This document discusses best practices for running Node.js applications in production environments. It recommends: 1) Designing applications to fail and recover at multiple levels from single nodes to entire datacenters; 2) Avoiding failures by relying on services like databases in the cloud whenever possible; and 3) Isolating applications and their dependencies to prevent failures in one part from affecting others. Regular monitoring, logging and analysis of applications is also advised to identify issues and guide scaling decisions.