5. Major causes of death in children under 5 years with disease-
specific contribution of undernutrition
6.
7.
8. Calderon who suffer from chronic malnutrition
fail to grow to their full genetic potential both
mentally physically the main symptom of this
measures is stunting- shorting of hight compare
to same of their age group and take relatively
long time to develop
Two boys born on the same day
Stunting in children is manifested through a cycle of malnourished mothers,
resulting in underweight babies, which experience stunted growth and
chronic malnutrition over time.
10. Hurdles to Combat against stunting
• We are under the a influence of Stereotype, that STUNTING is
all about of poor nutrition and hygiene
11. Other aspect in along nutritional deficiency need to be taken in account
These factors are some adjuvant which making
the task more difficult
Incapability to absorbed nutrient from food
Dysbiosis
Genetic and epigenetic factors
Stress
Lifestyle
Cultural/Social practise
15. Microbiomes and
Childhood Malnutrition:
What are the Evidence?
Iddrisu, I., et.al., 2021. Malnutrition and gut microbiota in children. Nutrients,
Changes in the gut microbiota associated with childhood malnutrition and key
factors linked with such changes
16. Malnutrition and Gut Microbiota in Children
Balasubramaniam, C., et.al.,., 2021. Gut bacterial profile in Indian children of varying nutritional status: European journal of nutrition
The bacterial taxonomy analysis of 16S rRNA gene amplicon sequencing data revealed
the higher abundance of phylum Actinobacteria and its member with lower prevalence of
Lactobacillus in healthy children. The pattern of gut microbiota profile in malnourished
subjects suggests a dysbiotic gut depleted in Bifdobacteria, a core member of the
consortia of beneficial anaerobes of the healthy child gut
17. Relative abundance (percentage of sequences) of the dominant
bacterial phyla in the gut of healthy and malnourished children.
Each individual of two groups of children (healthy, H1 ∼ H7;
malnourished, M1 ∼ M7) showing relative abundance
(percentage of sequences) of the dominant gut bacteria
18. A. Prevotella 9; B. Coprobacter; C. Alloprevotella; D. Senegalimassilia; E. Family XIII AD3011 group within the
Clostridiales, F. Butyrivibrio; G. Coprococcus 3, H. Ruminococcaceae UCG-010; I. an uncultured genus of
Erysipelotrichaceae; J. Lachnospira; K. an unidentified genus from Enterobacteriaceae; L. Enterobacter, M. an uncultured
genus of Mollicutes (RF9); N. another uncultured genus of Mollicutes nutritional status (N; red) and stunted (S; green)
19.
20. Steps need to be taken
Cohort studies along with biological sample analysis is essential to
understand the community composition of gut microbiome in
undernourished population
Comparative gut microbiome study among the different parts of
country/world is required to understand the geographical,
environmental, genetic and other aspects
Most of the studies till today are pilot studies need to be explore in
large population
A study with all controlled parameter is required to asses the real
contribution of gut microbiome in malnutrition
21. How will the Action Against Stunting Hub help?
The Action Against Stunting Hub is
designed to challenge existing research by
much-needed interdisciplinary research. We
are working to enhance global
understanding of the drivers that lead to
good growth versus no/slow growth in
children living in low and middle income
countries
this study provide important insights into the distinctive compositions of colonic microbiota, showing that the healthy children possessed significantly higher number of OTU in their gut than that of the malnourished children
the healthy children had a significantly higher number of operational taxonomic unit in their gut than that of the malnourished children (healthy vs. malnourished: 546 vs. 310). In malnourished children, bacterial population of the phyla Proteobacteria and Bacteroidetes accounted for 46 and 18%, respectively. Conversely, in healthy children, Proteobacteria and Bacteroidetes accounted for 5% and 44, respectively (p < 0.001). In malnourished children, the phylum Proteobacteria included pathogenic genera, namely Klebsiella and Escherichia, which were 174-fold and 9-fold higher, respectively, than their healthy counterpart. The predominance of potentially pathogenic Proteobacteria and minimal level of Bacteroidetes as commensal microbiota might be associated to the ill health of malnourished children in Bangladesh.
he microbiota of control children was enriched in probiotic species Bifidobacterium longum and Lactobacillus mucosae, whereas that of stunted children was enriched in inflammogenic taxa including those in the Desulfovibrio genus and Campylobacterales order
