The document summarizes the identification and isolation of harmaline, a beta-carboline alkaloid, from the leaves of Passiflora foetida. The leaves were extracted using hydroalcohol and the extract was subjected to column chromatography to isolate harmaline. Harmaline was identified using UV, H-1 NMR, and mass spectroscopy. The isolation method provides an effective and economic means to obtain harmaline from P. foetida, as synthetic approaches are costly and time-consuming.
Design, Synthesis, Biological Evaluation, and In Silico ADMET Studies of 1,8-...BRNSS Publication Hub
In the present study, 1,8-naphthyridine-3-carboxylic acid derivatives (5a1, 5a2, 5b1, and 5b2) were
designed, synthesized, and screened for their in vitro H1-antihistaminic activity. H1R inhibitory activity
of the synthesized derivatives was calculated by the modified Van Arman technique, histamine-induced
bronchoconstriction in guinea pigs. A good bronchorelaxant effect of compounds was observed in
histamine-contracted guinea pig tracheal chain through H1-receptor antagonism. In addition, the
hypothetically resulted compounds are checked for their reliability on other in silico drug designing
online web services like SwissADME predictor. In silico ADMET analysis results show that all the
derivatives had negligible toxicity, good absorption, and solubility profile. These compounds may serve
as possible lead for establishing safe and effective antihistaminic agent(s).
Design, Synthesis, Biological Evaluation, and In Silico ADMET Studies of 1,8-...BRNSS Publication Hub
In the present study, 1,8-naphthyridine-3-carboxylic acid derivatives (5a1, 5a2, 5b1, and 5b2) were
designed, synthesized, and screened for their in vitro H1-antihistaminic activity. H1R inhibitory activity
of the synthesized derivatives was calculated by the modified Van Arman technique, histamine-induced
bronchoconstriction in guinea pigs. A good bronchorelaxant effect of compounds was observed in
histamine-contracted guinea pig tracheal chain through H1-receptor antagonism. In addition, the
hypothetically resulted compounds are checked for their reliability on other in silico drug designing
online web services like SwissADME predictor. In silico ADMET analysis results show that all the
derivatives had negligible toxicity, good absorption, and solubility profile. These compounds may serve
as possible lead for establishing safe and effective antihistaminic agent(s).
Non-Extractive Spectrophotometric Determination of Palladium in Biological Sa...IJAEMSJORNAL
A very simple, highly selective and non-extractive spectrophotometric method for the trace amounts of palladium(II) has been developed. Pyridoxal thiosemicarbazone (PTSC) has been proposed as a new analytical reagent for the direct non-extractive spectrophotometric determination of palladium (II). The reagent reacts with palladium in acidic medium(pH 2.0, CH3COONa and Con. HCl ) to form a pale yellow coloured 1: 2 (M : L) complex. The reaction is instantaneous and the maximum absorption was obtained at 420 nm and remains stable for 2 hrs. The molar absorptivity and sandell’s sensitivity were found to be 1.63 x 104 L mol-1 cm-1 and 0.635 μg cm-2 respectively. Linear calibration graphs were obtained for 0.9- 10.0 μg/ml of palladium(II). The method is highly selective for palladium and successfully used for determination of palladium in various hydrogenation catalysts.
Austin Journal of Analytical and Pharmaceutical Chemistry is an international, open access, peer review Journal publishing original research & review articles in all the related fields of Analytical and Pharmaceutical Chemistry. Austin Journal of Analytical and Pharmaceutical Chemistry focus upon the latest research happenings in the development and the validation of separation methods for drugs or metabolites from biological origin, the analysis of pharmaceuticals, in simple or complex matrices. Austin Journal of Analytical and Pharmaceutical Chemistry provides a new podium for all researchers, scientists, scholars, students to publish their research work & update the latest research information.
Austin Journal of Analytical and Pharmaceutical Chemistry is an inclusive of all multidisciplinary fields that fall within the Journal scope. We provide unlimited access towards accessing our literature center with immense range of articles. The journal aims to publish high quality, diverse article types such as Research, Review, Mini Review, Rapid Communications, Perspectives, Editorials and Letters.
Austin Journal of Analytical and Pharmaceutical Chemistry strongly support the scientific upgradation and fortification in related research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, mutual and promotion of multidisciplinary science.
Austin Journal of Analytical and Pharmaceutical Chemistry is an international, open access, peer reviewed Journal publishing various article types in all the related fields of Analytical and Pharmaceutical Chemistry. Austin Journal of Analytical and Pharmaceutical Chemistry provides a new plinth to update the latest research information.
Speciation And Physicochemical Studies of Some Biospecific CompoundsIOSR Journals
Abstract: A green, safer , efficient , eco-friendly approach for the synthesis of novel compounds which reveal biological and spermicidal activity. The nature of the pharmacophore decides the physiological reactivity of the compound.
Synthesis and Characterization of Nano Hydroxyapatite with Agar-Agar Bio-PolymerIJERA Editor
Hydroxyapatite used for bone replacement is one of the most active areas of ceramic biomaterials research currently. It is a desirable implant material due to its biocompatibility and osteoconductive properties. Agar agar is a biological polymer frequently used in tissue engineering and pharmaceutical for potential use in bone replacement. Nano hydroxyapatite was successfully synthesized by wet chemical precipitation method . In this work nHAp/agar composite were synthesized and characterization of the compound were done by using characterization Fourier transform infrared(FTIR), X-ray diffract ration (XRD), Transmission electron microscope(TEM) and Energy dispersive analysis of X-ray spectrum(EDAX).
Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended...Ratnakaram Venkata Nadh
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good
to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT
assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in
vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole
nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine
kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have
been discussed
Research Inventy : International Journal of Engineering and Scienceinventy
Research Inventy : International Journal of Engineering and Science is published by the group of young academic and industrial researchers with 12 Issues per year. It is an online as well as print version open access journal that provides rapid publication (monthly) of articles in all areas of the subject such as: civil, mechanical, chemical, electronic and computer engineering as well as production and information technology. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published by rapid process within 20 days after acceptance and peer review process takes only 7 days. All articles published in Research Inventy will be peer-reviewed.
Solubility and dissolution enhancement of BCS class ii drug Piroxicam by soli...Makrani Shaharukh
The Present study was conducted to improve solubility and dissolution of poor water soluble drug Piroxicam. In this research work, Piroxicam Solid Dispersion was prepared kneading method by using, Guar Gum as a carrier. Drug and carriers weight ratio were1:1 to 1:5. The properties of solid were evaluated using Fourier Transform Infra red (FTIR) Spectroscopy, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and solubility and dissolution studies. The FTIR Spectroscopy showed no chemical interaction between Piroxicam and carrier. DSC studies indicated their no change of melting point of Piroxicam in Solid Dispersion. SEM result showed that Piroxicam was dispersed and was present as amorphous state in the solid dispersions. Solubility of Solid dispersions was highest at Ratio 1:5 is 0.319±0.02 mg/mL. The drug release data of solid dispersion revealed that formulation F5 exhibited more than 95 % drug release after 60 min. Finally we conclude that the solubility & dissolution enhancement is depend on nature and amount of the carrier and when increases the carrier increase the solubility of Piroxicam. Solid dispersion system of Piroxicam and carriers used could improve the solubility and dissolution rate of Piroxicam.
Determination of Satranidazole through Ion-Associative Complex ReactionRatnakaram Venkata Nadh
A simple, selective, accurate and low-cost spectrophotometric method
has been described for determination of satranidazole in bulk and
pharmaceutical formulations. The developed method involves the
formation of chloroform extractable colored ion-association complex
of satranidazole with Tropaeolin OOO (TPooo). The extracted colored
complex showed absorbance maximum at wavelength 484 nm and
obeying Beer′s law in the concentration 4-20 μg mL-1 with the
correlation coeffiecent of 0.9998. The results of statistical analysis of
the proposed method reveals high accuracy and good precession. Thus,
the proposed method can be used commercially for the determination
of satranidazole in bulk and pharmaceutical formulations.
Phytochemicals and plant growth inhibitory activity of Ageratum conyzoides L....IOSR Journals
Ageratum conyzoides leaves have afforded six compounds which were identified as tritriacontane, henitriacontane, 23-pentatetraacontanone, 3,4,-seco-lup- 20 (29)-en-3-OMe, 3°butyl triacosanoate and methyl tetracosanoate. All are being reported first time from this plant. The different fractions viz. hexane, benzene, ethyl acetate and methanol Ageratum conyzoides leaves were tested for their plant growth inhibitory activity against germination of radish seeds. The percent growth inhibition of radish seeds by different fractions are being reported in this paper.
Non-Extractive Spectrophotometric Determination of Palladium in Biological Sa...IJAEMSJORNAL
A very simple, highly selective and non-extractive spectrophotometric method for the trace amounts of palladium(II) has been developed. Pyridoxal thiosemicarbazone (PTSC) has been proposed as a new analytical reagent for the direct non-extractive spectrophotometric determination of palladium (II). The reagent reacts with palladium in acidic medium(pH 2.0, CH3COONa and Con. HCl ) to form a pale yellow coloured 1: 2 (M : L) complex. The reaction is instantaneous and the maximum absorption was obtained at 420 nm and remains stable for 2 hrs. The molar absorptivity and sandell’s sensitivity were found to be 1.63 x 104 L mol-1 cm-1 and 0.635 μg cm-2 respectively. Linear calibration graphs were obtained for 0.9- 10.0 μg/ml of palladium(II). The method is highly selective for palladium and successfully used for determination of palladium in various hydrogenation catalysts.
Austin Journal of Analytical and Pharmaceutical Chemistry is an international, open access, peer review Journal publishing original research & review articles in all the related fields of Analytical and Pharmaceutical Chemistry. Austin Journal of Analytical and Pharmaceutical Chemistry focus upon the latest research happenings in the development and the validation of separation methods for drugs or metabolites from biological origin, the analysis of pharmaceuticals, in simple or complex matrices. Austin Journal of Analytical and Pharmaceutical Chemistry provides a new podium for all researchers, scientists, scholars, students to publish their research work & update the latest research information.
Austin Journal of Analytical and Pharmaceutical Chemistry is an inclusive of all multidisciplinary fields that fall within the Journal scope. We provide unlimited access towards accessing our literature center with immense range of articles. The journal aims to publish high quality, diverse article types such as Research, Review, Mini Review, Rapid Communications, Perspectives, Editorials and Letters.
Austin Journal of Analytical and Pharmaceutical Chemistry strongly support the scientific upgradation and fortification in related research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed member journals under one roof thereby promoting knowledge sharing, mutual and promotion of multidisciplinary science.
Austin Journal of Analytical and Pharmaceutical Chemistry is an international, open access, peer reviewed Journal publishing various article types in all the related fields of Analytical and Pharmaceutical Chemistry. Austin Journal of Analytical and Pharmaceutical Chemistry provides a new plinth to update the latest research information.
Speciation And Physicochemical Studies of Some Biospecific CompoundsIOSR Journals
Abstract: A green, safer , efficient , eco-friendly approach for the synthesis of novel compounds which reveal biological and spermicidal activity. The nature of the pharmacophore decides the physiological reactivity of the compound.
Synthesis and Characterization of Nano Hydroxyapatite with Agar-Agar Bio-PolymerIJERA Editor
Hydroxyapatite used for bone replacement is one of the most active areas of ceramic biomaterials research currently. It is a desirable implant material due to its biocompatibility and osteoconductive properties. Agar agar is a biological polymer frequently used in tissue engineering and pharmaceutical for potential use in bone replacement. Nano hydroxyapatite was successfully synthesized by wet chemical precipitation method . In this work nHAp/agar composite were synthesized and characterization of the compound were done by using characterization Fourier transform infrared(FTIR), X-ray diffract ration (XRD), Transmission electron microscope(TEM) and Energy dispersive analysis of X-ray spectrum(EDAX).
Design, synthesis and anti-tumour activity of new pyrimidine-pyrrole appended...Ratnakaram Venkata Nadh
The new pyrimidine-pyrrole scaffolds (7a–7m) with substituted 1,2,3-traizole moiety were synthesized in good
to mild yields and subjected for anti-cancer activity against melanoma and breast cancer cell lines using MTT
assay. The compounds 7f and 7m exhibited highest anti-cancer activity against both the tested cell lines in in
vitro assay. The molecular docking analysis provided the insights of binding orientation of pyrimidine-pyrrole
nucleus of current ligands and their crucial interactions with Cys797 and other residues of the EGFR tyrosine
kinase active site. The interactions of triazole and its various substituted groups with EGFR tyrosine kinase have
been discussed
Research Inventy : International Journal of Engineering and Scienceinventy
Research Inventy : International Journal of Engineering and Science is published by the group of young academic and industrial researchers with 12 Issues per year. It is an online as well as print version open access journal that provides rapid publication (monthly) of articles in all areas of the subject such as: civil, mechanical, chemical, electronic and computer engineering as well as production and information technology. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published by rapid process within 20 days after acceptance and peer review process takes only 7 days. All articles published in Research Inventy will be peer-reviewed.
Solubility and dissolution enhancement of BCS class ii drug Piroxicam by soli...Makrani Shaharukh
The Present study was conducted to improve solubility and dissolution of poor water soluble drug Piroxicam. In this research work, Piroxicam Solid Dispersion was prepared kneading method by using, Guar Gum as a carrier. Drug and carriers weight ratio were1:1 to 1:5. The properties of solid were evaluated using Fourier Transform Infra red (FTIR) Spectroscopy, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and solubility and dissolution studies. The FTIR Spectroscopy showed no chemical interaction between Piroxicam and carrier. DSC studies indicated their no change of melting point of Piroxicam in Solid Dispersion. SEM result showed that Piroxicam was dispersed and was present as amorphous state in the solid dispersions. Solubility of Solid dispersions was highest at Ratio 1:5 is 0.319±0.02 mg/mL. The drug release data of solid dispersion revealed that formulation F5 exhibited more than 95 % drug release after 60 min. Finally we conclude that the solubility & dissolution enhancement is depend on nature and amount of the carrier and when increases the carrier increase the solubility of Piroxicam. Solid dispersion system of Piroxicam and carriers used could improve the solubility and dissolution rate of Piroxicam.
Determination of Satranidazole through Ion-Associative Complex ReactionRatnakaram Venkata Nadh
A simple, selective, accurate and low-cost spectrophotometric method
has been described for determination of satranidazole in bulk and
pharmaceutical formulations. The developed method involves the
formation of chloroform extractable colored ion-association complex
of satranidazole with Tropaeolin OOO (TPooo). The extracted colored
complex showed absorbance maximum at wavelength 484 nm and
obeying Beer′s law in the concentration 4-20 μg mL-1 with the
correlation coeffiecent of 0.9998. The results of statistical analysis of
the proposed method reveals high accuracy and good precession. Thus,
the proposed method can be used commercially for the determination
of satranidazole in bulk and pharmaceutical formulations.
Phytochemicals and plant growth inhibitory activity of Ageratum conyzoides L....IOSR Journals
Ageratum conyzoides leaves have afforded six compounds which were identified as tritriacontane, henitriacontane, 23-pentatetraacontanone, 3,4,-seco-lup- 20 (29)-en-3-OMe, 3°butyl triacosanoate and methyl tetracosanoate. All are being reported first time from this plant. The different fractions viz. hexane, benzene, ethyl acetate and methanol Ageratum conyzoides leaves were tested for their plant growth inhibitory activity against germination of radish seeds. The percent growth inhibition of radish seeds by different fractions are being reported in this paper.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Phytochemical Screening of Caralluma lasiantha Isolation of C21 Pregnane SteroidRatnakaram Venkata Nadh
Phytochemical screening of Caralluma lasiantha was carried out and one C21 pregnane steroid was isolated from chloroform extract. Based on spectroscopic studies (IR, 1H NMR, 13C NMR and ESI-MS) the isolated compound is 3b,14b-dihydroxy-14b-pregn-5-en-20-one which was earlier isolated from other species.
Design, Synthesis, and Characterization of New 1,3,5-Trisubstituted-2-pyrazol...BRNSS Publication Hub
Objective: The objective of the paper was to design, synthesis, and characterization of new 1,3,5-trisubstituted-2-pyrazolines derivative and to evaluate for analgesic potential. Materials and Methods: The 1,3,5-tri-substituted-2-pyrazolines derivatives have been synthesized by the reaction of chalcone derivatives with 4-hydrazinylbenzene sulfonamide hydrochloride and phenyl hydrazine hydrochloride. Total 16 compounds have been synthesized and characterized by the IR, 1HNMR, and mass spectral analysis. Proposed compounds have been evaluated for analgesic activity. The synthesized compounds also evaluated for the analgesic activity by the following two methods, that is, hot plate test method and acetic acid induced writhing in mice. Pentazocine and acetyl acetic acid were used as standard drug for compare the efficacy. Results and Discussion: The analgesic activity of the 16 synthesized compound series A1-A8, and B1-B8 has been evaluated using hot plate test method and acetic acid induced writhing in mice. The results of the evaluation have been viewed by taking pentazocine and acetyl acetic acid as the standard drug. In hot plate test, series A1-A8, shown delay the paw withdrawal latency time for compound A2 (10.30 s), A4 (9.45 s), A7 (11.65 s), and A8 (11.26 s) after 90 min. In series, B1-B8 shown delay the paw withdrawal latency time for compound B2 (9.10 s) and B7 (10.42 s) after 90 min, inhibit the pain sensation, and inhibit pain produced by thermal means. Synthesized compounds of series A1-A8, compounds A2, A5, A6, A7, and A8 were shown 83.00, 76.01, 80.34, 86.99, and 88.15 were shown percent inhibition, significantly (p<0.05 and p<0.001, respectively) and reduced the number of wriths induced by 0.6% acetic acid at the dose of 10 mg/kg. Acetylsalicylic acid (10 mg/kg) appears to be better effective in reducing the number of wriths, it significantly (P < 0.001) reduced the number of wriths by 99.0%. The compounds B1, B3, and B4 have shown least active activity. These all finding suggest that these synthesized compounds have the potential as analgesic agent. Conclusion: The 1,3,5-pyrazoline derivatives has been successfully synthesized and evaluated for analgesic activity of mice model and results data indicate that compounds A2, A5, A6, A7, and A8 were shown 83.00, 76.01, 80.34, 86.99, and 88.15%, and compounds B2, B7, and B8 were shown 72.25, 74.27, and 74.56% inhibitions. The presence of SO2NH2 is essential for analgesic activity.
Phytochemical Investigation of Caralluma lasiantha: Isolation of Stigmasterol...Ratnakaram Venkata Nadh
Stigmasterol, a phytosteroid was isolated for the first time from C. lasiantha using n-hexane as a solvent. Stigmasterol was characterized on the basis of physical, chemical and spectral data (IR, 1H NMR, 13C NMR, 1HNMR, DEPT-45, 90 & 135, and MS) analysis as well as by comparing them to their literature data. A sequence of steps was adopted like saponification, fractional crystallization and gradient elution column chromatography to isolate stigmasterol because some phytosterols possess identical physical properties which makes it difficult to isolate the constituents.
New Flavone from the Aerial Parts of Bougainvillea Glabraijceronline
International Journal of Computational Engineering Research (IJCER) is dedicated to protecting personal information and will make every reasonable effort to handle collected information appropriately. All information collected, as well as related requests, will be handled as carefully and efficiently as possible in accordance with IJCER standards for integrity and objectivity.
HPTLC determination of carotenoid profile in the leaf and bark samples of lor...Jing Zang
Influence of host plants on the carotenoid profile of Loranthus longiflorus leaf and bark samples collected from Casuarina equisetifolia and Ficus religiosa host trees were determined by HPTLC method. The methanol extract of L. longiflorus leaf samples obtained from C. equisetifolia host trees showed 9 compounds while it was 8 compounds in the leaf samples collected from F. religiosa host tree. Among the compounds, 5 and 3 compound in each sample, respectively, was identified as carotinoids while the others were unknown. Four compounds from each leaf samples collected from C. equisetifolia (peak no. 4- 6 & 8) and F. religiosa (peak no. 1-3 & 6) host trees showed similar Rf values (0.15, 0.19, 0.23 & 0.53, respectively). Similarly, the methanol extract of L. longiflorus bark sample collected from C. equisetifolia and F. religiosa host trees contained 8 compounds each. Of these compounds only 3 from each sample was identified as carotenoids whereas others were unknown and none of these compounds showed any similar Rf values. One compound from leaf and park samples of L. longiflorus collected from C. equisetifolia (peak no. 6 & 4) and F. religiosa (peak no. 4 & 3) showed similar Rf values (0.23 & 0.26), respectively.
Synthesis and Anti-Inflammatory activity of Sulpha/substituted 1,2-Diazolesinventionjournals
A Novel compound namely N1 (3 Nicotinoyl) 3,5 dimethyl-4-(N-4-sulfamoyl-azo)-1,2-diazoles has been synthesized by two step processes. Synthesis of N1 -4-sulfamoylphenylhydrazono-3,5-dimethyl propane-1,3-dione and sulfonamide, which interacting with 3-Nicotinoyl hydrazine to form final compound. The newly synthesized compound N1 -(3-Nicotinoyl)-3,5-dimethyl 4-(N1 -4-sulfamoyl phenyl azo) 1,2-diazoles was screened for antiinflammatory activity
Synthesis and Anti-Inflammatory activity of Sulpha/substituted 1,2-Diazolesinventionjournals
A Novel compound namely N1 (3 Nicotinoyl) 3,5 dimethyl-4-(N-4-sulfamoyl-azo)-1,2-diazoles has been synthesized by two step processes. Synthesis of N1 -4-sulfamoylphenylhydrazono-3,5-dimethyl propane-1,3-dione and sulfonamide, which interacting with 3-Nicotinoyl hydrazine to form final compound. The newly synthesized compound N1 -(3-Nicotinoyl)-3,5-dimethyl 4-(N1 -4-sulfamoyl phenyl azo) 1,2-diazoles was screened for antiinflammatory activity
Synthesis of Novel Piperidine Compounds As Anticholinesterase Agentsinventionjournals
Donepezil is a piperidine based agent that is used for treatment of Alzheimer’s diseases. This agent acts as acetylcholine esterase inhibitor and therefore, synthesis of piperidine compounds to evaluate anticholinesterase activity is very popular field in medicinal chemistry. Thus, in this study some novel piperidine derivatives were synthesized in order to observe their probable anticholinesterase effects. Structures of obtained compounds were confirmed by IR, NMR and Mass spectroscopic methods. Anticholinesterase activity of the synthesized compounds were tested by using Ellman’s method. Some of the compounds in the series indicated good enzyme inhibitory activity
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
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2. Heatmap utilization for testing
3. Optimization of testing processes
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SAP heatmap example with demo
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Harmaline from passiflora foetida
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Original Article HARMALINE FROM PASSIFLORA FOETIDA
*Krishnaveni A, Santh Rani Thaakur
*Institute
of Pharmaceutical Technology,
Sri Padmavathi Mahila Viswavidyalayam (Women’s University),
Tirupati, Andhra Pradesh, India - 517502.
Print 2231 – 3648
ISSN
Online 2231 – 3656
Abstract
The present experimental study was carried through extraction and characterization of the hydrpalcoholic
extract of leaf of Passiflora foetida. The leaf material was defatted further extracted with hydroalcohol,
concentrated in vacuo. Column chromatography was adopted for the separation of phytoprinciple present in
the Passiflora foetida. Column chromatragraphy was packed with silica gel by wet method, solvents were
eluted over in the increasing order of polarity. Considerable amount of chloroform fractions were collected
identified by thin layer chromatography, pooled, subjected to physical, chemical and spectral methods.
Spectral techniques includes ultraviolet, H1 NMR and mass spectrum were used. Harmaline, a betacarboline
alkaloid was identified and its structure was confirmed by spectroscopic methods (including ultraviolet, H1
NMR and mass spectra) as harmaline (7-methoxy, 3, 4 -dihydro betacarboline). Harmaline is found to have
monoamaine oxidase inhibitory effect, useful for the antidepressant activity. The present method is simple,
rapid, economic and effective method used for the separation of harmaline from the Passiflora. Synthetic
approaches for the harmaline are costly and time consuming; hence this alternate procedure can be adopted
for the plant source. Beta carboline alkaloid acts against stress and proved protective role in oxidative stress.
The above specified reports evidenced scientifically that harmaline was present in Passiflora foetida and
envisages additional research towards its other pharmacological action.
Key words: Betacarboline, Harmaline, Passifloraceae, Passiflora foetida.
Introduction
Preliminary phytochemical studies revealed the
Passiflora foetida belongs to Passifloraceae, is
presence of alkaloids, tannins and flavanoids [14]. The
commonly named as stinking passion flower used by
present investigation was performed to identify and
the Gond tribe of India to treat cancer [1]. The plant is
isolate harmaline from the alcoholic extract of
used as sedative; its prepartions are used to treat
Passiflora foetida.
asthma, giddiness, menstrual and nervous disorders [2-5].
The plant also exhibited insect deterrent activity,
hypoglycemic, antiproliferative, antibacterial,
antioxidant and antimelanogenesis[6-11].Previous studies
revealed the isolation of passifloricins, alpha pyrones
and vitexin from leaves of Passsiflora foetida [12, 13].
Figure 01: Structure of Harmaline
Author for Correspondence:
Krishnaveni A, Plant Material
Institute of Pharmaceutical Technology,
Sri Padmavathi Mahila Viswavidyalayam Leaves of Passiflora foetida were collected from the
(Women’s University), A.P, India – 517 502. foot hills of Tirumala, Tirupathi, Andhra Pradesh, India
Email: akrishnaveni72@rediffmail.com during the year 2006 was identified by Dr.Madhav
Int. J. Pharm & Ind. Res Vol - 01 Issue - 04 Oct – Dec 2011
2. 323
Shetty, Taxonomist, Dept. of Botany, S.V.University, The fragmentation and fragments of the mass spectra
Tirupathi, Andhra Pradesh, India. The voucher specimen were 214(M+100%), 202(10%), 199.9(53%), 186
was kept in our college for further reference. (10%), 170(37%), 153(10%), 143(10%), 128(4%),
115(6.4%), 107(8%), 90(4%), 84(5%) and 74(5%).
Apparatus used
Column chromatography (1:50cm) silica gel (Column Result and discussion
chromatography grade,S.D.fine chemicals, Mumbai, The isolated compound showed positive response
India. Spectral analysis were recorded using UV- with specific harmaline alkaloidal test and exhibited
Visible spectrophotometer (UV-1800 Shimadzu), H1 UV absorption band showed the maxima absorbance
NMR (AV Bruker AVIII, DMSO, 500 MHz,) were at 270 and 375 nm indicated the aromatic band of
recorded. Co-TLC was performed using silica gel alkaloids. The H1 NMR spectrum added the
precoated plates (Merck, Germany) with the mobile confirmation of alkaloidal structure and depicted the
phase ethanol: chlororform : acetic acid(40:60:6).Mass presence of protons at position H-14, H-6, H-5, H-10,
spectra was analysed by EIMS at 70eV using JEOL H-12 and H-9. It showed three doublets (one doublelet
insertion probe. of doublet at δ 6.35, 6.22, 7.52 (1H, dd
J=8.49,1.51,H-12; 1H, dd J=8.49, 1.51, H-10; 1H,dd,
Processing of the plant material J=8.49,1.43,H-9) and two doublets of doublet at δ
The collected plant material was dried in shade, 2.98, 3.05, 3.43, 3.55 (1H, ddd J=13.3, 9.62, 4.42 H-
coarsely powdered and subjected to extraction and 6), 1H, ddd, J=13.30, 4.70, 1.64, H-3),1H, ddd
stored in air tight container for further use. J=13.24, 9.62, 4.70, H-14, 1H, ddd J=13.24, 4.42,
1.64, H-5) and singlet at δ 2.07 and δ 3.71(1H, s
Extraction and Isolation J=3, H-14and 3H, s, H-7,OCH3). The Mass spectra
Powdered leaf of Passiflora foetida was extracted with show the fragmentation pattern 214(100%), 202(5%),
70% alcohol by Soxhlet extraction process after liberation of carbon atom 199.9(20%), 186(20%),
defatting. The extract was further concentrated in
170(11.6%), 153 (9.6%), 143(8%), 128(0.4%),
vacuo. About 5 gram of the extract was placed over 114(8.38%), 106(10%), 90(9%), 84 and 75(5%)
column chromatography packed with silica gel eluted indicated the presence of molecular base peak (M+)
with various solvents ranging from petroleum ether to at 214(M+100%) and the fragments indicated the
methanol [10]. The phytoconstiutent (compound 1, Rf presence of one hydrogen atom, another hydrogen
0.66,10 mg) (figure1) was obtained from chloroform
atom, one imino (NH group), one oxygen atom, one
fractions were separated based on TLC studies. The hydroxyl atom(OH molecule), five hydrogen atoms, one
isolated compound was yellowish brown crystals, methyl group, one nitrogen atom, four hydrogen atoms,
subjected to chemical and spectral methods. The one oxygen atom, three hydrogen atom respectively.
structure of the compound was established in It also revealed the empirical formula C13H14N2O.
accordance with the previous literature.
Therefore, UV, H-NMR and EI-MS data led to the
identification of compound 1 as harmaline (3,4
Spectroscopic data
dihydro,7-methoxy betacarboline) and its structure
UV absorption band (lambda maxima, in methanol)
was depicted in figure1. The derived spectra was a
was found at 270 and 375 nm was identical with that
marked pattern of betacarboline alkaloids especially
of harmaline. H1NMR (AV-BrukerAVIII, DMSO,
harmaline. The structure of the isolated compound was
500MHz) δ 2.07 (1H, s, J=3, methyl group), δ 2.98 (1H,
confirmed as harmaline and was in good agreement
ddd, J=13.3, 9.66, 4.33, H-6), δ 6.35(1H, ddd, J=13.30,
with the earlier literature.
4.70,1.64. H-12), δ 3.43( 1H,ddd,13.24, 9.62, 4.70 H-
14), δ3.55 1H, ddd, ,13.24, 4.42, 1.66, H-5), δ
Conclusion
3.71(3H,s,OCH3), δ 6.22 (1H, dd J=8.49, 1.51, H-10),
Harmaline belonging to beta carboline group reported
,δ7.52(1H,dd,J=8.49,1.43,H-9),δ 3.05(1H, dd,J=13.297,
to possess monoamine oxidase inhibitory activity and
4.650, H-3).
acting as antidepressant drug. The present method
EI-MS (70eV, m/z)
Int. J. Pharm & Ind. Res Vol - 01 Issue - 04 Oct – Dec 2011
3. 324
may be helpful to separate the harmaline on large 8. Mohanasundari.C, Natarajan.D, Srinivasan.K, Uma
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