This document introduces a new methodology for integrating Failure Mode and Effects Analysis (FMEA) with Kepner-Tregoe (KT) method to efficiently handle issues in semiconductor fabrication plant (fab) daily management. The methodology follows the steps of a quality control (QC) story. Potential causes of issues are identified from an existing FMEA database. KT analysis techniques like the "3W1H table" and "IS/IS NOT" questions are used to analyze causes and narrow down the most probable one. Both possibility and feasibility of causes are considered to identify high-priority causes to verify first. The methodology was successfully applied to resolve an actual process abnormality issue in a fab.