Therigy has built a proprietary suite of technology products for specialty pharmacies to deliver best-in-class patient support.
Therigy’s data analytics solutions support the complex data capture and unique reporting requirement in the specialty space.
Healthcare Savings Via Pharmacy Benefit Management ProgramsThe Partners Group
Optimize your employees’ drug benefit costs, while decreasing costs and simultaneously improving overall drug benefit coverage.
Pharmacy benefit costs are the fastest growing segment of national health expenditures… rising at a rate faster than hospital care and physician services combined. Learn how employers are achieving significant savings via the TPG Proprietary Pharmacy Benefit Program.
In This Seminar We Cover:
• Options for controlling health care pharmacy costs without impacting your membership.
• Overview of the latest trends in the pharmacy benefits arena and new programs that will improve members’ RX utilization and lower your self-funded prescription drug spend.
• Methods to establish true transparency into the cost of your plan’s prescription drug program and how to continuously monitor your drug costs vs. the pharmacy contract.
• Real life case studies of actual plan savings from the 2014 plan year.
• How to become eligible for a pharmacy audit completed by The Partners Group.
Free medicines are available through the pharmaceutical companies’ Patient Assistance Programs (PAPs), which may be accessed for individual prescriptions using The Pharmacy Connection (TPC) software or through a bulk replacement / Institutional PAP. Learn about Rx Partnership, Virginia’s innovative bulk replacement program.
20091207 Elements to Consider for Alternative Treatment Centersguestcf34e2
This workshop was presented at the World HealthCare Congress Leadership Summit in Dallas on 12/7/09. John Corpus established the content of the workshop; Ken Berndt and Bruce Shepard presented the content of the PPT. John, Ken, and Bruce contributed to the structure and content of the PPT.
Health Systems face the same drug cost management challenges as many other organizations. They may also have the added component of shouldering risk from payers without the ability to fully manage this important aspect of care. A new model is emerging that will afford Health Systems the opportunity to better manage risk by taking a collaborative approach to managing pharmacy benefits for their employees and their risk partners.
This webinar covers:
- The basics of traditional pharmacy benefit management revenue strategies
- Potential misalignment between a traditional pharmacy benefit model and an integrated model
- Benefits of an Integrated PBM
- How to put the model into practice
Healthcare Savings Via Pharmacy Benefit Management ProgramsThe Partners Group
Optimize your employees’ drug benefit costs, while decreasing costs and simultaneously improving overall drug benefit coverage.
Pharmacy benefit costs are the fastest growing segment of national health expenditures… rising at a rate faster than hospital care and physician services combined. Learn how employers are achieving significant savings via the TPG Proprietary Pharmacy Benefit Program.
In This Seminar We Cover:
• Options for controlling health care pharmacy costs without impacting your membership.
• Overview of the latest trends in the pharmacy benefits arena and new programs that will improve members’ RX utilization and lower your self-funded prescription drug spend.
• Methods to establish true transparency into the cost of your plan’s prescription drug program and how to continuously monitor your drug costs vs. the pharmacy contract.
• Real life case studies of actual plan savings from the 2014 plan year.
• How to become eligible for a pharmacy audit completed by The Partners Group.
Free medicines are available through the pharmaceutical companies’ Patient Assistance Programs (PAPs), which may be accessed for individual prescriptions using The Pharmacy Connection (TPC) software or through a bulk replacement / Institutional PAP. Learn about Rx Partnership, Virginia’s innovative bulk replacement program.
20091207 Elements to Consider for Alternative Treatment Centersguestcf34e2
This workshop was presented at the World HealthCare Congress Leadership Summit in Dallas on 12/7/09. John Corpus established the content of the workshop; Ken Berndt and Bruce Shepard presented the content of the PPT. John, Ken, and Bruce contributed to the structure and content of the PPT.
Health Systems face the same drug cost management challenges as many other organizations. They may also have the added component of shouldering risk from payers without the ability to fully manage this important aspect of care. A new model is emerging that will afford Health Systems the opportunity to better manage risk by taking a collaborative approach to managing pharmacy benefits for their employees and their risk partners.
This webinar covers:
- The basics of traditional pharmacy benefit management revenue strategies
- Potential misalignment between a traditional pharmacy benefit model and an integrated model
- Benefits of an Integrated PBM
- How to put the model into practice
Healthcare Supply Chain Management in the USLevi Shapiro
Healthcare Supply Chain Management in the US, presentation by Robert Burkholder, SVP Supply Chain, Jefferson Health System. Delivered on May 11, 2021 for mHealth Israel. Includes an overview of Jefferson, organization chart for Supply Chain Management department, overview of financing Healthcare in the US, discussion about M&A in the US healthcare providers sector, description of how Payers, Providers and Supliers are chasing scale, Jefferson's merger timeline, approach toward Integrating Legacy Supply Chain Departments, breakdown of the Fragile Global Supply Chain, efforts toward Supply Chain Resiliency, Value analysis in the healthcare supply chain, Enterprise Value Analysis, Strategic Sourcing and Purchasing, strategic sourcing model, Sourcing Prioritization Pipeline, Proposed prioritization map, Sourcing Prioritization Matrix, Advanced Analytics
After more than a year of challenges, healthcare organizations are now faced with CMS' requirement to publish standard charges for a minimum of 300 services in order to provide a shoppable experience for those seeking health care. With price transparency going into effect this year, providers must get used to the idea that information previously held close to the chest will now be on public display. Additionally, for providers that don't comply, CMS is imposing daily fines and in some cases, corrective action plans.
During this webinar, we'll review CMS regulations and what’s required from providers. While reviewing strategies for selecting shoppable services, we’ll also talk about risk areas that may impact the accuracy of reporting and how CMS is currently responding to providers that haven't implemented yet. We’ll also touch on what we consider the “silver lining” of the requirement with benefits to price transparency.
Gates Healthcare Associates is a consulting firm that provides extensive clinical, regulatory, real estate, contract evaluation and business development services and expertise to pharmacies, medical practices, hospitals, and healthcare organizations
PYA Highlights Next Steps of Meaningful UsePYA, P.C.
At the 2013 AICPA Healthcare Industry Conference, PYA Principal David McMillan and Senior Manager Chris Wilson recently explored the “new normal” of meaningful use as compliance and strategic standards in new care/reimbursement-model development.
How To Boost Hospital Performance By Optimizing Your PharmacyCompleteRx
Assessing and managing productivity is a complex process that takes the rights tools and people. While pharmacy may seem to be a small part of an overall organization, it is actually one of the largest cost centers of a hospital, making it one of the most important departments to optimize and streamline. Learn how your pharmacy’s productivity can impact your hospital’s overall costs, quality, safety and patient satisfaction.
Key Points:
- Analyzing productivity
- Pros and cons of pharmacy productivity management tools
- Use of volume indicators
- Workflows to improve productivity and communication with nursing and hospital staff
5 Ways Your Pharmacy Can Boost Your Revenue CycleCompleteRx
With rising drug costs and decreasing reimbursements contributing to shrinking margins (in 2014, according to Modern Healthcare, 61.3 percent of healthcare providers reported decreased margins from the previous year), hospitals continue to scrutinize their revenue cycles to ensure they stay in the black, and there’s an oft-overlooked resource they would do well to consider: pharmacy. Historically, the hospital pharmacy has been labeled a cost generator, but there are actually many ways this strategic department can positively impact each stage of the revenue cycle – from point of service to claim submission and more. This webinar will explore innovative tactics, including optimized processes, improved data management, and creative patient programs, which hospital pharmacies across the country can leverage to boost overall hospital revenue.
Demystifying Commercial Reasonableness in Physician/Hospital TransactionsPYA, P.C.
PYA Principal Lyle Oelrich presented “Demystifying Commercial Reasonableness in Physician/Hospital Transactions” at the Georgia Society of Certified Public Accountants’ (GSCPA) 2016 Healthcare Conference, February 11, 2016, in Atlanta, Georgia.
Healthcare is Getting Disrupted... Is Pharmacy Ready?Hillary Blackburn
Change is coming for the healthcare industry, particularly as digital disruption is happening. Within the broader healthcare industry, pharmacy will be impacted and should be ready to help the profession grow and thrive.
How does the e-prescribing Software benefit Pharmacy Management?Shelly Megan
Pharmacy management system software is necessary to eliminate the myriad challenges encountered by the pharmacy community. E-prescribing software is one of the major components of pharmacy management. Its benefits include reduced prescription errors and better patient care, enhanced productivity for medical bodies, better workflow for pharmacies, and more convenience for patients in obtaining medication.
White Paper: Best Practices for Medical Benefit Management (MBM)Tai Freligh
Biologic, biotechnology-based, rare disease, or high-cost pharmaceuticals — collectively known as specialty drugs — can be covered under the pharmacy benefit, the medical benefit, or both depending on the benefit design plan sponsors require of the third-party administrator (including the pharmacy benefit manager – PBM; administrative service organization – ASO; or any administrator of a medical or pharmacy benefit).
On average, up to 50% of specialty drugs today are covered under the medical benefit.
With the exception of a few key therapy areas, traditional tools used to manage specialty drugs under the medical benefit, such as prior authorizations and medical benefit carve-outs (i.e., “white-bagging”), have yielded limited value to plan sponsors.
This thought leadership analysis, with insights from recognized industry experts, will provide an overview of the challenges.
Download the complete white paper to get the rest of the report, including a summary of the key issues plan sponsors must address and insights into best practices through an innovative new approach, Medical Benefit Drug Management (MBM).
Link: http://www.PharMedQuest.com/White-Paper
How to Drive ROI from Your Healthcare Projects: Practical Tools, Templates, a...Health Catalyst
At a time when average hospital’s margins are stagnating, executives should be asking tough questions about the ROI of “indispensable” technologies. Will new technologies prove their worth or drive them further into the red? How do you measure and track ROI?
Clinicians need more education on financial metrics and finance people need to learn more about the clinical processes and outcomes. One of the historical problems with calculating ROI has been the fundamental culture divide between clinicians and finance.
This slide set gives some practical tools, templates (Excel), and how tos based on years of experience to quickly and effectively develop the ability to measure and communicate ROI on healthcare IT and improvement projects.
How to Drive ROI In Your Healthcare Quality Improvement Projects Health Catalyst
At a time when average hospital’s margins are stagnating, executives should be asking tough questions about the ROI of "indispensable" technologies. Will new technologies prove their worth or drive them further into the red? How do you measure and track ROI?
We need to educate clinicians on financial metrics and finance people need to learn more about the clinical processes and outcomes. One of the historical problems with calculating ROI has been the fundamental culture divide between clinicians and finance. Gone should be the days that clinicians deliver care without knowing the financial cost of that care.
This slide set give practical advice on how to set goals, measure ROI and gives excel templates that are based on years of experience by the authors
Healthcare Supply Chain Management in the USLevi Shapiro
Healthcare Supply Chain Management in the US, presentation by Robert Burkholder, SVP Supply Chain, Jefferson Health System. Delivered on May 11, 2021 for mHealth Israel. Includes an overview of Jefferson, organization chart for Supply Chain Management department, overview of financing Healthcare in the US, discussion about M&A in the US healthcare providers sector, description of how Payers, Providers and Supliers are chasing scale, Jefferson's merger timeline, approach toward Integrating Legacy Supply Chain Departments, breakdown of the Fragile Global Supply Chain, efforts toward Supply Chain Resiliency, Value analysis in the healthcare supply chain, Enterprise Value Analysis, Strategic Sourcing and Purchasing, strategic sourcing model, Sourcing Prioritization Pipeline, Proposed prioritization map, Sourcing Prioritization Matrix, Advanced Analytics
After more than a year of challenges, healthcare organizations are now faced with CMS' requirement to publish standard charges for a minimum of 300 services in order to provide a shoppable experience for those seeking health care. With price transparency going into effect this year, providers must get used to the idea that information previously held close to the chest will now be on public display. Additionally, for providers that don't comply, CMS is imposing daily fines and in some cases, corrective action plans.
During this webinar, we'll review CMS regulations and what’s required from providers. While reviewing strategies for selecting shoppable services, we’ll also talk about risk areas that may impact the accuracy of reporting and how CMS is currently responding to providers that haven't implemented yet. We’ll also touch on what we consider the “silver lining” of the requirement with benefits to price transparency.
Gates Healthcare Associates is a consulting firm that provides extensive clinical, regulatory, real estate, contract evaluation and business development services and expertise to pharmacies, medical practices, hospitals, and healthcare organizations
PYA Highlights Next Steps of Meaningful UsePYA, P.C.
At the 2013 AICPA Healthcare Industry Conference, PYA Principal David McMillan and Senior Manager Chris Wilson recently explored the “new normal” of meaningful use as compliance and strategic standards in new care/reimbursement-model development.
How To Boost Hospital Performance By Optimizing Your PharmacyCompleteRx
Assessing and managing productivity is a complex process that takes the rights tools and people. While pharmacy may seem to be a small part of an overall organization, it is actually one of the largest cost centers of a hospital, making it one of the most important departments to optimize and streamline. Learn how your pharmacy’s productivity can impact your hospital’s overall costs, quality, safety and patient satisfaction.
Key Points:
- Analyzing productivity
- Pros and cons of pharmacy productivity management tools
- Use of volume indicators
- Workflows to improve productivity and communication with nursing and hospital staff
5 Ways Your Pharmacy Can Boost Your Revenue CycleCompleteRx
With rising drug costs and decreasing reimbursements contributing to shrinking margins (in 2014, according to Modern Healthcare, 61.3 percent of healthcare providers reported decreased margins from the previous year), hospitals continue to scrutinize their revenue cycles to ensure they stay in the black, and there’s an oft-overlooked resource they would do well to consider: pharmacy. Historically, the hospital pharmacy has been labeled a cost generator, but there are actually many ways this strategic department can positively impact each stage of the revenue cycle – from point of service to claim submission and more. This webinar will explore innovative tactics, including optimized processes, improved data management, and creative patient programs, which hospital pharmacies across the country can leverage to boost overall hospital revenue.
Demystifying Commercial Reasonableness in Physician/Hospital TransactionsPYA, P.C.
PYA Principal Lyle Oelrich presented “Demystifying Commercial Reasonableness in Physician/Hospital Transactions” at the Georgia Society of Certified Public Accountants’ (GSCPA) 2016 Healthcare Conference, February 11, 2016, in Atlanta, Georgia.
Healthcare is Getting Disrupted... Is Pharmacy Ready?Hillary Blackburn
Change is coming for the healthcare industry, particularly as digital disruption is happening. Within the broader healthcare industry, pharmacy will be impacted and should be ready to help the profession grow and thrive.
How does the e-prescribing Software benefit Pharmacy Management?Shelly Megan
Pharmacy management system software is necessary to eliminate the myriad challenges encountered by the pharmacy community. E-prescribing software is one of the major components of pharmacy management. Its benefits include reduced prescription errors and better patient care, enhanced productivity for medical bodies, better workflow for pharmacies, and more convenience for patients in obtaining medication.
White Paper: Best Practices for Medical Benefit Management (MBM)Tai Freligh
Biologic, biotechnology-based, rare disease, or high-cost pharmaceuticals — collectively known as specialty drugs — can be covered under the pharmacy benefit, the medical benefit, or both depending on the benefit design plan sponsors require of the third-party administrator (including the pharmacy benefit manager – PBM; administrative service organization – ASO; or any administrator of a medical or pharmacy benefit).
On average, up to 50% of specialty drugs today are covered under the medical benefit.
With the exception of a few key therapy areas, traditional tools used to manage specialty drugs under the medical benefit, such as prior authorizations and medical benefit carve-outs (i.e., “white-bagging”), have yielded limited value to plan sponsors.
This thought leadership analysis, with insights from recognized industry experts, will provide an overview of the challenges.
Download the complete white paper to get the rest of the report, including a summary of the key issues plan sponsors must address and insights into best practices through an innovative new approach, Medical Benefit Drug Management (MBM).
Link: http://www.PharMedQuest.com/White-Paper
How to Drive ROI from Your Healthcare Projects: Practical Tools, Templates, a...Health Catalyst
At a time when average hospital’s margins are stagnating, executives should be asking tough questions about the ROI of “indispensable” technologies. Will new technologies prove their worth or drive them further into the red? How do you measure and track ROI?
Clinicians need more education on financial metrics and finance people need to learn more about the clinical processes and outcomes. One of the historical problems with calculating ROI has been the fundamental culture divide between clinicians and finance.
This slide set gives some practical tools, templates (Excel), and how tos based on years of experience to quickly and effectively develop the ability to measure and communicate ROI on healthcare IT and improvement projects.
How to Drive ROI In Your Healthcare Quality Improvement Projects Health Catalyst
At a time when average hospital’s margins are stagnating, executives should be asking tough questions about the ROI of "indispensable" technologies. Will new technologies prove their worth or drive them further into the red? How do you measure and track ROI?
We need to educate clinicians on financial metrics and finance people need to learn more about the clinical processes and outcomes. One of the historical problems with calculating ROI has been the fundamental culture divide between clinicians and finance. Gone should be the days that clinicians deliver care without knowing the financial cost of that care.
This slide set give practical advice on how to set goals, measure ROI and gives excel templates that are based on years of experience by the authors
A CEO's Keys to Continuous Quality ImprovementHealth Catalyst
Healthcare organizations will not survive this unstable environment without a vision and a plan. Even with rapidly declining reimbursement that makes resource allocation tight, a CEO must address what it will cost to sustain a commitment to quality and then move forward in building capacity into the organization to provide that quality.
Join Greg Stock, chief executive officer of Thibodaux Regional Medical Center, as he shares how Thibodaux strives for the Triple Aim using the following keys to successful continuous quality improvement:
Engaging physicians and other influencers to bring together the right people for effective collaboration
Leveraging a data warehouse to identify opportunities for improvement, have a single source of truth to support decisions, and rapidly implement change
Spreading expertise across the organization, or ensuring individuals take the knowledge and skills they have acquired and apply them to other problem areas throughout the organization
Don’t miss hearing this CEO’s experiences with a methodology that The Joint Commission calls “best practice in how to use data and get physicians engaged.”
Strengthening Financial Performance - Learn how New England Cancer Specialists increased productivity by 36%. Access the complete webinar from within the ppt.
How to thrive in the new value based care delivery worldHealth Catalyst
As Healthcare shifts from fee-for-service towards value-based care, many healthcare systems struggle with this challenging transition.
Join Tom Burton, Co-founder of Health Catalyst, as he describes the journey of many health systems working through the complexities, capabilities and strategies required to thrive through the transition.
You will come to understand:
How analytics can help to better manage at risk contracts in value-based care delivery settings
How network optimization through appropriate provider selection can reduce out of network leakage
How a balanced approach to care management increases your return on investment
The three key capabilities required for systematic population health management
Principles and Pracitces of Accountable Care TransformationHealth Catalyst
Facing the most sweeping payment transformation in history, healthcare systems are balancing two competing mandates: build the competencies needed to succeed under value-based payment models while remaining financially viable in the current fee-for-service landscape. Across the next decade, changing payment models will drive a fundamental transformation in care delivery, emphasizing dramatically lower costs and improvements in quality. While this final destination is clear, today’s health care leaders face high stakes and a great deal of uncertainty as they architect the path for their organizations' survival and success not only under value-based payment, but—critically—during the transition period.
Join Marie Dunn, Director of Analytics, as she outlines the key near-term priorities for health care organizations transitioning to value-based payment models, with a particular focus on the importance of leveraging data to drive effective decision making. She will also use Health Catalyst solutions to demonstrate these principles.
Marie will cover:
State of the transition from fee-for-service to value-based payment models
Near-term priorities for organizations looking to build the competencies to successfully manage at-risk contracts, including:
At-risk contract management: monitor performance against contractual requirements and leverage data to drive payer negotiations.
Network management: reduce leakage and improve referral patterns and network composition.
Care management: focus care team efforts by leveraging data to identify the patients in greatest need of support.
Performance monitoring: identify opportunities to improve performance on quality measures, like the ACO quality measures.
Strategies for balancing near-term priorities with long-term efforts to drive care transformation across the delivery system
GoTelecare Medical Billing & Coding ServicesGoTelecare
GoTelecare is a leading global provider of Business and Knowledge Process Outsourcing services in the US healthcare domain. We deliver proprietary technologies, workflow and business processes to cater to various medical billing & coding requirements of our clients. We specialize in turnkey Revenue Cycle Management services, account receivables recovery & clean-up, DME billing and a complete range of billing & coding services for pharmacies, physicians, hospitals, nursing homes, urgent care centers, drug rehab centers and more.
Hospital Management Business Plan Powerpoint Presentation SlidesSlideTeam
Introducing our Hospital Management Business Plan PowerPoint Presentation Slides to help you build a firm foundation for the public health system. Select our professionally curated health administration PPT templates to provide an understanding of key demand and supply drivers like consumer demographics and geographics. Highlight the global medical spending statistics on crucial trends like robotics companions, ingestible health sensors, health technology, smart nutrition technology, and mobile applications through this PPT slideshow. You can employ our hospitality PowerPoint layouts to elaborate on building blocks of optimized health systems like technical content, management skills, operational and finance systems. Highlight the structure of important stakeholders and the importance of effective healthcare administration using these hospital sector PPT visuals. Showcase the framework of corporate and hospital tie-ups with our hospital network PowerPoint presentation in a well-organized format. Click the download button and make this healthcare management PowerPoint deck your source to educate the audiences about the essential public health services. These content-specific slides effectively convey the importance of proper medical care comprehensively. https://bit.ly/3tNrHhU
As pharmaceutical and biopharmaceutical manufacturers are receiving more attention, legal scrutiny and activity from government and other entities regarding various components of their patient support services programs, this survey analyzes responses from close to 30 small, mid-size, and large pharmaceutical organizations (9 of the Top 20 pharmaceutical companies) to provide insights as it relates to risk mitigation and emerging strategies for managing patient interactions in a compliant manner.
Value-Based Purchasing in healthcare is here to stay. Though the industry has come to terms with this reality, there are still more updates and changes than most of us can keep up with. In a world of accountable care, quality measures, shared savings, and bundled payments, everyone seems to have more questions than answers.
Bobbi Brown, Vice President, Financial Engagements outlines the latest announcements on Value-Based and how to prepare your organization for success in this new reality. Having previously worked in healthcare administration and finance for Kaiser, Sutter, and Intermountain, Bobbi is no stranger to translating complex legislative requirements for complex health systems.
Bobbi discusses the various programs offered by CMS, in particular:
What the programs are
How these programs are measured
What the current incentives are
Results of the programs to date
Organizational changes needed for the shift in programs
Automated Medication Compliance Tools for the Provider and PatientHealth Catalyst
When it comes to sustaining patient health outcomes, compliance and adherence to medication regimens are critically important, especially as providers manage patients with complex care needs and multiple medications. But, with provider burnout and staffing shortages at an all-time high, an efficient solution is critical. The use of automated medication management workflows to decrease provider burnout, while improving both medication compliance and patient engagement, is the way forward.
With the patient at the true center of next generation care, it is critical to stay on the cutting edge of what is required for compliance monitoring, particularly for specialty products. With a focus on patient interactions and associated programs, this Helio presentation highlights how the automation of a company's compliance monitoring and implementation of an analytics engine can produce real-time results and identify best practices to be applied to business intelligence for future activities.
Surviving Value-Based Purchasing in Healthcare: Connecting Your Clinical and ...Health Catalyst
Reducing healthcare costs is a major driving force in bundled payments, home-centered medical care, and accountable care organizations. But each new delivery model is built on the premise of reducing revenue per patient. So how can a health system win? Find out what you can do financially survive in today’s environment.
Access 2-healthcare company introduction deck - English - Apr 2019Access-2-Healthcare
Market Entry for Medical Technology / Medical Device companies, in Asia Pacific, Europe, US
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Convert non-medtech company to create medtech portfolio
Regulatory framework for government agencies
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Similar to How Specialty Pharmacies Can Use Data to Drive Revenue (20)
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
High cost of specialty therapies means SPs need to provide high quality care
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