Colonoscopy is an important procedure for diagnosing and preventing colorectal cancer (CRC), however it can be difficult to perform. Some key challenges include it taking more time than other endoscopic procedures, and having a lower completion rate. Both patient and colonoscopist factors can impact difficulty, such as patient anatomy, BMI, previous operations, and colonoscopist experience and practice volume. New technologies and techniques aim to help overcome challenges and improve adenoma detection rates, including narrow-band imaging, articulating endoscopes, and over-tube devices.