Bronchial Thermoplasty (BT) Novel Treatment for Patients with Severe AsthmaBassel Ericsoussi, MD
Do our Asthma Patients Know What They Are Missing?Now, A Revolutionary Procedure Can Help Them Lead A Fuller Life.
Bronchial Thermoplasty (BT) Novel Treatment For Patients With Severe Asthma
Bronchial Thermoplasty (BT) Novel Treatment for Patients with Severe AsthmaBassel Ericsoussi, MD
Do our Asthma Patients Know What They Are Missing?Now, A Revolutionary Procedure Can Help Them Lead A Fuller Life.
Bronchial Thermoplasty (BT) Novel Treatment For Patients With Severe Asthma
There are 2 reasons for which patients come to Mayo Hospital:
1. Someone in the periphery tells them,that Mayo is the only place where they'll find best facilities and "Multidisciplinary Management" by which they are able to cure incurables.
2. They don't have money to afford any other hospital.
I'm not exaggerating but we really try to live up to these expectation. Case below is a classical example of that. This Patient had been managed by 3 hospitals,and for 11month he was living his days waiting for his death due to a benign disease. Alhamdulillah Dr Haroon Rafi Ul Islam and his team successfully managed the case,and this orphan,only child of a widow,is doing perfectly well. We are thankful to our Gastroenterology Department, Radiology Department for helping us reach the diagnosis, Our House Officers for bringing this Patient to us and donating their own blood for him. We especially want to thank SPWS for arranging blood donations for this Patient. God bless you all.
There are 2 reasons for which patients come to Mayo Hospital:
1. Someone in the periphery tells them,that Mayo is the only place where they'll find best facilities and "Multidisciplinary Management" by which they are able to cure incurables.
2. They don't have money to afford any other hospital.
I'm not exaggerating but we really try to live up to these expectation. Case below is a classical example of that. This Patient had been managed by 3 hospitals,and for 11month he was living his days waiting for his death due to a benign disease. Alhamdulillah Dr Haroon Rafi Ul Islam and his team successfully managed the case,and this orphan,only child of a widow,is doing perfectly well. We are thankful to our Gastroenterology Department, Radiology Department for helping us reach the diagnosis, Our House Officers for bringing this Patient to us and donating their own blood for him. We especially want to thank SPWS for arranging blood donations for this Patient. God bless you all.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. EPIDEMIOLOGIJA
• POTROŠNJA RIBE U HRVATSKOJ JE
MALA
• RIBA JE OSNOVNA PREHRAMBENA
NAMIRNICA U NEKIM ZEMLJAMA
3. COMPLICATIONS ASSOCIATED WITH 327 FOREIGN BODIES OF
THE PHARYNX, LARYNX, AND ESOPHAGUS. ANN OTOL RHINOL
LARYNGOL 1997 SINGH ET ALL, BROOKLIN NY
• DVIJE DOBNE SKUPINE; DESET
GODINA
• 64 MLAĐE:36%STARIJE
• NIJE BILO SMRTNOG ISHODA
4.
5. ZAKLJUČCI BRUKLINĆANA
• ZAČUDNO, RIBLJA KOST NAJČEŠĆI JE
UZROK RETROFARINGEALNOG APSCESA U
STARIJIH OD 10 GODINA
• VJEROJATNO JE TOMU TAKO JER JE RIBLJA
KOST TEŠKO RTG DETEKTABILNA
• NEMA RAZLIKE U MORBIDITETU OBZIROM
NA METODU EKSTRAKCIJE U DJECE
6. A PROSPECTIVE STUDY OF FOREIGN BODY INGESTION IN 311
CHLIDREN, INTERNATIONAL JOURNAL OF PEDIATRIC ORL,
2001, WAI PACK AT ALL, HONG KONG
7. ZANIMLJIVOSTI IZ HONG KONGA
• SVA STRANA TIJELA DIJAGNOSTICIRANA SU
BEZ POMOĆI ETA E
• 57% ŠPATULOM, 27% TRANSNAZALNOM
ENDOSKOPIJOM, ( MACINTOSH, ILS)
• KOD DJETETA NEMA IMAPKTIRANOG
STRANOG TIJELA ISPOD KRIKOFARINGEUSA
• RIBLJE KOSTI NA RTG u- VISOKA
SPECIFIČNOST, NISKA SENZITIVNOST- NE
PROPRUČUJE SE RTG UKLJUČITI U RUTINSKI
PROTOKOL
8. A PROSPECTIVE STUDY OF FISH BONE INGESTION-EXPIRIENCE
OF 358 PATIENTS, ANN SURG, 1990, NGAN ET ALL, HONG KONG
STARIJI OD
12 GODINA
9. • MORBIDITET 1%
• 40 MINUTA
ODSTRANJIVANJE
• 35 PACIJENATA ODBILO
JE ENDOSKOPIJU TE JE
JEDAN (3%) RAZVIO
RETROFARINGEALNI
APSCES NAKON 14
DANA
10. FISH BONE AS A FOREIGN BODY, THE JOURNAL OF
LARYNGOLOGY ET OTOLOGY, 2003, KUMAR ET ALL,
NEWPORT UK
• U NEKIM BOLNICAMA NAJČEŠĆE
HITNO STANJE
• INTERVJU S 30 BOLNICA 1.
OSLIKAVATE LI RTG OM RIBLJE KOSTI
2. ZNATE LI DA RADIOLUCENTNOS
OVISI O RIBLJOJ VRSTI?
• SVI OSLIKAVAJU, DVIJE BOLNICE
IMAJU POPIS RADIOLUCENTNIH VRSTA
11. • OSLIKAVALI SU KOSTI
RTG OM NAJČEŠĆIH
VRSTA RIBE U
BRITANIJI
• KOKOŠJA KOST
SLUŽILA JE KAO
KONTROLA
• TRI GRUPE KOSTIJU
• OČITAVALI
RENTGENOLOZI
12. VISOKO
OPACIFICIRA
SREDNJE MINIMALNO
LOSOS PASTRVA HARINGA
BAKALAR DEVERIKA SARDINA
CIPAL ROMB LOKARDA
LIST SKUŠA PAPAPALINA
LUBIN SABLJARKA OSLIĆ
KOKOT GRDOBINA
(KOKOŠ)
13. PAPARELLA, MOHR: “ENDOSKOPY AND FOREIGN
BODY REMOVAL”
“ DOBRO PROMISLITE PRIJE NO ŠTO SE
UPUSTITE U INSTRUMENTIRANU
EZOFAGOSKOPIJU. SMRT NAVIRUJE
OD TAMO. POVIJEST NAS OPOMINJE. A
NEMA POTREBE DA REKAPITULIRATE
POVIJEST.”
14. THE USFULNESS OF COMPUTED TOMOGRAPHY IN THE
DIAGNOSIS OF IMPACTED FISH BONES IN THE OESOPHAGUS,
THE JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1998,
WATANABE ET ALL, JAPAN
• RIBLJE KOSTI RIJETKO ZASTAJU U
JEDNJAKU
• PARA I RETROAZOFAGEALNI APSCES
• PLUĆNI PASCES
• EZOFAGO KAROTIDNA ILI AORTNA
FISTULA
• RIBLJA KOST U JEDNJAKU:
RAZRIJEŠITI URGENTNO!!
15.
16. 25 SLUČAJEVA
• 56% IMALO JE KOST KOJU JE RTG
PREVIDIO
• 19% INDIREKTNI ZNAKOVI KOSTI ( OTOK
PREVERTEBRALNIH ČESTI, ZRAK)
• RTG ZAKAZUJE I ZBOG OSIFIKATA I
HRSKAVICA VRATA
• 75% ODSTRANJENO S EZOFAGOSKOPOM,
• 1 LATERALNA CERVIKOTOMIJA
17. • NA RTG U NAJBOLJE VIDLJIVE KOSTI PARALELNE S
MEDIOSAGITALNOM RAVNINOM
• OSLIKAVANJE 2 MM SLOJEM NAĆI ĆE SVAKU KOST, SLOJEVI
SVAKAKO MANJI OD 10 MM
• NEMA RAZLIKE U UPOTREBI TKIVNOG I KOŠTANOG
“PROZORA”
• CT MOĆNO PRIKAZUJE OKOLNU REAKCIJU I STANJE TKIVA
18. DIAGNOSTIC AND THERAPEUTIC APPROACH TO MIGRATING
FOREIGN BODIES, ANN OTOL RHINOL LARINGOL, 1999, CHEE,
SETHI, SINGAPORE
• POZITIVNA
ANAMNEZA,
NEGATIVAN
EZOFAGOSKOPSKI
NALAZ, POZITIVAN
EKSTRALUMINALNI
CT NALAZ
• 24 PACIJENTA
• IPSILATERALNA BOL
U VRATU
• JEDAN APSCES
19. • LINEARNE, 0,7 DO 3 CM DUŽINE
• 16 INTRAMURALNIH, 8
EKSTRALUMINALNIH
• 6 HORIZONTALNO, 18 VERTIKALNO ILI
KOSO ORIJENTIRANIH
• EZOFAGOSKOPSKI 9 NORM, 15
RAZDEROTINA, VRIJEDOVA ILI EDEMA
20. PENETRIRAJUĆE
ZANIMLJIVOSTI
• 24 EKSPLORACIJE VRATA, 12 EZOFAGOSTOMA, 1
PAREZA REKURENSA
• NIJE BILO DJECE
• NEFILETIRANA RIBA, ČIŠĆENJE UZ ŽVAKANJE
• 3 MM SLOJEVI, NAZOGASTRIČNA SONDA DA
SPRIJEČI KOLAPS, OLAKŠA ORIJENTACIJU
• NE KORISTITI RELACIJU KRALJEŠAK – STRANO
TIJELO ZA ORIJENTACIJU
• PRIJE SVEGA IDENTIFICIRATI REKURENS
• ROLATI JEDNJAK IZMEĐU PRSTIJU, RAZREZATI
MUSKULARIS BEZ MUKOZE, KORISTITI LUPU I
MIKROSKOP
21. PENETRIRAJUĆI ZAKLJUČCI
• (18 OD 24 MANJE OD DANA OD INGESTIJE)
• SVAKAKO ČINITI EZOFAGOSKOPIJU
• OBLIK, ČUVATI SE HORIZONTALNO
ORIJENTIRANIH
• ORIJENTACIJSKE TOČKE: KRIKOID, HIOID,
ŠTITNA, KAROTIDA
• ZAHVAT JE “URGETNO PLANIRAN”
• EZOFAGOSTOMIJA NE POVEĆAVA
MORBIDITET
22. THE USE OF TOLUIDINE BLUE GARGLES TO AID THE
DETECTION OF IMPACTED PHARYNGEAL FISH BONES, THE
JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1999, JASSAR
AT ALL. UNITED KINGDOM