Leading universities across the world use Gecko to improve the way they recruit students, drive efficiencies in enquiry acquisition and increase conversion rates. Read their stories and get inspired by their success.
Leading universities across the world use Gecko to improve the way they recruit students, drive efficiencies in enquiry acquisition and increase conversion rates. Read their stories and get inspired by their success.
Friction less mechanics in orthodontics /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Design of Quadruped Walking Robot with Spherical Shelldrboon
We propose a new quadruped walking robot with a spherical shell, called "QRoSS." QRoSS is a transformable robot that can store its legs in the spherical shell. The shell not only absorbs external forces from all directions, but also improves mobile performance because of its round shape. In rescue operations at a disaster site, carrying robots into a site is dangerous for operators because doing so may result in a second accident. If QRoSS is used, instead of carrying robots in, they are thrown in, making the operation safe and easy. This paper reports details of the design concept and development of the prototype model. Basic experiments were conducted to verify performance, which includes landing, rising and walking through a series of movements.
Performance Evaluation of Friction Belt Apparatus Using Indigenous Materials IJMER
This project presents performance evaluation of a designed and constructed friction belt
apparatus, using locally available materials. The aim is to explore the possibility of producing
cheaper alternative testing apparatus for quality control laboratories and institutions in Nigeria. The
locally produced friction belt apparatus has the main body frame ; pulley ; bearing ; stud ; hangers ;
masses; Tommy bar ; and belts as components. The apparatus was tested with V-belt and flat belt with
constant load as T1 (kg) and varying load masses as T2(kg) at different angles of wrap and thereafter
compared with results using similar procedures on fabricated apparatus and standard imported
friction belt apparatus. The comparisons were done, using graphical presentation to study the trend
and t-Test was used to investigate the significant difference in the results. t-Test shows that, for flat
belt experiment, t-Stat value (1.378189195303) is lesser than the critical value (2.17898812792408)
and also for V-belt experiment, t-Stat value (1.06852895427649) is lesser than the critical value
(2.17881279240828), for two tail analysis. These confirmed that there is no significant difference
between the two results. (t-stat value < critical value). It was established that the result of the friction
belt apparatus obtained for all the experiments carried out using standard imported apparatus and
locally produced apparatus have no significant difference at 95% confidence limit. The production
cost of the locally produced apparatus is N33,520.00k, as against the sum of $960.00 for the purchase
of standard imported apparatus.
Seismic Analysis of Framed R.C. Structure with Base Isolation Technique using...ijtsrd
A Natural Calamity like an earthquake has taken a million lives throughout in our past. The force induced due to earthquake is dangerous and last for short duration of time. There are various techniques that can be used resist the force of an earthquake such as base isolation, bracing etc. The principle of base isolation is to isolate the structure from the motion of an earthquake and protect the structure and also reduce the force being transmitted to the building due to earthquake. For this study, G 13 storied R.C. frame building is considered and time history analysis is carried out using E Tabs 2017 software, and also study investigates structural behavior of multi story building with or without base isolation subjected earthquake ground motion. The Lead Rubber Bearing LRB is designed as per UBC 97 code and the same was used for the analysis of base isolation system. Here we shall studying earthquake resistivity of structure by analyzing the base isolation structure to compare its structural performance with fixed base isolation. Rohan G Raikar | Dr. Shivakumaraswamy | Dr. S Vijaya | M. K Darshan "Seismic Analysis of Framed R.C. Structure with Base Isolation Technique using E-Tabs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33166.pdf Paper Url :https://www.ijtsrd.com/engineering/civil-engineering/33166/seismic-analysis-of-framed-rc-structure-with-base-isolation-technique-using-etabs/rohan-g-raikar
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Recent advances in orthodontic wires /certified fixed orthodontic courses by ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Recent advances in orthodontic wires /certified fixed orthodontic courses by ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Self ligatingbrackets /certified fixed orthodontic courses by Indian dental a...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Friction less mechanics in orthodontics /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Design of Quadruped Walking Robot with Spherical Shelldrboon
We propose a new quadruped walking robot with a spherical shell, called "QRoSS." QRoSS is a transformable robot that can store its legs in the spherical shell. The shell not only absorbs external forces from all directions, but also improves mobile performance because of its round shape. In rescue operations at a disaster site, carrying robots into a site is dangerous for operators because doing so may result in a second accident. If QRoSS is used, instead of carrying robots in, they are thrown in, making the operation safe and easy. This paper reports details of the design concept and development of the prototype model. Basic experiments were conducted to verify performance, which includes landing, rising and walking through a series of movements.
Performance Evaluation of Friction Belt Apparatus Using Indigenous Materials IJMER
This project presents performance evaluation of a designed and constructed friction belt
apparatus, using locally available materials. The aim is to explore the possibility of producing
cheaper alternative testing apparatus for quality control laboratories and institutions in Nigeria. The
locally produced friction belt apparatus has the main body frame ; pulley ; bearing ; stud ; hangers ;
masses; Tommy bar ; and belts as components. The apparatus was tested with V-belt and flat belt with
constant load as T1 (kg) and varying load masses as T2(kg) at different angles of wrap and thereafter
compared with results using similar procedures on fabricated apparatus and standard imported
friction belt apparatus. The comparisons were done, using graphical presentation to study the trend
and t-Test was used to investigate the significant difference in the results. t-Test shows that, for flat
belt experiment, t-Stat value (1.378189195303) is lesser than the critical value (2.17898812792408)
and also for V-belt experiment, t-Stat value (1.06852895427649) is lesser than the critical value
(2.17881279240828), for two tail analysis. These confirmed that there is no significant difference
between the two results. (t-stat value < critical value). It was established that the result of the friction
belt apparatus obtained for all the experiments carried out using standard imported apparatus and
locally produced apparatus have no significant difference at 95% confidence limit. The production
cost of the locally produced apparatus is N33,520.00k, as against the sum of $960.00 for the purchase
of standard imported apparatus.
Seismic Analysis of Framed R.C. Structure with Base Isolation Technique using...ijtsrd
A Natural Calamity like an earthquake has taken a million lives throughout in our past. The force induced due to earthquake is dangerous and last for short duration of time. There are various techniques that can be used resist the force of an earthquake such as base isolation, bracing etc. The principle of base isolation is to isolate the structure from the motion of an earthquake and protect the structure and also reduce the force being transmitted to the building due to earthquake. For this study, G 13 storied R.C. frame building is considered and time history analysis is carried out using E Tabs 2017 software, and also study investigates structural behavior of multi story building with or without base isolation subjected earthquake ground motion. The Lead Rubber Bearing LRB is designed as per UBC 97 code and the same was used for the analysis of base isolation system. Here we shall studying earthquake resistivity of structure by analyzing the base isolation structure to compare its structural performance with fixed base isolation. Rohan G Raikar | Dr. Shivakumaraswamy | Dr. S Vijaya | M. K Darshan "Seismic Analysis of Framed R.C. Structure with Base Isolation Technique using E-Tabs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33166.pdf Paper Url :https://www.ijtsrd.com/engineering/civil-engineering/33166/seismic-analysis-of-framed-rc-structure-with-base-isolation-technique-using-etabs/rohan-g-raikar
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Recent advances in orthodontic wires /certified fixed orthodontic courses by ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Recent advances in orthodontic wires /certified fixed orthodontic courses by ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Self ligatingbrackets /certified fixed orthodontic courses by Indian dental a...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Cancer Research: Effects of Insulin-like Factor -2 (IGF-2), Collagen, and Fib...Raul Soto
Cancer Research: Effects of Insulin-like Factor -2 (IGF-2), Collagen, and Fibronectin on the Proliferation and α5-Integrins Expression of the Rhabdomyosarcoma-derived (RD) Cell Line
Implantation of a Tissue-engineered Heart Valve from Human Fibroblasts Exhibi...Raul Soto
Cardiovascular Tissue Engineering and Repair: Implantation of a Tissue-engineered Heart Valve from Human Fibroblasts Exhibiting Short Term Function in the Sheep Pulmonary Artery
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. Mobile robots able to climb
and maneuver on vertical
surfaces are useful for
inspection, surveillance, and
disaster relief applications
Kim (2008)
5. Four legs,
Each with four degrees of freedom
Actuation at the wrist to expand beyond vertical-
only climbing of the first platform.
At the body level, Stickybot has 12 servomotors
32 degrees of freedom (DOFs), making it highly
underactuated.
6. Each motor has a local microprocessor-based
servo controller.
The feet are detachable.
Stickybot III can currently climb at 5 cm/sec.
The robot has a snout-vent length of 36 cm, and
the tail adds an additional 40 cm.
The smoother the surface is, the easier Stickybot
III can climb it
7. The robot has rotatable ankles.
When a gecko goes down a wall upside-down, it will
reverse its back feet such that they point upward.
All computation is done on the robot using a 40 MHz
PIC microcontroller.
A computer can send commands such as 'start' and
'stop' over a Bluetooth connection, but the robot
does not require an external computer or sensors.
8. Bar mechanism to keep the
stroke and elbow servos
close to the body.
The red joints are active;
green joints are passive.
The ankle motor is intended
to keep the feet aligned so
that tangential forces are in
the correct direction for the
directional adhesives.
Rotates in and out of the
plane of the screen using
another "wing angle" servo
motor
http://bdml.stanford.edu/pmwiki
9. The wing moves the
foot towards or away
from the wall.
The wing servo rotates
a carriage that holds
the stroke and elbow
servos.
10. Helps reduce the pitch-back
torque on the robot.
The lowest point on the
robot presses into the
window since the center-of-
mass is a significant
distance from the wall.
Using a tail means the back
feet can act as adhesives.
Without a tail, only the
front feet would be
adhering to the window in
tension and the back feet
would be in compression.
11. The tail and body are held
together using strong
magnets.
This allows the tail to break-
away during a fall, but also
detach for storage as well
as for demonstrations on
the utility of the tail.
The tail's hinge has a
thumb-screw to adjust the
angle and interchangeable
springs to adjust the
stiffness.
12.
13. Four segmented toes
molded with two grades of
polyurethane that sandwich
a thin polyester fabric
The fabric flexes easily, but
is relatively inextensible
Transmits shear stresses
across the surface of the
foot
Avoids the buildup of stress
concentrations
Peeling, at the proximal
regions of the toes.Kim, S. et al. 2007
14. Conform to gently curved
surfaces.
Peel backward in a
motion
like hyperextension of
geckos toes detachment.
Servomotor connected
via push–pull cables in
sleeves,
Attached to a rocker–
bogie linkage located at
the foot
16. Anisotropic hairs
comprised of Shore-A
polyurethane.
Hairs measure 380 μm
in diameter at the base.
The base angle is 20◦
and the tip angle is 45◦.
17.
18. 1 2
3 4
Not in contact with the wall
In contact with the wall
• Legs 1 and 4 make contact
with the wall.
•Weight is transferred from
one pair to the other.
• Legs 2 and 3 release from
the wall.
19. 5 highly flexible digits
Each has toe pads with hundreds of thousands of setae
Each seta has a stalk of hundreds of 200 nm – wide spatular tips
Adhesion via Van DerWaals forces!
Autumn (2006)
23. Lever principle : the longer the
hair, the lesser the force
needed
Detachment occurs in path of
least effort
First rotation of hair, then
peeling
MR > Madh : moment due to
external force applied to hair >
moment over rotation axis due
to adhesion force
Berenguer (2007)
24. ML : maximum load a hair can
support
MR and ML depend on shape of
footprint
Different footprint shapes =
different MR / ML ratios
High MR / ML ratio : support higher
load, lower release force needed
Triangle-shaped footprint has
higher MR / ML ratio, for a
constant area, length, adhesion
pressure
Berenguer (2007)
25. When load acts on lower extreme of
setae, hairs detach one by one in a
coordinated way
The more contact points => more
efficient adhesion system
Peak detachment force and
maximum load capacity are
proportional to the number of
contact points
Berenguer (2007)
26. Due to curvature of the hairs
Stiffer hairs are easier to detach
from non-flat surface
(+/-) Δx: decrease/increase distance
d between load cell and stage
(+/-) y: hair in tension / compression
When hair changes from tension to
compression, its stiffness increases
by almost 3x
kT = 1.5 g/m => kC = 4 g/m
Berenguer (2007)
27. Ability to distribute a big load into smaller loads to each hair
Curved shape of gecko hairs distribute loads and tensions
homogeneously
If forces and tensions are not distributed homogeneously, some
hairs will detach => peeling crack will propagate => loss of
adhesion in whole foot
28.
29. Autumn, K. et al. 2006. Effective Elastic Modulus of Isolated Gecko Setal Arrays. Journal of
Experimental Biology. 209:3558-3568.
Autumn, K. et al. 2006. Frictional Adhesion: A New Angle on Gecko Attachment. Journal of
Experimental Biology. 209:3569-3579.
Berengueres, J. et al. 2007. Structural Properties of a Scales Gecko Foot-Hair. Bioinsp. Biomim.
2:1-8.
Kim, S. et al. 2007. Whole Body Adhesion: Hierarchival, directional and distributed control of
adhesive forces for a climbing robot. 2007 IEEE International Conference on Robotics and
Automation. 10-14 April 2007.
Kim, S. et al. 2008. SmoothVertical Surface Climbing With Directional Adhesion. IEEE
Transactions on Robotics. 24(1):65-74.
http://bdml.stanford.edu/pmwiki