acute liver failure. While hepatocyte transplantation is less invasive than liver transplantation and allows multiple patients to be treated from a single donor, challenges remain such as ensuring an adequate number of engrafted cells and long-term correction of the metabolic abnormality without immunosuppression. Current research is focused on overcoming these hurdles to expand the clinical application of hepatocyte transplantation.
Dr kamlesh patel bone marrow transplantation
Stem cell transplantation involves transplanting stem cells from bone marrow, peripheral blood, or umbilical cord blood to treat diseases like cancer or blood disorders. There are two main types - autologous transplants using a patient's own stem cells and allogeneic transplants using donor stem cells. Umbilical cord blood is now commonly used as it contains young stem cells and a better HLA match is tolerated. The transplantation process involves conditioning the patient with chemotherapy or radiation, infusing the stem cells, and managing side effects like graft-versus-host disease and infections during recovery.
Hsct
Hematopoietic stem cell transplantation involves intravenous infusion of stem cells collected from bone marrow, peripheral blood, or umbilical cord blood to reestablish hematopoietic function in patients with damaged bone marrow or immune systems. It is potentially curative for various disorders. Stem cells are collected via bone marrow harvest or apheresis and may be manipulated before infusion. Complications can include mucositis, sinusoidal obstructive syndrome, and graft-versus-host disease.
Side Effects due to Fluorouracil Sample
In present scenario, John happens to be the patient of colorectal cancer that has been affecting men as well as women and happens to be the most common cause of cancer related death. The patient recently underwent a surgery and agreed to receive doses of Fluorouracil as a part of his chemotherapy treatment (Swan 2006). But after a few cycles, he developed some side effects in form of feeling very tired even after sleeping for a span of 9 hours. Due to this, he has reduced the work schedule to three days, in the rest of the days he looks after his grand children. No changes have been made by him in his dietary regime which happens to be the same which was before the diagnosis. The present essay has tried to present a brief over view about the relation between Fluorouracil and the side-effects faced by John. It will also focus on priority interventions so as to manage the side effects in form of fatigue. Persuasive interventions will also be constructed so as to develop a persuasive argument for the above mentioned intervention (Espie and et al. 2008).
Lec 2 erythropoesis & rbc senescence
This document summarizes information about erythropoiesis and red blood cell destruction from lecture slides. It discusses the definition of erythropoiesis, sites of erythropoiesis in the fetal period and after birth. It covers the biological processes in erythropoiesis including differentiation, proliferation, hemoglobin synthesis and maturation. Regulation of erythropoiesis by cytokines like erythropoietin is also summarized. The document then discusses red blood cell lifespan, methods to measure lifespan, routes of destruction including spleenic entrapment and factors affecting deformability.
More Related Content
What's hot
autologous bone marrow transplant
Autologous bone marrow transplant involves harvesting a patient's own bone marrow stem cells, storing them, and later re-infusing them after high-dose chemotherapy or radiation treatment to destroy cancerous cells. The stem cells help repopulate the bone marrow and restore the immune system. Complications can include infections during the neutropenic phase, graft-versus-host disease, and mucositis. Long term effects may include secondary cancers or sterility. Autologous transplants are commonly used to treat blood cancers like lymphoma or multiple myeloma.
Stem cell transplant
This document provides an overview of hematopoietic stem cell transplantation (HSCT). It discusses the history and development of HSCT, the types of transplants including autologous and allogeneic, stem cell sources, the transplant process from collection and storage to conditioning and infusion, complications, and management considerations. Key events in the history of HSCT are highlighted, such as the first successful transplant between identical twins in 1956 and advances that enabled unrelated donor transplants.
Hematopoietic stem cell transplantation in Pediatrics
This document discusses hematopoietic stem cell transplantation in pediatrics. It defines hematopoietic stem cell transplantation as any procedure where stem cells from any donor or source are given to a recipient with the intention of repopulating or replacing their hematopoietic system. The document then reviews the history of stem cell transplantation, different stem cell sources including bone marrow, peripheral blood, and umbilical cord blood, and types of transplantation including autologous, allogeneic, and syngeneic. It also discusses procedures, conditioning regimens, and applications of autologous transplantation.
Haematopoietic stem cell transplantation
Hematopoietic stem cell transplant (HSCT) involves transplanting hematopoietic stem cells to re-establish normal bone marrow function in patients with blood disorders or cancer. HSCT has become an established treatment for many malignant and non-malignant blood diseases. HSCT sources include bone marrow, peripheral blood, and umbilical cord blood. The transplant process involves stem cell collection, processing, conditioning chemotherapy, stem cell infusion, and recovery. Complications can include graft-versus-host disease. Matching HLA antigens between donor and recipient is important for transplant success, especially in allogeneic HSCT. Advances have improved outcomes, but further progress is still needed.
White Paper 2012
Machine pulsatile perfusion is a novel technique for isolating stem cells from the entire afterbirth, including placenta and umbilical cord, which results in a 2-5x higher yield of CD34+ stem cells compared to cord blood alone. The technique mimics the human heart and gently extracts stem cells using perfusate chemistry matched to normal body conditions. Studies show afterbirth-derived stem cells isolated using this method have similar performance to cord blood stem cells for blood and immune cell production and it is being explored as a new source of stem cells for transplantation therapies.
BONE MARROW TRANSPLANT
Bone marrow transplantation involves replacing damaged or destroyed bone marrow with healthy bone marrow stem cells. There are three types of bone marrow transplants: autologous using the patient's own stem cells collected before treatment, allogeneic using a donor's stem cells, and syngeneic using an identical twin's stem cells. Preparations for transplant include testing and treatments to suppress the immune system to prevent rejection of the donor cells. Risks include infection, graft failure or rejection, and complications from the immune suppression. Nurses monitor patients closely during transplant for issues like pain, fatigue, infection risk, and fluid imbalances.
Bone Marrow Transplant in Oncology
A brief presentation on Bone Marrow Transplant in Oncology by S K Rezaul, proudly presented by Biomedicz (www.biomedicz.com).
Bone marrow trans
Bone marrow transplantation replaces damaged or destroyed bone marrow with healthy stem cells. It is used to treat certain cancers, blood disorders, and chemotherapy side effects. There are three main types: autologous uses the patient's own stem cells; allogeneic uses a donor's stem cells; umbilical cord blood transplantation uses stem cells from umbilical cord blood. Preparations include testing and treatment for both the recipient and donor. Risks include infections, graft failure, and graft-versus-host disease. A multidisciplinary team oversees the transplant process.
Bone marrow transplantation
The bone marrow is the soft, fatty tissue inside bones that produces blood cells. It contains stem cells that give rise to red blood cells, white blood cells, and platelets. A bone marrow transplant replaces damaged or destroyed bone marrow with healthy stem cells from either the patient (autologous transplant) or a donor (allogenic transplant). Proper donor matching through HLA typing is important for success of an allogenic transplant to reduce graft-versus-host disease.
Nihms 356918
1) Hematopoietic stem cells (HSCs) emerge through distinct developmental stages in different anatomical sites as the embryo develops. Early in development, primitive hematopoiesis occurs in the yolk sac, followed by emergence of adult repopulating HSCs in the aorta-gonad-mesonephros region.
2) HSCs are thought to originate directly from hemogenic endothelial cells in the embryo, though their exact developmental origin is still debated.
3) HSC development is regulated by transcriptional factors and signaling molecules that direct HSCs to maintain a balance of self-renewal and differentiation throughout embryonic development and after birth.
Bone marrow transplant
Bone marrow is the soft tissue inside bones that produces blood cells. A bone marrow transplant replaces unhealthy blood-forming cells with healthy ones from a donor. This procedure treats life-threatening blood disorders like leukemia and bone marrow cancers. There are two main types of bone marrow transplants - autologous, using the patient's own cells, and allogeneic, using cells from a donor matched to the patient. Both aim to rescue the body's blood cell production after chemotherapy or cure a genetic disorder affecting blood cells.
Bone marrow transplantation
Bone marrow transplantation involves harvesting stem cells from either the patient (autologous) or a donor (allogeneic) and administering high-dose chemotherapy to eliminate malignant or damaged bone marrow cells. Allogeneic transplants can provide a graft-versus-tumor effect from donor immune cells attacking cancer cells, but also risk graft-versus-host disease as donor cells may attack patient tissues. The choice of donor, degree of tissue matching, and immuno-modulation of the graft influence efficacy and complications like relapse and GVHD. Further research aims to maximize the graft-versus-tumor effect while minimizing graft rejection and side effects.
Presentation of stem cell and bone marrow tranplan tation
The document discusses stem cell and bone marrow transplantation. It defines stem cells, embryonic stem cells, and adult stem cells. It also defines bone marrow transplantation and describes the different sources of bone marrow stem cells including peripheral blood, bone marrow harvest, and umbilical cord blood. The document outlines the indications for bone marrow stem cell transplantation and the types including autologous and allogeneic transplants. It provides details on the procedures for bone marrow transplantation and post-transplantation care and discusses common side effects.
Bone marrow transplant-some facts to know.
With many advances and techonological progress bone marrow transplants are a feasible option and provide much needed hope, comfort and relief to the families of patients.
The collection and processing of hematopoietic
BASICS OF HSC COLLECTION AND PROCESSING INCLUDING ALL THE THREE SOURCES, A BRIEF ABOUT STEM CELL MOBILIZATION, STEM CELL SELECTION CRYOPRESERVATION AND DMSO
Ubc's
In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologically and genetically part of the fetus and, (in humans), normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta. Conversely, the fetal heart pumps deoxygenated, nutrient-depleted blood through the umbilical arteries back to the placenta.
The blood within the umbilical cord, known as cord blood, is a rich and readily available source of primitive, undifferentiated stem cells (of type CD34-positive and CD38-negative). These cord blood cells can be used for bone marrow transplant.
Some parents choose to have this blood diverted from the baby's umbilical blood transfer through early cord clamping and cutting, to freeze for long-term storage at a cord blood bank should the child ever require the cord blood stem cells (for example, to replace bone marrow destroyed when treating leukemia).
In the future, cord blood-derived embryonic-like stem cells (CBEs) may be banked and matched with other patients, much like blood and transplanted tissues. The use of CBEs could potentially eliminate the ethical difficulties associated with embryonic stem cells (ESCs).
All about cord blood banking
Cord blood banking involves collecting and storing the blood from the umbilical cord and placenta after a baby is born. This blood contains stem cells that can be used for transplants to treat diseases like leukemia. While there are debates around cord blood banking, it has been used in thousands of successful transplants worldwide to treat over 70 diseases. The process of cord blood collection is simple and poses no risks to mother or baby. Banking cord blood provides a stem cell source for transplants and may help treat more diseases as research continues.
Hepatocyte transplant.dr quiyum
Hepatocyte transplantation is an alternative to liver transplantation that aims to restore hepatic function without replacing the entire organ. It involves transplanting isolated hepatocytes from donor livers into patients with liver-based metabolic disorders or acute liver failure. While hepatocyte transplantation is less invasive than liver transplantation and allows multiple patients to be treated from a single donor, challenges remain such as ensuring an adequate number of engrafted cells and long-term correction of the metabolic abnormality without immunosuppression. Current research is focused on overcoming these hurdles to expand the clinical application of hepatocyte transplantation.
Dr kamlesh patel bone marrow transplantation
Stem cell transplantation involves transplanting stem cells from bone marrow, peripheral blood, or umbilical cord blood to treat diseases like cancer or blood disorders. There are two main types - autologous transplants using a patient's own stem cells and allogeneic transplants using donor stem cells. Umbilical cord blood is now commonly used as it contains young stem cells and a better HLA match is tolerated. The transplantation process involves conditioning the patient with chemotherapy or radiation, infusing the stem cells, and managing side effects like graft-versus-host disease and infections during recovery.
Hsct
Hematopoietic stem cell transplantation involves intravenous infusion of stem cells collected from bone marrow, peripheral blood, or umbilical cord blood to reestablish hematopoietic function in patients with damaged bone marrow or immune systems. It is potentially curative for various disorders. Stem cells are collected via bone marrow harvest or apheresis and may be manipulated before infusion. Complications can include mucositis, sinusoidal obstructive syndrome, and graft-versus-host disease.
What's hot (20)
Hematopoietic stem cell transplantation in Pediatrics
Hematopoietic stem cell transplantation in Pediatrics
Presentation of stem cell and bone marrow tranplan tation
Presentation of stem cell and bone marrow tranplan tation
Viewers also liked
Side Effects due to Fluorouracil Sample
In present scenario, John happens to be the patient of colorectal cancer that has been affecting men as well as women and happens to be the most common cause of cancer related death. The patient recently underwent a surgery and agreed to receive doses of Fluorouracil as a part of his chemotherapy treatment (Swan 2006). But after a few cycles, he developed some side effects in form of feeling very tired even after sleeping for a span of 9 hours. Due to this, he has reduced the work schedule to three days, in the rest of the days he looks after his grand children. No changes have been made by him in his dietary regime which happens to be the same which was before the diagnosis. The present essay has tried to present a brief over view about the relation between Fluorouracil and the side-effects faced by John. It will also focus on priority interventions so as to manage the side effects in form of fatigue. Persuasive interventions will also be constructed so as to develop a persuasive argument for the above mentioned intervention (Espie and et al. 2008).
Lec 2 erythropoesis & rbc senescence
This document summarizes information about erythropoiesis and red blood cell destruction from lecture slides. It discusses the definition of erythropoiesis, sites of erythropoiesis in the fetal period and after birth. It covers the biological processes in erythropoiesis including differentiation, proliferation, hemoglobin synthesis and maturation. Regulation of erythropoiesis by cytokines like erythropoietin is also summarized. The document then discusses red blood cell lifespan, methods to measure lifespan, routes of destruction including spleenic entrapment and factors affecting deformability.
9. Blood, Lymph and Immunity
The document describes the functions of blood, lymph, and immunity. It discusses the composition of blood including plasma, red blood cells, white blood cells, and platelets. It describes hematopoiesis, the production of blood cells in the bone marrow. It also covers the lymphatic system and immune system, including innate immunity provided by white blood cells and adaptive immunity involving lymphocytes and antibody production.
Approach to pancytopenia .Dr ABHIJEET BARUA MD PGT.KOL.MED.CLG.
Pancytopenia is a reduction in red blood cells, white blood cells, and platelets caused by decreased bone marrow production or destruction of blood cells. Evaluation of pancytopenia involves examining the complete blood count, peripheral smear, and bone marrow aspiration and biopsy to determine if the cause is aplasia, deficiencies, infections, infiltrative disorders, or primary bone marrow diseases like myelodysplastic syndrome. Management depends on the underlying etiology based on history, examination, and specific diagnostic tests.
parasites
The document discusses parasite-host relationships, defining a host as any organism that allows another to live on or in it, while the parasite lives off the host. It provides examples of parasite life cycles, noting parasites must find nutrition, protection, and a way to reproduce from the host. The complex life cycles allow parasites to constantly reinfect new hosts. Understanding these cycles is important for preventing and treating parasite infections and developing new drugs to combat resistant parasites.
An introduction to Medical Parasitology
Medical parasitology: “the study and medical implications of parasites that infect humans”. A parasite: “a living organism that acquires some of its basic ...
Viewers also liked (6)
Approach to pancytopenia .Dr ABHIJEET BARUA MD PGT.KOL.MED.CLG.
Approach to pancytopenia .Dr ABHIJEET BARUA MD PGT.KOL.MED.CLG.
Similar to Hsc quiescence online
HSC_heterogeneity_definition
Hematopoietic stem cells (HSCs) show significant heterogeneity at the functional level, even when isolated as pure populations based on marker expression. Studies have identified distinct HSC subtypes with different engraftment kinetics, self-renewal capacities, lineage biases, and cell cycle or metabolic states. Recent work further distinguished HSC subtypes based on levels of the marker CD150, finding subsets with latent repopulation abilities but strong self-renewal potential that may represent the top of the HSC hierarchy. These findings challenge the current assay-based definition of HSCs and suggest it needs modification to account for HSC heterogeneity.
Jc Rethinking Of Hsc Assays
This document discusses the importance of choosing appropriate assays and models when studying hematopoietic stem cells (HSCs) and how results can be misleading if different assays and models are used. It summarizes several examples where different assays/models led to contradictory findings about leukemia stem cell phenotypes and the role of the Hedgehog signaling pathway in HSCs. The document advocates for using purified HSC populations and non-irradiated recipient mice when assessing HSC properties to avoid potential discrepancies between phenotype and function. It also discusses factors like cell variability, circadian rhythms and irradiation status of recipient mice that can influence variability in HSC assay results.
Spleen hsc online
The document discusses studies of hematopoietic stem cells (HSCs) in the adult mouse spleen. It was found that shielding the spleen allowed mice to survive lethal irradiation, and spleen fragments from infant mice could rescue irradiated mice. This suggests HSCs exist in the adult spleen. The document questions whether spleen HSCs reside in or circulate from the spleen, how they differ from bone marrow HSCs, and whether isolated spleen HSCs can engraft and rescue irradiated mice. A study characterized spleen HSCs at the single cell level, finding they have equal repopulating activity to bone marrow HSCs but cycle more rapidly and are long-term residents of the spleen rather than circulating cells.
CellTherapyTrends10
The document summarizes current trends in cell therapy, including:
1) Attempts to expand hematopoietic stem cells for clinical use have not achieved long-term engraftment, though total CD34+ cells are expanded with benefits.
2) Cord blood banking trends involve improving quality over quantity, and cord blood may be used for non-hematological diseases.
3) Over 3000 patients have been treated safely for heart diseases with cell therapy, and the field is growing rapidly though mechanisms are better understood as trophic rather than differentiation.
Research sigma xi presentation 2015
This document describes a study investigating autophagy in Huntington's disease (HD) using mutant huntingtin (mHtt) knock-in striatal cell lines. The study finds that lysosomes accumulate in the perinuclear region of HD model cells but remain evenly distributed in normal cells, indicating impaired vesicular trafficking in HD. Expressing normal huntingtin in HD model cells promotes even lysosomal distribution. Autophagosomal quantities differ between cell lines and in response to starvation, suggesting mHtt causes premature autophagosome-lysosome fusion. Blocking microtubule deacetylation disperses lysosomes in HD model cells, demonstrating a relationship between huntingtin, lysosomal positioning, and autophagy dysfunction in
Liver stem-cell
Liver stem/progenitor cells (LSPCs), also known as oval cells in rodents, are thought to be bipotential precursors to liver parenchymal cells. Transplant of LSPCs has been done via injection into the spleen or veins, but this causes a severe fibrogenic response driven by progenitor activation and requires immunosuppression. The ability of LSPCs to fully differentiate into hepatocytes remains unclear. Adult LSPCs are limited in supply, and use of human fetal LSPCs faces ethical issues. Directed differentiation of human embryonic stem cells into hepatic progenitors may be an alternative approach.
stem cell transplant.pptx
Hematopoietic stem cell transplantation (HSCT) involves replacing a patient's bone marrow with healthy stem cells from a donor. The document provides an overview of HSCT, including its history, types of transplants, the transplant process, and potential complications. It discusses how stem cells are collected from bone marrow, peripheral blood, or umbilical cord blood and cryopreserved. The transplant process includes conditioning chemotherapy/radiation, stem cell infusion, and recovery. Complications can include graft-versus-host disease and infection. Careful donor matching and screening is important for transplant success.
Peripheral blood stem cell transplantation- sources mobilization preservation...
Human Stem Cells- Introduction
Types of HSC transplants
Indications
Sources of stem cells
Collection and mobilization
Types of Mobilizing agents
Processing
Cryopreservation and storage
PBSC Transplant
Quality control
Complications
Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier
This summary provides the key points from the document in 3 sentences:
Mutant mouse models containing a loss-of-function Kit mutation were developed to improve models for human hematopoietic stem cell (HSC) transplantation analysis. These Kit mutant mice enabled robust, uniform, and sustained engraftment of human HSCs in adult mice without irradiation conditioning. Using this new model, the document shows that differential KIT expression identifies two functionally distinct subpopulations of human HSCs, demonstrating the potential of this approach for furthering human HSC research.
Project: defining the endothelial hematopoietic symbiosis
1. The proposal aims to characterize the heterogeneity of the bone marrow endothelium and its impact on hematopoietic stem and progenitor cells (HSPCs) biology using novel genetic tools.
2. New mouse lines will be used to visualize and profile the localization and cell cycle stage of proliferating endothelial and hematopoietic cells in vivo to create a spatiotemporal map of endothelial proliferation and its effects.
3. The research will investigate how modulation of endothelial proliferation impacts adjacent HSPCs and how HSPCs impact endothelial biology, with the goal of providing insights into endothelial-hematopoietic interactions that could inform new therapeutic strategies for blood diseases.
Cell synchronization
INTRODUCTION
HISTORY
NEED OF SYNCHRONIZATION
SYNCHRONOUS CULTURES CAN BE OBTAINED IN SEVERAL WAYS:
Physical fractionation .
Chemical appro ach
CENTRIFUGAL ELUTRIATION
Inhibition of DNA synthesis
Nutritional deprivation
SYNCHRONIZATION AT LOW TEMPERATURE
CELLULAR TOTIPOTENCY
SOME HIGHLIGHTS OF CELL SYNCHRONIZATION
REFERENCES
CBC Part 2 - WBC Differential & Morphology.pdf
This document provides instructions for a multi-part study exercise on the complete blood cell count (CBC). It focuses on the second part which covers the white blood cell (WBC) differential count and morphology. A peripheral blood smear stained with Wright's stain is used for microscopic examination to identify and classify WBCs, including immature and abnormal cell types. Performing a WBC differential count provides information on the frequency distribution of different WBC lineages and can help identify diseases.
New insights into leukemic niche in bone marrow
1. Leukemic stem cells home to and reside in the endosteal niche in the bone marrow, outcompeting normal hematopoietic stem cells. They rely on interactions with the microenvironment including secreted factors like SCF.
2. Neutralizing SCF disrupts the migration of normal hematopoietic progenitor cells to the leukemic niche and restores their mobilization by G-CSF, demonstrating SCF mediates the abnormal behavior of normal cells in the leukemic niche.
3. Targeting the SCF pathway may be a potential therapeutic strategy to disrupt the leukemic niche and improve outcomes for bone marrow transplantation and stem cell harvesting in leukemia patients.
No adjust csc model 1
This document discusses the evolving concept of cancer stem cells over time. It begins by describing how the concept of normal stem cells developed based on studies of blood cell formation and tissue regeneration in the 1970s. This provided a framework for later investigating cancer stem cells. The concept of cancer stem cells originated in the 1940s from studies of teratocarcinomas showing they contained both differentiated and undifferentiated malignant cells. Further work in the 1960s demonstrated the clonal origin of teratocarcinomas from single malignant stem cells. Since then, advances in defining normal stem cell properties and the multistep nature of cancer have led to new insights into cancer stem cells and their role in tumor propagation and heterogeneity.
Secondary cell culture
Secondary cell cultures refer to cells that have been subcultured, or transferred, from a primary culture to a new culture vessel. Subculturing provides fresh nutrients and space for continuously growing cell lines. Cell lines can be finite or continuous depending on their lifespan in culture. Characterization of cell lines is important to confirm identity and purity through analysis of biochemical, genetic, and chromosomal parameters such as karyotyping.
Federico Garnier - France - Tuesday 29 - Hematopoietic Stem Cells
The document discusses umbilical cord blood transplantation. It notes that umbilical cord blood is an important source of hematopoietic stem cells for transplantation. The advantages of using cord blood include faster availability, tolerance to some HLA mismatching, and lower risk of infections. However, cord blood transplants have limitations like lower cell doses and risk of graft failure or delayed engraftment. Studies show improved outcomes with higher cell doses or double cord blood transplants. Cell dose and HLA matching remain important factors for transplant success.
Acute myelogenous leukemia (aml)
Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow characterized by the rapid growth of abnormal white blood cells that build up in the bone marrow and interfere with normal blood cell production. AML results from genetic mutations that cause immature myeloid cells to proliferate uncontrollably. Diagnosis involves blood tests, bone marrow aspiration and biopsy, and cytogenetic analysis. Treatment consists of induction chemotherapy to achieve remission followed by consolidation chemotherapy to destroy any remaining leukemia.
Hematopoietic stem cell transpalantation (Harrison based).pptx
Hematopoietic stem cell transplantation involves replacing a patient's abnormal or diseased hematopoietic system with healthy stem cells from a donor. It is used to treat both malignant and non-malignant hematological disorders. There are various sources of stem cells including bone marrow, peripheral blood, and umbilical cord blood. Complications after transplantation can include graft-versus-host disease, infections, and transplant-related toxicities. Close monitoring and management is required after transplantation to monitor engraftment and address any complications that may arise.
Ohio State's 2016 ASH Review Blood and Marrow Trasplantation (with Turning Po...
Ohio State’s 2016 ASH Review
Blood and Marrow Transplantation
Basem M. William, MD, MRCP(UK), FACP
Assistant Professor of Internal Medicine
Blood and Marrow Transplant Program
Cml final
Molecular monitoring of CML patients and aims of treatment and management with illustration of the mechanism of action of different drugs (Tyrosine Kinase inhibitors) used in the management of the chronic myeloid leukemia (CML)
Similar to Hsc quiescence online (20)
Peripheral blood stem cell transplantation- sources mobilization preservation...
Peripheral blood stem cell transplantation- sources mobilization preservation...
Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier
Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier
Project: defining the endothelial hematopoietic symbiosis
Project: defining the endothelial hematopoietic symbiosis
Federico Garnier - France - Tuesday 29 - Hematopoietic Stem Cells
Federico Garnier - France - Tuesday 29 - Hematopoietic Stem Cells
Hematopoietic stem cell transpalantation (Harrison based).pptx
Hematopoietic stem cell transpalantation (Harrison based).pptx
Ohio State's 2016 ASH Review Blood and Marrow Trasplantation (with Turning Po...
Ohio State's 2016 ASH Review Blood and Marrow Trasplantation (with Turning Po...
Recently uploaded
Journal Article Review on Rasamanikya
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptxMGM SCHOOL/COLLEGE OF NURSING
Identification and nursing management of congenital malformations REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
It includes regulation of combination products and medical devices. FDA and industry liaisons.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
The Best Ayurvedic Antacid Tablets in India
Treat the symptoms of indigestion, heartburn and stomach reflux with the 10 Best Ayurvedic Antacid Tablets in India.
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...chandankumarsmartiso
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel With 100% Satisfaction
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
ABDOMINAL TRAUMA in pediatrics part one.
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Efficacy of Avartana Sneha in Ayurveda
Avartana Sneha is a unique method of Preparation of Sneha Kalpana in Ayurveda, mainly it is indicated for the Vataja rogas.
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidadeProf. Marcus Renato de Carvalho
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Top 10 Best Ayurvedic Kidney Stone Syrups in India
we have mentioned the best 10 ayurvedic Kidney Stone Syrups. You can check all these products and choose the best one for yourself.
Top Effective Soaps for Fungal Skin Infections in India
Swisschem Dermacare has mentioned the List of The Best Antifungal Soap In India 2022. All of these soaps are trusted by various Dermatology Experts.
Recently uploaded (20)
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in India
Hsc quiescence online
- 1. Revised: Cell cycle kinetics of hematopoietic stem cells Alexey Bersenev Journal Club May 12, 2011
- 3. Cycling cell fate decisions: quiescence senescence apoptosis proliferation self-renewal differentiation/ maturation dormancy?
- 5. active dormant feedback loop long-term progenitors short-term HSC quiescence self-renewal Conventional model Dormancy model mature blood cells LSK/34-/Flk2-/48-/150+ Dormancy model of hematopoiesis:
- 6. Dormant versus active HSC Andreas Trumpp 2008-2009, Linheng Li, Hans Clevers 2010 characteristics dormant HSC active HSC synonyms quiescent primed, self-renewing phenotype LSK/CD34-/Flk2-/CD48-/CD150+ % in HSC pool ~ 15% ~ 85% quiescence +++ + self-renewal rate +++ + proliferation + +++ replication machinery off on metabolism hibernation/hypoxia active function repair in emergency normal blood turnover niche endosteal vascular signaling Wnt-off/ BMP-on Wnt-on/ BMP-off activation signals active HSC depletion/ INF-α progenitors delpetion feedback loop +++ +
- 15. Challenge the dormancy model: Long-term repopulation HSC are not necessarily permanently split into subpopulations with different cycling kinetics
- 16. Hypothetical models of steady state hematopoiesis turnover rate: HSC divide every 17.8 days (BrdU/ biotin) aHSC divide every 9-36 days (H2B) dHSC divide every 56-145d HSC divide every 39 days – 18 divisions during lifetime (CFSE)
- 17. “ Dynamic repetition” model - Some HSC dominate blood formation for a time, subsequently enter a quiescent state in which other HSC increase hematopoietic contribution, and get reactivated again – repetitive cycles “ dynamic equilibrium” between quiescent fraction and cycling fraction within the HSC population For the first time was proposed by Ingmar Glauche et al. Stem cell proliferation and quiescence--two sides of the same coin . PLoS Comput Biol. 2009 Jul;5(7):e1000447 2009 Glauche concept: HSC flexibly and reversibly adapt their cycling state according to systemic needs