Deretil with more than 50 years of experience in performing technological solutions aimed to improve the quality of life, is one of the leading companies worldwide in the fields of research, development, manufacturing and sales of raw materials for the production of semisynthetic antibiotics, such as penicillins and cephalosporins. Deretil has over 50 years of experience in the pharmaceutical industry and is a global leader in the production of semisynthetic antibiotics. The most important antibiotics consumed globally and world’s best-known brands are made with the products manufactured by Deretil. External acknowledgements obtained by the company include certification of our Comprehensive Quality, Health and Safety Management System in accordance with the following standards: ISO 9001 / ISO 14001. Our values and philosophy: Health, Safety and Environment Product life cycle stewardship Ongoing training ISO 14001 Certification Responsible Care Commitment

1. www.deretil.com
January 2021
CORPORATE PRESENTATION

2. From north to south
the Mediterranean
coastline joins
Barcelona and Villaricos,
where Deretil has its
manufacturing site.
LOCATIONS
January 2021

3. OUTSTANDING
SITUATION
 The strategic layout of the factory, the
financial and commercial office provide us the
right prospect of our present and a great
overview of the future.
 Manufacturing site:
Villaricos, Cuevas del Almanzora,
Almería, Spain
January 2021

4. 2021
Villaricos
HISTORICAL
FACTS
Villaricos
1978
1961
1981
1996
1975
1992
1998
Creation of Derivados
del Etilo, S.A.
Active in Bromine till 1983
Start in side chains
manufacturing (PGCH)
Start-up of Phenylglycine
Base (PG Base)
Start of Parahidroxy
Phenylglycine
Enzymatic production
Line (PHPG)
Deretil was acquired by
DSM. NV
(Dutch multinational
Company)
New Parahidroxy
Phenylglycine plant
(PHPG)
1998/9
New waste-water
treatment plant

5. HISTORICAL
FACTS
2003
2005
2002
2004
2006
New Products:
Allantoin,
PH Glycol Ester
Purimox® plant
(enzymatic amoxicillin)
New expansion of
PHPG plant
Start of Strategic Plan
2005-2007
Expansion projects and
Customer Service
2007
2008
2009
FDA approval in Good
Manufacturing
Practices (cGMP)
Management
Buy-out
Introduction of New Products,
Custom Manufacturing, etc)

6. HISTORICAL
FACTS
2015
2011-13
2016
Standard FDA Inspection,
Management Priorities and
Customer Service
Consolidation of the
Quality & SHE
Management System
and the business
Standard FDA Inspection
2017-18
Implementation of
SAP ERP System
2019
2020
Recertifications w.r.t. the
Integrated Quality, Safety,
Health & Environment
Management System:
 ISO 9001:2015
 ISO 14001:2015
Recertifications in cGMP:
 FDA/AEMPS Amoxicillin
 ISO 22716:2008 Cosmetics
Adaptation to the latest
Versions of:
 ISO 9001:2015
 ISO 14001:2015
Start of SAP ERP System
Project

7. Principal
Industrial
advantages
Expertises in handling
large volumes
(solid/liquid)
Dedicated
Production plants
Enzymatic
technology,
fermentation
Principles of
Manufacturing
Excellence
Integrated
Q+SHE
System
Biological waste-water
treatment plant
(sea water)
Side chains
Manufactured
By Deretil
Side chains
Manufactured
By Deretil
Use in the manufacture of
Betalactamic antibiotics
Danfenil® =
D(-)Alpha
Phenylglycine Dane
Salt, Ethyl Potassium
Ampicillin
Cefaclor
Cefalexine
PGA =
D(-)Phenylglycine
Amide
Cefalexine
PHPG =
D(-)Alpha Parahydroxy
Phenylglycine
Amoxicillin
Cefadroxil
HPGM =
D(-)Alpha Parahydroxy
Phenylglycine,
Methyl Esther
Amoxicillin
Cefadroxil
Danoxi® =
D(-)Alpha Parahydroxy
Phenylglycine,
Methyl Potassium
Amoxicillin
Cefadroxil
PRODUCTS AND APPLICATIONS
January 2021

8. PRODUCTION
Production plants
The factory in Villaricos comprises six industrial plants,
where a like number of products are manufactured:
 Parahidroxy Phenylglycine Dane Salt Danoxi®
Commercialized since 1990
 D (-) Phenylglycine Dane Salt - Danfenil®
Marketed since 1990
 D (-) Parahidroxy Phenylglycine
Two industrial facilities: Manufactured since 1992
and expanded with a second plant in 1998
 Purimox®
Amoxicillin, an antibiotic produced since 2002
 Multi–purpose plant
Allantoin
Phenylglycine Amide
January 2021

9. TOP PRIORITIES
Ongoing training
Safety, Health and the Environment Policy encourages our
ongoing training activities. Deretil’s efforts in this area have
led to maintain workplaces almost injury-free, which have
been recognised by the Spanish Independent Commission
for Safety and Hygiene in Chemical Industries.
 Registered in cGMP by the FDA for API: Purimox®
 Certificate of cGMP Compliance by the Spanish
Agency of Health
 ISO 9001:2015
 ISO 14001:2015
 ISO 22716:2008 (Cosmetic cGMP)
January 2021

10. ORGANIZATION
Management Team
Knowing how to coach means knowing how to entrust. We believe and bet on the human value of
a great team, who keep together and are prepared to continue replying to the society’s needs.
GENERAL MANAGER
Mr. Antonio Arroyo
FINANCE & CONTROL
Mr. Ferran Barral
MANUFACTURING
Mr. Gracian
Gutiérrez
PRODUCTION
Almería
COMMERCIAL
Mr. Antonio Arroyo
January 2021

11. ORGANIZATIONAL CHART
Barcelona Headquarters
General Manager
Antonio Arroyo
Finance & Control
Ferran Barral
Commercial
Antonio Arroyo
Sales
Cristian
Izquierdo
Purchasing
& Logistics
Gerardo Frontera
Treasurership
Sandra
Izquierdo
Administration
Deputy Manager
Mireia Martin
Controller
Mar Reis
January 2021

12. ORGANIZATIONAL CHART
Almeria Site
SITE DIRECTOR
G. Gutierrez
QUALITY CONTROL
A. Sánchez-Fresneda
QUALITY ASSURANCE
M. C. Navarro
PERSONNEL &
GENERAL AFFAIRS
R. López
PURCHASING
C. López
PRODUCTION
J.A. Torres
ENGINEERING
E. Cruz
PRODUCTION &
FACILITIES
Plant Managers &
Shift supervisors
A-4000 A-9000 A-10000 A-14000
A-15000
PURIMOX ®
SERVICES:
Legal, Medical,+
Administration,
Vigilance, etc.
LOGISTICS
B. Gonzalez
A-6000
A-8000
SAFETY, HEALTH &
ENVIRONMENT
F.J. Martínez
DERETIL VITATECH
R&D
M. Santiandreu
January 2021
MAINTENANCE
A. Alonso

13. PEOPLE AND
TECHNOLOGY
TOGETHER WE MAKE
DERETIL INJURY-FREE
 Motivation and quality of our staff
Fundamental for our goals achievement.
 Essential
Direct engagement of our employees in the
process of optimizing operations and the way
of learning from each other.
 Staff evolution 2020:
- Barcelona ………. 16 employees
- Almeria …………. 182 employees
TOTAL ………….. 198 employees
January 2021

14. PEOPLE AND
TECHNOLOGY  DERETIL, S.A.U. operates 24 hours a
day, 7 days a week in three shifts.
 The shift breakdown is:
Shift 1 = 6.00 am through 2.00 pm
Shift 2 = 2.00 pm through 10:00 pm
Shift 3 = 10:00 pm through 6:00 am
January 2021

15. SITE LAND
 PROPERTY – TOTAL ……. 77 hec.
- Total industrial soil ……… 36 hec.
- Total rustic land …………. 33 hec.
- Other applications ………. 8 hec.
January 2021

16. Manufacturing
Installations
 The factory is a self-sufficient site
provided with all necessary facilities
and services:
Electricity Cogeneration
Plant
Steam
Water
Sea water
N2 production
Air
Brine
WWTP
Warehouses
January 2021

17. LEGAL NAME
AND ADDRESSES
January 2021
Office:
Deretil, S.A.U.
Calle La Llacuna, 161, 2º
08018 Barcelona
(Spain)
Tel. +34 93 467 71 17
Fax +34 93 467 71 31
Factory:
Deretil, S.A.U.
Villaricos, s/nº
04616 Cuevas del Almanzora
(Almeria, Spain)
Tel. +34 950 618 000
Fax +34 950 467 401
www.deretil.com

18. www.deretil.com
January 2021
SIDE CHAINS