This document discusses pilots of telemedicine projects in the Aquitaine region of France and the challenges of scaling them up regionally. It describes three pilot projects in nursing home teleconsultation, telestroke treatment, and a secure messaging platform for healthcare professionals. Barriers to wider adoption include economic issues, regulatory frameworks, institutional silos, and resistance to change. However, the region is taking a multi-pronged approach of promoting telemedicine in education, industry, practitioner communities, and through political support to help drive systemic organizational change and regional coordination of projects.