The document discusses the challenges and opportunities for activism on access to medicines (a2m) in the context of global political and economic pressures. It highlights the threats posed by populist governments and neoliberal policies that undermine democratic culture and social welfare, as well as the fragmentation of social movements and difficulties in coalition-building. Despite these challenges, the document emphasizes the importance of community activism in advocating for health rights and equitable medicine access while maintaining core values of universality, social justice, and human rights.