On 16th Apr 2014, The Food and Drug Administration (FDA) is advising consumers not to purchase or use S.W.A.G (Sex With A Grudge).

1. Dr. P.Naina Mohamed
Pharmacologist

2.  On 16th Apr 2014,The Food and Drug
Administration (FDA) is advising consumers not
to purchase or use S.W.A.G (SexWith A Grudge).
 S.W.A.G is promoted and sold for sexual
enhancement on various websites, including
www.SexWithAGrudge.com, and in some retail
stores.
 FDA laboratory analysis confirmed that S.W.A.G
contains Sildenafil.
 Sildenafil is a Phosphodiesterase 5 (PDE 5)
inhibitor, useful for the treatment of Erectile
Dysfunction (ED).

3. S.W.A.G (SexWith A Grudge)
Undeclared Sildenafil
Inhibition of Phosphodiesterase 5 (PDE 5)
Inhibition of Breakdown of cGMP
Increase the concentration of cGMP in smooth muscle of
corpus cavernosum and penile arteries
Smooth muscle relaxation
Increase the blood flow to corpus cavernosum
Penile Erection

4. S.W.A.G (SexWith A Grudge)
Undeclared Sildenafil
Interact with prescription drugs like nitrates (Nitroglycerin)
Excessive dilation of smooth muscle of blood vessels
Potentiation of Hypotensive effects
Blood pressure reduced to dangerous levels
Contraindicated

5. S.W.A.G (SexWith A Grudge)
Undeclared Sildenafil
Interact with Protease Inhibitors like Saquinavir, Ritonavir,
Indinavir, Nelfinavir, Amprenavir, Fosamprenavir, Lopinavir,
Atazanavir, ,Tipranavir and Darunavir
Protease Inhibitors block CYP3A4-mediated sildenafil metabolism
Increased plasma levels of sildenafil
Increased risk of sildenafil adverse effects (hypotension, visual changes,
priapism)
Contraindicated

6. S.W.A.G (SexWith A Grudge)
Undeclared Sildenafil
Interact with CYP3A4 Inhibitors like Macrolide antibiotics
(Telithromycin, Erythromycin, Clarithromycin) and Antifungals
(Voriconazole, Itraconazole, Ketoconazole)
CYP3A4 Inhibitors block CYP3A4-mediated sildenafil metabolism
Increased plasma levels of sildenafil
Increased risk of sildenafil adverse effects (hypotension, visual changes,
priapism)

7.  FDA warns the Consumers should stop using this
product immediately and throw it away.
 FDA advises the Consumers who have experienced
any negative side effects should consult a health care
professional as soon as possible.
 FDA announces to the public of a growing trend of
dietary supplements or conventional foods with
hidden drugs and chemicals. These products are
typically promoted for sexual enhancement, weight
loss, and body building, and are often represented as
being “all natural.”
 FDA claims that they are unable to test and identify all
products marketed as dietary supplements on the
market that have potentially harmful hidden
ingredients.
 FDA advises the Consumers to exercise caution before
purchasing any product in the above categories.

8.  http://www.fda.gov/Drugs/ResourcesForYou/Consumers/Buy
ingUsingMedicineSafely/MedicationHealthFraud/ucm393557
.htm?source=govdelivery&utm_medium=email&utm_sourc
e=govdelivery
 http://www.micromedexsolutions.com
 Goodman & Gilman'sThe Pharmacological Basis of
Therapeutics, 12e
Laurence L. Brunton, BruceA. Chabner, BjörnC. Knollmann
 Harrison's Online
Featuring the complete contents of Harrison's Principles of
Internal Medicine, 18e
Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen
L. Hauser, J. Larry Jameson, Joseph Loscalzo, Eds.
 Hurst'sThe Heart, 13e
Valentin Fuster, Richard A.Walsh, Robert A. Harrington
 Basic & Clinical Pharmacology, 12e
Bertram G. Katzung, Susan B. Masters, Anthony J.Trevor
 Clinician's Pocket Reference, 11e
Leonard G. Gomella, Steven A. Haist

9.  http://www.nlm.nih.gov/medlineplus/dr
uginfo/meds/a699015.html
 http://www.rxlist.com/viagra-
drug/clinical-pharmacology.htm
 http://www.medicinenet.com/sildenafil/
article.htm
 http://www.pfizer.com/files/products/us
pi_viagra.pdf