This presentation provides an overview of redox signaling and how it relates to ASEA. Redox signaling involves molecules that help cells communicate and repair damage. It is an important but not well understood area of science. The presentation discusses how redox signaling molecules in ASEA are similar to those naturally found in the body and help support cellular communication and repair. Studies have shown ASEA generates antioxidants and enhances cell function without toxicity. The presentation argues increasing redox signaling through ASEA can significantly benefit health and is a promising area of medical innovation.
Slides Rishi Kumar recently used in his discussion w/ mentees of The Product Mentor.
The Product Mentor is a program designed to pair Product Mentors and Mentees from around the World, across all industries, from start-up to enterprise, guided by the fundamental goals…Better Decisions. Better Products. Better Product People.
Throughout the program, each mentor leads a conversation in an area of their expertise that is live streamed and available to both mentee and the broader product community.
http://TheProductMentor.com
Slides Rishi Kumar recently used in his discussion w/ mentees of The Product Mentor.
The Product Mentor is a program designed to pair Product Mentors and Mentees from around the World, across all industries, from start-up to enterprise, guided by the fundamental goals…Better Decisions. Better Products. Better Product People.
Throughout the program, each mentor leads a conversation in an area of their expertise that is live streamed and available to both mentee and the broader product community.
http://TheProductMentor.com
Working remotely as a developers before and after Covid-19Aude Barral
With the Covid-19 health crisis came profound changes in terms of remote work and organizational patterns.
How can we expect these changes to affect our work life long-term? We decided to dig further into developers’ teleworking aspirations.
In June 2020, over 2,000 developers from 94 countries across the globe, shared with us their expectations and experience when it comes to working remotely.
I am a spiritual life coach, and I am launching a website you can sign up for coaching sessions, check out the resources page for freebies, and other goodies.
Work–life balance is the term used to describe the balance that an individual needs between time allocated for work and other aspects of life. Areas of life other than work–life can be, but not limited to personal interests, family and social or leisure activities.
http://www.RedoxSignalingMolecules.ca - Frequently Asked Questions (And Answers)
1. What is ASEA?
ASEA is an immune boosting molecular complex consisting of reactive molecules, all native to the human body and naturally balanced. These molecules include a perfect balance of antioxidant enhancers that are balanced to support the immune system, detoxify the body and protect and fortify healthy tissue.
2. What Are Reactive Molecules?
Reactive molecules are either active electron acceptors (prone to take on electrons) or electron donors (prone to give up electrons). When these two classes of molecules are chemically balanced in our body, our immune systems can function at its optimal level.
3. How Do These Reactive Molecules Work?
There are two major roles for these reactive molecules in the body. First, they pair up with the natural antioxidants already in our body to help detoxify and fortify healthy tissue. Secondly, they supply the raw materials that the immune system needs in order to perform its natural function to detect and destroy harmful invaders and damaged cells.
4. How Much ASEA Should I Take?
ASEA has been proven to be entirely non-toxic at any reasonable dose. It can be taken orally, applied topically or inhaled without causing irritation. The recommended maintenance amount is 4 oz. per day for adults. ASEA is not recommended for pregnant or breastfeeding women. Consult with a physician if you are sensitive to salt intake.
5. Can I Apply ASEA To My Skin, Scrapes, Cuts, Or Burns?
ASEA is a natural disinfectant and antimicrobial and yet is soothing to the touch. ASEA can be used in a spray bottle for use on scrapes, burns and abrasions and can be liberally sprayed on the skin and will not cause irritation. ASEA contains a very small amount of chlorine. If you are allergic to chlorine, it is not recommended for use on the face. As always, consult a physician if there are any concerns.
6. Is ASEA Safe?
Testing has shown ASEA to be entirely safe and non-toxic no matter how it is consumed or applied. It has shown literally zero endotoxicity, cytotoxicity, and genotoxicity (mutagenic properties) in all 16 years of studies that were performed. Consult with a physician if you are sensitive to salt intake.
To order or join ASEA, Visit:
http://www.RedoxSignalingMolecules.ca or Call 1-416-335-4716
Redox signaling molecules are cellular message carriers created within every cell of the body that help protect, rejuvenate, and restore cells. Scientists have known about it since the earlier part of last century, but now this burgeoning area of biological health is beginning to command attention.
METABOLISM & STAMINA: Double-blind, 3rd-party, placebo-controlled human trials at Appalachian State Human Performance Lab, North Carolina Research Campus saw remarkable changes in 43 metabolites ("fingerprints" of bio-chemical reactions), massive release of fat to be used as fuel, and an unheard-of 12% increase in endurance (measured by ventilatory threshold, VO2max, time to "hitting the wall.") In a follow-up study, mice ran 29% farther.
Dr.Ir. Gatot Trimulyadi : The adsorption behavior of chitin and its concerns with various degree of deacetylization. This high adsorption capacity was ascribable primarily to its remarkable hydrophilicity in cooperation with the relatively high amino group content. It is indicate that the importance of hydrophlicity and suggest that, in order to develop adsorbents of high capacity, it is make indicate the importance of hydrophilicity essential to make chitin derivatives highly hydrophylic and yet insoluble in water.
Working remotely as a developers before and after Covid-19Aude Barral
With the Covid-19 health crisis came profound changes in terms of remote work and organizational patterns.
How can we expect these changes to affect our work life long-term? We decided to dig further into developers’ teleworking aspirations.
In June 2020, over 2,000 developers from 94 countries across the globe, shared with us their expectations and experience when it comes to working remotely.
I am a spiritual life coach, and I am launching a website you can sign up for coaching sessions, check out the resources page for freebies, and other goodies.
Work–life balance is the term used to describe the balance that an individual needs between time allocated for work and other aspects of life. Areas of life other than work–life can be, but not limited to personal interests, family and social or leisure activities.
http://www.RedoxSignalingMolecules.ca - Frequently Asked Questions (And Answers)
1. What is ASEA?
ASEA is an immune boosting molecular complex consisting of reactive molecules, all native to the human body and naturally balanced. These molecules include a perfect balance of antioxidant enhancers that are balanced to support the immune system, detoxify the body and protect and fortify healthy tissue.
2. What Are Reactive Molecules?
Reactive molecules are either active electron acceptors (prone to take on electrons) or electron donors (prone to give up electrons). When these two classes of molecules are chemically balanced in our body, our immune systems can function at its optimal level.
3. How Do These Reactive Molecules Work?
There are two major roles for these reactive molecules in the body. First, they pair up with the natural antioxidants already in our body to help detoxify and fortify healthy tissue. Secondly, they supply the raw materials that the immune system needs in order to perform its natural function to detect and destroy harmful invaders and damaged cells.
4. How Much ASEA Should I Take?
ASEA has been proven to be entirely non-toxic at any reasonable dose. It can be taken orally, applied topically or inhaled without causing irritation. The recommended maintenance amount is 4 oz. per day for adults. ASEA is not recommended for pregnant or breastfeeding women. Consult with a physician if you are sensitive to salt intake.
5. Can I Apply ASEA To My Skin, Scrapes, Cuts, Or Burns?
ASEA is a natural disinfectant and antimicrobial and yet is soothing to the touch. ASEA can be used in a spray bottle for use on scrapes, burns and abrasions and can be liberally sprayed on the skin and will not cause irritation. ASEA contains a very small amount of chlorine. If you are allergic to chlorine, it is not recommended for use on the face. As always, consult a physician if there are any concerns.
6. Is ASEA Safe?
Testing has shown ASEA to be entirely safe and non-toxic no matter how it is consumed or applied. It has shown literally zero endotoxicity, cytotoxicity, and genotoxicity (mutagenic properties) in all 16 years of studies that were performed. Consult with a physician if you are sensitive to salt intake.
To order or join ASEA, Visit:
http://www.RedoxSignalingMolecules.ca or Call 1-416-335-4716
Redox signaling molecules are cellular message carriers created within every cell of the body that help protect, rejuvenate, and restore cells. Scientists have known about it since the earlier part of last century, but now this burgeoning area of biological health is beginning to command attention.
METABOLISM & STAMINA: Double-blind, 3rd-party, placebo-controlled human trials at Appalachian State Human Performance Lab, North Carolina Research Campus saw remarkable changes in 43 metabolites ("fingerprints" of bio-chemical reactions), massive release of fat to be used as fuel, and an unheard-of 12% increase in endurance (measured by ventilatory threshold, VO2max, time to "hitting the wall.") In a follow-up study, mice ran 29% farther.
Dr.Ir. Gatot Trimulyadi : The adsorption behavior of chitin and its concerns with various degree of deacetylization. This high adsorption capacity was ascribable primarily to its remarkable hydrophilicity in cooperation with the relatively high amino group content. It is indicate that the importance of hydrophlicity and suggest that, in order to develop adsorbents of high capacity, it is make indicate the importance of hydrophilicity essential to make chitin derivatives highly hydrophylic and yet insoluble in water.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Redox Signaling is an Exploding
Field of Science
Books
•Redox Biochem
•Ruma Banerjee Journals Conferences
•Antioxidant and Redox •The Gordon Research
Regulation of Genes
•Antiox & Redox Signaling
Conference on Thiol‐based
•Chandan K Sen •Physiol Genomics Redox Regulation and Signaling
•Redox Signaling in Biology and •Am. J. of Physiology •4th International Conference
Medicine on Oxidative/Nitrosative Stress
•Claus Jacob
•The J. of Immunology
and Disease
•Redox‐Mediated Signal •PNAS •International Symposium on
Transduction: Methods and •Arteriosclerosis, Thromb. the Pathophysiology of
Protocols Reactive Oxygen and Nitrogen
•John T Hancock
Vasc.
Species
•Redox Protemics •Hundreds More •Many more
•Nick Lane
•And More
3. Signaling Molecules in ASEA Come From
Salt and Water
Salt
Na+ Cl - Water
H
H
O
N N O
H
Nitrogen H
REDuction OXidation
H
H
H Super
Hydrogen Oxides
Peroxide O O
O O
More Cl
Nitric
than 20 H
Hypo
N O
Oxide Molecule O chlorites
s …
… …
5. What are Redox Signaling
Molecules?
• They are produced inside our cells
• They help cells communicate with each other
• They help tissues heal themselves
• The redox signaling molecules in ASEA are
actual molecules made from salt and water
6. How Do Redox Signaling Molecules
Work?
• They help cells communicate with each other
• They increase the “bars” on our “cell phones”
• When our cells have a problem, they need to
talk to each other
• If they cannot talk the problems become worse
• If they can talk, the problems can be solved
8. Cells are Like Houses that Shelter Life‐
Sustaining Activity
Fireplace, Furnace, Stove, Heaters ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Mitochondria
Mail Slots and Sorting ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Receptors, Vesicles, Golgi
Appliances, Tools, etc. ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Micromachines
Walls, Floors, Plumbing, Wires ‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐> Membranes, tubules
9. We can think of Cells as
Houses Along Streets
C
C e
e l
l l
l
M
ai
M l
ai b
l o
b x
o
x
C
C e
e
l
Blood l
l
Street
l Vessel
M
ai
M l
ai b
l o
b x
o
x
C
C e
e l
l l
l
M
ai
M l
ai b
l o
b x
o
x
11. When Cells Have a Problem
They Need Emergency Response
C CC C C
e ee e e
l ll l l
l ll l l
M M M M M
ai aiai ai ai
l ll l l
b bb b b
o oo o o
x xx x x
C C C C
e e e e
l l l l
l l l l
M M
M M
M M
ai ai
ai ai
ai ai
l l
l l
l l
b b
b b
b b
o o
o o
o o
x x
x x
x x
C C C CC
e e e ee
l l l ll
l l l ll
M M M MM
ai ai ai ai
ai
l l l ll
b b b b b
o o o o o
x x x xx
12. Redox Signaling Helps Cells Detect the
Extent of the Damage
Normal
Healthy Cells
Have Fires
and Smoke
(Controlled
Oxidation )
When the
Fire and
Smoke Get
out of
Controll,
Cells need
Help
13. What Happens When Cells Need
Help?
• They must be able to send a “redox” signal
• Redox Signaling Molecules carry the signals
• Fire Marshalls see these “smoke” signals and
call in the fire crew
• Fire Crews put out the fires (with antioxidants)
and help repair the damage or destroy and
rebuild the house
14. Why Do I Need Redox Signaling
Molecules?
• Your body has tens of billions of cells that
need repair or replacement every day, even
more if you are sick or sore
• As you age and especially if you are sick you
do not have enough redox signaling molecules
to handle the demand
• If your cells are not able to call for help, they
will continue to “burn” (oxidize) and will not
be repaired or replaced fast enough
21. Redox Signaling Technology is Destined
to Fuel the Greatest Advances in Medical
Science This Century
• Redox Signaling is fundamental to all
biological multi‐cellular processes
• It is non‐specific, non‐toxic and applicable
to a broad range of processes and pathways
• It is at the very core of mediating and
regulating the mechanisms that restore
functionality and health
22. Increasing Proper Redox Signaling in Your
Body is the Single Most Important Thing
You Can Do For Your Health
• Redox Signaling is absolutely necessary for all
living things on earth with more than one cell
• Redox Signaling Molecules in proper balance
cannot hurt you, they are in all of your cells
already, you just need more of them to keep
the cells healthy
• You need Redox Signaling Molecules so that
your body can restore and maintain its health
23. Stable Balanced Redox Signaling
Molecules in ASEA Confirmed
• ASEA contains a balance of ROS and RS
• Fluorescent Indicators Detect ROS
Components in ASEA
• ESR and EPR methods were used to verify
existence of stable ROS components
• Low Temperature Mass Spectroscopy used
find several ionic components of ASEA
26. Groundwork Toward Redox Signaling
Development
• Can stable complexes of Redox Signaling
Molecules be manufactured? YES.
• Can the bioactivity of such be
characterized? YES.
• Can such complexes be non‐toxic and
readily absorbed? YES.
• Can such a technology be commercialized?
It is up to you!