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Vivitra 150mg injection consist a targeted cancer drug known as Trastuzumab, which is Pharmacologically grouped as humanized monoclonal antibody produced by recombinant DNA technology
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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ASA GUIDELINE
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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RX
GEMCITABINE POWDER
FOR SOLUTION FOR
INFUSION USP
200 MG, 1000 MG
1.NAME OF THE MEDICINAL
PRODUCT
Gemcitabine 200mg Powder for Solution for
Infusion
Gemcitabine 1g Powder for Solution for
Infusion
2. QUALITATIVE AND
QUANTITATIVE COMPOSITION
One vial contains gemcitabine hydrochloride,
equivalent to 200 mg gemcitabine.
One vial contains gemcitabine hydrochloride,
equivalent to 1 g gemcitabine.
After reconstitution, the solution contains 38
mg/ml gemcitabine (as hydrochloride).
Excipients
Each 200 mg vial contains approximately 3.5
mg (0.15 mmol) sodium.
Each 1 g vial contains approximately 17.5 mg
(0.75 mmol) sodium.
For a full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
Powder for solution for infusion (powder for
infusion)
White to off-white plug or powder.
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Bladder Cancer:
Locally advanced or metastatic bladder cancer,
in combination with cisplatin.
Pancreatic Cancer:
Locally advanced or metastatic adenocarcinoma
of the pancreas.
Non-Small Cell Lung Cancer:
First-line treatment of patients with locally
advanced or metastatic non-small cell lung
cancer, in combination with cisplatin.
Gemcitabine monotherapy can be considered in
elderly patients or those with performance status
2.
Ovarian Cancer:
Locally advanced or metastatic epithelial
ovarian carcinoma, in combination with
carboplatin, in patients with relapsed disease
following a recurrence-free interval of at least 6
months after platinum-based, first line therapy.
Breast Cancer:
Unresectable, locally recurrent or metastatic
breast cancer, in combination with paclitaxel, in
patients experiencing a relapse after
adjuvant/neoadjuvant chemotherapy. The
preceding chemotherapy should have included
an anthracycline, unless clinically
contraindicated.
4.2 Posology and method of administration
For intravenous infusion, following
reconstitution. Upon reconstitution a colourless
or slightly yellow solution is produced.
Gemcitabine should only be prescribed by a
physician qualified in the use of anti-cancer
chemotherapy.
Bladder cancer (combination therapy):
Adults: The recommended dose for gemcitabine
is 1000 mg/m2
, given as a 30 minute infusion.
The dose should be given on days 1, 8, and 15 of
each 28 day cycle in combination with cisplatin.
Cisplatin is given at a recommended dose of 70
mg/m2
on day 1 following gemcitabine, or day 2
of each 28 day cycle. This four week cycle is
then repeated. Dosage reduction with each cycle
or within a cycle may be applied, based upon the
amount of toxicity experienced by the patient.
Pancreatic Cancer:
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Adults: The recommended dose of gemcitabine
is 1000 mg/m2
, given by 30 minute intravenous
infusion. This should be repeated once weekly
for up to 7 weeks, followed by a one week rest
period. Subsequent cycles should consist of
gemcitabine infusions once weekly for 3
consecutive weeks out of every four weeks.
Dosage reduction with each cycle or within a
cycle may be applied, based upon the amount of
toxicity experienced by the patient.
Non-small cell lung cancer (monotherapy):
Adults: The recommended dose of gemcitabine
is 1000 mg/m2
, given by 30 minute intravenous
infusion. This should be repeated once weekly
for three weeks, followed by a one week rest
period. This four-week cycle is then repeated.
Dosage reduction with each cycle or within a
cycle may be applied, based upon the amount of
toxicity experienced by the patient.
Non-small cell lung cancer (combination
therapy):
Adults: The recommended dose of gemcitabine
is 1250 mg/m2
, given by 30 minute intravenous
infusion, on days 1 and 8 of each 21 day cycle.
Dosage reduction with each cycle or within a
cycle may be applied, based upon the amount of
toxicity experienced by the patient.
Cisplatin has been used at doses between 75-100
mg/m2
once every 3 weeks.
Ovarian cancer (combination therapy):
The recommended dose of gemcitabine, when
used in combination with carboplatin, is 1000
mg/m2
, given by 30 minute intravenous infusion
on days 1 and 8 of each 21 day cycle. After
gemcitabine, carboplatin will be given on day 1,
consistent with a target Area Under Curve
(AUC) of 4.0mg/ml/min. Dosage reduction with
each cycle or within a cycle may be applied,
based upon the amount of toxicity experienced
by the patient.
Breast cancer (combination therapy):
Adults: It is recommended that gemcitabine is
used together with paclitaxel according to the
following procedure:
Paclitaxel (175 mg/m2
) is intravenously infused
over 3 hours on day 1, followed by gemcitabine
(1250 mg/m2
) intravenously infused for 30
minutes on days 1 and 8 of each 21 day
treatment cycle. Dosage reduction with each
cycle or within a cycle may be applied based
upon the amount of toxicity experienced by the
patient. The absolute granulocyte count should
be at least 1.5 x 109
/l before treatment with the
gemcitabine + paclitaxel combination.
Monitoring for toxicity and dose modification
due to toxicity
Dosage adjustment due to non haematological
toxicity:
Periodic physical examination and checks of
renal and hepatic function should be made to
detect non-haematological toxicity. Dosage
reduction with each cycle or within a cycle may
be applied, based upon the amount of toxicity
experienced by the patient. In general, for severe
(Grade 3 or 4) non-haematological toxicity,
except nausea/vomiting, therapy with
gemcitabine should be withheld or decreased
depending on the judgement of the treating
physician. Doses should be withheld until
toxicity has been resolved.
For cisplatin, carboplatin, and paclitaxel dosage
adjustment in combination therapy, please refer
to the corresponding Summary of Product
Characteristics.
Dosage adjustment in the presence of
haematological toxicity:
Initiation of a cycle
For all indications, patients must be monitored
before each dose for platelet and granulocyte
counts. Patients should have an absolute
granulocyte count of at least 1,500 (x106
/l) and a
platelet count of 100,000 (x106
/l) prior to the
administration of a cycle.
Within a cycle
Dose modifications of gemcitabine within a
cycle should be performed according to the
following tables:
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*Withheld treatment will not be reinstated
within a cycle before the absolute granulocyte
count reaches at least 0.5(x 109
/l) and the
platelet count reaches 50 (x 109
/l).
Dose modification of gemcitabine within a cycle for
ovarian cancer, given in combination with carboplatin
Absolute Granulocyte
Count
(x 109
/l)
Platelet Count
(x 109
/l)
% of
Total Dose
>1.5 and >100 100
1-1.5 or 75-100 50
<1 or <75 Withhold*
*Withheld treatment will not be reinstated
within a cycle. Treatment will start on day 1 of
the next cycle once the absolute granulocyte
count reaches at least 1.5(x 109
/l) and the
platelet count reaches 100 (x 109
/l)
Dose modification of gemcitabine within a cycle for breast
cancer, given in combination with paclitaxel
Absolute Granulocyte
Count
(x 109
/l)
Platelet Count
(x 109
/l)
% of
Total Dose
≥1.2 and >75 100
1-<1.2 or 50-75 75
0.7-<1 and ≥50 50
<0.7 or <50 Withhold*
*Withheld treatment will not be reinstated
within a cycle. Treatment will start on day 1 of
the next cycle once the absolute granulocyte
count reaches at least 1.5 (x 109
/l) and the
platelet count reaches 100 (x 109
/l).
Dose adjustment due to haematological
toxicity in subsequent cycles, for all
indications
The gemcitabine dose should be reduced to 75%
of the original cycle initiation dose, in the case
of the following haematological toxicities:
• Absolute granulocyte count < 0.5 x 109
/l for
more than 5 days
• Absolute granulocyte count < 0.1 x 109
/l for
more than 3 days
• Febrile neutropaenia
• Platelets <25 x 109
/l
• Cycle delay of more than one week due to
toxicity
Method of administration
Gemcitabine is tolerated well during infusion
and may be administered ambulant. If
extravasation occurs, generally the infusion must
be stopped immediately and started again in
another blood vessel. The patient should be
monitored carefully after the administration.
For instructions on reconstitution, see section
6.6
Special Populations
Patients with hepatic or renal impairment:
Gemcitabine should be used with caution in
patients with hepatic or renal impairment as
there is insufficient information from clinical
studies to allow for clear dose recommendations
for these patient populations (see sections 4.4
and 5.2).
Elderly population (>65 years):
Gemcitabine has been well tolerated in patients
over the age of 65. There is no evidence to
suggest that dose adjustments, other than those
already recommended for all patients, are
necessary in the elderly (see section 5.2).
Paediatric population (<18 years):
Gemcitabine is not recommended for use in
children under 18 years of age due to
insufficient data on safety and efficacy.
4.3 Contraindications
Hypersensitivity to gemcitabine or to any of the
excipients
Breast-feeding (see section 4.6)
4.4 Special Warnings and precautions for
use
Dose modification of gemcitabine within a cycle for
bladder cancer, pancreatic cancer, and NSCLC, given in
monotherapy or in combination with cisplatin
Absolute Granulocyte
Count
(x 109
/l)
Platelet Count
(x 109
/l)
% of
Total Dose
> 1 and >100 100
0.5-1 or 50-100 75
< 0.5 or <50 Withhold*
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Prolongation of the infusion time and increased
dosing frequency have been shown to increase
toxicity.
Haematological toxicity
Gemcitabine can suppress bone marrow function
as manifested by leucopaenia,
thrombocytopaenia, and anaemia.
Patients receiving gemcitabine should be
monitored prior to each dose for platelet,
leucocyte and granulocyte counts. Suspension or
modification of therapy should be considered
when drug-induced bone marrow depression is
detected (see section 4.2). However,
myelosuppression is short lived and usually does
not result in dose reduction and rarely in
discontinuation.
Peripheral blood counts may continue to
deteriorate after gemcitabine administration has
been stopped. In patients with impaired bone
marrow function, the treatment should be started
with caution. As with other cytotoxic treatments,
the risk of cumulative bone-marrow suppression
must be considered when gemcitabine treatment
is given together with other chemotherapy.
Hepatic impairment
Administration of gemcitabine to patients with
concurrent liver metastases or a pre-existing
medical history of hepatitis, alcoholism or
cirrhosis of the liver may result in exacerbation
of the underlying liver impairment.
Laboratory evaluation of renal and hepatic
function (including virological tests) should be
performed periodically.
Gemcitabine should be used with caution in
patients with hepatic insufficiency or with
impaired renal function as there is insufficient
information from clinical studies to allow clear
dose recommendation for this patient population
(see section 4.2).
Concomitant radiotherapy
Concomitant radiotherapy (given together or ≤7
days apart): Toxicity has been reported (see
section 4.5 for details and recommendations for
use).
Live vaccinations
Yellow fever vaccine and other live attenuated
vaccines are not recommended in patients
treated with gemcitabine (see section 4.5).
Cardiovascular
Due to the risk of cardiac and/or vascular
disorders with gemcitabine, particular caution
must be exercised with patients presenting a
history of cardiovascular events.
Pulmonary
Pulmonary effects, sometimes severe (such as
pulmonary oedema, interstitial pneumonitis, or
adult respiratory distress syndrome (ARDS),
have been reported in association with
gemcitabine therapy. The aetiology of these
effects is unknown. If such effects develop,
consideration should be given to discontinuing
gemcitabine therapy. Early use of supportive
care measures may help ameliorate the
condition.
Renal
Clinical findings consistent with the haemolytic
uraemic syndrome (HUS) were rarely reported
in patients receiving gemcitabine (see section
4.8). HUS is a life-threatening disease.
Treatment should be discontinued at the first
signs of any evidence of micro-angiopathic
haemolytic anaemia, such as rapidly falling
haemoglobin levels with concurrent
thrombocytopenia, elevation of serum bilirubin,
serum creatinine, blood urea nitrogen or lactate
dehydrogenase (LDH). Renal failure may not be
reversible with discontinuation of therapy, and
dialysis may be required.
Fertility
In fertility studies, gemcitabine caused
hypospermatogenesis in male mice (see section
5.3). Therefore, men being treated with
gemcitabine are advised not to father a child
during and up to 6 months after treatment and to
seek further advice regarding cryoconservation
of sperm prior to treatment because of the
possibility of infertility due to therapy with
gemcitabine (see section 4.6).
Sodium
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Gemcitabine 200 mg contains 3.5 mg (0.15
mmol) sodium per vial. This should be taken
into consideration by patients on a sodium-
controlled diet.
Gemcitabine 1 g contains 17.5 mg (0.75 mmol)
sodium per vial. This should be taken into
consideration by patients on a sodium-controlled
diet.
Gemcitabine 1 g contains 35 mg (1.5 mmol)
sodium per vial. This should be taken into
consideration by patients on a sodium-controlled
diet.
4.5 Interaction with other medicinal
products and other forms of interaction
No specific interaction studies have been
performed (see section 5.2)
Radiotherapy
Concurrent (given together or ≤ 7 days apart) -
Toxicity associated with this multimodality
therapy is dependent on many different factors,
including dose of gemcitabine, frequency of
gemcitabine administration, dose of radiation,
radiotherapy planning technique, the target
tissue, and target volume.
Pre-clinical and clinical studies have shown that
gemcitabine has radiosensitising activity. In a
single trial, where gemcitabine at a dose of
1,000 mg/m2
was administered concurrently for
up to 6 consecutive weeks with therapeutic
thoracic radiation to patients with non-small cell
lung cancer, significant toxicity in the form of
severe, and potentially life threatening
mucositis, especially oesophagitis, and
pneumonitis was observed, particularly in
patients receiving large volumes of radiotherapy
[median treatment volumes 4,795 cm3
]. Studies
done subsequently have suggested that it is
feasible to administer gemcitabine at lower
doses with concurrent radiotherapy with
predictable toxicity, such as a phase II study in
non-small cell lung cancer, where thoracic
radiation doses of 66 Gy were applied
concomitantly with an administration with
gemcitabine (600 mg/m2
, four times) and
cisplatin (80 mg/m2
twice) during 6 weeks. The
optimum regimen for safe administration of
gemcitabine with therapeutic doses of radiation
has not yet been determined in all tumour types.
Non-concurrent (given >7 days apart) -
Available information does not indicate any
enhanced toxicity when gemcitabine is
administered more than 7 days before or after
radiation, other than radiation recall. Data
suggest that gemcitabine can be started after the
acute effects of radiation have resolved or at
least one week after radiation.
Radiation injury has been reported on targeted
tissues (e.g. oesophagitis, colitis, and
pneumonitis) in association with both concurrent
and non-concurrent use of gemcitabine.
Others
Yellow fever and other live attenuated vaccines
are not recommended due to the risk of
systemic, possibly fatal, disease, particularly in
immunosuppressed patients.
4.6 Fertility, Pregnancy and lactation
Pregnancy:
There are no adequate data from the use of
gemcitabine in pregnant patients. Studies in
animals have shown reproductive toxicity (see
section 5.3). Based on results from animal
studies and the mechanism of action of
gemcitabine, this substance should not be used
during pregnancy, unless clearly necessary.
Women should be advised not to become
pregnant during treatment with gemcitabine and
to warn their attending physician immediately,
should this occur.
Lactation:
It is not known whether gemcitabine is excreted
in human milk and adverse events on the
suckling child cannot be excluded. Breast-
feeding must be discontinued during
gemcitabine therapy.
Fertility:
In fertility studies, gemcitabine caused
hypospermatogenesis in male mice (see section
5.3). Therefore, men being treated with
gemcitabine are advised not to father a child
during and up to 6 months after treatment and to
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seek further advice regarding cryoconservation
of sperm prior to treatment because of the
possibility of infertility due to therapy with
gemcitabine.
4.7 Effects on ability to drive and use
machines
No studies on the effects on the ability to drive
and use machines have been performed.
However, gemcitabine has been reported to
cause mild to moderate somnolence, especially
in combination with alcohol consumption.
Patients should be cautioned against driving or
operating machinery until it is established that
they do not become somnolent.
4.8 Undesirable Effects
The most commonly reported adverse reactions
associated with gemcitabine treatment include:
nausea, with or without vomiting, and raised
liver transaminases ( (AST/ ALT) and alkaline
phosphatase, reported in approximately 60% of
patients; proteinuria and haematuria reported in
approximately 50% of patients; dyspnoea
reported in 10-40% of patients (highest
incidence in lung cancer patients); allergic skin
rashes occurring in approximately 25% of
patients, and are associated with itching in 10%
of patients.
The frequency and severity of the adverse
reactions are affected by the dose, infusion rate,
and intervals between doses (see section 4.4).
Dose-limiting adverse reactions are reductions in
thrombocyte, leucocyte, and granulocyte counts
(see section 4.2).
Clinical trial data
Frequencies are defined as: Very common
(≥1/10); common (≥1/100 to <1/10); uncommon
(≥1/1,000 to <1/100); rare (≥1/10,000 to
<1/1,000); very rare (<1/10,000).
System Organ Class Frequency Grouping
Blood and lymphatic
system disorders
Very common:
• Leucopenia (Neutropaenia grade 3
=19.3% ; grade 4 =6%)
• Thrombocytopaenia
• Anaemia
Bone marrow suppression is usually
mild to moderate and mostly affects
the granulocyte count (see section
4.2)
Common:
• Febrile neutropenia
Very rare:
• Thrombocytosis
Immune system
disorders
Very Rare:
• Anaphylactoid reaction
Metabolism and nutrition
disorders
Common:
• Anorexia
Nervous system
disorders
Common:
• Headache
• Insomnia
• Somnolence
Uncommon
Cerebrovascular accident
Cardiac disorders Uncommon:
• Arrhythmias, predominantly
supraventricular in nature
• Heart failure
Rare:
• Myocardial infarct
Vascular disorders Rare:
• Clinical signs of peripheral vasculitis
and gangrene
• Hypotension
Respiratory, thoracic and
mediastinal disorders
Very common:
• Dyspnoea -usually mild and passes
rapidly without treatment
Common:
• Cough
• Rhinitis
Uncommon:
• Interstitial pneumonitis (see section
4.4)
• Bronchospasm – usually mild and
transient but may require parenteral
treatment
Rare:
• Pulmonary oedema
• Adult respiratory distress syndrome
(see section 4.4)
Gastrointestinal
disorders
Very common:
• Vomiting
• Nausea
Common:
• Diarrhoea
• Stomatitis & ulceration of the mouth
• Constipation
Very rare:
• Ischaemic colitis
Hepatobiliary disorders Very common:
• Elevation of liver transaminases
(AST and ALT) and alkaline
phosphatase
Common:
• Increased bilirubin
Uncommon:
• Serious hepatotoxicity, including liver
failure and death
Rare:
• Increased gamma glutamyl
transferase (GGT)
Skin and subcutaneous
tissue disorders
Very common:
• Allergic skin rash frequently
associated with pruritus
• Alopecia
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Common:
• Itching
• Sweating
Rare:
• Severe skin reactions, including
desquamation and bullous skin
eruptions
• Ulceration
• Vesicle and sore formation
• Scaling
Very rare:
• Toxic epidermal necrolysis
• Stevens-Johnson Syndrome
Musculoskeletal and
connective tissue
disorders
Common:
• Back pain
• Myalgia
Renal and urinary
disorders
Very common:
• Haematuria
• Mild proteinurea
Uncommon:
• Renal failure (see section 4.4)
• Haemolytic uraemic syndrome (see
section 4.4)
General disorders and
administration site
conditions
Very common:
• Influenza-like symptoms -the most
common symptoms are fever,
headache, chills, myalgia, asthenia,
and anorexia. Cough, rhinitis, malaise,
perspiration and sleeping difficulties
have also been reported.
• Oedema/peripheral oedema –
including facial oedema. Oedema is
usually reversible after stopping
treatment
Common:
• Fever
• Asthenia
• Chills
Rare:
• Injection site reactions -mainly mild
in nature
Injury, poisoning, and
procedural complications
Rare:
• Radiation toxicity (see section 4.5)
• Radiation recall
Combination use in breast cancer
The frequency of grade 3 and 4 haematological
toxicities, particularly neutropaenia, increases
when gemcitabine is used in combination with
paclitaxel. However, the increase in these
adverse reactions is not associated with an
increased incidence of infections or
haemorrhagic events. Fatigue and febrile
neutropaenia occur more frequently when
gemcitabine is used in combination with
paclitaxel. Fatigue, which is not associated with
anaemia, usually resolves after the first cycle.
Grade 3 and 4 Adverse Events. Paclitaxel
versus gemcitabine plus paclitaxel:
Number (%) of Patients
Paclitaxel Arm
(n= 259)
Gemcitabine plus
Paclitaxel Arm (n=
262)
Grade 3 Grade 4 Grade 3 Grade 4
Laboratory
Anaemia 5(1.9) 1 (0.4) 15 (5.7) 3 (1.1)
Thrombocytopaenia 0 0 14 (5.3) 1 (0.4)
Neutropaenia 11 (4.2) 17 (6.6)* 82 (31.3) 45 (17.2)*
Non-laboratory
Febrile neutropenia 3 (1.2) 0 12 (4.6) 1 (0.4)
Fatigue 3 (1.2) 1 (0.4) 15 (5.7) 2 (0.8)
Diarrhoea 5 (1.9) 0 8(3.1) 0
Motor neuropathy 2 (0.8) 0 6 (2.3) 1 (0.4)
Sensory neuropathy 9 (3.5) 0 14 (5.3) 1 (0.4)
* Grade 4 neutropenia lasting for more than 7
days occurred in 12.6% of patients in the
combination arm and 5.0% of patients in the
paclitaxel arm.
Combination use in bladder cancer
Grade 3 and 4 Adverse Events. MVAC versus
gemcitabine plus cisplatin:
Number (%) of Patients
MVAC
(methotrexate,
vinblastine,
doxorubicin and
cisplatin) Arm (n=
196)
Gemcitabine plus
cisplatin Arm (n=
200)
Grade 3 Grade 4 Grade 3 Grade 4
Laboratory
Anaemia 30 (16) 4 (2) 47 (24) 7 (4)
Thrombocytopaenia 15 (8) 25 (13) 57 (29) 57 (29)
Non-laboratory
Nausea and vomiting 37 (19) 3 (2) 44 (22) 0 (0)
Diarrhoea 15 (8) 1 (1) 6 (3) 0 (0)
Infection 19 (10) 10 (5) 4 (2) 1 (1)
Stomatitis 34 (18) 8 (4) 2 (1) 0 (0)
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Combination use in ovarian cancer
Grade 3 and 4 Adverse Events. Carboplatin
versus gemcitabine plus carboplatin:
Number (%) of Patients
Carboplatin Arm
(n= 174)
Gemcitabine plus
carboplatin Arm
(n= 175)
Grade 3 Grade 4 Grade 3 Grade 4
Laboratory
Anaemia 10 (5.7) 4 (2.3) 39 (22.3) 9 (5.1)
Neutropaenia 19
(10.9)
2 (1.1) 73 (41.7) 50 (28.6)
Thrombocytopaenia 18
(10.3)
2 (1.1) 53 (30.3) 8 (4.6)
Leucopaenia 11 (6.3) 1 (0.6) 84 (48.0) 9 (5.1)
Non-laboratory
Haemorrhage 0 (0.0) 0 (0.0) 3 (1.8) (0.0)
Febrile neutropaenia 0 (0.0) 0 (0.0) 2 (1.1) (0.0)
Infection without
neutropaenia
0 (0) 0 (0.0) (0.0) 1 (0.6)
Sensory neuropathy was also more frequent in
the combination arm than with single agent
carboplatin.
4.9 Overdose
There is no known antidote for overdose of
gemcitabine. Single doses of up to 5.7 g/m2
have
been administered as intravenous infusions over
30 minutes every two weeks, with clinically
acceptable toxicity. In the event of suspected
overdose, the patient should be monitored with
appropriate blood counts and should receive
supportive therapy as necessary.
5. PHARMACOLOGICAL
PROPERTIES
5.1 Pharmacodynamic properties
Pharmacotherapeutic group: pyrimidine
analogues
Cytotoxic Activity in Cell Culture Models:
Gemcitabine exhibits significant cytotoxicity
activity against a variety of cultured murine and
human tumour cells. It exhibits cell phase
specificity, primarily killing cells undergoing
DNA synthesis (S-phase) and under certain
conditions blocking the progression of cells
through the G1/S-phase boundary. In vitro the
cytotoxic action of gemcitabine is both
concentration and time dependent.
Antitumour Activity in Preclinical Models:
In animal tumour models, the antitumour
activity of gemcitabine is schedule dependent.
When gemcitabine is administered daily, high
animal mortality but minimal antitumoural
activity is seen. If, however, gemcitabine is
given every third or fourth day, it can be
administered in non-lethal doses with substantial
antitumoural activity against a broad spectrum
of mouse tumours.
Cellular Metabolism and Mechanisms of
Action:
Gemcitabine (dFdC), which is a pyrimidine
antimetabolite, is metabolised intracellularly by
nucleoside kinase to the active diphosphate
(dFdCDP) and triphosphate (dFdCTP)
nucleosides. The cytotoxic action of gemcitabine
is due to inhibition of DNA synthesis by two
actions of dFdCDP and dFdCTP. First, dFdCDP
inhibits ribonucleotide reductase, which is
uniquely responsible for catalysing the reactions
that generate the deoxynucleoside triphosphates
(dCTP) for DNA synthesis. Inhibition of this
enzyme by dFdCDP causes a reduction in the
concentrations of deoxynucleosides in general,
and especially in that of dCTP. Second, dFdCTP
competes with dCTP for incorporation into
DNA (self-potentiation).
Likewise, a small amount of gemcitabine may
also be incorporated into RNA. Thus, the
reduction in the intracellular concentration of
dCTP potentiates the incorporation of dFdCTP
into DNA. DNA polymerase epsilon is
essentially unable to remove gemcitabine and
repair the growing DNA strands. After
gemcitabine is incorporated into DNA, one
additional nucleotide is added to the growing
DNA strands. After this addition there is
essentially a complete inhibition in further DNA
synthesis (masked chain termination). After
incorporation into DNA, gemcitabine then
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appears to induce the programmed cellular death
process known as apoptosis.
Clinical data:
Bladder cancer: A randomised phase III study
of 405 patients with advanced or metastatic
urothelial transitional cell carcinoma showed no
difference between the two treatment arms,
gemcitabine/cisplatin versus
methotrexate/vinblastine/adriamycin/cisplatin
(MVAC), in terms of median survival (12.8 and
14.8 months respectively, p=0.547), time to
disease progression (7.4 and 7.6 months
respectively, p=0.842) and response rate (49.4%
and 45.7% respectively, p=0.512). However, the
combination of gemcitabine and cisplatin had a
better toxicity profile than MVAC.
Pancreatic cancer: In a randomised phase III
study of 126 patients with advanced or
metastatic pancreatic cancer, gemcitabine
showed a statistically significant higher clinical
benefit response rate than 5-fluorouracil (23.8%
and 4.8% respectively, p=0.0022). Also, a
statistically significant prolongation of the time
to progression from 0.9 to 2.3 months (log-rank
p<0.0002) and a statistically significant
prolongation of median survival from 4.4 to 5.7
months (log-rank p<0.0024) was observed in
patients treated with gemcitabine compared to
patients treated with 5-fluorouracil.
Non small cell lung cancer: In a randomised
phase III study of 522 patients with inoperable,
locally advanced or metastatic NSCLC,
gemcitabine in combination with cisplatin
showed a statistically significant higher response
rate than cisplatin alone (31.0% and 12.0%,
respectively, p<0.0001). A statistically
significant prolongation of the time to
progression, from 3.7 to 5.6 months (log-rank
p<0.0012) and a statistically significant
prolongation of median survival from 7.6
months to 9.1 months (log-rank p<0.004) was
observed in patients treated with
gemcitabine/cisplatin compared to patients
treated with cisplatin.
In another randomised phase III study of 135
patients with stage IIIB or IV NSCLC, a
combination of gemcitabine and cisplatin
showed a statistically significant higher response
rate than a combination of cisplatin and
etoposide (40.6% and 21.2%, respectively,
p=0.025). A statistically significant prolongation
of the time to progression, from 4.3 to 6.9
months (p=0.014) was observed in patients
treated with gemcitabine/cisplatin compared to
patients treated with etoposide/cisplatin.
In both studies it was found that tolerability was
similar in the two treatment arms.
Ovarian carcinoma: In a randomised phase III
study, 356 patients with advanced epithelial
ovarian carcinoma who had relapsed at least 6
months after completing platinum based therapy
were randomised to therapy with gemcitabine
and carboplatin (GCb), or carboplatin (Cb). A
statistically significant prolongation of the time
to progression of disease, from 5.8 to 8.6 months
(log-rank p= 0.0038) was observed in the
patients treated with GCb compared to patients
treated with Cb. Differences in response rate of
47.2% in the GCb arm versus 30.9% in the Cb
arm (p=0.0016) and median survival 18 months
(GCb) versus 17.3 (Cb) (p=0.73) favoured the
GCb arm.
Breast cancer: In a randomised phase III study
of 529 patients with inoperable, locally recurrent
or metastatic breast cancer with relapse after
adjuvant/neoadjuvant chemotherapy,
gemcitabine in combination with paclitaxel
showed a statistically significant prolongation of
time to documented disease progression from
3.98 to 6.14 months (log-rank p=0.0002) in
patients treated with gemcitabine/paclitaxel
compared to patients treated with paclitaxel.
After 377 deaths, the overall survival was 18.6
months versus 15.8 months (log rank p=0.0489,
HR 0.82) in patients treated with
gemcitabine/paclitaxel compared to patients
treated with paclitaxel and the overall response
rate was 41.4% and 26.2% respectively (p=
0.0002).
5.2 Pharmacokinetic properties
The pharmacokinetics of gemcitabine have been
examined in 353 patients in seven studies. The
121 women and 232 men ranged in age from 29
to 79 years. Of these patients, approximately
45% had non-small cell lung cancer and 35%
were diagnosed with pancreatic cancer. The
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following pharmacokinetic parameters were
obtained for doses ranging from 500 to 2,592
mg/m2
that were infused from 0.4 to 1.2 hours.
Peak plasma concentrations (obtained within 5
minutes of the end of the infusion) were 3.2 to
45.5 µg/ml. Plasma concentrations of the parent
compound following a dose of 1,000 mg/m2
/30-
minutes are greater than 5 μg/ml for
approximately 30-minutes after the end of the
infusion, and greater than 0.4 μg/ml for an
additional hour.
Distribution
The volume of distribution of the central
compartment was 12.4 l/m2
for women and 17.5
l/m2
for men (inter-individual variability was
91.9%). The volume of distribution of the
peripheral compartment was 47.4 l/m2
. The
volume of the peripheral compartment was not
sensitive to gender.
The plasma protein binding was considered to be
negligible.
Half-life: This ranged from 42 to 94 minutes
depending on age and gender. For the
recommended dosing schedule, gemcitabine
elimination should be virtually complete within
5 to 11 hours of the start of the infusion.
Gemcitabine does not accumulate when
administered once weekly.
Metabolism:
Gemcitabine is rapidly metabolised by cytidine
deaminase in the liver, kidney, blood, and other
tissues.
Intracellular metabolism of gemcitabine
produces the gemcitabine mono, di, and
triphosphates (dFdCMP, dFdCDP, and
dFdCTP), of which dFdCDP and dFdCTP are
considered active. These intracellular
metabolites have not been detected in plasma or
urine.
The primary metabolite, 2'-deoxy-2',2'-
difluorouridine (dFdU), is not active and is
found in plasma and urine.
Excretion:
Systemic clearance ranged from 29.2 l/hr/m2
to
92.2 l/hr/m2
depending on gender and age (inter-
individual variability was 52.2%). Clearance for
women is approximately 25% lower than the
values for men. Although rapid, clearance for
both men and women appears to decrease with
age. For the recommended gemcitabine dose of
1,000 mg/m2
given as a 30 minute infusion,
lower clearance values for women and men
should not necessitate a decrease in the
gemcitabine dose.
Urinary excretion: Less than 10% is excreted as
unchanged drug.
Renal clearance was 2 to 7 l/hr/m2
.
During the week following administration, 92 to
98% of the dose of gemcitabine administered is
recovered, 99% in the urine, mainly in the form
of dFdU and 1% of the dose is excreted in
faeces.
dFdCTP Kinetics:
This metabolite can be found in peripheral blood
mononuclear cells and the information below
refers to these cells.
Intracellular concentrations increase in
proportion to gemcitabine doses of 35-350
mg/m2
/30 min, which give steady-state
concentrations of 0.4-5 µg/ml. At gemcitabine
plasma concentrations above 5 µg/ml, dFdCTP
levels do not increase, suggesting that the
formation is saturable in these cells.
Half-life of terminal elimination: 0.7-12 hours.
dFdU Kinetics:
Peak plasma concentrations (3-15 minutes after
end of 30 minute infusion, 1,000 mg/m2
):
28-52µg/ml.
Trough concentration following once weekly
dosing:
0.07-1.12 µg/ml, with no apparent accumulation.
Triphasic plasma concentration versus time
curve, mean half-life of terminal phase:
65 hours (range 33-84 hours).
Formation of dFdU from parent compound:
91%-98%.
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Mean volume of distribution of central
compartment:
18 l/m2
(range 11-22 l/m2
).
Mean steady-state volume of distribution (Vss):
150 l/m2
(range 96-228 l/m2
).
Tissue distribution:
Extensive.
Mean apparent clearance:
2.5 l/hr/m2
(range 1-4 l/hr/m2
).
Urinary excretion:
All.
Gemcitabine and Paclitaxel Combination
Therapy:
Combination therapy did not alter the
pharmacokinetics of either gemcitabine or
paclitaxel.
Gemcitabine and Carboplatin Combination
Therapy:
When given in combination with carboplatin the
pharmacokinetics of gemcitabine were not
altered.
Renal impairment:
Mild to moderate renal insufficiency (GFR from
30 ml/min to 80 ml/min) has no consistent,
significant effect on gemcitabine
pharmacokinetics.
5.3 Preclinical safety data
In repeated dose studies of up to 6 months
duration in mice and dogs, the principal finding
was schedule and dose-dependent haematopoetic
suppression, which was reversible. Gemcitabine
showed mutagenic potential in an in-
vitro mutation test and in an in-vivo bone
marrow micronucleus test. Long-term animal
studies have not been conducted to evaluate the
carcinogenic potential of gemcitabine.
In fertility studies, gemcitabine caused
reversible hypospermatogenesis in male mice.
No effect on the fertility of females has been
detected.
Evaluation of experimental animal studies has
shown reproductive toxicity e.g. birth defects
and other effects on the development of the
embryo or foetus, the course of gestation or peri-
and postnatal development.
6. PHARMACEUTICAL
PARTICULARS
6.1 List of excipients
Mannitol, E421
Sodium acetate trihydrate
Hydrochloric acid (for pH-adjustment)
Sodium hydroxide (for pH-adjustment)
6.2 Incompatibilities
This medicinal product must not be mixed with
other medicinal product except those mentioned
in section 6.6.
6.3 Shelf life
As packaged for sale:
2 years
After reconstitution:
Chemical and physical in-use stability has been
demonstrated for 35 days at 25°C.
From a microbiological point of view, the
product should be used immediately.
Solutions should not be refrigerated, as
crystallisation may occur.
6.4 Special precautions for storage
As packaged for sale:
This medicinal product does not require any
special storage conditions.
In-use:
For storage condition of the reconstituted
medicinal product, see section 6.3.
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6.5 Nature and contents of container
Type I clear glass vial with bromobutyl stopper.
Vials may be sheathed in protective ONCO-
TAIN sleeves.
Pack sizes: carton containing a single vial or
packs of 5 single vial cartons. Not all pack sizes
may be marketed.
6.6 Special precautions for disposal and
other handling
Reconstitution:
For single use only
This medicinal product has only been shown to
be compatible with sodium chloride 9 mg/ml
(0.9%) solution for injection. Accordingly, only
this diluent should be used for reconstitution.
Compatibility with other active substances has
not been studied. Therefore, it is not
recommended to mix this medicinal product
with other active substances when reconstituted.
Reconstitution at concentrations greater than 38
mg/ml may result in incomplete dissolution, and
should be avoided.
To reconstitute, slowly add the appropriate
volume of sodium chloride 9 mg/ml (0.9%)
solution for injection (as stated in the table
below) and shake to dissolve.
The appropriate amount of medicinal product
may be further diluted with sodium chloride 9
mg/ml (0.9%) solution for injection.
Parenteral medicinal products should be
inspected visually for particulate matter and
discolouration, prior to administration, whenever
solution and container permit.
Any unused solution should be discarded as
described below.
Guidelines for the Safe Handling of Cytotoxic
Medicinal Products:
Local guidelines on safe preparation and
handling of cytotoxic medicinal products must
be adhered to. Cytotoxic preparations should not
be handled by pregnant staff. The preparation of
injectable solutions of cytotoxic agents must be
carried out by trained specialist personnel with
knowledge of the medicines used. This should
be performed in a designated area. The work
surface should be covered with disposable
plastic-backed absorbent paper.
Suitable eye protection, disposable gloves, face
mask and disposable apron should be worn.
Precautions should be taken to avoid the
medicinal product accidentally coming into
contact with the eyes. If accidental
contamination occurs, the eye should be washed
with water thoroughly and immediately.
Syringes and infusion sets should be assembled
carefully to avoid leakage (use of Luer lock
fittings is recommended). Large bore needles are
recommended to minimise pressure and the
possible formation of aerosols. The latter may
also be reduced by the use of a venting needle.
Actual spillage or leakage should be mopped up
wearing protective gloves. Excreta and vomit
must be handled with care.
Disposal:
Adequate care and precaution should be taken in
the disposal of items used to reconstitute this
medicinal product. Any unused dry product or
contaminated materials should be placed in a
high-risk waste bag. Sharp objects (needles,
syringes, vials, etc) should be placed in a
suitable rigid container. Personnel concerned
with the collection and disposal of this waste
should be aware of the hazard involved. Waste
material should be destroyed by incineration.
Any unused product or waste material should be
disposed of in accordance with local
requirements.
Presentation Volume of
sodium chloride
9 mg/ml (0.9%)
solution for
injection to be
added
Displacement
volume
Final
concentration
200 mg 5 ml 0.26 ml 38 mg/ml
1 g 25 ml 1.3 ml 38 mg/ml
2 g 50 ml 2.6 ml 38 mg/ml
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7. MANUFACTURER:
Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
Survey No.188/1 to 189/1,190/1 to 4,
Athiyawad, Dabhel,
Daman- 396210 (INDIA)