2. From north to south
the Mediterranean
coastline joins
Barcelona and Villaricos,
where Deretil has its
manufacturing site.
LOCATIONS
March 2023
3. OUTSTANDING
SITUATION
❑ The strategic layout of the factory, the
financial and commercial office provide us the
right prospect of our present and a great
overview of the future.
❑ Manufacturing site:
Villaricos, Cuevas del Almanzora,
Almería, Spain
January 2024
❑ Head office:
Barcelona, Spain
4. 2024
Villaricos
HISTORICAL
FACTS
Villaricos
1961
1961
1981
1996
1975
1992
1998
Creation of Derivados
del Etilo, S.A.
Active in Bromine till 1983
Start in side chains
manufacturing (PGCH)
Start-up of Phenylglycine
Base (PG Base)
Start of Parahidroxy
Phenylglycine
Enzymatic production
Line (PHPG)
Deretil was acquired by
DSM. NV
(Dutch multinational
Company)
New Parahidroxy
Phenylglycine plant
(PHPG)
1998/9
New waste-water
treatment plant
January 2024
5. HISTORICAL
FACTS
2003
2005
2002
2004
2006
New Products:
Allantoin,
PH Glycol Ester
Purimox® plant
(enzymatic amoxicillin)
New expansion of
PHPG plant
Start of Strategic Plan
2005-2007
Expansion projects and
Customer Service
2007
2008
2009
FDA approval in Good
Manufacturing
Practices (cGMP)
Management
Buy-out
Introduction of New Products,
Custom Manufacturing, etc)
January 2024
6. HISTORICAL
FACTS
2015
2011-13
2016
Standard FDA Inspection,
Management Priorities and
Customer Service Consolidation of the
Quality & SHE
Management System
and the business
Standard FDA Inspection
2017-18
Implementation of
ISO 45001:2018
Safety & Health
ISO 50001:2018
Energy Management
2019
2022
Recertifications w.r.t. the
Integrated Quality, Safety,
Health & Environment
Management System:
➢ ISO 9001:2015
➢ ISO 14001:2015
Recertifications in cGMP:
➢ FDA/AEMPS Amoxicillin
➢ ISO 22716:2008 Cosmetics
Adaptation to the latest
Versions of:
➢ ISO 9001:2015
➢ ISO 14001:2015
Start of SAP ERP System
Project
January 2024
2023
Standard FDA Inspection
7. PRODUCTS AND APPLICATIONS
January 2024
Side chains
manufactured by Deretil
Molecular
structure
Use in the manufacture of
Betalactamic antibiotics
7-ADCA 6-APA
Danfenil = D(-)Alpha Phenyglycine
Dane Salt, Ethyl Potassium
Ampicillin
Cefaclor
Cephalexine
PGA = D(-)Phenylglycine Amide Cephalexine
PHPG = D(-)Alpha Parahydroxy
Phenylglycine
Amoxicillin
Cefadroxil
HPGM = D(-)Alpha Parahydroxy
Phenylglycine, Methyl Esther
Amoxicillin
(Purimox®)
Cefadroxil
Danoxi = D(-)Alpha Parahydroxy
Phenylglycine, Methyl Potassium
Amoxicillin
Cefadroxil
8. PRODUCTION
Production plants
The factory in Villaricos comprises the following industrial
plants, where a like number of products are manufactured:
❑ Parahidroxy Phenylglycine Dane Salt Danoxi®
Commercialized since 1990
❑ D (-) Phenylglycine Dane Salt - Danfenil®
Marketed since 1990
❑ D (-) Parahidroxy Phenylglycine
Two industrial facilities: Manufactured since 1992
and expanded with a second plant in 1998
❑ Purimox®
Amoxicillin, an antibiotic produced since 2002
❑ D(-)Alpha Parahydroxy Phenylglycine Methyl Esther
since 2002
❑ Allantoin, a dermatological active ingredient,
manufactured for more than 20 years
❑ D (-) Phenylglycine Amide, manufactured for more than
20 years
❑ Chelating agents (Salfer H, Salfer S and Salfer B),
manufactured for more tan 10 years
January 2024
9. Deretil’s
Sustainability &
Certifications
Integrated Quality, Safety, Health and
Environment Management System
❑ Registered in cGMP by the US FDA for API: Purimox®
❑ Certificate of cGMP by the Spanish Agency of Medicines and
Sanitary Products for API: Purimox®
❑ ISO 9001:2015 Quality Management System
❑ ISO 14001:2015 Environmental Management System
❑ ISO 22716:2008 Cosmetics cGMP for Allantoin
❑ ISO 50001:2018 Energy Management System
❑ ISO 45001:2018 Safety and Health Management System
❑ AMR Industry Alliance.- Deretil belongs to the International
Alliance (PSCI) for zero antibiotics emissions and wastewater
discharges without any human or environmental impact.
❑ Responsible Care.- Deretil has got a voluntary sustainability
program in place to safeguard the employees’ health and safety,
the neighbouring communities and the Environment.
January 2024
11. ORGANIZATIONAL CHART
Barcelona Headquarters
General Manager
Antonio Arroyo
Finance & Control
Ferran Barral
Commercial
Antonio Arroyo
Sales
Cristian
Izquierdo
Purchasing
& Logistics
Gerardo Frontera
Treasurership
Sandra
Izquierdo
Administration
Deputy Manager
Mireia Martin
Controller
Mar Reis
January 2024
Information
Technology
Manuel Esteban
12. ORGANIZATIONAL CHART
Almería site - Factory
SITE DIRECTOR
J.A. Torres
QUALITY CONTROL
A. Sánchez-Fresneda
QUALITY ASSURANCE
M. L. Ortega
PERSONNEL &
GENERAL AFFAIRS
R. López
PURCHASING
C. López
HEAD OF
ENGINEERING &
MAINTENANCE
E. Cruz
HEAD OF
PRODUCTION
J.F. Almendros
A-4000 A-10000 / 9000 A-14000
A-15000
PURIMOX ®
SERVICES
(Legal, medical and
surveillance)
LOGISTICS
B. Gonzalez
A-8000
SAFETY, HEALTH &
ENVIRONMENT
J.A. Muñoz
DERETIL VITATECH
R&D
M. Santiandreu
January 2024
PRODUCTION &
FACILITIES
Plant Managers &
Shift supervisors
A-6000
ADMNISTRATION
& TRAINING
D. Espin
13. Safety, Health &
The Environment
January 2024
Safety Performance & Trend
• Recordable accidents (RA): LWC accidents and medical treatments
1999-2020 Dupont – Stop program
2021-2024 BBS Industrial– Prevensis – Safe Behaviour Program
14. PEOPLE AND
TECHNOLOGY
❑ Staff evolution 2023:
- Barcelona ………. 16 employees
- Almeria …………. 175 employees
TOTAL ………….. 191 employees
❑ Deretil, S.A. operates 24 hours a day, 7
days a week in three shifts.
❑ The shift breakdown is:
Shift 1 = 6.00 am through 2.00 pm
Shift 2 = 2.00 pm through 10:00 pm
Shift 3 = 10:00 pm through 6:00 am
January 2024
15. SITE LAND
❑ PROPERTY – TOTAL ……. 77 hec.
- Total industrial soil ……… 36 hec.
- Total rustic land …………. 33 hec.
- Other applications ………. 8 hec.
January 2024
16. Manufacturing
Installations
❑ The factory is a self-sufficient site
provided with all necessary facilities
and utilities:
Electricity
Steam
Water
Sea water
N2 production
Air
Brine
WWTP
Warehouses
January 2024
17. LEGAL NAME
AND ADDRESSES
Head office:
Deretil, S.A.
Passatge Mas de Roda, 6-14
08005 Barcelona (Spain)
Tel. +34 93 467 71 17
Factory:
Deretil, S.A.
Villaricos, s/nº
04616 Cuevas del Almanzora
(Almeria, Spain)
Tel. +34 950 618 000
Fax +34 950 467 401
www.deretil.com
January 2024
