Caridy Patiño presented on the challenges of building mobile HTML5 applications. Some key challenges include browser fragmentation across devices, network failures, and the need to optimize applications for different runtime environments and adapt them for varying screen sizes and features. Patiño advocated writing applications using a single language, JavaScript, and customizing output per runtime and context while adapting the UI per form factor and feature detection. The goal is to build flexible applications that can run on multiple platforms.