Hello I have a paper that is due this wednesday and would like to know if you would do this for me.  Please message me if you are willing and able. I have also attached the first part of the assignment along with the new assignment that is needed, this needs to go along with what I currenently have.  Please see the professors notes to make the necessary changes. This is what was done so far (with teachers comments) and then below that is the assignment.   Methadone, An Effective Alternative to Opiate Dependency and its Safety ,  please be sure to open up your attachment below for more detailed feedback that you will need to make revisions for future assignments . If you have any questions let me know.  Assignment 3 Grading Criteria Maximum Points Created a research question  based on a research topic approved by the instructor and submitted a testable hypothesis.  Your research question and hypothesis are missing. Your next step will be to develop both a research question, which should be just that a question you have about our topic and then you need your hypothesis. Your hypothesis should be a one sentence declarative statement that makes a prediction. It should answer your own research question. 0/15 Submitted citations in the form of an  APA-style reference page  for five articles and  included a paragraph summarizing each article  and discussing its relevance.  There are some documents in Doc Sharing that give some tips on APA formatting.  In addition, there are templates you need to be using for each of the assignments accept M3_A2. Be sure to watch the videos posted in the Webliography as well. 39/40 Ensured that all the articles are from peer-reviewed journals.  Very nice, your articles are relevant and all from peer-reviewed journals. :-) 20/20 Submitted a title page for the submission. 5/5 Wrote in a clear, concise, and organized manner; demonstrated ethical scholarship in accurate representation and attribution of sources; displayed accurate spelling, grammar, and punctuation. 20/20 Total: 84/100 Greenwald, M. K. (2002). Heroin craving and drug use in opioid-maintained volunteers: Effects of methadone dose variations. Experimental and Clinical Psychopharmacology, 10 (1),  39-46. Retrieved from http://search.proquest.com/docview/614364383?accountid=34899 [YB1] The research questions being investigated in this article was to determine whether or not methadone dose variations would increase or decrease the craving of heroin (2002).  The method involved volunteers that were found in the Detroit area through advertisement and through word of mouth, there were eighteen volunteers in total that completed the study out of 35, seventeen were disqualified due to continued heroin or other drug use or for not showing up when needed and each were given money for their participation (2002). There were 10 men and 8 women with 11 being African-American and 7 Caucasian. The study was conducted in two (2) phases, the first phase included.

1. Hello I have a paper that is due this wednesday and would like
to know if you would do this for me. Please message me if you
are willing and able.
I have also attached the first part of the assignment along with
the new assignment that is needed, this needs to go along with
what I currenently have. Please see the professors notes to
make the necessary changes.
This is what was done so far (with teachers comments) and then
below that is the assignment.
Methadone, An Effective Alternative to Opiate Dependency and
its Safety
,
please be sure to open up your attachment below for more
detailed feedback that you will need to make revisions for
future assignments
. If you have any questions let me know.
Assignment 3 Grading Criteria
Maximum Points
Created a research question
based on a research topic approved by the instructor and
submitted a testable hypothesis.
Your research question and hypothesis are missing. Your next
step will be to develop both a research question, which should
be just that a question you have about our topic and then you
need your hypothesis. Your hypothesis should be a one sentence
declarative statement that makes a prediction. It should answer
your own research question.
0/15
Submitted citations in the form of an

2. APA-style reference page
for five articles and
included a paragraph summarizing each article
and discussing its relevance.
There are some documents in Doc Sharing that give some tips
on APA formatting.
In addition, there are templates you need to be using for each of
the assignments accept M3_A2. Be sure to watch the videos
posted in the Webliography as well.
39/40
Ensured that all the articles are from peer-reviewed journals.
Very nice, your articles are relevant and all from peer-reviewed
journals. :-)
20/20
Submitted a title page for the submission.
5/5
Wrote in a clear, concise, and organized manner; demonstrated
ethical scholarship in accurate representation and attribution of
sources; displayed accurate spelling, grammar, and punctuation.
20/20
Total:
84/100
Greenwald, M. K. (2002). Heroin craving and drug use in
opioid-maintained volunteers: Effects of methadone dose
variations.
Experimental and Clinical Psychopharmacology,
10
(1),
39-46. Retrieved from
http://search.proquest.com/docview/614364383?accountid=3489
9

3. [YB1]
The research questions being investigated in this article was to
determine whether or not methadone dose variations would
increase or decrease the craving of heroin (2002). The method
involved volunteers that were found in the Detroit area through
advertisement and through word of mouth, there were eighteen
volunteers in total that completed the study out of 35, seventeen
were disqualified due to continued heroin or other drug use or
for not showing up when needed and each were given money for
their participation (2002). There were 10 men and 8 women
with 11 being African-American and 7 Caucasian. The study
was conducted in two (2) phases, the first phase included each
volunteer going into the clinic to have methadone given to them
with the dosage increasing daily to where the withdrawal
symptoms of the opiate use would decrease all together (2002).
Each day they would come in, they were to let the physician
know of the withdrawal symptoms and signs that they were
experiencing and the dose of methadone would increase 5mg-
10mg. this happened over a period of 36 days (2002). During
phase 2, the volunteers were being weaned off of the methadone
slowly to see if the craving of the opiates would come back and
to see if there were signs of possible relapse, this occurred over
a 36 day period. During each session, urine was taken and
testing was done to ensure that there were no other opiates in
their system. It was found that in Phase 2, the decrease in
methadone did in fact have impact on the volunteers and each
experienced withdrawal symptoms and signs of cravings for
heroin and that two of the volunteers dropped out (2002). The
results revealed that the detoxification process for each
individual is different, therefore they were unable to state
whether or not methadone actually does take the craving of
heroin away completely, they did find that while the volunteers
were on the methadone, the craving for heroin had in fact gone
away once the dosage for each was maintained at the level that
worked best for each (2002). One thing that should have been

4. taken into consideration would have been to have the volunteers
stay at the clinic the entire time the study was conducted, if this
would have been the case, then the experimenter could have
seen how long the methadone lasted for and see the signs of
withdrawal and distress for themselves. If this would have
happened then they would have been able to incorporate this
into their study rather than letting the volunteers go home and
then coming in the following day and then asking them a series
of questions.
Cohen, L. J., Gertmenian-King, E., Kunik, L., Weaver, C.,
London, E. D., & Galynker, I. (2005). Personality measures in
former heroin users receiving methadone or in protracted
abstinence from opiates.
Acta Psychiatrica Scandinavica,
112
(2), 149-158. doi:
http://dx.doi.org/10.1111/j.1600-0447.2005.00546.x
The objective in this article is the effectiveness of methadone
maintenance therapy among those addicted to opiates, it
compares personality traits between previous heroin addicts and
those that are receiving methadone maintenance therapy to see
if there is a difference between the selections of treatment
(2005). The method used is 26 former heroin addicts that are
receiving treatment through methadone maintenance therapy, 33
former heroin addicts that are withdrawn from the methadone
maintenance therapy, and 43 individuals that are healthy with
each having been compared on the Million Clinical Multiaxial
Inventory-II along with the Temperament and Character
Inventory (2005). The results showed that the 26 heroin addicts
receiving methadone treatment therapy had a higher novelty
seeking and lower self-directedness scores on the Temperament
and Character Inventory and that both the 26 former heroin
addicts receiving methadone treatment along with the 33 former
heroin addicts withdrawn from methadone treatment scored

5. higher in many scales on the Million Clinical Multiaxial
Inventory-II than the 43 healthy individuals (2005). The 33
former heroin addicts scored higher on two cluster A Scales and
the delusion disorder scale than both the 43 healthy individuals
and the 26 heroin addicts that are currently receiving methadone
treatment. In conclusion, it appeared that those who were
previous opiate addicts may require additional treatment options
than previously recognized and that therapeutic treatment may
also be effective alongside of the Methadone Treatment Therapy
(2005).
Rass, O., Kleykamp, B. A., Vandrey, R. G., Bigelow, G. E.,
Leoutsakos, J., Stitzer, M. L., . . . Mintzer, M. Z. (2014).
Cognitive performance in methadone maintenance patients:
Effects of time relative to dosing and maintenance dose level.
Experimental and Clinical Psychopharmacology,
22
(3), 248-256. doi:
http://dx.doi.org/10.1037/a0035712
The objective in this article is to investigate the cognitive and
psychomotor performance in in 51 methadone maintenance
patients from the last methadone dose along with the
maintenance dose level, these doses range from 40mg-200mg
(2014). The participants were 51 methadone maintenance
patients with 59% being women were recruited from an
outpatient methadone clinic in Baltimore, these participants
have been in the program for at least 6 months and the dosage
varied for each. All of the participants were informed of what
the study entailed and each signed a consent and were paid for
their participation. The study was conducted by the participants
completing two performance testing sessions within a week of
each other. The participants would attend their regular clinic for
dosing and then on session days, they would report to the
research unit located at John Hopkins Behavioral
Pharmacology. The participants were administered an oral
solution 120 minutes before, and immediately after the

6. performance testing battery for each of the two sessions. The
testing that was performed were sensory processing,
psychomotor function, attention, working memory, and episodic
memory and metamemory (2014). Analysis was then conducted
on each dependent measure in the cognitive battery, each
session was relative to their dosing of methadone both during
both the peak session of the methadone and their maintenance
dose level. Results showed that both the cognitive and the
psychomotor performances were worse at the peak time (120
minutes after taking the methadone) versus the maintenance
level (about 26 hours after the methadone dose), however there
was not enough to be clinically significant (2014).
Sarkar, S., & Mattoo, S. K. (2012). Newer approaches to opioid
detoxification.
Industrial Psychiatry Journal
,
21
(2), 163–167. doi:10.4103/0972-6748.119652
The objective in this article is to find other methods of
detoxification for those that suffer from addiction to opiates.
The strategy was that was conducted in October of 2011 was
that 659 peer reviewed articles were identified using PubMed
and PsychInfo databases with keywords used such as opioid and
detoxification (2012). The researchers then gathered the results
and method used from each of these articles and then further
studied those (2012). The results showed that many of the non-
opioids that have been used for detoxification have been
effective in taking the cravings and withdrawal symptoms away,
however if tapered off to quickly, the relapse rate is high. The
medications that are be used for detoxification have proven to
be effective, but the potential to misuse this medication is still
an ongoing concern. Currently there is still no known
medication that has been found that does not have potential for
abuse that is cost effective, safe, and requires minimal
monitoring (2012).

7. Amato L, Davoli M, Minozzi S, Ferroni E, Ali R, Ferri M.
Methadone at tapered doses for the management of opioid
withdrawal. Cochrane Database of Systematic Reviews 2013,
Issue 2. Art. No.: CD003409. DOI:
10.1002/14651858.CD003409.pub4.
The objective in this article is to evaluate how effective the
tapering is of methadone compared to the many other
detoxification treatments and placebo for those addicted to
opiates from withdrawal symptoms to the completion of the
detoxification process (2013). This study also will show the
relapse rate as well. There were 23 trials that took place among
2,467 people in which the researchers compared methadone to
any other pharmacological treatment, and it was found that
there was no difference (2013). There were 19 other studies
that were completed on 1,381 participants, however the
researchers found it to be impossible to pool the data for these
individuals due to each experiencing different symptoms and
each being on different dosages and different programs (2013).
The conclusion showed that tapering methadone slowly was the
most effective way for the opiate addict, however the relapse
rate was still very high (2013).
So the question here is:
Methadone, is this an effective alternative to opiate dependency
and is it safe?
When reading these articles, I expected to have my hypothesis
confirmed along with more eye opening accounts to assist me in
my personal and honest life situation. These articles have been
very informative and helpful and will fit in with the research
paper that is being done on effective treatment and chemical
dependency. It shows that methadone can be very helpful and
that given the right dose, it does take away the cravings and
withdrawal symptoms and use of heroin, however, when it
comes to tapering off of methadone, the process will take longer
depending on the individual themselves. Successful recovery is
not very high, but with the right supports in place, it appears as
though it is possible, another factor to take in, is the mindset of

8. the addict and their willingness and desire to quite using
opiates. Through close monitoring of a physician, it is possible
that this is an effective treatment option for those suffering
addiction from opiates. Ongoing counseling to determine the
root cause of the addiction along with possible future
medication monitoring for the damages that the opiates may
have caused is an another method that should fall hand and hand
with the above statement.
[YB1]
Be sure to double space all of your work and papers, and all
lines after the first line of each entry in your reference list
should be indented one-half inch from the left margin. This is
called hanging indentation. Otherwise very nice formatting.
J
Assignment 2: Final Project: Sampling
Based on the feedback you received on your submission from
last week, submit a revised draft of your paper with this
additional information:
Five additional references that could be used for your research
paper and include a 1-2 sentence description for each of the five
additional references, explaining how they fit with the research
topic and the research question proposed. Make sure that these
references come from scholarly sources using Argosy's library
resources.
A very detailed
outline
of what you would like to cover in the intro/lit review of your
paper. Write it as an outline and think about what you want each
paragraph or section to cover. Paste your references into each

9. section where the information from that article applies to the
topic. Below is an example of the outline although the
references have not been pasted in yet:
Introduction or Statement of the Problem (e.g. Predictors of
Depression in Men)
Research question (E.g. What factors predict depression in men?
For example, age, marital status, family history, stressors).
Why is it important/implications (E.g. xx% of men are
depressed; less likely to seek treatment; if we can identify who
is at risk, may be able to direct them to treatment sooner)
Revised hypothesis based on feedback from the instructor
Review of the Literature (the following is an example for above
topic):
Brief description of depression, symptoms, and any unique
symptoms for men (Cite articles from which you will obtain this
information).
How widespread is it? Stats on depression in general but also
stats on depression in men (Cite articles from which you will
obtain this information).
List factors that put men at risk for depression (Cite articles).
Difficulty communicating distress or sadness (Cite articles).
Job/work pressures (Cite articles).
Demographic characteristics (Cite articles).
Relationship between age and depression (Cite articles).
Relationship between marital status and depression (Cite
articles).
A 1-2 page description of the sample you would like to use for
your study, that provides the answer to the following questions:
What sampling technique would you use?
Does the sample generalize to the population? Explain why or
why not.
What inclusion criteria would be used? What exclusion criteria
would be used, if any?
What ethical issues might be encountered when collecting your
information from this sample?
Be sure to also submit all your ten references (the five from last

10. week and the five new ones you added) in an APA-style
reference page. Be sure to also include an APA-style title page
with your submission. Your paper should be at least 2-3 pages
long. Make sure you write in a clear, concise, and organized
manner; demonstrate ethical scholarship in accurate
representation and attribution of sources; display accurate
spelling, grammar, and punctuation.
Submit your assignment to the
M2: Assignment 2 Dropbox
by
Wednesday, March 4, 2015
. All written assignments and responses should follow APA
rules for attributing sources.
Assignment 2 Grading Criteria
Maximum Points
Provided five additional valid references and explained the
reasoning behind their selection.
20
Discussed the sampling technique for the proposed study and
included the aspects of generalization, inclusion, and ethical
issues as requested in the assignment.
25
Provided a detailed outline of the intro/literature review section
of the paper, along with revised hypothesis.
25
Included an APA-style title page and reference page (with at
least 10 references).
10
Wrote in a clear, concise, and organized manner; demonstrated
ethical scholarship in accurate representation and attribution of
sources; displayed accurate spelling, grammar, and punctuation.
20
Total:
100