Gangrene refers to the death of body tissue due to lack of blood flow or bacterial infection, often affecting the extremities or skin. It can be caused by infection, tight bandages or plasters, injury, or obstruction of blood vessels. There are three main types of gangrene: dry gangrene occurs due to blood vessel diseases like atherosclerosis and presents as dry, shriveled skin; wet gangrene develops after injuries and is common in diabetics, appearing swollen and blistered; gas gangrene affects deep muscle tissue and causes a bubbly appearance, usually from clostridium infection. Management of gangrene involves surgery to remove dead tissue, antibiotics to reduce infection, vasodilators to maintain circulation,