1) Gastroretentive drug delivery systems aim to prolong the gastric residence time of drugs to target drug release in the upper gastrointestinal tract. This summary focuses on floating drug delivery systems, a type of gastroretentive system.
2) Floating drug delivery systems remain buoyant on the gastric contents due to their lower density than gastric fluids. This prolongs gastric retention. Systems can be effervescent, using gas-generating agents, or non-effervescent, using polymers that swell upon contact with gastric fluid.
3) Key factors that affect the gastric retention time of these systems include their size, shape, density and the fed state of the patient. Floating drug delivery can enhance
Gastroretentive drug delivery systems are designed to prolong the gastric residence time of drugs and help improve their bioavailability. These systems can remain in the stomach for several hours. The main types are floating drug delivery systems and expandable drug delivery systems. Floating systems remain buoyant in the stomach without affecting gastric emptying. This results in increased gastric retention time and sustained drug release. Gastroretentive systems are useful for drugs that need to be released in the upper gastrointestinal tract or have a narrow absorption window in the small intestine.
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
This document discusses approaches for gastric retention drug delivery systems (GRDDS). It begins by introducing the benefits of controlled release drug delivery and factors that affect oral drug absorption. It then discusses needs for gastric retention like drugs that are absorbed in the upper GI tract or have a narrow absorption window. Approaches for gastric retention discussed include floating systems, bioadhesive systems, swelling/expanding systems, high density systems, and incorporating food agents to delay gastric emptying. Floating systems remain buoyant in the stomach without affecting emptying rate, while bioadhesive and swelling systems prolong gastric retention time.
This document provides an overview of gastroretentive drug delivery systems (GRDDS). It discusses how GRDDS can prolong the gastric retention of dosage forms to target drug release in the stomach. It describes different approaches for GRDDS, including floating and non-floating systems. Floating drug delivery systems have a density less than gastric fluids and remain buoyant, while non-floating systems are retained through mechanisms like bioadhesion, unfolding designs, or high density. The document reviews the merits of GRDDS and factors affecting performance, as well as common evaluation methods and concludes that GRDDS have potential but also challenges to optimize drug absorption.
Gastro retentive drug delivery systems by shubham patilShubham Patil
This document discusses gastro-retentive drug delivery systems (GRDDS), which aim to retain dosage forms in the stomach for an extended period of time to slowly release drugs. It describes several approaches for GRDDS, including high density systems, magnetic systems, swellable systems, floating drug delivery systems, and bioadhesive/mucoadhesive systems. The document provides examples of drug candidates suitable for each approach and explains the mechanisms by which they prolong gastric retention times. It also lists some advantages and limitations of GRDDS.
1. Floating drug delivery systems are aimed to achieve increased bioavailability of drugs by retaining the dosage form in the stomach for a prolonged period of time through buoyancy. This allows for site-specific delivery and absorption of drugs that act in the upper gastrointestinal tract.
2. Floating drug delivery systems can be single or multiple unit systems, and work through effervescent or non-effervescent mechanisms to temporarily reduce the density of the dosage form and allow it to float in the gastric fluids.
3. These systems provide benefits like sustained drug release over extended periods, enhanced absorption of drugs that act in the upper GI tract, and ability to deliver drugs locally for conditions like gastric ulcers. Evaluation
This document discusses gastroretentive drug delivery systems (GRDDS), which are oral dosage forms designed to remain in the stomach for an extended period of time to prolong drug release. It covers the rationale for using GRDDS, factors controlling gastric residence time, and various approaches for prolonging gastric retention including floating systems, high-density systems, and bioadhesive or magnetic systems. Floating systems include non-effervescent and effervescent types that float due to low density or gas generation. High-density systems do not float but remain in the stomach through bioadhesion, magnetic forces, swelling to a large size, or raft formation on gastric fluids.
Gastroretentive drug delivery system by mali vvVidhyaMali1
This document provides an overview of gastro-retentive drug delivery systems (GRDDS). It defines GRDDS as a drug delivery system that can retain a dosage form in the stomach for an extended period of time to slowly release medication. The document discusses the anatomy of the stomach and factors controlling gastric retention. It also outlines several approaches for GRDDS, including floating drug delivery systems, bioadhesive/mucoadhesive systems, and expandable/swellable systems. The advantages and applications of GRDDS are noted.
Gastroretentive drug delivery systems are designed to prolong the gastric residence time of drugs and help improve their bioavailability. These systems can remain in the stomach for several hours. The main types are floating drug delivery systems and expandable drug delivery systems. Floating systems remain buoyant in the stomach without affecting gastric emptying. This results in increased gastric retention time and sustained drug release. Gastroretentive systems are useful for drugs that need to be released in the upper gastrointestinal tract or have a narrow absorption window in the small intestine.
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
This document discusses approaches for gastric retention drug delivery systems (GRDDS). It begins by introducing the benefits of controlled release drug delivery and factors that affect oral drug absorption. It then discusses needs for gastric retention like drugs that are absorbed in the upper GI tract or have a narrow absorption window. Approaches for gastric retention discussed include floating systems, bioadhesive systems, swelling/expanding systems, high density systems, and incorporating food agents to delay gastric emptying. Floating systems remain buoyant in the stomach without affecting emptying rate, while bioadhesive and swelling systems prolong gastric retention time.
This document provides an overview of gastroretentive drug delivery systems (GRDDS). It discusses how GRDDS can prolong the gastric retention of dosage forms to target drug release in the stomach. It describes different approaches for GRDDS, including floating and non-floating systems. Floating drug delivery systems have a density less than gastric fluids and remain buoyant, while non-floating systems are retained through mechanisms like bioadhesion, unfolding designs, or high density. The document reviews the merits of GRDDS and factors affecting performance, as well as common evaluation methods and concludes that GRDDS have potential but also challenges to optimize drug absorption.
Gastro retentive drug delivery systems by shubham patilShubham Patil
This document discusses gastro-retentive drug delivery systems (GRDDS), which aim to retain dosage forms in the stomach for an extended period of time to slowly release drugs. It describes several approaches for GRDDS, including high density systems, magnetic systems, swellable systems, floating drug delivery systems, and bioadhesive/mucoadhesive systems. The document provides examples of drug candidates suitable for each approach and explains the mechanisms by which they prolong gastric retention times. It also lists some advantages and limitations of GRDDS.
1. Floating drug delivery systems are aimed to achieve increased bioavailability of drugs by retaining the dosage form in the stomach for a prolonged period of time through buoyancy. This allows for site-specific delivery and absorption of drugs that act in the upper gastrointestinal tract.
2. Floating drug delivery systems can be single or multiple unit systems, and work through effervescent or non-effervescent mechanisms to temporarily reduce the density of the dosage form and allow it to float in the gastric fluids.
3. These systems provide benefits like sustained drug release over extended periods, enhanced absorption of drugs that act in the upper GI tract, and ability to deliver drugs locally for conditions like gastric ulcers. Evaluation
This document discusses gastroretentive drug delivery systems (GRDDS), which are oral dosage forms designed to remain in the stomach for an extended period of time to prolong drug release. It covers the rationale for using GRDDS, factors controlling gastric residence time, and various approaches for prolonging gastric retention including floating systems, high-density systems, and bioadhesive or magnetic systems. Floating systems include non-effervescent and effervescent types that float due to low density or gas generation. High-density systems do not float but remain in the stomach through bioadhesion, magnetic forces, swelling to a large size, or raft formation on gastric fluids.
Gastroretentive drug delivery system by mali vvVidhyaMali1
This document provides an overview of gastro-retentive drug delivery systems (GRDDS). It defines GRDDS as a drug delivery system that can retain a dosage form in the stomach for an extended period of time to slowly release medication. The document discusses the anatomy of the stomach and factors controlling gastric retention. It also outlines several approaches for GRDDS, including floating drug delivery systems, bioadhesive/mucoadhesive systems, and expandable/swellable systems. The advantages and applications of GRDDS are noted.
This document discusses gastroretentive drug delivery systems (GRDDS). GRDDS are designed to remain in the stomach for an extended period of time to allow for prolonged release of drugs and improved bioavailability. The document outlines several approaches for GRDDS, including floating systems, high density systems, inflatable systems, and gastroadhesive systems. It discusses the advantages and limitations of different approaches and provides examples of drugs that can benefit from GRDDS formulations.
DRUG DELIVERY SYSTEM (gastro retentive drug delivery system)
Oral route is the most acceptable route for drug administration. Apart from conventional dosage forms several other forms were developed in order to enhance the drug delivery for prolonged time period and for delivering drug to a particular target site. Gastro-retentive drug delivery system (GRDDS) has gainned immense popularity in the field of oral drug delivery recently. it is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. different innovative approaches are being applied to fabricate GRDDS. Gastroretentive drug delivery is an approach to prolong gastric residence time, there by targeting site-specific drugs release in the upper gastrointestinal tract (GIT) for local or systemic effects. It is obtained by retaining dosage form into stomach and by releasing the in controlled manner.
Ankit gastro retentive drug delivery systemAnkit Malik
Gastro-retentive drug delivery systems (GRDDS) are designed to prolong the gastric retention time of drugs and increase their absorption in the upper gastrointestinal tract. This document discusses various strategies for developing GRDDS, including high density systems, floating systems, bioadhesive systems, and swellable systems. It also covers the advantages of GRDDS in improving bioavailability and drug delivery, as well as potential disadvantages like unsuitability for certain drug types. Evaluation methods are outlined to determine properties like floating time and drug release kinetics.
Gastro retentive drug delivery system (GRDDS)Ravish Yadav
gastro retentive drug delivery system topic include
1. introduction
2.advantages
3.technology
4.evaluation
5.disadvantages
6. matrix tablet
and other relative information regarding the topic
Sustained release effervescent floating bilayer tablets - A review of Novel A...Dhaneshwar P
This document reviews sustained release effervescent floating bilayer tablets as a novel drug delivery approach. It begins with an introduction that describes the challenges of oral drug delivery given variability in gastric emptying rates. It then discusses gastroretentive drug delivery systems (GRDFs) that are designed to prolong drug retention in the stomach. The document focuses on sustained release effervescent floating bilayer tablets as a GRDF that can provide sustained release of drugs that are incompatible with traditional floating formulations. It reviews the principles, technology, applications, advantages and evaluation methods of these bilayer floating tablets as a novel approach for improving oral drug bioavailability.
2.GASTRORETENTIVE DRUG DELIVERY SYSTEM.pptxKhemBhattarai
This document discusses gastroretentive drug delivery systems. It defines terms like gastric retention time (GRT) and gastric emptying time (GET). It then describes different approaches for gastroretentive drug delivery systems, including high density systems, floating drug delivery systems, and adhesion or bioadhesion systems. Floating drug delivery systems are desirable as they remain buoyant in the stomach without affecting gastric emptying rate. The document outlines factors that control gastric retention time and types of floating drug delivery systems, including effervescent and non-effervescent systems.
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
An overview on Gastroretentive drug delivery systemsSriramNagarajan18
This document provides an overview of gastroretentive drug delivery systems (GRDDS). It discusses how GRDDS are designed to prolong the gastric retention time of orally administered drugs to improve their bioavailability. The document describes various approaches for GRDDS, including floating systems that float in the stomach, high density systems that sink to the bottom of the stomach, bioadhesive systems that adhere to the stomach lining, and unfoldable systems that expand in the stomach. It also discusses factors that influence gastric retention and the advantages of GRDDS for drugs that need to remain in the stomach.
This document discusses gastroretentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs to allow for increased drug absorption in the stomach or upper gastrointestinal tract. It provides information on appropriate drug candidates for GRDDS, factors affecting gastric retention, advantages and disadvantages of GRDDS, and various approaches to GRDDS design including floating systems, high density systems, swelling systems, and bioadhesive systems. The document also discusses gastric physiology and emptying relevant to GRDDS performance.
Gastric emptying is a complex process, one that is highly variable and makes in vivo performance of drug delivery systems uncertain. A controlled drug delivery system with prolonged residence time in the stomach can be great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter- and intra-subject variability of gastrointestinal (GI) transit time and to the non-uniformity of drug absorption throughout the alimentary canal. Floating drug delivery systems are useful in such applications. Floating microspheres have been gaining attention due to the uniform distribution of these multiple-unit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. The present research briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. Floating microsphere were prepared by solvent evapouration method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. The shape and surface morphology of the microspheres were characterised by differential scanning calorimetry and scanning electron microscopy.
The document discusses gastro-retentive drug delivery systems (GRDDS) which are dosage forms that can be retained in the stomach for a prolonged period of time. This increases the gastric retention time of drugs and helps to improve bioavailability. Various approaches to increase gastric retention time include high-density systems, low-density (floating) systems, bio-adhesive systems, gas generating systems, raft forming systems, and magnetic systems. Floating drug delivery systems are low-density systems that float in the gastric fluid due to their lower density than gastric fluids.
A REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM
SUBMITTED BY
MO SUHEB ANSARI
Assistant Professor
Department of Pharmaceutics
Faculty of pharmacy
Jahangirabad Institute of Technology Barabanki, Lucknow, Uttar Pradesh
This document provides an overview of gastroretentive drug delivery systems (GRDDS). It discusses appropriate candidate drugs, advantages and limitations of GRDDS. The document outlines various approaches to gastric retention including high density systems, floating systems, swelling systems, and mucoadhesive systems. Evaluation methods for GRDDS are also summarized, including in vitro tests to assess buoyancy, floating time, swelling, and dissolution behavior. The goal of GRDDS is to prolong gastric retention time of drugs and enable sustained release at the target site in the stomach.
This document summarizes floating drug delivery systems (FDDS), which are designed to remain in the stomach for a prolonged period of time. The document begins by describing gastric physiology and emptying processes. It then classifies and describes different types of FDDS, including single and multiple unit systems that are effervescent (gas-generating) or non-effervescent. Effervescent systems use carbon dioxide to float, while non-effervescent systems swell upon contact with gastric fluid. The document also discusses evaluation methods and applications of FDDS to improve drug bioavailability.
This document discusses gastroretentive drug delivery systems (GRDDS), which are designed to increase the gastric retention time of drugs. There are four main approaches for GRDDS: floating systems, bioadhesive systems, high density systems, and swellable systems. Floating systems have a lower density than gastric fluids and float on the stomach contents, releasing the drug slowly. Bioadhesive systems bind to gastric cells and increase retention time. High density systems use coatings like barium sulfate or zinc oxide to increase the dosage form density above gastric fluids. Swellable systems swell upon ingestion to a size that prevents exiting the pylorus and prolongs retention time. GRDDS provide benefits like enhanced bioavailability,
GASTRO RETENTIVE DRUG DELIVERY SYSTEM (GRDDS)JayeshRajput7
This document discusses gastroretentive drug delivery systems (GRDDS), which are designed to prolong the gastric residence time of drugs and promote local or systemic drug delivery in the upper gastrointestinal tract. It describes the anatomy and physiology of the GI tract and factors that influence gastric emptying. Several approaches for GRDDS are outlined, including floating, swelling, bioadhesive, and high density systems. Advantages include improved bioavailability and drug targeting to the stomach or upper small intestine. Drugs that may benefit from these systems include those that are poorly soluble at high pH or have a narrow absorption window in the upper GI tract.
Controlled drug delivery system by Bhola rautBholakant raut
This document discusses controlled and sustained release drug delivery systems. It defines controlled release as delivering a drug at a predetermined rate over an extended period, while sustained release aims for constant drug release but not necessarily at a predetermined rate. Controlled release offers benefits like improved compliance, consistent effects, and reduced side effects. Challenges include stability issues and increased manufacturing costs. The document then describes various approaches to controlled release, including dissolution-controlled, diffusion-controlled, and floating drug delivery systems which remain buoyant in the stomach.
This document discusses gastroretentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs to target drug release in the upper gastrointestinal tract. GRDDS are needed because oral drugs often have short gastric retention times and unpredictable emptying, resulting in incomplete drug release. The document outlines several approaches to achieving gastric retention, including floating, bioadhesive/mucoadhesive, expandable/unfoldable, and magnetic systems. It provides examples of drug candidates that could benefit from GRDDS and evaluates the advantages of these systems.
This presentation discusses gastroretentive drug delivery systems (GRDDS). GRDDS are designed to prolong the gastric retention time of drugs to target drug release in the upper gastrointestinal tract. The presentation defines GRDDS and provides examples like floating, high density, and mucoadhesive systems. It outlines the need for GRDDS to improve drug absorption and compliance. Key factors affecting gastric retention time are also summarized, including dosage form size, shape, density, and food intake. The presentation concludes with the advantages of GRDDS in maintaining drug levels and potential disadvantages related to certain drug and patient characteristics.
This document provides a review of gastroretentive drug delivery systems (GRDDS). It begins with an introduction to drug delivery systems and defines GRDDS as systems that prolong the gastric residence time to target drug release in the upper gastrointestinal tract. It then discusses the anatomy and physiology of the stomach, factors that influence gastric emptying, and advantages and limitations of GRDDS. The document reviews various approaches to GRDDS including floating, high density, swelling and bioadhesive systems. It also discusses technologies used in GRDDS and provides examples of marketed GRDDS products. In conclusion, the document states that GRDDS can enhance bioavailability and control drug delivery.
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
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This document discusses gastroretentive drug delivery systems (GRDDS). GRDDS are designed to remain in the stomach for an extended period of time to allow for prolonged release of drugs and improved bioavailability. The document outlines several approaches for GRDDS, including floating systems, high density systems, inflatable systems, and gastroadhesive systems. It discusses the advantages and limitations of different approaches and provides examples of drugs that can benefit from GRDDS formulations.
DRUG DELIVERY SYSTEM (gastro retentive drug delivery system)
Oral route is the most acceptable route for drug administration. Apart from conventional dosage forms several other forms were developed in order to enhance the drug delivery for prolonged time period and for delivering drug to a particular target site. Gastro-retentive drug delivery system (GRDDS) has gainned immense popularity in the field of oral drug delivery recently. it is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. different innovative approaches are being applied to fabricate GRDDS. Gastroretentive drug delivery is an approach to prolong gastric residence time, there by targeting site-specific drugs release in the upper gastrointestinal tract (GIT) for local or systemic effects. It is obtained by retaining dosage form into stomach and by releasing the in controlled manner.
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Gastro-retentive drug delivery systems (GRDDS) are designed to prolong the gastric retention time of drugs and increase their absorption in the upper gastrointestinal tract. This document discusses various strategies for developing GRDDS, including high density systems, floating systems, bioadhesive systems, and swellable systems. It also covers the advantages of GRDDS in improving bioavailability and drug delivery, as well as potential disadvantages like unsuitability for certain drug types. Evaluation methods are outlined to determine properties like floating time and drug release kinetics.
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gastro retentive drug delivery system topic include
1. introduction
2.advantages
3.technology
4.evaluation
5.disadvantages
6. matrix tablet
and other relative information regarding the topic
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This document reviews sustained release effervescent floating bilayer tablets as a novel drug delivery approach. It begins with an introduction that describes the challenges of oral drug delivery given variability in gastric emptying rates. It then discusses gastroretentive drug delivery systems (GRDFs) that are designed to prolong drug retention in the stomach. The document focuses on sustained release effervescent floating bilayer tablets as a GRDF that can provide sustained release of drugs that are incompatible with traditional floating formulations. It reviews the principles, technology, applications, advantages and evaluation methods of these bilayer floating tablets as a novel approach for improving oral drug bioavailability.
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This document discusses gastroretentive drug delivery systems. It defines terms like gastric retention time (GRT) and gastric emptying time (GET). It then describes different approaches for gastroretentive drug delivery systems, including high density systems, floating drug delivery systems, and adhesion or bioadhesion systems. Floating drug delivery systems are desirable as they remain buoyant in the stomach without affecting gastric emptying rate. The document outlines factors that control gastric retention time and types of floating drug delivery systems, including effervescent and non-effervescent systems.
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
An overview on Gastroretentive drug delivery systemsSriramNagarajan18
This document provides an overview of gastroretentive drug delivery systems (GRDDS). It discusses how GRDDS are designed to prolong the gastric retention time of orally administered drugs to improve their bioavailability. The document describes various approaches for GRDDS, including floating systems that float in the stomach, high density systems that sink to the bottom of the stomach, bioadhesive systems that adhere to the stomach lining, and unfoldable systems that expand in the stomach. It also discusses factors that influence gastric retention and the advantages of GRDDS for drugs that need to remain in the stomach.
This document discusses gastroretentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs to allow for increased drug absorption in the stomach or upper gastrointestinal tract. It provides information on appropriate drug candidates for GRDDS, factors affecting gastric retention, advantages and disadvantages of GRDDS, and various approaches to GRDDS design including floating systems, high density systems, swelling systems, and bioadhesive systems. The document also discusses gastric physiology and emptying relevant to GRDDS performance.
Gastric emptying is a complex process, one that is highly variable and makes in vivo performance of drug delivery systems uncertain. A controlled drug delivery system with prolonged residence time in the stomach can be great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter- and intra-subject variability of gastrointestinal (GI) transit time and to the non-uniformity of drug absorption throughout the alimentary canal. Floating drug delivery systems are useful in such applications. Floating microspheres have been gaining attention due to the uniform distribution of these multiple-unit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. The present research briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. Floating microsphere were prepared by solvent evapouration method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. The shape and surface morphology of the microspheres were characterised by differential scanning calorimetry and scanning electron microscopy.
The document discusses gastro-retentive drug delivery systems (GRDDS) which are dosage forms that can be retained in the stomach for a prolonged period of time. This increases the gastric retention time of drugs and helps to improve bioavailability. Various approaches to increase gastric retention time include high-density systems, low-density (floating) systems, bio-adhesive systems, gas generating systems, raft forming systems, and magnetic systems. Floating drug delivery systems are low-density systems that float in the gastric fluid due to their lower density than gastric fluids.
A REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM
SUBMITTED BY
MO SUHEB ANSARI
Assistant Professor
Department of Pharmaceutics
Faculty of pharmacy
Jahangirabad Institute of Technology Barabanki, Lucknow, Uttar Pradesh
This document provides an overview of gastroretentive drug delivery systems (GRDDS). It discusses appropriate candidate drugs, advantages and limitations of GRDDS. The document outlines various approaches to gastric retention including high density systems, floating systems, swelling systems, and mucoadhesive systems. Evaluation methods for GRDDS are also summarized, including in vitro tests to assess buoyancy, floating time, swelling, and dissolution behavior. The goal of GRDDS is to prolong gastric retention time of drugs and enable sustained release at the target site in the stomach.
This document summarizes floating drug delivery systems (FDDS), which are designed to remain in the stomach for a prolonged period of time. The document begins by describing gastric physiology and emptying processes. It then classifies and describes different types of FDDS, including single and multiple unit systems that are effervescent (gas-generating) or non-effervescent. Effervescent systems use carbon dioxide to float, while non-effervescent systems swell upon contact with gastric fluid. The document also discusses evaluation methods and applications of FDDS to improve drug bioavailability.
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This document discusses gastroretentive drug delivery systems (GRDDS), which are designed to prolong the gastric residence time of drugs and promote local or systemic drug delivery in the upper gastrointestinal tract. It describes the anatomy and physiology of the GI tract and factors that influence gastric emptying. Several approaches for GRDDS are outlined, including floating, swelling, bioadhesive, and high density systems. Advantages include improved bioavailability and drug targeting to the stomach or upper small intestine. Drugs that may benefit from these systems include those that are poorly soluble at high pH or have a narrow absorption window in the upper GI tract.
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This document discusses controlled and sustained release drug delivery systems. It defines controlled release as delivering a drug at a predetermined rate over an extended period, while sustained release aims for constant drug release but not necessarily at a predetermined rate. Controlled release offers benefits like improved compliance, consistent effects, and reduced side effects. Challenges include stability issues and increased manufacturing costs. The document then describes various approaches to controlled release, including dissolution-controlled, diffusion-controlled, and floating drug delivery systems which remain buoyant in the stomach.
This document discusses gastroretentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs to target drug release in the upper gastrointestinal tract. GRDDS are needed because oral drugs often have short gastric retention times and unpredictable emptying, resulting in incomplete drug release. The document outlines several approaches to achieving gastric retention, including floating, bioadhesive/mucoadhesive, expandable/unfoldable, and magnetic systems. It provides examples of drug candidates that could benefit from GRDDS and evaluates the advantages of these systems.
This presentation discusses gastroretentive drug delivery systems (GRDDS). GRDDS are designed to prolong the gastric retention time of drugs to target drug release in the upper gastrointestinal tract. The presentation defines GRDDS and provides examples like floating, high density, and mucoadhesive systems. It outlines the need for GRDDS to improve drug absorption and compliance. Key factors affecting gastric retention time are also summarized, including dosage form size, shape, density, and food intake. The presentation concludes with the advantages of GRDDS in maintaining drug levels and potential disadvantages related to certain drug and patient characteristics.
This document provides a review of gastroretentive drug delivery systems (GRDDS). It begins with an introduction to drug delivery systems and defines GRDDS as systems that prolong the gastric residence time to target drug release in the upper gastrointestinal tract. It then discusses the anatomy and physiology of the stomach, factors that influence gastric emptying, and advantages and limitations of GRDDS. The document reviews various approaches to GRDDS including floating, high density, swelling and bioadhesive systems. It also discusses technologies used in GRDDS and provides examples of marketed GRDDS products. In conclusion, the document states that GRDDS can enhance bioavailability and control drug delivery.
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Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
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mitigated, at least in part.
Immersive Learning That Works: Research Grounding and Paths ForwardLeonel Morgado
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
ESPP presentation to EU Waste Water Network, 4th June 2024 “EU policies driving nutrient removal and recycling
and the revised UWWTD (Urban Waste Water Treatment Directive)”
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
The cost of acquiring information by natural selectionCarl Bergstrom
This is a short talk that I gave at the Banff International Research Station workshop on Modeling and Theory in Population Biology. The idea is to try to understand how the burden of natural selection relates to the amount of information that selection puts into the genome.
It's based on the first part of this research paper:
The cost of information acquisition by natural selection
Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom
bioRxiv 2022.07.02.498577; doi: https://doi.org/10.1101/2022.07.02.498577
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
2. Gastro-retentive drug
delivery system
Submitted By
Pandhari Vithoba ingle
B. Pharm final yr. (7th sem
Guded by
MR. Amol G. Jadhao
(M.Pharm, Ph. D.Pursuing)
(Assit. prof. of pharmaceutics department)
3. INTRODUCTION
Ganstroretention drug delivery in a newly discover erred drug delivery system main approach of this
delivery is to prolong the drugs gastric resid ence time, thus Targeting site- specific drug release in the
upper GIT for local or systemin effects.
1) High Density(sinking)system: In this system, the drug is retained in the bottom of the stomach.
2) Low Density (Footing) System: This system causes buoyancy in gastric fluid.
3) Mucoadhesive System : This system causes bioadhesion of the drugs to stomach mucosa.
4) Unfordable, Extendible, or Swellable System: This system limits emptying of the dosage forms through the
pyloric sphincter of stomach.
5) Superporous Hydrogel System And Magnetic system: These are some other examples of GRDDS.
4. ADVANTAGES
1) It increases the bioavailability and curative efficiency of drugs.
2) It increases the economic usage of dosage.
3) It reduces the risk of antibiotic resistance by stabiles ing therapeutic levels over prolonged
period by removing fluctuations.
4) It increases the efficiency of drug release in case of short half-life drugs.
5) It causes flip-flop of pharmacokinetics.
6) It provides a narrow curative index.
7) It reduces any fluctuations in drug concentration and their effects.
8) It is a highly efficient system due to reduced counter activity by the baby.
9) It provides controlled rates of fluctuation thus a wider array is provided for selectivity in
receptor activation.
10) Being a systemic and controlled drug delivery system, it reduces the checks of drug over-
exposure at the diseased site.
11) It is u Sed to tret problems related to stomach and small intestine as the system sustains the
drug release, thus inscribes the gastric residence time and provides local therapy on these
organs.
5. disadvantages
1) It increases the level of fluids required in the stomach.
2) It is not suitable for drug having low solubility in gastric fluid, causing gastrointestinal
irritation, inflection in acidic environment, and meant for selection release in the colon.
3) In such a system, adherence of drugs with the mucus cannot be predicted due to the
continuous renewal of mucus wall of stomach.
4) GRDDS is fed into the system after the meal; the drugs residence time in stomach depends on
digestive stets of the subject.
5) The drugs residence time in stomachs depends on the subj etc being positioned upright.
6) Drugs which are formulated as hydrogel-based swelling system takes longer time to swell.
6. Floating Drug Delivery System
EFFERVESCENT
SYSTEM
NON-
EFFERVACENT
SYSTEM
1. Gas- generating system:
2. Single layer floating
tablet
3. Multiple unit type pills
4. Bilayer floating tablet
5. Floating system with
ion exchange resin
2) Volatile liquid containing system
I) Intragastric
gastrointestinal
II) Inflatable
gastrointestinal
1) Expandable and
Swellable systems
2)Inherently low density
system
Classification of floating drug delivery system
7. application
1) FOLLOWINGARETHEAPPLICATIONSOFTHEGRDDS:
2) Enhanced Bioavailability: Riboflavin Gastroretentive Dos age From (GRDF) shows enhanced
bioavailability as compared to the non-GRDP polymeric formulations. Many other processes,
related to drug absorption and transit in the GIT, act concurrently to influence the drug
absorption rate,
3) Sustained Drug Delivery/Reduced Frequency of Dosing: Drugs having short biological half-
life, and sustained and slow input from GRDF enhance the pharmacokinetic factors and
decrease the dosing frequency. This property increases patient compliance, and thus improves
therapy.
4) Targeted Therapy for Local Ailments in the Upper GIT: Local therapy can be exerted
on stomach and small intestine with prolonged and sustained administration of the drug from
GRDF to the stomach. Such targeted therapy helps to achieve the therapeutic drug
concentrations locally; while, minimal systemic concentrations are achieved after drug
absorption and distribution.
5) Reduced Fluctuations of Drug Concentration: By continuous intake of the drug following
GRDF administration, blood-drug concentrations can be maintained within a narrower range
as compared to the immediate release dosage forms. This minimises the fluctuations in drug
effects and prevents the adverse effects caused due to higher concentration.
6) Site Specific Drug Delivery: Drugs having limited absorption sites in upper small intestine
can be formulated as a floating dosage form. Controlled and slow delivery of drug to the
stomach provides local therapeutic levels and also limits the systemic exposure to the drug.
This apron ach also dec
8. FactorsAffectingGastricRetentionTimeoftheDosageFormFollowingfactorsaffectthegastricretentiontimeof thedosage
form
1) Density: Dosage form should have a less density than that of the gastric contents
(1.004g/ml).
2) Size: Dosage form with a diameter of more than 7.5mm show more gastric residence
time as compared to the dosage form having 9.9mm diameter.
3) Shape of the Dosage Form: The tetrahedron-shaped dosage form remains for a longer
period in the stomach than other devices of similar size. More predictable release profile
is observed for single or multiple unit formulation, along with insignificantly impaired
performance due to failure of the units.
4) As compared to single unit dosage form, multiple unit formulations allow co-
administration of u nits with different release profile or showing incompatibility with
gastric substances and have a large safety margin against dosage form failure.
5) Fed or Unfed State: During fasting the gastrointestinal motility shows periods of strong
motor activity at intervals of 1.5-2 hours. The Migrating Motor Complex (MMC) allows
passing of undigested food material from the stomach and if the timing of the
formulation coincides with that of MMC, the GRT of the unit can be very short, but,
MMC is delayed and GRT is longer during fasting
6) Nature of Meal: The motility pattern of the stomach changes to a fed state due to intake
of indigestible polymers or fatty acids. This reduces the gastric empty ing rate and
prolongs the drug release.
7) Caloric Content: Due to intake of high caloric food (such as protein and fat), GRT can
be increased by 4-10 times.
8) Frequency of Feed: If successive meals are given, the GRT can be increased over 400
minutes in comparison to the single meal due to low frequency of MMC.
9) Gender: Mean ambulatory GRT in males (3.4 hours) is less er than that of females (4.6
hours) of the same age and race, irrespective of height, weight, and body surface.
10) Age: Significantly longer GRT is observed in people of more than 70 years of age.
11) Concomitant Drug Administr ation: Anticholinergic drugs (eg, atropineand
propantheline) and opiates (e.g., codeine) can extend the GRT
9. Effervescent System
In effervescent systems, gas -generating agents, carbonates ( e.g.,
sodium bicarbonate), and other organic acids (e.g., citric acid and
tartaric acid) are used to produce carbon dioxide (C*O_{2}) gas. This
decreases the density of system and allows it to float on the gastric
fluid. An alternative of this systeminvolvesincorporating matrix-
containing portion of liquid, which produces a gas that evaporates at
body temperature.
10. Effervescent systems are further categorised into the following
two types:
1) Effervescent/Gas-Generating System: This system generates
gas bubbles to achieve floatability or buoyancy. Such a buoyant
system uses matrices made-up of swellable polymers, such as
polysaccharides (e.g., chitosan), and effervescent components
e.g., sodium bicarbonate, citric acid or tartaric acid).The optimal
stoichiometric ratio of citric acid and sodium bicarbonate for gas
generation should be 0.76: 1. In gas-generating system, carbon
dioxide is released and the formulations tarts floating in the
stomach
11. Low Density or Floating Drug Delivery System A careful gastric retention can achieve optimum level of drug
bioavailability, and
floating drug delivery system is a novel approach used for the same purpose. Drugs that
undergo absorption in the stomach or upper small intestine formulated in this system. This
method has no effect on the rate of gastric emptying over a prolonged time. Since the
density of floating drug delivery system is lower than that of gastric fluid, the drugs remain
buoyant in the stomach and are released slowly. In stomach, the emptying of residual
system is followed by the drug release. This increases the gastric retention time and
controls the fluctuations in plasma drug concentration. Following are the pre-
requisites for floating drug delivery system:
1) It requires a reservoir for slow content release.
2) It should be maintained at a s pecific gravity lower than that of gastric contents (1.004-
1.01gm/cm³)
3) It should form a cohesive gel barrier.
12. Mechanism of Floating Drug Delivery System
Siow release of drug is accompanied with the required rate
during the system flow on the gastric contents. Release of
drug is followed by removal of the residual system from the
stomach. However, minimum levels of gastric contents and
an appropriate level of floating force (F) are required to
achieve buoyancy retention principle and to keep the
dosage form buoyant over meal surface
13. High Density (Sinking) or Non Delivery System -Floating Drug
In high density or non-floating drug delivery system, dosage forms having density
more than that of the normal stomach content (~1.004gm/cm 3) are formulated.
Such formulations are prepared by coating the drug on a heavy core or by mixing
the drug with inert materials (like iron powder er, barium sulphate, zinc oxide,
titanium oxide, etc.). These materials increase the density by up to 15-24ga/cm². A
density of about 2.5 gm/cm² is essential for significant prolongation of gastric
residence time, But, this system is not effect humans, and thus such dosage form are
not marketed
14. Super-Porous Hydrogel System
The super-porous hydrogel system is different from the conventional type
system to warrant separate classification. This system involve s improvement
of the gastric retention time of super porous hydrogels of average pore size
>100 µm. The super-porous hydrogels swell to equilibrium size within 60
seconds due to rapid water uptake by capillary wetting through numerous
interconnected open pores. The super-porous hydrogels swell to a large size
(swelling ratio: 100 or more) and gain sufficient mechanical stern goths to
withstand pressure by gastric contraction. The super-porous hydrogel system is
used to formulate hydrophilic particulate materials.
15. Magnetic System
The magnetic system is used to increase the gastric retention time. It is based on the
principle that the dosage form contains a small internal magnet, and a magnet placed on
the abdomen over the position of stomach. Although it has been observed that magnetic
system works, the external magnet should be placed with a degree of precision that might
compromise patient compliance
16. Non-Effervescent System
1. The non-effervescent floating drug delivery system works on the mechanism
of
2. swelling of polymer or bioadhesion to mucosal layer in GIT. This system
utilises
3. gel-forming or highly swellable cellulose tyre hydrocolloids, hydrophilic
gums,
4. polysaccharides, and matrix-forming materials (e.g., polycarbonate,
polyacrylate,
5. polymethacrylate, polystyrene), and bioadhesive polymers (e.g., chitosan) as
the
most common excipients.
The non-effervescent system is of the following types:
17. Expandable or Swellable System:
1) If the dosage form is bigger than the
2) pyloric sphincter, it will withstand gastric transit in the stomach. But the
3) dosage form should be small enough to be swallowed, and should not cause
4) gastric obstruction, either alone or by accumulation. Therefore, expandable or
swellable system (figure 7.10) is formulated such to prolong the gastric
retention time:
1) A small configuration for oral intake,
1) An expanded Gastroretentive form, and
iii) A final small form that enables evacuation after drug release from the
18. Bioadhesive or Mucoadhesive or Gast Ro adhesive Drug Delivery System
In gastropathies drug delivery syst em, a mucoadhesive polymer is used that
adheres to the gastric mucosal surface and prolong its gastric retention time in
the GIT. The property of mucoadhesive polymers to adhere to the mucus layer
makes them very useful excipients in GRRDS. Mucoadhesive polymers can
be of natural origin (e.g., sodium alginate, gelatine, guar gym, etc.) or of
semi-synthetic (e.g. HPMC, Carbopol, sodium carboxymethyl cellulose).
polymers can be cationic, anionic, or neutral. Mucoadhesive
19. 1)Hydration-Mediated Adhesion:
Some hydrophilic polymers acquire
bioadhesive properties by imbibing a large amount of water and becoming
sticky. By controlling the dissolution rate of the polymers, the prolonged
gastroretention of the bio/muco-adhesive delivery system can he controlled.
2) Bonding-Mediated Adhesion:
In this type of adhesion, polymers adhere to
mucus/epithelial cell surface
through various bonding mechation
Deposition and inclusion of the adhesive material in the crevices of muons
may form physical or mechanical 1 bonds. Secondary chemical bonds, that