Altus Alliance 2016 - How to Plan a Pain-Free UpgradeSparkrock
Presentation by Diana Budreau on February 5th, 2016.
With the fast innovative pace of today’s technology, you are likely to upgrade you Altus Dynamics solution every 2 to 3 years. View this presentation to determine the right timing, the right plan for going forward, and what upgrade option will work best for your organization. Both the Evergreen upgrade plan and the traditional upgrade method will be covered.
Altus Alliance 2016 - How to Plan a Pain-Free UpgradeSparkrock
Presentation by Diana Budreau on February 5th, 2016.
With the fast innovative pace of today’s technology, you are likely to upgrade you Altus Dynamics solution every 2 to 3 years. View this presentation to determine the right timing, the right plan for going forward, and what upgrade option will work best for your organization. Both the Evergreen upgrade plan and the traditional upgrade method will be covered.
Every day, parents observe the growing behavioural repertoirBetseyCalderon89
Every day, parents observe the growing behavioural
repertoires of their infants and young children, and
the corresponding changes in cognitive and emotional
functions. These changes are thought to relate to normal
brain development, particularly the development of the
hippocampus, the amygdala and the frontal lobes, and
the complex circuitry that connects these brain regions.
At the other end of the age spectrum, we observe changes
in cognition that accompany aging in our parents. These
changes are related to both normal and pathological
brain processes associated with aging.
Studies in animals and humans have shown that
during both early childhood and old age the brain
is particularly sensitive to stress, probably because it
undergoes such important changes during these periods.
Furthermore, research now relates exposure to early-life
stress with increased reactivity to stress and cognitive
deficits in adulthood, indicating that the effects of stress
at different periods of life interact.
Stress triggers the activation of the hypothalamus-
pituitary-adrenal (HPA) axis, culminating in the pro-
duction of glucocorticoids by the adrenals (FIG. 1).
Receptors for these steroids are expressed throughout
the brain; they can act as transcription factors and so
regulate gene expression. Thus, glucocorticoids can have
potentially long-lasting effects on the functioning of the
brain regions that regulate their release.
This Review describes the effects of stress during pre-
natal life, infancy, adolescence, adulthood and old age on
the brain, behaviour and cognition, using data from ani-
mal (BOX 1) and human studies. Here, we propose a model
that integrates the effects of stress across the lifespan,
along with future directions for stress research.
Prenatal stress
Animal studies. In animals, exposure to stress early in
life has ‘programming’ effects on the HPA axis and the
brain1. A single or repeated exposure of a pregnant
female to stress2 or to glucocorticoids3 increases mater-
nal glucocorticoid secretion. A portion of these gluco-
corticoids passes through the placenta to reach the fetus,
increasing fetal HPA axis activity and modifying brain
development4. In rats prenatal stress leads to long-term
increases in HPA axis activity 5. Controlling glucocor-
ticoid levels in stressed dams by adrenalectomy and
hormone replacement prevents these effects, indicating
that elevations in maternal glucocorticoids mediate the
prenatal programming of the HPA axis6.
Glucocorticoids are important for normal brain
maturation: they initiate terminal maturation, remodel
axons and dendrites and affect cell survival7; both sup-
pressed and elevated glucocorticoid levels impair brain
development and functioning. For example, admin-
istration of synthetic glucocorticoids to pregnant rats
delays the maturation of neurons, myelination, glia
and vasculature in the offspring, significantly altering
neuronal structure and synaps ...
Overview of Discussion-
About Substance P (SP)
Discovery of SP
SP Receptor
Functions mediated by SP
Clinical significance of the SP-NK1R
NK1 receptor antagonists
This is the presentation of my systems theory of autistogenesis made at the Western Psychological Association, the Autism Society, and the American Psychological Association. Since that time, new information has continued to support this theoretical perspective and I am now moving into experimental studies to confirm.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Every day, parents observe the growing behavioural repertoirBetseyCalderon89
Every day, parents observe the growing behavioural
repertoires of their infants and young children, and
the corresponding changes in cognitive and emotional
functions. These changes are thought to relate to normal
brain development, particularly the development of the
hippocampus, the amygdala and the frontal lobes, and
the complex circuitry that connects these brain regions.
At the other end of the age spectrum, we observe changes
in cognition that accompany aging in our parents. These
changes are related to both normal and pathological
brain processes associated with aging.
Studies in animals and humans have shown that
during both early childhood and old age the brain
is particularly sensitive to stress, probably because it
undergoes such important changes during these periods.
Furthermore, research now relates exposure to early-life
stress with increased reactivity to stress and cognitive
deficits in adulthood, indicating that the effects of stress
at different periods of life interact.
Stress triggers the activation of the hypothalamus-
pituitary-adrenal (HPA) axis, culminating in the pro-
duction of glucocorticoids by the adrenals (FIG. 1).
Receptors for these steroids are expressed throughout
the brain; they can act as transcription factors and so
regulate gene expression. Thus, glucocorticoids can have
potentially long-lasting effects on the functioning of the
brain regions that regulate their release.
This Review describes the effects of stress during pre-
natal life, infancy, adolescence, adulthood and old age on
the brain, behaviour and cognition, using data from ani-
mal (BOX 1) and human studies. Here, we propose a model
that integrates the effects of stress across the lifespan,
along with future directions for stress research.
Prenatal stress
Animal studies. In animals, exposure to stress early in
life has ‘programming’ effects on the HPA axis and the
brain1. A single or repeated exposure of a pregnant
female to stress2 or to glucocorticoids3 increases mater-
nal glucocorticoid secretion. A portion of these gluco-
corticoids passes through the placenta to reach the fetus,
increasing fetal HPA axis activity and modifying brain
development4. In rats prenatal stress leads to long-term
increases in HPA axis activity 5. Controlling glucocor-
ticoid levels in stressed dams by adrenalectomy and
hormone replacement prevents these effects, indicating
that elevations in maternal glucocorticoids mediate the
prenatal programming of the HPA axis6.
Glucocorticoids are important for normal brain
maturation: they initiate terminal maturation, remodel
axons and dendrites and affect cell survival7; both sup-
pressed and elevated glucocorticoid levels impair brain
development and functioning. For example, admin-
istration of synthetic glucocorticoids to pregnant rats
delays the maturation of neurons, myelination, glia
and vasculature in the offspring, significantly altering
neuronal structure and synaps ...
Overview of Discussion-
About Substance P (SP)
Discovery of SP
SP Receptor
Functions mediated by SP
Clinical significance of the SP-NK1R
NK1 receptor antagonists
This is the presentation of my systems theory of autistogenesis made at the Western Psychological Association, the Autism Society, and the American Psychological Association. Since that time, new information has continued to support this theoretical perspective and I am now moving into experimental studies to confirm.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. Il centro del controllo dello stress è l’amigdala, cui fa da supporto l’ippocampo.
All’amigdala arrivano segnali nervosi che mostrano un ambiente ostile o
sconosciuto e l’amigdala risponde facendo partire risposte ormonali in particolare
attivando la produzione di cortisolo
3. PVN Nucleo mediale paraventricolare
dell’ipotalamo
Regolazione neuroendocrina dello stress: recenti acquisizioni FLAVIO POZZI, GAETANO FRAJESE
NÓO ς 3:2004; 143-154
Ma il cortisolo e altri elementi
possono tornare ad amigdala e
ippocampo danneggiandoli
5. Nel neonato l’effetto è simile, ma in più abbiamo due fatti
Un’immaturità e fragilità delle cellule nervose dell’intero encefalo
Una difficoltà visuale e culturale a riconoscere che il neonato soffre lo stress
come e più che un adulto
Gli effetti dello stress sul neonato
sono studiati soprattutto su animali.
E si riferiscono a studi che mostrano
gli effetti sul cervello della
sottrazione della mamma; oppure di
ripetuti stimoli dolorosi
6. • In humans, exposure to childhood abuse or
neglect, for example, has been associated
with an increased risk of anxiety and mood
disorders, obesity, cardiovascular disease
and addiction.
7. anxiety- and depression-
like phenotypes, such as
reduced negative-
feedback of the HPA axis
and Neophobia.
une addiction
pour l’alcool
alterations in
arginine
vasopressin
(AVP) expression
dépendance à la
morphine
by impairments in
learning and memory
tasks such as the
Morris water maze
and novel object
recognition.
increased levels of novelty
induced anxiety, indicated by
increased startle responses,
decreased exploration in
novel environment and
increased latencies to enter a
novel environment
2011
2014
8.
9. Dorsal Root Gamglion
Rostroventral medulla
Periaqueductal Grey Matter Paraventral Nucleus of Hypothalamus
When the animal reaches adulthood, a decrease in phasic inhibitory signalling is observed, due to a selective reduction in glycine receptor (GlyR)-mediated
input to GABAergic and glutamatergic lamina II neurons and a decreased density of tonic GlyR-mediated current in the glutamatergic population (Liet al.,
2013)
10. Figure 1. Cortical thickness at age 7 years in relation to neonatal pain-related stress adjusted for clinical
confounders.
Ranger M, Chau CMY, Garg A, Woodward TS, Beg MF, et al. (2013) Neonatal Pain-Related Stress Predicts Cortical Thickness at
Age 7 Years in Children Born Very Preterm. PLoS ONE 8(10): e76702. doi:10.1371/journal.pone.0076702
http://journals.plos.org/plosone/article?id=info:doi/10.1371/journal.pone.0076702
11. I meccanismi con cui lo stress danneggia il cervello neonatale
sono vari:
Aumento della pressione del sangue e del liquido cerebrale
Aumento di produzione di aminoacidi eccitatori e radicali liberi
Alterazione dell’espressione di alcuni geni-chiave per l’integrità
del cervello, come quello che regola la pressione (gene della
vasopressina), la plasticità cerebrale e i recettori del cortisone
12.
13.
14.
15. Brain-derived neurotrophic factor)
Marija Kundakovic,Frances A Champagne:
Early-Life Experience, Epigenetics, and the Developing Brain.
Neuropsychopharmacology REVIEWS (2015) 40, 141–153
Nel cervello, è attivo nell'ippocampo, corteccia cerebrale, e prosencefalobasale -
aree vitali per l'apprendimento, la memoria, e il pensiero.
16. Marija Kundakovic,Frances A Champagne:
Early-Life Experience, Epigenetics, and the Developing Brain.
Neuropsychopharmacology REVIEWS (2015) 40, 141–153
The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily
3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind
In rodents, maternal licking
and grooming over the first
days of life cause reduced
HPA-axis reactivity and
anxiety-like behaviors
mediated via increased GR
expression accounted for,
at least in part, by
demethylation at exon 1–7
promoter of the rat GR
gene (Nr3c1) in the
hippocampus of the
offspring.
17. C Murgatroyd.
Translational Psychiatry (2015) 5, e560
Child NR3C1 1-F promoter methylation percent by standardized maternal stroking scores.
The child’s raw methylation percent decreases with maternal stroking for children with mothers who
reported low prenatal but high postnatal depression scores (solid line).
No such decrease is seen for the remainder of the children (dashed).
19. Guzzetta A et al:
The Journal of Neuroscience 2009 •
29(18):6042– 6051
20.
21. E infants showed a significantly smaller increase than C infants in umWM volume
E infants showed decreased coherence (green arrows), likely representing the pruning of C-group
hyper-connectivities
22. Attenzione però alle fonti di stress nascosto.
Lo stesso parto può essere onte di stress, e dipende dal tipo di
parto che il bambino subisce.
E non va dimenticato che il primo fattore di rischio di stress per il
bambino è avere infermieri e medici stressati…
Editor's Notes
Short-term survival of newly generated cells is reduced by stress. A , B , Histological evaluation of BrdU-positive cells in animals examined 1 week after the stress episode (Fig. 1 C, experiment 2) revealed a robust population of BrdU-positive cells in the dentate gyrus of control animals ( A ), but an obvious reduction in cell number for intruder rats ( B ). C–F , Higher magnification of the boxed region shows BrdU-positive cells at various focal planes. Some cells present at one focal plane ( C , D , arrows) are not observed at a deeper focal plane when other BrdU-positive cells come into focus ( E , F , arrowheads). The three-dimensional distribution of cells within the section thickness shows the need for stereological quantitation. Scale bars: A , B , 250 μm; C–F , 25 μm.