Helix Genomics introduces a Biological Operating System (BOS) designed to streamline drug discovery and bioinformatics through customizable, scalable tools that integrate multiple functions and reduce unproductive time. The document outlines the market challenges in bioinformatics, emphasizing the need for standardization and the potential growth of analytical software in the sector. Helix Genomics aims to dominate the bioinformatics landscape by becoming a one-stop solution for biological programming and data management.

1. Helix Genomics HELIX GENOMICS

2. BOS – Biological Operating System Helix Genomics Prasad Burra, Ph.D Founder, MD & CTO programming life Helix Genomics

3. protein DNA mutant Drug Discovery phase (5-7Y) 8-1 $1.3B Helix Genomics HELIX GENOMICS Market pain Science

4. Market pain : Software Not 'systems biology' ready One algorithm – one tool Tools not scalable, extensible Tools are scattered No flowchart or process automation Enormous unproductive time – searching , learning, customizing, benchmarking No standardization No integration Data Redundancy Restrictive Helix Genomics

5. Novel BOS paradigm The Researcher Custom data Best Results Output 'systems biology' ready One-language solution Biological design & intuitive Customizable, extensible and flexible Flowchart or process automation On-the-fly biological programming – no compilation, no linking Rich source of reusable and tested biological objects Easy testing, validation and benchmarking Cuts cost and time by ~55% Scientific exploration & inquiry Faster & alternative solutions Process / Flowchart implementation Reliable, Reusable & Consistent Application Frameworks Helix Genomics Our Solution:'a must have'

6. ...The analytical software segment .. posting .. fastest growth rate... Global Bioinformatics Market Outlook, Research Report, Sept 2007 Evolving bioinformatics software Competitive Matrix Helix Genomics 1 st Gen 2 nt Gen 3 ed Gen 4 th Gen 1970- -- 1980-- 2000- -- 2002- -- Functions ( Sequence Comparison) Tools Like Blast Accelrys Bio perl / Bipjava Helix Genomics / Bos Integration / Visualization 0 10 10 10 programming & Automation 0 10 3 8 ( customization, scripting, extensibility) 0 0 6 10 Biological design implementatin 0 0 1 10

7. BOS – one-stop, one-language solution Standardization is possible with BOS which is mentioned as a major challenge in recent market reports GBMO, Research Report, Sept 2007 Integration / Visualization Biological Design Programming & Automation Biological Functions Helix Genomics

8. Market size Bioinformatics tools - market size: The bioinformatics market is forecast to grow at a CACR of 23% to $4.5bn by 2011 Market segmentation Database providers – 45% (2006) - $US 0.8b Drug Discovery research – 55% - $US 1.0b Genomics – 60% Proteomics – 40% Helix Genomics GBMO, Research Report, Sept 2007

9. Market growth ...it is the analytical software segment that is posting the fastest growth rate ... ( Global Bioinformatics Market Outlook, RNCOS, Sept 2007) ‏ Helix Genomics Market Category 1980 2002 2005 Data Suppliers 49% 38% 30% Analytical Software Providers 39% 43% 55% Enterprise System Providers (Accelrys etc…) ‏ 12% 19% 15%

10. Target market Drug Discovery research Co's Pharmaceutical Biotech Life Science Academia Helix Genomics Source: Nature Biotechnology, 2000

11. Target size Bioinformatics R&D and Educational Establishments* Helix Genomics *Estimates based on 'Growing the Nation's Bioscience sector:, BIO, April 2006 USA Europe India Total Degree Colleges/ Post Graduate Centers 1250 1070 2000 4670 Engineering Colleges/Universities/Depts. 350 Research Institutes/Labs 2050 1850 75 3975 Biotech /Life Science Cos 1120 990 20 2130 Pharma Cos/CROs 1580 1320 30 2930 Total 6000 2530 2475 13705

12. Technology Licensing Contract Services Contract Research Service and Outsourcing Custom biological databases Custom algorithms, custom software tools Drug discovery, genomic, proteomic & HT data analysis Product Service Online bioinformatics lab Helix Genomics Revenue models

13. Current Status Helix Genomics HELIX GENOMICS

14. Growth & Sustainability Patent Protected Technology Exploitation Product Road Map BioVPE ‏ BOS Client/Server BOS Online Bio SDK ‏ Helix Genomics BOS on Cloud Computing/ GRID/ Mobile / Parallel

15. Exit strategy Helix Genomics HELIX GENOMICS

16. BOS – Biological Operating System programming life Helix Genomics Goal : BOS on every PC (in 10 years) ‏ Google of Bioinformatics (Internet market) ‏ Microsoft of Bioinformatics (PC market) ‏

17. Helix Genomics Additional Slides

18. BOS –Data curation through analysis to publishing 500 Biological Objects 15000 methods/functions 25 Algorithm Implementation 15 Database Input formats 3 Output formats 7 Biological Libraries Several Sequence and Structure specific objects Statistics and Matrix functions 300,000 lines of Code Dynamic Intelli Help Programmatic interface for connecting to databases Protein Prediction Algorithms Protein Homology modeling Genome wide analysis Helix Genomics HELIX GENOMICS Encouraging Innovation, Enabling Expression of Biological Intuition

19. Technically me 2.5 years in Web Designing – Wikis, Web CMSs using AJAX – [X|D]HTML, CSS, Javascript, MySQL, PHP 4 years of teaching & training in Bioinformatics & Computational Biology 6 years of entrepreneurial activity – Director / Founder / CEO / CTO 12 years of research into Bioinformatics, Bio-software, Genomics, Proteomics, Systems Biology 15 years of Programming – C++ / Shell Scripting / *nix OS / Helix Genomics

20. Excerpts supporting BOS timing ...it is the analytical software segment that is posting the fastest growth rate...( Sept 2007) ‏ ...lack of standardization remain the biggest challenge for the bioinformatics industry...(Sept 2007) ... outsourcing is expected to emerge as a definitive trend in the bioinformatics industry, according to a new report by Frost & Sullivan(Sep, 06) ...if the tools are put in the hands of the actual users , the entire user base will increase , making it an attractive proposition for the bioinformatics companies...(Aug 05) ‏ it is necessary to capture the student/academic community first...(Oct, 05) ‏ the market for bioinformatics isn't large enough to support a company built around one or two high-cost software programs targeted to a relatively small user group...(Nov, 04) Helix Genomics

21. BOS programming guide : Helix Genomics BOS programming guide:

22. Life Cycle of Biological Query Data Generation (Experimental)‏ Data Processing Tools Data Reduction Tools Data Annotation Tools Data Mining Tools Data Analysis Tools Data Representation Tools Data Publishing Tools Domain of a Computational Biologist With BOS one can accomplish all these computational tasks and queries Helix Genomics

23. BOS Algorithms – Generic Object Oriented Biological Algorithms - GOOBA Self Repeat Algo. Helix Genomics Encouraging Innovation, Enabling Expression of Biological Intuition.