The Mariana Trench is the deepest natural point in the oceans, located in the western Pacific Ocean, at a depth of approximately 36,000 feet. The immense water pressure at this depth affects human physiology, with each additional 33 feet of depth adding another atmosphere of pressure and impacting respiratory, excretory, and integumentary systems. To survive a dive, specialized equipment like scuba gear, wet suits, and regulators are necessary to overcome these physiological challenges and allow humans to explore this remote, high-pressure environment.