George Wheen led several successful branding campaigns for Coca-Cola and Powerade. For Coca-Cola, he unified four distinct brands into a single Coca-Cola brand with a new visual identity and launched a "Choose Happiness" campaign that achieved unprecedented YouTube views. For Powerade, he developed the "Inner Gear" campaign using athletes like Wayne Rooney and Jessica Ennis to establish Powerade's role in hydration and drive awareness. His campaigns increased market shares and brand sales significantly.