The document discusses evidence related to whether a fetus can experience pain. It summarizes the development of anatomical structures and pathways involved in pain perception in a fetus from 8 weeks gestation onwards. It also discusses physiological evidence from preterm infants that suggests nociceptive pathways are functional from 24-26 weeks gestation. The document considers arguments that a fetus may experience pain in a primitive way without requiring consciousness, self-consciousness, or previous experience. It notes evidence that early painful experiences can have long-term effects on stress responses and sensitivity to pain.
There are multiple characteristics to examine during fetal brain growth and development. Cortical surface area and cerebral volume are closely correlated with gestational age. Grey matter and white matter volume increase dramatically during the last few weeks of the third trimester. At the cellular and molecular levels, diffused white matter is involved with mylelination, cytostructural support, and communication. Myelination is closely related to the quality of neuronal connectivity.
There are multiple characteristics to examine during fetal brain growth and development. Cortical surface area and cerebral volume are closely correlated with gestational age. Grey matter and white matter volume increase dramatically during the last few weeks of the third trimester. At the cellular and molecular levels, diffused white matter is involved with mylelination, cytostructural support, and communication. Myelination is closely related to the quality of neuronal connectivity.
Which of the following receptors is most likely to exhibit tonic adap.pdfarhamnighty
Which of the following receptors is most likely to exhibit tonic adaptation? olfactory
nociceptors thermoreceptors pacinian gustatory True or False - Otoliths can only detect
rotational acceleration, they cannot provide information about the relative position of the head in
space True False Which membrane is responsible for our ability to detect pitch due to its
structure of being narrow and stiff on one end and wide and flexible on the other? basilar
membrane tympanic membrane tutorial membrane vestibular membrane The Insane Clown
Posse Why do humans begin needing reading glasses around the age of 45? the zonular fibers
attached to the lens lose their elasticity and can no longer flatten the lens as needed cone cells
within the fovea begin dying off and cannot be replaced the lens becomes inflexible and can no
longer get as spherical as needed to focus on nearby objects the lens becomes cloudy and no
longer allows the proper amount of light through it parents just really want to embarrass their
kids when they are ordering food in a public restaurant A person born with a mutation which
prevented their body from making retinal would likely experience which of the following? they
would suffer from myopia and only be able to see objects that were very to them they would not
be able to transition from bright rooms to dark rooms as well as person with functional retinal
would be able to they would have enhanced night vision because their retina would be unable to
absorb excess light their photoreceptors would respond as if there were in constant bright light
their photoreceptors would respond as if they were in constant darkness
Solution
16. Tonic receptors adapt slowly to a stimulus and continue to produce action potentials over the
duration of the stimulus. In this way it conveys information about the duration of the stimulus.
In contrast, phasic receptors adapt rapidly to a stimulus. The response of the cell diminishes very
quickly and then stops. It does not provide information on the duration of the stimulus.
An example of a tonic receptor is pain receptor. Therefore option (b) nociceptors is most likely
to exhibit tonic adaptation. Once it gets stimulated, it sends a signal along the nerves to the brain
as long as the pain stimulus continues.
Odor, touch, temperature, taste all are examples of phasic receptors. Pacinian corpuscles are
sensitive to vibration and pressure and an example of phasic receptors.
17. The Vestibular system is the sensory system in mammals that provides the contribution to the
sense of balance and spatial orientation for the purpose of balance and coordinated movement.
The \"Otolithic organs\" in the human ear are the utricle and saccule.
The Otolith organs sense gravity and linear acceleration such as from due to initiation of
movement in a straight line. Persons or animals without otolith organs or defective otoliths have
poorer abilities to sense motion as well as orientation to gravity.
The Otolith membrane serves.
Which of the following receptors is most likely to exhibit tonic adap.pdfarhamnighty
Which of the following receptors is most likely to exhibit tonic adaptation? olfactory
nociceptors thermoreceptors pacinian gustatory True or False - Otoliths can only detect
rotational acceleration, they cannot provide information about the relative position of the head in
space True False Which membrane is responsible for our ability to detect pitch due to its
structure of being narrow and stiff on one end and wide and flexible on the other? basilar
membrane tympanic membrane tutorial membrane vestibular membrane The Insane Clown
Posse Why do humans begin needing reading glasses around the age of 45? the zonular fibers
attached to the lens lose their elasticity and can no longer flatten the lens as needed cone cells
within the fovea begin dying off and cannot be replaced the lens becomes inflexible and can no
longer get as spherical as needed to focus on nearby objects the lens becomes cloudy and no
longer allows the proper amount of light through it parents just really want to embarrass their
kids when they are ordering food in a public restaurant A person born with a mutation which
prevented their body from making retinal would likely experience which of the following? they
would suffer from myopia and only be able to see objects that were very to them they would not
be able to transition from bright rooms to dark rooms as well as person with functional retinal
would be able to they would have enhanced night vision because their retina would be unable to
absorb excess light their photoreceptors would respond as if there were in constant bright light
their photoreceptors would respond as if they were in constant darkness
Solution
16. Tonic receptors adapt slowly to a stimulus and continue to produce action potentials over the
duration of the stimulus. In this way it conveys information about the duration of the stimulus.
In contrast, phasic receptors adapt rapidly to a stimulus. The response of the cell diminishes very
quickly and then stops. It does not provide information on the duration of the stimulus.
An example of a tonic receptor is pain receptor. Therefore option (b) nociceptors is most likely
to exhibit tonic adaptation. Once it gets stimulated, it sends a signal along the nerves to the brain
as long as the pain stimulus continues.
Odor, touch, temperature, taste all are examples of phasic receptors. Pacinian corpuscles are
sensitive to vibration and pressure and an example of phasic receptors.
17. The Vestibular system is the sensory system in mammals that provides the contribution to the
sense of balance and spatial orientation for the purpose of balance and coordinated movement.
The \"Otolithic organs\" in the human ear are the utricle and saccule.
The Otolith organs sense gravity and linear acceleration such as from due to initiation of
movement in a straight line. Persons or animals without otolith organs or defective otoliths have
poorer abilities to sense motion as well as orientation to gravity.
The Otolith membrane serves.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Fetal pain and implications for research and practice
1. British Journal of Obstetrics and Gynaecology
September 1999, Vol106, pp. 881-886
RE VIEW
Fetal pain: implications for research and practice
Pain is a subjective experience. The fetus cannot tell us sive and ascending process, with the cerebral cortex the
what it is feeling, and there is no objective method for last region to develop.
the direct measurement of pain. To address the question Connections from the periphery to the spinal cord are
of pain in the fetus, one must use indirect evidence from formed early, at about eight weeks; C fibres begin to
a variety of sources, and then make an informed guess. grow into the human fetal spinal cord at about 10
This approach is similar to that which we use with ani- weeks4. The substantia gelatinosa in the dorsal horn is
mals. We cannot ask animals how they feel, but infer the spinal cord region of interneurones which is thought
from a variety of indirect approaches including study of to play a major part in the modulation of noxious inputs;
their behaviour, anatomy, and physiology. by 30 weeks of gestation it has most features of the
adult4. The cerebral cortex starts to form at 10 weeks,
although at that stage it is isolated from the rest of the
Does the fetus feel pain? brain5. Cortical development involves the structural dif-
ferentiation and maturation of cortical neurones, fibres,
Consciousness
glia and blood vessels, and this starts only at about 17
To feel pain, or suffer discomfort, one needs to be con- weeks of gestation with layers VI and V, but continues
scious, to be aware. We do not know when, if at all, con- until long after birth. From 15 weeks, the cortex is
sciousness starts in the fetus. The biological basis of underlain by the subplate zone, a layer of neurones
consciousness is little understood although at least in below the cortex that is specific to the fetus. Synapses
adult humans, the evidence suggests that it is in some appear within the cortical plate from mid-gestation. The
way associated with electrical activity in the cerebral subplate zone expands considerably between 17 and 20
cortex. Crick' has suggested that one is conscious of weeks, while from about 17 weeks, there is a shifting
something when there is electrical activity in specific population of connections from the thalamus to this
large neural cortical networks, particularly in layers IV region6. Thalamic fibres penetrate the cortical plate
to VI of the cerebral cortex2. from 24 to 28 weeks'~~, at this stage the full anatom-
and
Greenfield has emphasised that one should not think ical pathways necessary for nociception are in place.
of consciousness as an all or none phenomenon, rather I. Kostovic, who has been involved in many of the
that it may come on like a dimmer switch. This concept fundamental human fetal neuroanatomical studiesG9,
of evolving consciousnesscould apply to the developing has written in a personal communication: Between 22
fetus, in whom experience is most unlikely to be the and 26 weeks of gestation the subplate zone contains an
same as that of an adult. Furthermore, the fetus may not abundant mixture of cholinergic, thalamo-cortical and
have the same physical basis for conscious experience corticocortical waiting neurones, and there are tran-
as the older human. Frogs, for example, do not have a sient fetal synaptic circuits between the subplate and
developed cerebral cortex, lacking layers IV to VI. If cortical plate neurones. It seems probable that extrinsic
they are conscious at all, their experience must be asso- influences (via the thalamocortical pathways at least)
ciated with activity in a less complex neuronal network, could change the activity of the neocortical alange at
possibly more analogous to the fetal subplate zone3. that stage, and possibly even earlier e.g. in a 20 week
fetus when thalamocortical and cholinergic afSerents
already have synapses with upper subplate neurones,
Anatomical evidence
and these neurones very probably send axons into the
The most important evidence is anatomical. For the cortical plate. At least from mid-gestation onwards it
fetus to feel pain, it is necessary for the requisite noci- seems that extrinsic influences (via thalamo-cortical
ceptive pathways to be developed. This involves neural pathways) can act through demonstrable synapses,
connections between peripheral receptors and the spinal which, ifphysiologically active, may be involved in the
cord, upward transmission via the spinal cord to the tha- modulation of the activity of thefetal neocortex.
lamus, and from there to the outer cerebral layers. The Assuming that activity in the cerebral cortex or sub-
development of the human nervous system is a progres- plate zone is necessary for consciousness, then for the
0 RCOG 1999 British Jounzal of Obstetrics and Gynaecology 881
2. 882 REVIEW
fetus to be conscious of an external experience, these sound, over the next few weeksi6. It can respond to
regions need to be connected with incoming nervous sound from 20 weeks and discriminate between differ-
activity. Most incoming pathways, including nocicep- ent tones from 28 weeks17.
tive ones, are routed through the thalamus and, as stated With the preterm baby, who now can be kept alive
above, penetrate the subplate zone from about 17 weeks. from 23 weeks, one can observe behavioural responses
However, the earliest cortical links with the external to various clinical interventions. Such babies show a
world are formed even earlier than this; these comprise distinct pattern of behaviour to painful stimuli, such as a
the catecholamine pathways of noradrenergic and heel prick. This includes a wide range of facial expres-
dopaminergic neurones, and do not pass through the tha- sions and behaviours, including screwing up the eyes,
lamus. These monoamine fibres start to invade the sub- opening the mouth, as well as clenching the hands and
plate zone at 13 weeks and reach the cortex at about 16 limb withdrawal, which an older baby would also show,
weeks6,'o.''.This puts an early limit on when it is likely if in paini8. Most nurses and mothers looking after
that the fetus might be aware of anything that is going preterm babies are convinced that they are both sentient
on in its body or elsewhere. and feel pain. This type of evidence is similar to that
The last pathways in the nociceptive system to be from animals. Most people believe that their cat feels
formed are the inhibitory descending serotonin neu- pain if someone treads on its tail.
rones, which can block the ascending pathways. These
do not form until after birth4,raising the possibility that
the fetus may actually be more sensitive to noxious Theoretical considerations
stimuli than the older child, and may explain why the
Does one need previous experience to feel pain?
newborn shows exaggerated behavioural responses to
sensory provocation4. It has been argued that the fetus cannot feel pain,
because pain is a complex phenomenon affected by
previous e x p e r i e n ~ e ' ~It ~is . generally agreed that
- ~
Physiological evidence
stimulation of a particular nociceptive pathway in the
There is some evidence for a primitive electroen- adult can be associated with various types of conscious
cephalogram from 19 to 20 weeks, and sustained elec- experience, even in the same individual. Such varia-
troencephalogram from 22 weeks; these have been tion may depend on previous experience, or on other
obtained from very preterm infantsy.'*. Electroen- simultaneous occurrences. It is well known, for exam-
cephalic patterns are clearly measurable in older ple, that a soldier wounded in battle often feels nothing
preterm babies and have been well characterised from at the time. It is also possible to sensitise the experi-
28 weeks to termg. Studies of evoked responses in ence: people who are depressed often feel more pain
preterm babies show that both visual and somatosensory than at other times. This complexity of the experience
potentials can be elicited from as early as 24 weeks and of pain in adults is not controversial. However, the fact
are well developed by 27 weeks". The fact that a primi- that the suffering associated with nociceptive stimula-
tive somatosensory potential can be evoked at 24 weeks tion in adults can be affected by activity in other parts
suggests that the nociceptive pathways from the periph- of the brain, does not prove that in a ndve being, such
ery to the cortex are functional from that timei4. The as the fetus, there can be no experience of pain. The
flexor reflex, a measure of nociceptive function in the fact that the sensation of pain can be affected by previ-
central nervous system, is also present in preterm infants ous experience, does not entail the conclusion that pre-
tested from 26 weeks4.This evidence thus suggests that vious experience is necessary to feel pain. Such an
the nociceptive system is functional from at least 24-26 argument would suggest that a newborn baby could not
weeks, but gives little information concerning earlier feel pain either. The view that to experience pain it is
gestations. necessary to have experienced pain previously is self
defeating: there could never be a first experience of
pain.
Behavioural responses
One has to be cautious about interpreting behavioural
Is self consciousness needed?
responses in terms of conscious experience, for some, at
least, could be purely reflex. It is well known that decor- It has also been suggested that consciousness implies
ticate experimental animals show a wide range of self consciousness, and as the fetus is not self conscious
behavioural responses to noxious stimuli. it cannot be conscious eithe9'. However, consciousness
The fetus starts to make movements in response to does not necessarily imply self consciousness in the
being touched from eight weeks15, and more complex adult sense. All that is needed for the fetus to feel pain, is
movements build up, as detected by real-time ultra- that it has a simple awareness of what is going on in
0 RCOG 1999 Br J Obstet Gynaecol 106,881-886
3. itself. It does not need the more complex understanding ovine, fetus is capable of an acute brain sparing
that it itself is different from the outside world. response.
What then is the use of measuring stress responses? In
considering stress responses in relation to the question
Stress responses of fetal pain, the ‘null hypothesis’ is of relevance: if
Recent research has concentrated on the stress responses there were no change in stress hormone level, it would
of the fetus to various interventions, just as neonatal be very unlikely that the fetus was experiencing pain.
research did in the previous It is important to Stress responses can also be used to give some sort of
clarify the relevance of this work to a discussion of pain. index, though imperfect, of the degree of trauma
Stress responses, defined as an activation of specific involved, and further determine the effect of analgesia
hormonal and neurotransmitter systems, do not provide or anaesthesia. Finally, high levels of stress hormones
a direct index of pain. Although stress hormones are may have long term consequences, as discussed
usually increased when a subject is experiencing pain, below”.
there are many other situations which are not painful, It was the demonstration of stress responses in the
such as exercise, which also can increase their levels. newborn during surgery, that precipitated the change in
Furthermore, production and release of stress hormones attitude in the medical and nursing care of newborn
such as cortisol can be mediated by the hypothalamus, infants. It must be emphasised, however, with both the
without involvement of the cortex or other higher brain fetus and the newborn, that a stress response in itself
regions involved in sentience. does not tell us directly what the baby is feeling.
There is now evidence that the human fetus can
mount substantial stress responsesz4.These have been
Long term implications
shown both by examining stress hormone levels in the
blood before and after invasive procedure^^^^*^ and by There is evidence to suggest that a single early painful
examining the redistribution of blood flow within the or stressful experience can have long term effects, and
fetus27.We have shown that after intrauterine transfu- sensitise the child to pain and stress later. A recent
sions carried out at the placental cord insertion, which is prospective study showed that male babies who had
not innervated, there is little or no change in any of these been circumcised at five days or less, four to six months
variables. However, after procedures through the intra- later cried more, and showed more often other forms of
hepatic vein, that involve piercing the fetal abdomen, pain behaviour in response to their vaccination jab, than
which is innervated, there are major changes. Cortisol, those who had not been circumcised”. It has also been
j3-endorphin and noradrenaline rise substantially after shown that repeated insults, such as heel lancing, may
blood transfusions, a slow procedure that takes at least induce a state of hypersenitivity in the response to
10 minutes. With shorter interventions, such as fetal pain32.Reynolds and F i t ~ g e r a l d ~ ~ shown in a rat
have
blood sampling without transfusion, cortisol and j3- model that in the neonatal period there can be long last-
endorphin remained constant after procedures at either ing sensory nerve sprouting at the site of a wound; this
site. There is, however, evidence of a more rapid could be one mechanism for long term hypersensitivity
increase in noradrenaline, with procedures that involve to pain.
piercing the fetal abdomen, from at least 18 weeks of Animal studies suggest that brief fetal or neonatal
gestation, although this response seems variablez6. stress can have long term effects. The developing ner-
With Doppler ultrasound, our group has also shown vous system appears to be at a very plastic stage and
that with invasive procedures there is a significant fall in vulnerable to insult. In rats born at a stage equivalent to
the pulsatility index in the middle cerebral artery, con- the late fetus in man early postnatal handling perma-
sistent with a redistribution of blood flow to the brain nently increases both the density of glucocorticoid
(‘brain sparing’). It has been found after procedures that receptors in the hippocampu~~~, the behavioural
and
involve piercing the fetal trunk, and occurs rapidly, as responses to stress throughout life. Handled rats
early as 70 s after the These include fetal secreted less corticosterone and showed a faster return
blood sampling, tissue and urine sampling, body cavity to basal levels in a stressful situation. Handling in the
aspirations, and insertion of feto-amniotic shunts. These first postpartum week had greater long term effects, than
responses have been found at all gestations studied from handling in the subsequent two weeks35.
as early as 16 weeks. It has been well established that Fuji et u Z . ~showed that exposure of pregnant rats to
~
this cerebral redistribution response occurs in the human hydrocortisone for only three days, affected the long
fetus during the chronic stress associated with intrauter- term development and behaviour of the offspring. A sin-
ine growth restriction and hypoxaemia, and in response gle dose of dexamethasone administered to the rhesus
to the acute stresses of haemorrhage or hypoxaemia in macaque was sufficient to damage fetal hippocampal
animal modelsz9.It thus appears that the human, like the formation, especially the CA3 region37.Prenatal stress
Q RCOG 1999 Br J Obstet Gynaecol 106,881-886
4. 884 REVIEW
of pregnant rhesus monkeys has also been shown to 20 and 24 weeks and only a very few after that. Late ter-
have long term effects on the offspring, especially aug- minations may cause pain to the fetus if they involve an
menting their hormonal and behavioural responses to invasive procedure, such as surgical dismemberment.
new stress or^^^.^^. This may, at least in part, be due to the Modification of the technique, such as preparatory
direct transfer of some maternal cortisol across the pla- occlusion of the umbilical cord, may be ap~ropriate~~.
centaN. Whether potassium-induced termination of pregnancy
Whether fetal experience of pain or the activation of at a viable gestation or the hypoxaemia caused by uter-
major stress responses, either in utero or at birth, has ine contractions in terminations induced by prosta-
any long term effects in humans is not known. These glandins cause pain or discomfort is hard to assess.
animal experiments suggest that it may be possible and
that this is an important area for future research.
Childbirth
The experience of the baby during birth is not usually
Clinical implications
considered. It is generally assumed that as birth is a nat-
The fetus is currently treated as though it feels nothing, ural phenomenon, undergone for thousands of years
and is given no analgesia or anaesthesia for potentially without pain relief, that it is painless for the baby. This
painful interventions.This is similar to the way in which may not be the case.
newborn babies used to be treated, until the major Noradrenaline levels in umbilical cord blood after
change of practice which arose out of the work of Ayns- spontaneous vaginal delivery are 10 to 20 times those
ley Green, Anand and colleague^^^*^^*^'. They compared before labouP, and several times higher than contem-
newborn infants undergoing cardiac surgery who poraneous maternal levels. Babies born by elective cae-
received deep anaesthesia with sufentanil with those sarean section have smaller rises in cortisol,
given a lighter regimen of halothane and morphine. The noradrenaline, met-enkephalin and P-endorphin than
sufentanil group, in whom the responses of cortisol and those born by vaginal delivery4749.Vaginal delivery
noradrenaline were reduced to the baseline, had a much seems advantageous for transitional respiratory adapta-
better post-operative outcome in terms of sepsis and tion at birth, and catecholamines are known to facilitate
mortality, than the latter, in whom the stress hormone resorption of pulmonary fluidSo. Thus a degree of stress
response was not reduced to the same extent4*.Now at birth assists the baby's adaptation to the external
such pain relief is routinely given to babies not just for world. The rise in stress hormones, however, can be
open surgery, but for more minor procedure^^^. How- considerably greater in assisted than in normal vaginal
ever, it is possible that opiate drugs may themselves deliveries". Elevation of fetal catecholamines in the
have long term adverse effects, and research is needed umbilical cord are associated with p02 and pH levels
to determine their risk-benefit ratio for different inter- suggestive of h y p ~ x i aIt ~ . likely that the mechanical
~ is
ventions, both in the fetus and in the neonate. effects of instrumental delivery may add to this stress,
and it may be that in the future obstetricians will con-
sider giving analgesia before, or immediately after, such
Znvasive procedures
deliveries.
There are several areas where it is appropriate to con-
sider pain relief or anaesthesia in the fetusu. Firstly,
Analgesia for the fetus
therapeutic interventions, such as shunt insertions or
blood transfusions which are carried out for the benefit Failure to provide adequate analgesia for preterm babies
of the fetus. Many of these procedures are carried out in is now considered substandard and unethical practice52.
the third trimester at gestational ages comparable to There have been similar calls for fetuses to be given
preterm infants, who would be given analgesia. Sec- analgesia during invasive procedure^^^*^^, even though
ondly, there are diagnostic sampling or aspiration proce- there is no current evidence that analgesia blunts noci-
dures in the fetus which are only of concern in this ceptive responses in utero, or how analgesia may be
context if the procedure transgresses the fetal body; this safely and effectively administered.
will not be the case with needle insertion of the placenta, The opioid agonists, such as fentanyl, are the drugs
amniotic fluid or umbilical cord. most widely used for sedation and analgesia in neona-
tology. Fentanyl has been given directly intravenously
to fetuses before open fetal surgery, without apparent
Termination of pregnancy
adverse effect, but also without any proof that it workP.
The majority of terminations of pregnancy are camed Direct administration requires intravenous injection to
out before 13 weeks of gestation, but 10% are per- the fetus, and this is known to have risks. These could be
formed between 13and 19 weeks, less than 1%between reduced but not abolished by direct fetal intramuscular
0 RCOG 1999 Br J Obstet Gynaecol 106,881486
5. REVIEW 885
administration, the stress of which is likely to be rela- available anatomical and physiological evidence. The
tively minor, but would prolong the procedure in order physical system for nociception is present and func-
to await absorption. Intra-amniotic injections of lipid tional by 26 weeks and it seems likely that the fetus is
soluble opiods results in sub-therapeutic levels in the capable of feeling pain from this stage. The first neu-
fetuss6. rones to link the cortex with the rest of the brain are
Intravenous administration of fentanyl in the mother monoamine pathways, and reach the cortex from about
is unsatisfactory since the rate of transfer across the pla- 16 weeks of gestation. Their activation could be associ-
centa is slow: 10 minutes after administration of 1 pgkg ated with unpleasant conscious experience, even if not
the average fetal:maternal ratio was 0.31”. Larger doses pain. Thalamic fibres first penetrate the subplate zone at
may cause respiratory depression in the mother. Intra- about 17 weeks of gestation, and the cortex at 20 weeks.
venous benzodiazepines cross freely into the fetal circu- These anatomical and physiological considerations are
lation, with fetomaternal equilibrium occurring within important, not only because of immediate suffering, but
5-10 minute^^^.^^. However, not only do they cause also because of possible long term adverse effects of this
sedation, they may also have adverse behavioural early experience. Research in these areas is urgently
effects if delivery soon follows, impairing fetal respon- required.
siveness. General anesthesia has significant risks in The eighteenth century philosopher, Jeremy Ben-
pregnancy. The potential benefits of analgesia in the tham, wrote of animals The question is not Can they rea-
fetus need to be balanced against the risk of additional son?, noc Can they talk?, but Can they suffer?. This
procedures, and the potential for adverse long term drug caused a change in attitude towards animals and their
effects.Administration of safe and effective analgesia to treatment that is continuing to day, such that in the UK,
the fetus, without adverse effects in the mother, is a con- even frogs and fishes are required by Act of Parliament
siderable challenge. to be protected by anaesthesia from possible suffering
due to invasive procedures. Why not human beings?
Medical versus scientific caution
Acknowledgements
There is clearly is not enough evidence to be certain if
and when the fetus starts to feel pain. By 26 weeks the The authors would like to thank Dr M. Marin-Padilla
full anatomical system for nociception has been formed, and Dr I. Kostovic for helpful information on fetal neu-
the electroencephalogramshows activity in the cerebral roanatomy. Our work in this area is funded by WellBe-
cortex, and the preterm baby of the same gestational ing, The Henry Smith Charity, and the Children
age, if delivered, shows a complex range of pain Nationwide Medical Research Fund.
behaviour. Some have concluded that it is not possible
for the fetus to be aware of events before 26 weeks of Vivette Glover, Reader & Nicholas M. Fisk, Professor
gestation20.60, not to feel pain until considerably later
and Division of Paediatrics, Obstetrics and Gynaecology,
than that6’. This seems unduly certain, given the avail- Imperial College School of Medicine, Queen
able evidence. Before 26 weeks, too little is known Charlotte’s and Chelsea Hospital, London
about the physical basis of consciousness in the fetus,
the function of the subplate zone, the function of tran- References
sient connections to the cortical plate and subplate zone, 1 Crick F. The Astonishing Hypothesis. London: Simon and Schuster
and the role of the monoamine innervation, to be sure Ltd, 1994.
that the fetus has no awareness. Given the anatomical 2 Greenfield SA. Journeys to the Centres of the Mind. Towards a Sci-
ence of Consciousness. New York: WH Freeman, 1995.
evidence, it is possible that the fetus can feel pain from 3 Marin-Padilla M. Ontogenesis of the pyramidal cell of the mam-
20 weeks and is caused distress by interventions from as malian neocortex and developmental cytoarchitectonics: a unifying
early as 15 or 16 weeks. This sets a limit to the earliest theory. J Comp Neuroll992; 321: 223-240.
4 Fitzgerald M. Development of pain pathways and mechanisms. In:
stage that analgesia might be considered. Anand KIS & McGrath PJ, editors. Pain Research and Clinical Man-
agement. Vol5. Pain in Neonates. Amsterdam: Elsevier. 1993: 1%38.
5 Marin-Padilla M. Structuralorganisation of the human cerebral cortex
Conclusion prior to the appearance of the cortical plate. Anat Embryo1 1983; 168:
21-40.
It is not possible to measure pain directly in the fetus. 6 Kostovic I, Rakic P. Developmental history of the transient subplate
Studies of stress responses can be used to give an index zone in the visual and somatosensory cortex of the macaque monkey
and human brain. J Comp Neurol1990; 297: 441470.
of the degree of trauma induced by different interven- 7 Mrzljak L, Uylings HBM, Kostovic I. van Eden CG. Prenatal devel-
tions, and also the response to analgesia or anaesthesia, opment of neurones in the human prefrontal cortex. J Comp Neurol
but they do not indicate what the fetus actually experi- 1988;271: 355-386.
8 Molliver M, Kostovic I, van der Loos H. The development of
ences. The assessment of whether or when the fetus is synapses in cerebral cortex of human fetus. Brain Res 1973; 50:
likely to feel pain has to be based on an evaluation of the 403-407.
0 RCOG 1999 Br J Obstet Gynaecol 106,8231-886
6. 886 REVIEW
9 Kostovic I, Knezevic S, Wisniewski HM, Spilich GJ, editors. Neu- adrenal stress response. Cell Mol Neumbioll993; 13: 321-347.
rodevelopment,Aging and Cognition. Boston: Birkhauser, 1992. 36 Fuji T, Horinaka M, Hata M. Functional effects of glucocorticoid
10 Berger B, Verney C, Golman-Rakic PS. Prenatal monoamine innerva- exposure during fetal life. Prog Neumpsychopharmacol Biol Psychiat
tion of the cerebral cortex: differences between rodents and primates. 1993; 17: 279-293.
In: Kostovic I, Knezevic S, Wisniewski HM, Spilich GJ, editors. Neu- 37 Uno H, Lohmiller L, Thieme C et al. Brain damage induced by prena-
rodevelopment, Ageing and Cognition. Berlin: Birkhauser: 1992: tal exposure to dexamethasone in fetal rhesus macaques. 1. H i p
18-36. pocampus. Dev Brain Res 1990,53: 157-167.
11 Zecevic N, Verney C. Development of the catecholamineneurons in 38 Clarke AS, Wittwer DJ, Abbott DH, Schneider ML. Long term effects
human embryos and fetuses, with special emphasis on the innervation of prenatal stress on HPA reactivity in juvenile rhesus monkeys. Dev
of the cerebral cortex. J Comp Neuroll995; 351: 509-535. Psychobioll994;27: 257-269.
12 Flower MJ. Neuromaturation of the human fetus. JMed Philos 1985; 39 Schneider ML, Coe CL, Lubach GR. Endocrine activation mimics the
1 0 237-25 1 . adverse effects of prenatal stress on the neufomotor development of
13 Klimach VJ, Cook RWI. Maturation of the neonatal somatosensory the infant primate Dev Psychobioll992;25: 427439.
evoked response in preterm infants. Dev Med Child Neumll988; 30: 40 Gitau R, Cameron A, Fisk NM,Glover V. Fetal exposure to m a t e d
208-214. cortisol. Lancet. 1998; 352 707-708.
14 Hrbek A, Karlberg P, Olsson T. Development of visual and 41 Anand KW, Sippell WG, Schofield NM, Aynsley-Green A. Does
somatosensory evoked responses in pre-term newborn infants. Elec- halothane anaesthesia decrease the metabolic and endocrine stress
tmenceph Clin Neumphysioll973;3 :225-232.
4 responses of newborn infants undergoing operation? BMJ 1988; 2 %
15 Prechtl HF. Ultrasound studies of human fetal behaviour. Early Hum 668-672.
Dev 1985; 12:91-98. 42 Anand KJS, Hickey PR. Halothanemorphine compared with high
16 De Vries J, Vissier G, Prechtl H. The emergence of fetal behaviour. dose sufenntanil for aneastheisa and postoperative analgesia in neona-
Early Hum Dev 1982; 12: 301-322. tal cardiac surgery. NEngl JMed 1992; 326 1-9.
17 Hepper PG, Shahidullah BS.The development of fetal hearing. Fetal 43 de Lima J, Lloyd-Thomas AR, Howard RF, Sumner E, Quinn TM.
Mat MedRev 1994;6: 167-179. Infant and neonatal pain: anaesthetists’ perceptions and prescribing
18 Grunau RVE, Craig KD. Pain expression in neonates: facial action patterns. BMJ 1996; 313: 787.
and cry. Pain 1987; 2 8 395410. 44 Glover V, Fisk N. Do fetuses feel pain? We don’t know; better to err
19 Derbyshire SWG. Fetal stress responses. Lancet 1994; 344:615. on the safe side from mid-gestation. BMJ 1996; 313: 796.
20 Derbyshire SWG, Furedi A. ‘Fetal pain’ is a misnomer. BMJ 1996; 45 Bennett P Fetal stress responses. Lancet 1994; 344: 615.
.
313 795. 46 GulmezogluAM, Mahomed K, Hofmeyr GJ, Nikodem VC, KramerT.
21 SzawarskiZ. Probably no pain in the absence of self. BMJ 1996; 313: Fetal and maternal catecholamine levels at delivery. J Perinat Med
796-797. 1996; 24: 687691.
22 Anand KJS, Brown MJ, Causon RC, Christofides ND, Bloom SR, 47 Procianoy RS, Cecin SKG. The influence of labor and delivery on
Aynsley-Green A. Can the human neonate. mount an endocrine and preterm fetal adrenal function. Acta Paediat Scand 1985; 7 4
metabolic response to surgery? J Paediatr Surg 1985; 2 0 4 1 4 8 . 4m04.
23 Anand KJS, Hickey PR. Pain and its effects in the human neonate and 48 Tropper PJ, Warren WB, Jozak SM, Conwell IM, Stark RI, Goland
fetus. NEngl J Med 1987; 317: 1321-1329. RS. Corticotropinreleasing hormone concentrations in umbilical cord
24 Glover V, Giannakoulopoulos X. Stress and pain in the fetus. In: blood of preterm fetuses. J Dev Physioll992; 1 8 81-85.
Aynsley-Green A, Platt W, Lloyd-ThomasAR. editors. Balliere’sC i ln 49 Hawdon JM, Ward Platt MP, Aynsley-Green A. Patterns of metabolic
Paediat. 1995:495-510. adaptation for preterm and term infants in the f i st postnatal week
25 Giannakoulopoulos X, Sepulveda W, Kourtis P, Glover V, Fisk N. Arch Dis Child 1992;67: 357-365.
Fetal plasma cortisol and b-endorphin response to intrauterine 50 Walters DV, Walters RE. The role of catecholamines in lung liquid
needling. Lancer 1994; 344:77-81. absorption at birth. Ped Res 1978; 12: 239.
26 GiannakoulopoulosX, Teixeira J, Fisk N, Glover V. Human fetal and 51 Rothenberg SJ, Chicz-DeMet A, Schnaas L, Karchmer S, Salinas V,
maternal noradrenaline responses to invasive procedures. Ped Res Guzman LA. Umbilical cord b-endorphin and early childhood motor
1999; 45: 494499. development. Ear Hum Dev 1996; 46:83-95.
27 Teixeira J, Fogliani R, Giannakoulopoulos X,Glover V,Fisk N. Fetal 52 Walco GA, Cassidy RC, Schechter NL.Pain, hurt and harm. N Eng J
haemodynamic stress response to invasive procedures. Lancet 1996; Med 1994; 331: 541-544.
347: 624. 53 Furness M. Diagnostic potential of fetal renal biopsy. Prenar Diagn
28 Teixeira J, Glover V, Fisk NM. Acute cerebral redistribution in 1994; 14:415.
response to invasive precedures in the human fetus. Am J Obster 54 Commission of Enquiry into Fetal Sentience. Human sentience before
Gynecoll999. In press. birth. London: Care T u t 1996.
rs,
29 Nathanielsz PW. The role of basic science in preventing low birth 55 Adzick NS, Harrison MR. Fetal surgical therapy. Lancer 1994; 343:
weight. Future Child 1995; 5: 57-70. 897-902.
30 Sapolsky RM. Why stress is bad for your brain. Science 1996; 273: 56 Sxto HH, Mann LI, Bhakthavathsalan A, Liu M, Inturrisi CE.
749-750. Meperidine pharmacokinetics in the maternal-fetal unit. J Phannacol
3 1 Taddio A, Katz J, nersich AL, Koren G. Effect of neonatal circumci- Exp Ther 1978; 206: 448459.
sion on pain response during subsequent routine examination. Lancer 57 Eisele J, We A. Newborn and maternal fentanyl levels at caesarean
1997; 349 599-603. section. Anesth Analg 1982; 61: 179-180.
32 Fitzgerald M, Millard C, Mchtosh N. Cutaneous hypersenstivity fol- 58 Bakke 0, Haam K. Time course of transplacental passage of
lowing peripheral tissue damage in newborn infants and its reversal diazepam: influence of injection-delivery interval on neonatal drug
with topical anaesthesia. Pain 1989;3 9 31-36. concentrations. Clin Pharmacokinet 1982; 7: 353-362.
33 Reynolds ML, Fitzgerald M. Long-term sensory hyperinnervation fol- 59 Guerre-Millo M, Rey E, Challier J, Turquais J. d’Athis P, GO. Trans-
lowing neonatal skin wounds. J Comp Neuroll995; 358: 487498. fer in vitro of three benzodiazepines across the human placenta. Eur J
34 Meaney M, Aitken DH. The effects of early postnatal handling on hip- Clin Pharmacoll979; 15: 171-173.
pocampal glucocorticoid receptor concentrations: temporal parame- 60 Wise. J. Fetuses cannot feel pain before 26 weeks. BMJ 1997; 315:
ters. Dev Brain Res 1985; 22: 301-304. ll-00
ll00.
35 Meaney M, Bhatnagar S, Diorio J et al. Molecular basis for the devel- 61 Derbyshire S. Locating the beginnings of pain. Bioethics 1999; 13:
opment of individual differences in the hypothalamic-pituitary- 1-31.
0 RCOG 1999 Br J Obstet Gynaecol 106,881-886