In this slidashare we have covered the anthelmintic medications. In this we have covered introduction,classification of the anthelmintic drugs,their mechanism of action,uses,side effects,etc...

1. PHARMACOLOGY
Presented by : -
Prashant Ingawale
Prashant Jatkar
Yogesh Pawar
Gaurav Deshpande
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3. INTRODUCTION
• DEFINITION :-
Anthelmintics are the drugs
either kill or expel infesting helminths
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4. Classification
1] For Roundworm,Hookworm,Pinworm:-
E.g:- Albendazole, Mebendazole, Piperazine,
Levamisole.
2] For Threadworm:- E.g:-
Ivermectin,Albendazole.
3] For Whipworm,Trichinella,Spiralis:-
E.g:- :- Albendazole, Mebendazole.
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5. 4] For Tapeworms:- E.g:- Praziquantel,
Niclosamide,
Albendazole
5] For Filariasis :- E.g :-
Diethylcarbamazine Citrate
Ivermectin
Albendazole
6] For Hydatid disease :- Albendazole,
Mebendazole
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6. Mebendazole
 MOA
 It acts by inhibiting microtubule synthesis
 It bind with parasite β-tubulin & inhibit its
polymerisation
 Mebendazole blocks the glucose uptake in parasite &
deplets its glycogen store
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7. ..
Adverse Effects –
Cause diarrhoea
Abdominal Pain
Sometimes Lower platelet count
Uses –
Used in the treatment of roundworm,
hookworm, threadworm
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8.  It act by altering organelle membrane of the
microfilarial promoting cell death
 Diethylcarbamazine (DEC) is a medication
used in the treatment
of filariasis including lymphatic filariasis,
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9.  Common Side Effects :
Itching,facial swelling,
headache and feeling tired
 Other side effects :
Vision loss
Dizziness
USES :
filarial diseases, including lymphatic
filariasis caused by infection with Wuchereria
bancrofti, Brugia malayi, or Brugia timori;
tropical pulmonary eosinophilia; and loiasis.
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10. Ivermectin
It acts through
glutamate gated Cl-
channel found only in
invertebrates
Potentiation of
gabaergic transmission
in the worms has also
been reported
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