This document discusses 4 key challenges for healthcare entities in harnessing big data and analytics: 1) Gaining access to different data streams from other organizations due to fragmented healthcare systems, technological hurdles, and strategic/privacy concerns. 2) Ensuring high quality data by addressing inconsistencies across data sources. 3) Developing robust algorithms and analytics that are supervised by domain experts and can evolve over time. 4) Investing in analytics solutions that are flexible and scalable given the rapidly changing technological environment.