Life expectancy has increased greatly over the past 100 years. Increased wealth, sanitation, and access to pharmaceutical innovation have contributed to our health, allowing us to live longer and healthier lives. We are on a tipping-point of healthcare mostly related to new technologies - big data and genomics, robotics, immunotherapy, remote monitoring, 3D printing, among others, will bring forth a new era in health and standards of care.
Digital and technological advancements and how they have impacted health. From data, IoT & wearables, 3D printing, personalized medicine, all of these trends can be levers to help with demographic shifts, increased access to healthcare and rising costs.
2016 Overview of significant trends in the life sciences (Biotechnology, Pharmaceutical, Device and Diagnostics) industry with Regenerative Medicine feature articles.
The Future of mHealth - Jay Srini - March 2011LifeWIRE Corp
Jay Srini's presentation of her take on the Future of mHealth, presented at the 3rd mHealth Networking Conference, March 30, 2011. Aside from being one of the preeminent thought leader in the area of innovation and mhealth, she holds a number of positions including Assistant Professor at the University of Pittsburgh and CIO for LifeWIRE Corp.
These are the upcoming life science trends we can expect to see more in 2019. While healthcare research in immunomodulation and gene therapy is relevant; data-sharing, purpose-driven analytics and AI is gaining more popularity within the industry. With these technological aspects in place, the research community hopes to drive for more discoveries and medical breakthroughs.
Presentation given at the 2014 Charité Entrepreneurship Summit in Berlin (5 may 2014, http://www.charite-summit.de/Summit2014.htm) about the 10 digital trends that are already impacting the way care is delivered and medicine is practiced. The presentation shows examples of innovation at Hospital Sant Joan de Déu (Barcelona) to prove that these trends are not futuristic but already here.
Digital and technological advancements and how they have impacted health. From data, IoT & wearables, 3D printing, personalized medicine, all of these trends can be levers to help with demographic shifts, increased access to healthcare and rising costs.
2016 Overview of significant trends in the life sciences (Biotechnology, Pharmaceutical, Device and Diagnostics) industry with Regenerative Medicine feature articles.
The Future of mHealth - Jay Srini - March 2011LifeWIRE Corp
Jay Srini's presentation of her take on the Future of mHealth, presented at the 3rd mHealth Networking Conference, March 30, 2011. Aside from being one of the preeminent thought leader in the area of innovation and mhealth, she holds a number of positions including Assistant Professor at the University of Pittsburgh and CIO for LifeWIRE Corp.
These are the upcoming life science trends we can expect to see more in 2019. While healthcare research in immunomodulation and gene therapy is relevant; data-sharing, purpose-driven analytics and AI is gaining more popularity within the industry. With these technological aspects in place, the research community hopes to drive for more discoveries and medical breakthroughs.
Presentation given at the 2014 Charité Entrepreneurship Summit in Berlin (5 may 2014, http://www.charite-summit.de/Summit2014.htm) about the 10 digital trends that are already impacting the way care is delivered and medicine is practiced. The presentation shows examples of innovation at Hospital Sant Joan de Déu (Barcelona) to prove that these trends are not futuristic but already here.
HealthXL: How Artificial Intelligence (AI) Can Improve Research & Care Models...Maeve Lyons
Artificial Intelligence in Pharma and Care Delivery Delivering on the Promise.
Earlier this week we published a blog about the state of AI in pharma and care delivery, and we also mentioned we’d be launching an accompanying report. We’re happy share our initial report presentation as part of HealthXL’s Big Data & AI Working Group above.
In the future, HealthXL’s Working Group will go deeper into use cases and discuss other relevant industry topics such as best practices for acquiring quality data, regulatory guidelines for AI solutions, leading academic centers, and much more!
https://healthxl.co/report-artificial-intelligence-pharma-care-delivery-delivering-promise/
A 45minute talk on the basics of Web 2, IT and medicine, particularly focussing on Web 2 tools that can be used by doctors and patients. Also a brief look at accessing these and other tools via portable means, demonstrated with my iPhone.
Redesigning healthcare, biohacking our lives (IMEC ITF2014)Koen Kas
On our way to redesign healthcare, we will learn to combine different layers of our biological code (now in reading but soon in writing mode), data from visible and invisible sensors, and the connected Internet of Bodies/Things. These guardian angels will open up unseen opportunities for the way we deal with ourselves in health and disease. With DNA soon becoming the new software, combining biology, electronics, attractive design & smart communication will provide the tools to (bio)hack our lives.
Appropriate use of different (nano)technologies will convert us into health consumers, with our doctors as (virtual) coaches. This will move us away from current curative healthcare to precise, preventive and even augmented healthcare. But smart technologies and the data they generate, are just a tool. When not trusted by the established care provider, when not integrated and available in a personal data platform, healthcare will only be pseudo modernized. The real magic happens when these tools allow you to engage and change behaviour. But even in a rapidly automating world, we can’t automate such change. Or can we?
The future of healthcare will see a shift from treating illness to sustaining wellness. Ageing could become a treatable disease in the future. Find out more: http://bit.ly/2wD13dL
Cemal H. Guvercin MedicReS 5th World Congress MedicReS
Ethical Issues in Artifical Intelligence Applied to Medicine Presentation to MedicReS 5th World Congress on October 19,25,2015 in New York by Cemal H. Guvercin, MD, PhD
Health: to insure or to ensure? Welcome in the new normalKoen Vingerhoets
Slideset about health and how it affects our culture. With the increasing pace of change, new business models emerge. They're supported by new technological evolutions (healthtech), enabling new companies to challenge incumbent insurance companies.
Healthcare, along with many other sectors, is facing increasing uncertainty driven by technology disruption and greater individual / patient empowerment. The barrier to entry into the sector is dropping fast enabling Asia entrepreneurs to significantly improve the Asia healthcare ecosystem
Thomas Willkens-El impacto de las ciencias ómicas en la medicina, la nutrició...Fundación Ramón Areces
El 29 de marzo de 2016 celebramos un Simposio Internacional sobre el 'Impacto de las ciencias ómicas en la medicina, nutrición y biotecnología'. Organizado por la Fundación Ramón Areces en colaboración con la Real Academia Nacional de Medicina y BioEuroLatina, abordó cómo un mejor conocimiento del genoma humano está permitiendo notables avances hacia una medicina de precisión.
Making DNA data actionable. Genomic intelligence for good health without pill...Omar Fogliadini
THE SMART WAY TO TAKE CHARGE OF YOUR HEALTH
Get so many insights from your DNA that no doctor could ever tell you
Hear what your body has to say and live better - by your own rules
A healthy lifestyle is especially hard to do alone. Now you've a Personal Health Coach that customizes your advice before you slip from being healthy into the early stage of an illness.
A scientific approach to wellness.
Try now.
PERSONALIZED HEALTH
PERSONALIZED NUTRITION
BRAIN POWER PERFORMANCE
Our digital health programs give you access to behavioral coaching via web or mobile, night or day - like having the world’s leading experts on call but tailored to you and your lifestyle.
Suisse Life Science is a biological big data analytics company that has developed a knowledge-discovery platform to extract cause-effect relationships directly from genetic interpretation – and at scale – linking them to lifestyle data from consumer devices in real time to provide actionable recommendations.
Suisse Life Science specializes in making DNA data useful for population health management.
Now, it’s easier than ever to develop innovative consumer products enhanced and personalized through the power of DNA
We help companies and institutions by providing a comprehensive nutritional, metabolic and lifestyle analysis and management program that includes nutrition intake and lifestyle monitoring, followed by a personalized nutritional, chronic disease prevention and fitness recommendations, tailored for the user, informed on their biomarkers and updated - in real-time - with life data from consumer devices (smartphones, wearables…).
Consumer are looking for more control over their health, and with the advent of affordable genetic testing there are new avenues for personalized treatment and precision medicine.
Concerns still remain that patients – and not a few physicians – don't always understand what the genetic results mean and just what to do about them. Even many doctors aren't well-trained in the clinical implications of genetics and genomics. Without burdening yourself, you can now deliver personalized treatments and behavioral health programs with a mobile AI assistant that provides genetic counseling, tailored to the user, and supports your customers 24/7.
What used to take weeks of painstaking manual curation can now be completed in days.
Our technology is ready-to-market and it can be customized according to your specific needs across the aging and age-related disease prevention and management.
We have all-in-one solutions including our proprietary genetic panels - or we can integrate existing inflows of genetic data.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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HealthXL: How Artificial Intelligence (AI) Can Improve Research & Care Models...Maeve Lyons
Artificial Intelligence in Pharma and Care Delivery Delivering on the Promise.
Earlier this week we published a blog about the state of AI in pharma and care delivery, and we also mentioned we’d be launching an accompanying report. We’re happy share our initial report presentation as part of HealthXL’s Big Data & AI Working Group above.
In the future, HealthXL’s Working Group will go deeper into use cases and discuss other relevant industry topics such as best practices for acquiring quality data, regulatory guidelines for AI solutions, leading academic centers, and much more!
https://healthxl.co/report-artificial-intelligence-pharma-care-delivery-delivering-promise/
A 45minute talk on the basics of Web 2, IT and medicine, particularly focussing on Web 2 tools that can be used by doctors and patients. Also a brief look at accessing these and other tools via portable means, demonstrated with my iPhone.
Redesigning healthcare, biohacking our lives (IMEC ITF2014)Koen Kas
On our way to redesign healthcare, we will learn to combine different layers of our biological code (now in reading but soon in writing mode), data from visible and invisible sensors, and the connected Internet of Bodies/Things. These guardian angels will open up unseen opportunities for the way we deal with ourselves in health and disease. With DNA soon becoming the new software, combining biology, electronics, attractive design & smart communication will provide the tools to (bio)hack our lives.
Appropriate use of different (nano)technologies will convert us into health consumers, with our doctors as (virtual) coaches. This will move us away from current curative healthcare to precise, preventive and even augmented healthcare. But smart technologies and the data they generate, are just a tool. When not trusted by the established care provider, when not integrated and available in a personal data platform, healthcare will only be pseudo modernized. The real magic happens when these tools allow you to engage and change behaviour. But even in a rapidly automating world, we can’t automate such change. Or can we?
The future of healthcare will see a shift from treating illness to sustaining wellness. Ageing could become a treatable disease in the future. Find out more: http://bit.ly/2wD13dL
Cemal H. Guvercin MedicReS 5th World Congress MedicReS
Ethical Issues in Artifical Intelligence Applied to Medicine Presentation to MedicReS 5th World Congress on October 19,25,2015 in New York by Cemal H. Guvercin, MD, PhD
Health: to insure or to ensure? Welcome in the new normalKoen Vingerhoets
Slideset about health and how it affects our culture. With the increasing pace of change, new business models emerge. They're supported by new technological evolutions (healthtech), enabling new companies to challenge incumbent insurance companies.
Healthcare, along with many other sectors, is facing increasing uncertainty driven by technology disruption and greater individual / patient empowerment. The barrier to entry into the sector is dropping fast enabling Asia entrepreneurs to significantly improve the Asia healthcare ecosystem
Thomas Willkens-El impacto de las ciencias ómicas en la medicina, la nutrició...Fundación Ramón Areces
El 29 de marzo de 2016 celebramos un Simposio Internacional sobre el 'Impacto de las ciencias ómicas en la medicina, nutrición y biotecnología'. Organizado por la Fundación Ramón Areces en colaboración con la Real Academia Nacional de Medicina y BioEuroLatina, abordó cómo un mejor conocimiento del genoma humano está permitiendo notables avances hacia una medicina de precisión.
Making DNA data actionable. Genomic intelligence for good health without pill...Omar Fogliadini
THE SMART WAY TO TAKE CHARGE OF YOUR HEALTH
Get so many insights from your DNA that no doctor could ever tell you
Hear what your body has to say and live better - by your own rules
A healthy lifestyle is especially hard to do alone. Now you've a Personal Health Coach that customizes your advice before you slip from being healthy into the early stage of an illness.
A scientific approach to wellness.
Try now.
PERSONALIZED HEALTH
PERSONALIZED NUTRITION
BRAIN POWER PERFORMANCE
Our digital health programs give you access to behavioral coaching via web or mobile, night or day - like having the world’s leading experts on call but tailored to you and your lifestyle.
Suisse Life Science is a biological big data analytics company that has developed a knowledge-discovery platform to extract cause-effect relationships directly from genetic interpretation – and at scale – linking them to lifestyle data from consumer devices in real time to provide actionable recommendations.
Suisse Life Science specializes in making DNA data useful for population health management.
Now, it’s easier than ever to develop innovative consumer products enhanced and personalized through the power of DNA
We help companies and institutions by providing a comprehensive nutritional, metabolic and lifestyle analysis and management program that includes nutrition intake and lifestyle monitoring, followed by a personalized nutritional, chronic disease prevention and fitness recommendations, tailored for the user, informed on their biomarkers and updated - in real-time - with life data from consumer devices (smartphones, wearables…).
Consumer are looking for more control over their health, and with the advent of affordable genetic testing there are new avenues for personalized treatment and precision medicine.
Concerns still remain that patients – and not a few physicians – don't always understand what the genetic results mean and just what to do about them. Even many doctors aren't well-trained in the clinical implications of genetics and genomics. Without burdening yourself, you can now deliver personalized treatments and behavioral health programs with a mobile AI assistant that provides genetic counseling, tailored to the user, and supports your customers 24/7.
What used to take weeks of painstaking manual curation can now be completed in days.
Our technology is ready-to-market and it can be customized according to your specific needs across the aging and age-related disease prevention and management.
We have all-in-one solutions including our proprietary genetic panels - or we can integrate existing inflows of genetic data.
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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2. “
”
It is easy to get a thousand prescriptions,
but hard to get one single remedy.
Chinese Proverb
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
3. I N D U S T R Y 4 . 0
CYBER-BIO-PHYSICAL
Industry 4.0
4. I N D U S T R Y 4 . 0
Tipping Point
2007
iPhone (January 9th, 2007)
VMWare: translation software
Hadoop: storage capacity
GitHub: Open-source writing & collaborating
FB: open to anyone >13 yrs. Old
Twitter
Change.org
Google buys YouTube (2006) and launches Android
Bitcoin: “Satoshi Nakamoto”
Amazon releases Kindle
Airbnb
1B internet users
Watson (IBM)
Intel: Non-silicon materials
5. F U L L D I G I T A L
Eric Teller, CEO of Google X Research & Development Lab
INTRODUCTION TO UBIQUITYRATEOFCHANGE
TEC H N OLOGY
TIME
CULTURAL ANGST
15 YRS. TO ADAPT
CONSTANT “CATCH UP” MODE
CHANGES:
TECHNOLOGICAL
GEOPHYSICIAL
SOCIAL
6. F A S T A N D F U R I O U S
Primary care physician would need 630 hours/month to keep up with his/her practice.
LEARNING
1950 Medical knowledge and data doubled every 50 years
1980 Medical knowledge and data doubled every 7 years
2010 Medical knowledge and data doubled every 3,5 years
2020 Medical knowledge and data doubled every 0,2 years or 73 days.
Source: Elsevier
Transactions of the American Clinical and Climatological Association
7. S T R A T E G I C A S S E T S
Asking the right questions is the key to our development.
LEARNABILITY
“THE ABILITY TO ANSWER
QUESTIONS WILL NOT
DISTINGUISH SOMEONE’S
INTELLIGENCE.
THE ABILITY TO ASK ALL THE
RIGHT QUESTIONS WILL BE
THE MARK OF TRUE GENIUS.”
JOHN KELLY
VP OF COGNITIVE SOLUTIONS AT IBM
KNOWLEDGE STOCKS: DEPRECIATE AT AN ACCELERATING RATE
KNOWLEDGE FLOWS: EXPAND AT AN ACCELERATING RATE
8. T R A N S F O R M A T I V E F O R C E S
IMPACT ON INDUSTRY
Urbanization, ageing, resources and work
9. C O N S U M E R H E A L T H
HONDAS
Hypertensive, Obese, Non-Compliant, Diabetic, Asthmatic
70% Of healthcare costs
INCREASED DEMAND. 2020 (F) = $1,6T USD
DEMOGRAPHY
INCREASED ACCESS TO HEALTHCARE
DISEASE TYPE: NON-CONTAGIOUS DISEASES
44M DEATHS/YEAR IN 2020
(INCREASE OF 15% VIS A VIS 2010)
More people, More sick people, More long-term treatments, More access
More COSTS and Resources!!!
Source: WHO
10. C H A N G I N G T H E M A T H
3PS OF HEALTHCARE
Providers:
↑ Demand for services
Strain on resources
Growth vs. Challenges: Mathematical Shock
Patients
↑ Control and Participation
Proactive health decisions
Payers
↑ Costs
Unsustainable System
11. T R A N S F O R M A T I V E F O R C E S
IMPACT ON INDUSTRY
Cloud, Processing, Data, AI, P2P
12. A H Y P E R L O O P
Gartner Hype Cycle
TIME TO IMPACT
13. T H E E Y E O F T H E S T O R M
DIGITAL VORTEX
Combination of surveys and
objective data.
Plotted 12 industries on a
digital vortex.
Industries on the outside are
least affected by digital
disruption.
Those closer to the middle
are most heavily impacted.
Source: IMD + Cisco
Velocity vs. Acceleration / Disruption vs. Displacement
14. Source: James Riley (data 1990 and earlier), Global Health Observatory, WHO
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
HOW LONG DO WE LIVE?
15. Better science makes for
better health.
“
”
The Preston Curve: Life Expectancy vs. Per Capita Income
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
16. Chronic diseases cause increasing number of
deaths worldwide.
o Heart Disease and Stroke
o Respiratory Infections and COPD
o Dementia
o Diabetes
MORTALITY AND CAUSES OF DEATH
Source: Global Health Observatory, WHO
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
17. YOU PROBABLY WILL BECOME A:
H
O
N
D
A
YPERTENSIVE
BESE
ON-COMPLIANT
IABETIC
STHMATIC
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
21. S C I E N C E A N D T E C H
Data is the new oil and Moore’s Law is the engine
STREGTHENING SCIENTIFIC BASE
In effect, two changes are taking place concurrently.
- Our technologies for collecting biological data are improving by many orders of
magnitude.
- Our technologies for synthesizing and analyzing that data are also becoming much
cheaper and more efficient.
Source: From Vision to Decision Pharma 2020. PWC
22. D A T A
Volume, Velocity & Variety
BIG DATA AND IOT
2,5MTetrabytes Data created daily
INDIVIDUAL LEVEL: WE CAN TRACE A DETAILED PORTRAIT OF A PATIENT’ S HEALTH
AGGREGATE LEVEL: DEEP RESERVOIRS OF KNOWLEDGE ABOUT ENTIRE DISEA SE
STATES AND PATIENT POPULATIONS.
Source: From Vision to Decision Pharma 2020. PWC
23. S C I E N C E A N D T E C H
AI and computational power
STRENGTHENING SCIENTIFIC BASE
Prognos (former Medico):
AI company.
Registry of:
5 Billion clinical records
100 M patients,
30 disease areas.
The registry enables earlier identification
of patients who can benefit from enhanced
treatment decision-making, risk
management, and quality improvement
under the HEDIS guidelines.
500 proprietary and learning clinical
algorithms.
23andMe: invite people who use its
testing service to share information
regarding medical history and
lifestyle contributing to genetic
research.
24. D A T A
Corus CAD test: integrates age, sex and gene expression to calculate a score
BIG DATA AND IOT
“Anywhere interface” technologies
Provides JIT information on how
patients respond to different
treatments
Ex. Oxford Nanopore’s MinION
DNA & RNA sequencer
BIOLOGICAL DATA + ANALYTICAL TOOLS = PERSONALIZED MEDICINE
CardioDX:
Specialized in cardiovascular genomics
R&D company that analyzed over
100M samples to identify
23 markers of coronary artery disease
Fuse genomics, biostatics, cardiology
and primary care
25. Targeted treatments based on:
o Specific Illness
o Unique Patient
The Basis for Personalized Medicine
MOLECULAR SCISSORS
G E N E T I C S
27. SELF-LOGGING
o Wearables
o Digital Tattoos
o Smart Clothes
o Smart Pill (Proteus)
o Senosis Health: mobile medical monitoring
device
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
28. CARE HUB:
o Personalized Dashboard
of Health indicators
o Network of Connected Care
o Real-time ability to respond
and act
o Remote operations
29. U B I Q U I T Y
MOBILE HEALTH
Apps and Wearables.
Sources. 2015Across Health Navigator ; IMS 2016
33%
21
%50
%
Of US patients use Health Apps in 2016 (vs. 16%
in 2014)
Use wearables for health purposes.
Of US Millennials agree with the statement
“I want my doctor to use my fitness tracker
and/or health app data.”
30. P L U G G I N G I N
Using mobile ubiquity to facilitate disease management.
MOBILE UBIQUITY
A new reusable glucose-monitoring smartphone case developed by engineers
at the University of California San Diego.
The added benefit is the ability to autonomously store, process, and send blood
glucose readings from the phone to a care provider or cloud service.
The device, called GPhone, is built into a smartphone case with an accompanying
app which lets patients record and track their glucose readings. The 3D-printed
case fits over the smartphone and has a permanent, reusable sensor on the
corner.
Reusable glucose-monitoring smartphone case developed by UC San Diego engineers
31. E V E R Y B O D Y L I E S
The most important V in data is Value.
DATA AS A TOOL FOR COMPLIANCE
Compliance It is believed that up to 50% of patients with chronic diseases are
noncompliant with medications.
In 2014, it was estimated that medical noncompliance adds between
$100-$300 billion annually in healthcare costs.
Proteus Digital Health have created the world’s first smart pill with an
ingestible sensor linked to a wearable patch that can record when a pill
is actually taken.
ABILIFY MYCITE is a drug-device combination product comprised of
oral aripiprazole tablets embedded with an Ingestible Event Marker
(IEM) sensor. FDA First Approval: Nov. 13, 2017
32. A I A N D I M A G I N G
Neural Networks and Data Sets
HEALTHCARE AND MACHINE LEARNING
Machine learning has enormous potential to disrupt healthcare.
Diabetic retinopathy is one of the leading causes of blindness that can be
treated if caught early. One early exemplar of AI in healthcare is the work that
Google (TensorFlow) research team did to classify retinal images to help
expand access and improve quality of care with machine learning solution.
Dermatologist-level classification of skin cancer with deep neural
networks. using a dataset of 129,450 clinical images. Tested its performance
against 21 board-certified dermatologists on biopsy-proven clinical images.
2 critical binary classification use cases:
i) keratinocyte carcinomas versus benign seborrheic keratosis
ii) malignant melanomas versus benign nevi.
https://www.nature.com/articles/nature21056
33. A I A N D I M A G I N G
The most important V in data is Value.
HEALTHCARE AND MACHINE LEARNING
https://www.nature.com/articles/nature21056
35. Reprogram Cells
3D bioprinters:
Tissues, Organs, Bones, Prosthetics
Tissue Replacement
Organovo: 1st blood vessels to be bioprinted
R E P L A C E M E N T P A R T S
36. N E W M A N U F A C T U R I N G
“Chemputer”: Produce when and where it is needed
3D PRINTING
Chemist Lee Cronin is working on a 3D printer that, instead of objects, is
able to print molecules. An exciting potential long-term application: printing
your own medicine using chemical inks.
Cronin has been awarded a 2018 RSC interdisciplinary prize, in
recognition of his ground-breaking work exploring complex chemical
systems and digitizing chemistry using artificial intelligence.
A new method of drug manufacture which uses 3D printers to create
pharmaceuticals on demand could lead to a ‘Spotify for chemistry’.
https://www.ted.com/talks/lee_cronin_print_your_own_medicine
Production of muscle relaxer Baclofen
40. Using VR for medical training
and or patient satisfaction during
treatment
The ability to see inside the body
in real time with the use of AR
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
IMAGING
41. M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
Breathtec
Sensor that “smells” Parkinsons,
MS, Crohn’s disease, ulcerative
colitis, IBS, hypertension and
ovarian, kindney & prostate
cancer
SENSORS
42. Can differentiate a single
hyperactive cancerous cell from
a normal cell.
Simple, noninvasive tool for early
cancer diagnosis
GRAPHENE
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
43. ROBOTICS:
Assistance for a better life
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
44. o Companion Robots (MIRO)
o Assistive Robots
o Nanotechnology: Repair &
Treat
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
MACHINES
45. REGENERATIVE MEDICINE
GENETICS REMOTE MONITORING
ROBOTICS
IMMUNOTHERAPY
DIAGNOSTICS
TECH HEALTH
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?
47. Friends and family make for a better life.“
”
SECRET TO LONGEVITY
ESSENCE OF HUMANITY
M E D H U M A N I T Y : W H O W A N T S T O L I V E F O R E V E R ?