2. Introduction
• Albendazole, also known as albendazolum, is a medication used for the treatment of a
variety of parasitic worm infestations.
• It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm
disease, and ascariasis, among other diseases.
• Albendazole is a broad-spectrum antihelminthic agent of the benzimidazole type.
• Albendazole was developed in 1975.
• It is on the World Health Organization's List of Essential Medicines.
• Though albendazole is effective in treating many diseases, it is only FDA-approved for
treating hydatid disease caused by dog tapeworm larvae and neurocysticercosis caused by
pork tapeworm larvae.
24-09-2020ABHIJITH SP CVAS POOKODE 2
3. Class
• Belongs to the Class: Benzimidazole.
• Contain Benzene ring and Imidazole Group.
• Albendazole is mainly used in cattle and sheep, but has found some use in
cats and dogs as well; it is also used in ratite birds for flagellate parasites and
tapeworms.
• It is also used off-label to treat endoparasites in goats and pigs.
24-09-2020ABHIJITH SP CVAS POOKODE 3
5. MOA
• Albendazole is a broad-spectrum anthelmintic.
• The principal mode of action for albendazole is by its inhibitory effect on tubulin
polymerization which results in the loss of cytoplasmic microtubules.
• Actually microtubule is composed of dimers made up by alpha tubulin and beta tubulin.
• This fusion to form dimer is inhibited by these drugs.
• So no microtubules are formed.
• Also it Blocks GLUT-2 Transporter.
• ATP production is decreased resulting in worm immobilization and death.
24-09-2020ABHIJITH SP CVAS POOKODE 5
11. Tips.
• Thiabendazole has least use due to most toxic among these and have more
side effects.
• Mebendazole is usually well tolerated.
• Thiabendazole was the first benzimidazole anthelmintic agent produced.
24-09-2020ABHIJITH SP CVAS POOKODE 11
