Evaluation of Phosphodiesterase-5 Inhibitory Potential of Biofield Energy Treated DMEM by Determining cGMP Level in Human Endothelial Cell Line_ Crimson Publishers
Evaluation of Phosphodiesterase-5 Inhibitory Potential of Biofield Energy Treated DMEM by Determining cGMP Level in Human Endothelial Cell Line by Snehasis Jana
Nutrition science seems to change on an almost daily basis and much of what was previously considered mainstream or consensus science is being challenged and changed as the new wave of more personalised intervention trials start to clarify many of the reasons behind why nutrition study results can be so conflicting.
No research area, it seems, is more subject to conflicting and confusing results than that of omega-3s which is why, here at Igennus, we do our best to stay on top of ALL the omega-3 research so we can not only help you unpick the fact from fiction (and answer all your questions about every single product on the market!), but also ensure our formulations and education reflect the most cutting edge and clinically proven ingredient research.
Dr Bailey’s ever-growing brain contains a veritable treasure chest of omega-3 knowledge and as we know you are big fans of the work she does, this webinar is dedicated to Dr Bailey’s brain and sharing with you all the latest updates, innovations and applied therapeutic research that she has been reading about over the last year. We aim to help you separate fish oil fact from fiction by answering as many of your omega-3 and fatty acid therapeutic-related questions as possible. Covering everything from which and how much omega-3 to take for certain conditions, how and when taking omega-3 can affect the benefit and amount absorbed, why very high doses can be dangerous, the truth behind what companies and headlines are telling you about omega-3s, to any other areas you want us to cover! We will do our best to cover the most common and important questions and concerns we hear about from you via phone or email and when out and about training in stores and at events every day. As always, we will also clarify some of the reasons behind the frustratingly confusing conflicts in the research and media and what exciting things are coming out of the omega-3 world.
During the webinar, Sophie covers in depth the new Restore and Maintain treatment protocol, including the unique benefits of a combination of strength, concentration and dose for providing the fastest acting, most effective, therapeutic omega-3 intervention strategy to support your clients’ health. She details how to use the Pharmepa range to provide truly personalised nutrition support to meet your clients’ individual omega-3 needs. After explaining the benefits of the protocol as a whole, Sophie covers the key conditions Pharmepa has been designed to support and the dosing guidelines for clients with these concerns.
The document discusses anthracycline nano-delivery systems to overcome multiple drug resistance (MDR). It provides an overview of commonly used anthracycline drugs like doxorubicin and challenges with MDR. The review then summarizes over ten types of anthracycline nano-delivery systems that have been developed to overcome MDR, including liposomes, polymeric micelles, nanoparticles, conjugates, and carbon nanotubes. Several of these nano-delivery systems have advanced to clinical trials with the goal of improving cancer treatment by circumventing MDR.
LACTOWHEY powder: Provides body’s defense against cancerSriramNagarajan18
Lactowhey powder is a whey protein supplement that provides several potential health benefits. It contains amino acids that help stimulate immunity and increase glutathione levels, which enhances the body's defense against cancer, free radicals, and carcinogens. Pre-clinical and clinical studies have shown that Lactowhey powder may help prevent muscle loss and weight loss in cancer patients by improving nutritional status and appetite. The whey proteins and other components in Lactowhey powder are easily absorbed and can promote muscle strength and immune function.
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
This study examined the effects of an aqueous fruit extract of Solanum macrocarpum on endocrine function in rats with chronic hyperlipidemia induced by triton-X. The extract was administered at doses of 25, 50, 100, and 200 mg/kg to hyperlipidemic rats, and endocrine markers including thyroid hormones, testosterone, estrogen, and insulin were measured at 24, 48, and 72 hours. The results showed that the extract significantly increased levels of TSH, T4, testosterone, estrogen and insulin in a dose-dependent manner, suggesting the extract may lower lipids by positively influencing endocrine function. The mechanisms by which the extract regulates lipids and potentially reduces heart disease risk require further
Tetrameric peptide purified from hydrolysates of biodiesel byproducts of nann...Van-Tinh Nguyen
The document describes a study that identified and characterized a peptide from biodiesel byproducts of the microalgae Nannochloropsis oculata that promotes osteoblast differentiation. Enzymatic hydrolysis of the byproducts yielded various peptides, and the alcalase hydrolysate exhibited the highest osteoblastic differentiation activity. Further purification using liquid chromatography identified a tetrameric peptide (MPDW, 529.2 Da). This peptide was found to promote osteoblast differentiation in human and murine cells by increasing markers of osteoblast phenotype and mineralization through activation of the MAPK and Smad signaling pathways.
Fatty acids carry out many functions that are necessary for maintaining optimal health, and the fatty acid status of a client provides valuable information that relates to both risk and progression of a range of diseases. Determining fatty acid status assists the practitioner in identifying those individuals who would benefit from omega-3 supplementation. The Igennus Opti-O-3 biomarker test is a safe, cost effective and minimally invasive dried blood spot (DBS) method that can be carried out by the client at home. In addition, the Opti-O-3 offers a personalised approach to condition management by focusing on optimising validated biomarkers of disease risk through identification of the client’s unique fatty acid requirements.
In this refresher webinar, Dr Bailey will discuss:
- Fatty acid testing: who, why and when?
- Why choose the Igennus Opti-O-3: a comparison of laboratories
- How to interpret results, including:
- New fatty acid reference ranges
- Overview of fatty acid functions
- Intervention considerations
- Personalised intervention
Inadequate long-chain omega-3 fatty acid status has a substantial impact on our health. Human RCT, observational, in vitro and in vivo animal studies all demonstrate that omega-3 fats from fish improve inflammatory regulation and its associated conditions. Yet, due to inconsistency in findings, the validity of omega-3 fatty acids as ‘treatments’ has been brought into question in the reporting of studies. To date, few studies have monitored the correlation between omega-3 dose, subsequent cellular enrichment of these fatty acids and clinical outcomes.
In this webinar, Dr Bailey presents the latest evidence for the importance of a biomarker-based, personalised approach to omega-3 treatment – one that significantly improves consistency in clinical outcomes and offers an antidote to the ‘one-size fits all’ approach that is responsible for significant individual variations in response in many published studies.
Nutrition science seems to change on an almost daily basis and much of what was previously considered mainstream or consensus science is being challenged and changed as the new wave of more personalised intervention trials start to clarify many of the reasons behind why nutrition study results can be so conflicting.
No research area, it seems, is more subject to conflicting and confusing results than that of omega-3s which is why, here at Igennus, we do our best to stay on top of ALL the omega-3 research so we can not only help you unpick the fact from fiction (and answer all your questions about every single product on the market!), but also ensure our formulations and education reflect the most cutting edge and clinically proven ingredient research.
Dr Bailey’s ever-growing brain contains a veritable treasure chest of omega-3 knowledge and as we know you are big fans of the work she does, this webinar is dedicated to Dr Bailey’s brain and sharing with you all the latest updates, innovations and applied therapeutic research that she has been reading about over the last year. We aim to help you separate fish oil fact from fiction by answering as many of your omega-3 and fatty acid therapeutic-related questions as possible. Covering everything from which and how much omega-3 to take for certain conditions, how and when taking omega-3 can affect the benefit and amount absorbed, why very high doses can be dangerous, the truth behind what companies and headlines are telling you about omega-3s, to any other areas you want us to cover! We will do our best to cover the most common and important questions and concerns we hear about from you via phone or email and when out and about training in stores and at events every day. As always, we will also clarify some of the reasons behind the frustratingly confusing conflicts in the research and media and what exciting things are coming out of the omega-3 world.
During the webinar, Sophie covers in depth the new Restore and Maintain treatment protocol, including the unique benefits of a combination of strength, concentration and dose for providing the fastest acting, most effective, therapeutic omega-3 intervention strategy to support your clients’ health. She details how to use the Pharmepa range to provide truly personalised nutrition support to meet your clients’ individual omega-3 needs. After explaining the benefits of the protocol as a whole, Sophie covers the key conditions Pharmepa has been designed to support and the dosing guidelines for clients with these concerns.
The document discusses anthracycline nano-delivery systems to overcome multiple drug resistance (MDR). It provides an overview of commonly used anthracycline drugs like doxorubicin and challenges with MDR. The review then summarizes over ten types of anthracycline nano-delivery systems that have been developed to overcome MDR, including liposomes, polymeric micelles, nanoparticles, conjugates, and carbon nanotubes. Several of these nano-delivery systems have advanced to clinical trials with the goal of improving cancer treatment by circumventing MDR.
LACTOWHEY powder: Provides body’s defense against cancerSriramNagarajan18
Lactowhey powder is a whey protein supplement that provides several potential health benefits. It contains amino acids that help stimulate immunity and increase glutathione levels, which enhances the body's defense against cancer, free radicals, and carcinogens. Pre-clinical and clinical studies have shown that Lactowhey powder may help prevent muscle loss and weight loss in cancer patients by improving nutritional status and appetite. The whey proteins and other components in Lactowhey powder are easily absorbed and can promote muscle strength and immune function.
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
This study examined the effects of an aqueous fruit extract of Solanum macrocarpum on endocrine function in rats with chronic hyperlipidemia induced by triton-X. The extract was administered at doses of 25, 50, 100, and 200 mg/kg to hyperlipidemic rats, and endocrine markers including thyroid hormones, testosterone, estrogen, and insulin were measured at 24, 48, and 72 hours. The results showed that the extract significantly increased levels of TSH, T4, testosterone, estrogen and insulin in a dose-dependent manner, suggesting the extract may lower lipids by positively influencing endocrine function. The mechanisms by which the extract regulates lipids and potentially reduces heart disease risk require further
Tetrameric peptide purified from hydrolysates of biodiesel byproducts of nann...Van-Tinh Nguyen
The document describes a study that identified and characterized a peptide from biodiesel byproducts of the microalgae Nannochloropsis oculata that promotes osteoblast differentiation. Enzymatic hydrolysis of the byproducts yielded various peptides, and the alcalase hydrolysate exhibited the highest osteoblastic differentiation activity. Further purification using liquid chromatography identified a tetrameric peptide (MPDW, 529.2 Da). This peptide was found to promote osteoblast differentiation in human and murine cells by increasing markers of osteoblast phenotype and mineralization through activation of the MAPK and Smad signaling pathways.
Fatty acids carry out many functions that are necessary for maintaining optimal health, and the fatty acid status of a client provides valuable information that relates to both risk and progression of a range of diseases. Determining fatty acid status assists the practitioner in identifying those individuals who would benefit from omega-3 supplementation. The Igennus Opti-O-3 biomarker test is a safe, cost effective and minimally invasive dried blood spot (DBS) method that can be carried out by the client at home. In addition, the Opti-O-3 offers a personalised approach to condition management by focusing on optimising validated biomarkers of disease risk through identification of the client’s unique fatty acid requirements.
In this refresher webinar, Dr Bailey will discuss:
- Fatty acid testing: who, why and when?
- Why choose the Igennus Opti-O-3: a comparison of laboratories
- How to interpret results, including:
- New fatty acid reference ranges
- Overview of fatty acid functions
- Intervention considerations
- Personalised intervention
Inadequate long-chain omega-3 fatty acid status has a substantial impact on our health. Human RCT, observational, in vitro and in vivo animal studies all demonstrate that omega-3 fats from fish improve inflammatory regulation and its associated conditions. Yet, due to inconsistency in findings, the validity of omega-3 fatty acids as ‘treatments’ has been brought into question in the reporting of studies. To date, few studies have monitored the correlation between omega-3 dose, subsequent cellular enrichment of these fatty acids and clinical outcomes.
In this webinar, Dr Bailey presents the latest evidence for the importance of a biomarker-based, personalised approach to omega-3 treatment – one that significantly improves consistency in clinical outcomes and offers an antidote to the ‘one-size fits all’ approach that is responsible for significant individual variations in response in many published studies.
This document describes a study that investigated whether the components of the antioxidant supplement Protandim synergistically induce heme oxygenase-1 (HO-1) expression. The study found that while individual components at low doses had little effect, all components together strongly induced HO-1 expression in a dose-dependent manner through multiple signaling pathways. This suggests that combining phytochemicals can efficiently induce antioxidant enzymes through synergistic effects.
This document discusses the therapeutic applications of peptides. It begins by providing background on peptides, their structures, and natural sources. It then discusses several therapeutic uses of peptides including as anticancer agents, hormones for treating conditions like prostate cancer, carriers for delivering cytotoxic drugs to cancer cells, treatments for diabetes, anti-obesity, and pre-term labor. The document also discusses peptide manufacturing methods, diagnostic uses of peptides, and antimicrobial peptides.
IPI-549 is a potent and selective inhibitor of PI3K-γ that has been shown to inhibit tumor growth in mouse models. IPI-549 blocks macrophage M2 polarization and migration in vitro. In mouse tumor models, IPI-549 treatment reduced tumor growth, decreased tumor-associated M2 macrophages and myeloid cells, and increased tumor-associated CD8+ T cells in a T cell-dependent manner. Combination of IPI-549 with checkpoint inhibitors showed enhanced anti-tumor effects over monotherapy in mouse models. These results suggest that targeting PI3K-γ with IPI-549 can alter the immune suppressive tumor microenvironment to support immune-mediated tumor growth inhibition.
The study objective was to evaluate the cardioprotective activity of Biofield Energized test item (DMEM) in rat cardiomyocytes (H9c2) cells. The test item (DMEM medium) was divided into three parts, first part received one-time Consciousness Energy Healing Treatment by a renowned Biofield Energy Healer, Dahryn Trivedi and was labeled as the one-time Biofield Energy Treated (BT-I) DMEM, while second part received the two-times Biofield Energy Treatment and is denoted as BT-II DMEM.
Propolis with its active component CAPE (Caffeic Acid Phenethyl Ester) stops breast cancer cell growth. These results of CAPE are present in the naturopathic formulation
of propolis, a widely available natural substance with an extended safety record, making it a naturally-occurring and readily available epigenetic agent with great potential in breast cancer and oncology in general. The ability to link the biological effects of a naturopathic remedy to the pharmacologic effects seen with an exciting class of drugs in the treatment of cancer opens the door to a host of new therapeutic opportunities for patients.
Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyeliti...degarden
This document discusses mitochondrial dysfunction and its role in the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). It presents the results of biochemical testing on neutrophils from 138 ME/CFS patients and 53 healthy controls. All patients showed measurable mitochondrial dysfunction correlated with illness severity. Patients divided into two groups based on how cellular metabolism compensates for the dysfunction. The testing provides a diagnostic tool for ME/CFS, though mitochondrial dysfunction is also seen in other illnesses.
1) Dietary supplements like glucosamine, chondroitin sulfate, vitamins, omega-3 fatty acids, and herbal extracts are commonly used to treat osteoarthritis (OA) symptoms, but their efficacy is unclear due to a lack of conclusive evidence.
2) Nutrigenomics research aims to define how genes and nutrients interact to influence health and disease, with the goal of developing personalized nutrition plans.
3) Curcumin and resveratrol show potential for treating OA by reducing inflammation and suppressing cartilage degradation, but more research is still needed, including well-designed clinical trials.
Mitochondria and MitoQ – A research updatemitoaction
Greg Macpherson presented an update on research related to mitochondria and MitoQ. Some key points include:
- MitoQ was discovered at Otago University in New Zealand and is a mitochondria-targeted antioxidant.
- Over 200,000 patient months of experience and availability in over 100 countries.
- Research has included over 50 million USD invested and 200+ published papers involving 70+ disease models.
- Clinical trials have shown benefits for conditions such as fibromyalgia, chronic fatigue syndrome, and type 2 diabetes.
- Mouse and human research has demonstrated reductions in oxidative stress, inflammation, and markers of disease from conditions such as liver fibrosis when taking MitoQ.
- Future research
Liver fi brosis is natural wound healing response to different etiologies of chronic liver insults leading to accumulation of Extra Cellular Matrix (ECM) due to imbalance between synthesis and degradation. Fibrogenesis is consequence of multicellular response; activation of Hepatic Stellate Cells (HSCs) and transdifferentiation into myofi broblasts are crucial for development of hepatic scar. Recent studies evidenced that liver fi brosis is potentially bidirectional regulated by complex cytokines, growth factors, genetic and epigenetic mechanisms (DNA methylation, histone modifi cations and miRNAs mediated gene silencing). Regression of liver fi brosis is due to increase in collagenolytic activity and increased Metalloproteinase (MMPs) activity with decreased expression and activity of Tissue Inhibitors of Metalloproteinases (TIMPs). Reversible epigenetic mechanisms, pro-fi brotic and anti-fi brotic miRNAs regulate progression and regression of liver fi brosis which initiates to discover diagnostic, prognostic and therapeutic should be comprehensively defi ned. Hence, in this review we made an attempt to understand molecular, genetic and epigenetic mechanisms of bidirectional liver fi brosis.
Liver fibrosis is natural wound healing response to different etiologies of chronic liver insults leading to accumulation of Extra Cellular Matrix (ECM) due to imbalance between synthesis and degradation. Fibrogenesis is consequence of multicellular response; activation of Hepatic Stellate Cells (HSCs) and transdifferentiation into myofibroblasts are crucial for development of hepatic scar. Recent studies evidenced that liver fibrosis is potentially bidirectional regulated by complex cytokines, growth factors, genetic and epigenetic mechanisms (DNA methylation, histone modifi cations and miRNAs mediated gene silencing).
This study investigated how insulin deficiency affects mitochondrial oxidative phosphorylation in the hearts of diabetic mice. The key findings were:
1) Activity of oxidative phosphorylation complex V (ATP synthase) was significantly reduced in the hearts of streptozotocin-induced diabetic mice.
2) Normalizing blood glucose with phlorizin treatment did not improve complex V activity, but insulin treatment did normalize it, indicating the reduction was caused by insulin deficiency rather than hyperglycemia.
3) Acute insulin stimulation induced phosphorylation and translocation of Akt to mitochondria in heart muscle. This translocation was enhanced in diabetic mice and blocked inhibition of Akt, blunting the activation of complex V by insulin.
Lactaptin, a peptide found in breast milk, has potential in cancer therapy. It induces apoptosis in cancer cells by activating caspases 3 and 7 and externalizing phosphatidylserine from the cell membrane. Lactaptin also inhibits the pro-cancer process of autophagy. Recombinant analogs of lactaptin like RL2 have been developed and shown to effectively induce apoptosis, suppress anti-apoptotic proteins, and inhibit tumor growth, demonstrating lactaptin's promise as a new molecule for anticancer drug development.
Journal of Nutritional Health and Food Engineering-02-00046Patricia Funk
This article reviews the role of glutamine, arginine, and β-hydroxy-β-methylbutyrate (HMB) supplements in enhancing athletic performance and benefiting the body during times of stress, illness, and wound healing. It finds that glutamine, arginine, and HMB may help preserve lean body mass, decrease muscle breakdown, and support immune function and wound healing. However, the evidence for their effects on athletic performance is limited and contradictory. Larger, well-designed studies are still needed to define the potential benefits of these supplements for enhancing athletic performance and lean body mass.
Grape Seed Extract : A potential Cancer suppressing agent sudharani028
Natural Polyphenol "Resveratrol" present predominantly in the grape seed plays an very important role in the treatment of devastating disorder Cancer (diseases involving abnormal and uncontrolled growth of cell with the potential to spread to other parts of the body)
- The document discusses cachexia, a wasting syndrome seen in many cancer patients, and the potential role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing or treating cancer-induced cachexia.
- It reviews the definition, etiology, complications, and current treatments for cachexia. It also discusses the roles, mechanisms, and early studies investigating omega-3 PUFAs for treating cachexia.
- The document provides background information on cachexia and omega-3 PUFAs to introduce and support the review of literature on efficacy of omega-3 PUFAs in preventing cancer-induced cachexia.
p53 Protein: Master Regulator of Apoptosis and its Application in Cancer TherapyBRNSS Publication Hub
Cancer is characterized by uncontrolled and abnormal cells growth. In the body, the cell growth and cell
division are governing by apoptosis. The process of apoptosis is mainly regulated by the p53 protein. p53
is a tumor suppressor protein. The amount of p53 in a cell is mainly controlled by the negative regulator
murine double minute 2 (MDM2), which on complex formation with p53 leads to an overall reduction
of the p53 level. Inhibition of p53 function will inhibit the apoptosis and leads to cancer. Consequently,
inhibition of the MDM2/p53 interaction using the small molecules activates the p53 function and apoptosis
in the cells which contain the wild-type p53. It is a promising new therapeutic strategy for the treatment
of cancers retaining wild-type p53. However, the safety window of this class of compounds must be
evaluated. Moreover, it has to require the development of compounds, which can also be able to target the
cells which contain the mutated or deleted p53.
This document discusses antibody-directed enzyme-prodrug therapy (ADEPT) for cancer treatment. ADEPT involves administering an antibody-enzyme fusion protein that localizes an enzyme to the tumor, followed by a prodrug that is non-toxic until converted to a cytotoxic drug by the localized enzyme. The document outlines the mechanism of ADEPT, various enzymes and prodrugs used, advances like improved antibody-enzyme complexes and clearance, phase I clinical trials results, and mathematical models to optimize ADEPT dosing and pharmacokinetics. It concludes that while clinical trials proved ADEPT's potential, further research is still needed to address toxicities in order to develop ADEPT as a successful
This study evaluated 122 cases of breast cancer treated with the Di Bella Method (DBM), an alternative therapy combining melatonin, retinoids, vitamins, and other supplements.
The results showed:
- For early-stage breast cancer, 4/9 cases achieved complete remission with DBM as first-line therapy alone. As adjuvant therapy, DBM achieved a 5-year survival rate of 100%, significantly higher than standard rates.
- For metastatic breast cancer, 2/4 cases achieved remission with DBM as first-line therapy. As adjuvant therapy after surgery, 3/6 cases achieved remission.
- Overall, the DBM approach improved survival rates, response rates,
Peptide Drug Conjugates (PDCs) Novel Targeted Therapeutics For Cancer.pdfDoriaFang
Peptide-drug conjugates (PDCs) are the next generation of targeted therapies after ADCs. PDCs has been developed as targeted therapeutic candidates for cancer, COVID-19, metabolic diseases, etc.
Research by Mahendra Kumar Trivedi - Evaluation of the Impact of Biofield Tre...john henrry
Research on Trivedi Effect - In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis.to read more visit http://www.academicroom.com/article/evaluation-impact-biofield-treatment-physical-and-thermal-properties-casein-enzyme-hydrolysate-and-casein-yeas-t-peptone
Research by Mahendra Kumar Trivedi - Evaluation of the Impact of Biofield Tre...Abby Keif
http://works.bepress.com/mahendra_trivedi/54/ - Research on Trivedi Effect - In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis.
Tomas Duraj - Cancer as a Mitochondrial Metabolic DiseaseDwightVillos
The document discusses cancer from the perspective of the mitochondrial metabolic theory. It proposes that cancer originates from mitochondrial dysfunction and defective respiration, rather than from genetic mutations alone. Cancer cells generate energy through substrate-level phosphorylation of glucose and glutamine without oxygen, resembling primitive prokaryotes. The document outlines a 3-level approach to cancer intervention focusing on lifestyle modifications like ketogenic diets and fasting to support mitochondrial health, supplementation, and potential drug therapies aimed at modulating cancer metabolism and inflammation.
This document describes a study that investigated whether the components of the antioxidant supplement Protandim synergistically induce heme oxygenase-1 (HO-1) expression. The study found that while individual components at low doses had little effect, all components together strongly induced HO-1 expression in a dose-dependent manner through multiple signaling pathways. This suggests that combining phytochemicals can efficiently induce antioxidant enzymes through synergistic effects.
This document discusses the therapeutic applications of peptides. It begins by providing background on peptides, their structures, and natural sources. It then discusses several therapeutic uses of peptides including as anticancer agents, hormones for treating conditions like prostate cancer, carriers for delivering cytotoxic drugs to cancer cells, treatments for diabetes, anti-obesity, and pre-term labor. The document also discusses peptide manufacturing methods, diagnostic uses of peptides, and antimicrobial peptides.
IPI-549 is a potent and selective inhibitor of PI3K-γ that has been shown to inhibit tumor growth in mouse models. IPI-549 blocks macrophage M2 polarization and migration in vitro. In mouse tumor models, IPI-549 treatment reduced tumor growth, decreased tumor-associated M2 macrophages and myeloid cells, and increased tumor-associated CD8+ T cells in a T cell-dependent manner. Combination of IPI-549 with checkpoint inhibitors showed enhanced anti-tumor effects over monotherapy in mouse models. These results suggest that targeting PI3K-γ with IPI-549 can alter the immune suppressive tumor microenvironment to support immune-mediated tumor growth inhibition.
The study objective was to evaluate the cardioprotective activity of Biofield Energized test item (DMEM) in rat cardiomyocytes (H9c2) cells. The test item (DMEM medium) was divided into three parts, first part received one-time Consciousness Energy Healing Treatment by a renowned Biofield Energy Healer, Dahryn Trivedi and was labeled as the one-time Biofield Energy Treated (BT-I) DMEM, while second part received the two-times Biofield Energy Treatment and is denoted as BT-II DMEM.
Propolis with its active component CAPE (Caffeic Acid Phenethyl Ester) stops breast cancer cell growth. These results of CAPE are present in the naturopathic formulation
of propolis, a widely available natural substance with an extended safety record, making it a naturally-occurring and readily available epigenetic agent with great potential in breast cancer and oncology in general. The ability to link the biological effects of a naturopathic remedy to the pharmacologic effects seen with an exciting class of drugs in the treatment of cancer opens the door to a host of new therapeutic opportunities for patients.
Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyeliti...degarden
This document discusses mitochondrial dysfunction and its role in the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). It presents the results of biochemical testing on neutrophils from 138 ME/CFS patients and 53 healthy controls. All patients showed measurable mitochondrial dysfunction correlated with illness severity. Patients divided into two groups based on how cellular metabolism compensates for the dysfunction. The testing provides a diagnostic tool for ME/CFS, though mitochondrial dysfunction is also seen in other illnesses.
1) Dietary supplements like glucosamine, chondroitin sulfate, vitamins, omega-3 fatty acids, and herbal extracts are commonly used to treat osteoarthritis (OA) symptoms, but their efficacy is unclear due to a lack of conclusive evidence.
2) Nutrigenomics research aims to define how genes and nutrients interact to influence health and disease, with the goal of developing personalized nutrition plans.
3) Curcumin and resveratrol show potential for treating OA by reducing inflammation and suppressing cartilage degradation, but more research is still needed, including well-designed clinical trials.
Mitochondria and MitoQ – A research updatemitoaction
Greg Macpherson presented an update on research related to mitochondria and MitoQ. Some key points include:
- MitoQ was discovered at Otago University in New Zealand and is a mitochondria-targeted antioxidant.
- Over 200,000 patient months of experience and availability in over 100 countries.
- Research has included over 50 million USD invested and 200+ published papers involving 70+ disease models.
- Clinical trials have shown benefits for conditions such as fibromyalgia, chronic fatigue syndrome, and type 2 diabetes.
- Mouse and human research has demonstrated reductions in oxidative stress, inflammation, and markers of disease from conditions such as liver fibrosis when taking MitoQ.
- Future research
Liver fi brosis is natural wound healing response to different etiologies of chronic liver insults leading to accumulation of Extra Cellular Matrix (ECM) due to imbalance between synthesis and degradation. Fibrogenesis is consequence of multicellular response; activation of Hepatic Stellate Cells (HSCs) and transdifferentiation into myofi broblasts are crucial for development of hepatic scar. Recent studies evidenced that liver fi brosis is potentially bidirectional regulated by complex cytokines, growth factors, genetic and epigenetic mechanisms (DNA methylation, histone modifi cations and miRNAs mediated gene silencing). Regression of liver fi brosis is due to increase in collagenolytic activity and increased Metalloproteinase (MMPs) activity with decreased expression and activity of Tissue Inhibitors of Metalloproteinases (TIMPs). Reversible epigenetic mechanisms, pro-fi brotic and anti-fi brotic miRNAs regulate progression and regression of liver fi brosis which initiates to discover diagnostic, prognostic and therapeutic should be comprehensively defi ned. Hence, in this review we made an attempt to understand molecular, genetic and epigenetic mechanisms of bidirectional liver fi brosis.
Liver fibrosis is natural wound healing response to different etiologies of chronic liver insults leading to accumulation of Extra Cellular Matrix (ECM) due to imbalance between synthesis and degradation. Fibrogenesis is consequence of multicellular response; activation of Hepatic Stellate Cells (HSCs) and transdifferentiation into myofibroblasts are crucial for development of hepatic scar. Recent studies evidenced that liver fibrosis is potentially bidirectional regulated by complex cytokines, growth factors, genetic and epigenetic mechanisms (DNA methylation, histone modifi cations and miRNAs mediated gene silencing).
This study investigated how insulin deficiency affects mitochondrial oxidative phosphorylation in the hearts of diabetic mice. The key findings were:
1) Activity of oxidative phosphorylation complex V (ATP synthase) was significantly reduced in the hearts of streptozotocin-induced diabetic mice.
2) Normalizing blood glucose with phlorizin treatment did not improve complex V activity, but insulin treatment did normalize it, indicating the reduction was caused by insulin deficiency rather than hyperglycemia.
3) Acute insulin stimulation induced phosphorylation and translocation of Akt to mitochondria in heart muscle. This translocation was enhanced in diabetic mice and blocked inhibition of Akt, blunting the activation of complex V by insulin.
Lactaptin, a peptide found in breast milk, has potential in cancer therapy. It induces apoptosis in cancer cells by activating caspases 3 and 7 and externalizing phosphatidylserine from the cell membrane. Lactaptin also inhibits the pro-cancer process of autophagy. Recombinant analogs of lactaptin like RL2 have been developed and shown to effectively induce apoptosis, suppress anti-apoptotic proteins, and inhibit tumor growth, demonstrating lactaptin's promise as a new molecule for anticancer drug development.
Journal of Nutritional Health and Food Engineering-02-00046Patricia Funk
This article reviews the role of glutamine, arginine, and β-hydroxy-β-methylbutyrate (HMB) supplements in enhancing athletic performance and benefiting the body during times of stress, illness, and wound healing. It finds that glutamine, arginine, and HMB may help preserve lean body mass, decrease muscle breakdown, and support immune function and wound healing. However, the evidence for their effects on athletic performance is limited and contradictory. Larger, well-designed studies are still needed to define the potential benefits of these supplements for enhancing athletic performance and lean body mass.
Grape Seed Extract : A potential Cancer suppressing agent sudharani028
Natural Polyphenol "Resveratrol" present predominantly in the grape seed plays an very important role in the treatment of devastating disorder Cancer (diseases involving abnormal and uncontrolled growth of cell with the potential to spread to other parts of the body)
- The document discusses cachexia, a wasting syndrome seen in many cancer patients, and the potential role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing or treating cancer-induced cachexia.
- It reviews the definition, etiology, complications, and current treatments for cachexia. It also discusses the roles, mechanisms, and early studies investigating omega-3 PUFAs for treating cachexia.
- The document provides background information on cachexia and omega-3 PUFAs to introduce and support the review of literature on efficacy of omega-3 PUFAs in preventing cancer-induced cachexia.
p53 Protein: Master Regulator of Apoptosis and its Application in Cancer TherapyBRNSS Publication Hub
Cancer is characterized by uncontrolled and abnormal cells growth. In the body, the cell growth and cell
division are governing by apoptosis. The process of apoptosis is mainly regulated by the p53 protein. p53
is a tumor suppressor protein. The amount of p53 in a cell is mainly controlled by the negative regulator
murine double minute 2 (MDM2), which on complex formation with p53 leads to an overall reduction
of the p53 level. Inhibition of p53 function will inhibit the apoptosis and leads to cancer. Consequently,
inhibition of the MDM2/p53 interaction using the small molecules activates the p53 function and apoptosis
in the cells which contain the wild-type p53. It is a promising new therapeutic strategy for the treatment
of cancers retaining wild-type p53. However, the safety window of this class of compounds must be
evaluated. Moreover, it has to require the development of compounds, which can also be able to target the
cells which contain the mutated or deleted p53.
p53 Protein: Master Regulator of Apoptosis and its Application in Cancer Therapy
Similar to Evaluation of Phosphodiesterase-5 Inhibitory Potential of Biofield Energy Treated DMEM by Determining cGMP Level in Human Endothelial Cell Line_ Crimson Publishers
This document discusses antibody-directed enzyme-prodrug therapy (ADEPT) for cancer treatment. ADEPT involves administering an antibody-enzyme fusion protein that localizes an enzyme to the tumor, followed by a prodrug that is non-toxic until converted to a cytotoxic drug by the localized enzyme. The document outlines the mechanism of ADEPT, various enzymes and prodrugs used, advances like improved antibody-enzyme complexes and clearance, phase I clinical trials results, and mathematical models to optimize ADEPT dosing and pharmacokinetics. It concludes that while clinical trials proved ADEPT's potential, further research is still needed to address toxicities in order to develop ADEPT as a successful
This study evaluated 122 cases of breast cancer treated with the Di Bella Method (DBM), an alternative therapy combining melatonin, retinoids, vitamins, and other supplements.
The results showed:
- For early-stage breast cancer, 4/9 cases achieved complete remission with DBM as first-line therapy alone. As adjuvant therapy, DBM achieved a 5-year survival rate of 100%, significantly higher than standard rates.
- For metastatic breast cancer, 2/4 cases achieved remission with DBM as first-line therapy. As adjuvant therapy after surgery, 3/6 cases achieved remission.
- Overall, the DBM approach improved survival rates, response rates,
Peptide Drug Conjugates (PDCs) Novel Targeted Therapeutics For Cancer.pdfDoriaFang
Peptide-drug conjugates (PDCs) are the next generation of targeted therapies after ADCs. PDCs has been developed as targeted therapeutic candidates for cancer, COVID-19, metabolic diseases, etc.
Research by Mahendra Kumar Trivedi - Evaluation of the Impact of Biofield Tre...john henrry
Research on Trivedi Effect - In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis.to read more visit http://www.academicroom.com/article/evaluation-impact-biofield-treatment-physical-and-thermal-properties-casein-enzyme-hydrolysate-and-casein-yeas-t-peptone
Research by Mahendra Kumar Trivedi - Evaluation of the Impact of Biofield Tre...Abby Keif
http://works.bepress.com/mahendra_trivedi/54/ - Research on Trivedi Effect - In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis.
Tomas Duraj - Cancer as a Mitochondrial Metabolic DiseaseDwightVillos
The document discusses cancer from the perspective of the mitochondrial metabolic theory. It proposes that cancer originates from mitochondrial dysfunction and defective respiration, rather than from genetic mutations alone. Cancer cells generate energy through substrate-level phosphorylation of glucose and glutamine without oxygen, resembling primitive prokaryotes. The document outlines a 3-level approach to cancer intervention focusing on lifestyle modifications like ketogenic diets and fasting to support mitochondrial health, supplementation, and potential drug therapies aimed at modulating cancer metabolism and inflammation.
This document summarizes recent advances in treatment approaches for genetic disorders. It discusses enzyme replacement therapy, which has proven effective for lysosomal storage disorders like Gaucher's disease and Hurler syndrome. It also reviews enzyme enhancement therapy, hematopoietic stem cell transplantation, organ transplantation, gene therapy, and hormonal therapies. The document indicates that while many treatment options now exist, high costs remain a major barrier, and there is still no cure for most genetic disorders.
Formulation and invivo evaluation of mucoadhesive microspheres embedded clero...SriramNagarajan19
In this study an attempt was made to prepare mucoadhesive microcapsules of Clerodendrum phlomidis extract using alginate polymers for prolonged release. Encapsulation of extract into sodium alginate polymer was done by ionic-gelation technique. In vivo testing of the mucoadhesive microcapsules in diabetic albino rats demonstrated significant antidiabetic effect of extract. The hypoglycemic effect obtained by mucoadhesive microcapsules was for more than 16 h whereas plain CP extract produced an antidiabetic effect for only 4 h suggesting that mucoadhesive microcapsules are a valuable system for the long term delivery of CP extract. In-vivo data obtained over a 120-h period indicate that CP extract loaded alginate microspheres from batch F7 showed the better glycemic control than control and a commercial brand of the drug.
Spices are equally healthy as wild herbs in traditional medicine and can provide green medicine, as they are easy and fast to grow, considered safe to consume globally, contain bioactive ingredients such as polyphenols, and are highly antioxidant in nature [3]. So there is huge export scope too. Ayurveda also promotes synergistic mixture of ingredients and it is proposed here for the most potent spices. Fat medium such as Ghee (clarified butter) enhances the bioavailability of polyphenols such as Curcumin, a flavanoid [4]. Castor oil is another popular Ayurveda treatment for treat MSD. So the combination of fat and spice decoction will be tested in this project.
Evaluation of the Impact of Biofield Treatment on Physical and Thermal Proper...wilhelm mendel
In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis. The FTIR results revealed that biofield treatment has caused reduction of amide group (amide-I and amide-II) stretching vibration peak that is associated with strong intermolecular hydrogen bonding in treated CEH as compared to control. However, no significant changes were observed in FTIR spectrum of treated CYP. The TGA analysis of treated CEH showed a substantial improvement in thermal stability which was confirmed by increase in maximum thermal decomposition temperature (217°C) as compared to control (209°C). Similarly, the treated CYP also showed enhanced thermal stability as compared to control. DSC showed increase in melting temperature of treated CYP as compared to control. However the melting peak was absent in DSC of treated CEH which was probably due to rigid chain of the protein. The surface area of treated CEH was increased by 83% as compared to control. However, a decrease (7.3%) in surface area was observed in treated CYP. The particle size analysis of treated CEH showed a significant increase in average particle size (d50) and d99 value (maximum particle size below which 99% of particles are present) as compared to control sample. Similarly, the treated CYP also showed a substantial increase in d50 and d99 values which was probably due to the agglomeration of the particles which led to formation of bigger microparticles. The result showed that the biofield treated CEH and CYP could be used as a matrix for pharmaceutical applications.
Evaluation of the Impact of Biofield Treatment on Physical and Thermal Proper...rachelsalk
In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis. The FTIR results revealed that biofield treatment has caused reduction of amide group (amide-I and amide-II) stretching vibration peak that is associated with strong intermolecular hydrogen bonding in treated CEH as compared to control. However, no significant changes were observed in FTIR spectrum of treated CYP. The TGA analysis of treated CEH showed a substantial improvement in thermal stability which was confirmed by increase in maximum thermal decomposition temperature (217°C) as compared to control (209°C). Similarly, the treated CYP also showed enhanced thermal stability as compared to control. DSC showed increase in melting temperature of treated CYP as compared to control. However the melting peak was absent in DSC of treated CEH which was probably due to rigid chain of the protein. The surface area of treated CEH was increased by 83% as compared to control. However, a decrease (7.3%) in surface area was observed in treated CYP. The particle size analysis of treated CEH showed a significant increase in average particle size (d50) and d99 value (maximum particle size below which 99% of particles are present) as compared to control sample. Similarly, the treated CYP also showed a substantial increase in d50 and d99 values which was probably due to the agglomeration of the particles which led to formation of bigger microparticles. The result showed that the biofield treated CEH and CYP could be used as a matrix for pharmaceutical applications.
1. The document discusses using vitamins, supplements, and herbs to support hormone health, specifically in augmenting bioidentical hormone replacement therapy (BHRT).
2. It provides examples of nutraceuticals and their roles in supporting estrogen metabolism, thyroid function, and liver detoxification which are important for hormone balance.
3. The document emphasizes that estrogen metabolism is important and outlines strategies like diet, exercise, and supporting the liver and bowel to help metabolize and clear estrogens in a healthy way.
The document discusses research on developing a nanoparticle drug delivery system for treating brain cancer. It summarizes that a compound called 3,3'-Diindolylmethane (DIM) shows anti-cancer effects but cannot cross the blood-brain barrier. The researchers encapsulated DIM in nanoparticles and modified the nanoparticle surface with a peptide that targets the somatostatin receptor SSTR2, which is expressed on brain cancer cells and blood vessels. In vivo tests in a rat brain tumor model showed the peptide-tagged DIM nanoparticles reduced tumor growth by regulating the EGFR pathway and inducing apoptosis. The nanoparticle formulation helped deliver an effective dose of DIM to the brain and showed potential for treating brain cancer.
A Comprehensive Review of Teneligliptin on its Pharmacological, Pharmaceutica...BRNSSPublicationHubI
Teneligliptin is a DPP-4 inhibitor used to treat type 2 diabetes. It works by inhibiting the DPP-4 enzyme, prolonging the effects of incretin hormones and promoting insulin secretion. Studies show it effectively lowers blood glucose levels. It is available in tablet and combination formulations, offering flexibility. Analytical methods ensure its purity, stability, and consistent dosing. Its efficacy, formulations, and analysis make it a valuable treatment for managing diabetes.
DLBS-3233 is a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa that has been shown in multiple clinical trials and studies to help manage type 2 diabetes. The following is a summary of the effects in 3 sentences:
DLBS-3233 improves glycemic control by reducing HbA1c, fasting plasma glucose, and post-prandial glucose levels. It also enhances insulin sensitivity and beta cell function. Multiple clinical studies demonstrate DLBS-3233 is safe and effective as an adjunct therapy for type 2 diabetes patients not adequately controlled by standard treatments alone.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
The document discusses a biotechnology company focused on developing products that regenerate or strengthen the human immune system. It summarizes results showing that the company's drug candidate Homspera stimulates hematopoietic stem cells, increasing white blood cell and platelet production. Studies also suggest Homspera may help resolve neutropenia caused by radiation exposure and chemotherapy by boosting white blood cell counts in irradiated animals.
Increase in Bone Mass Density and Overall Bone Health Following High-Impact o...CrimsonPublishers-SBB
Vitamin D3 and calcium are the main bone health supplements required for quality of life. The present study aimed to find out the role of Consciousness Energy Healing based vitamin D3 and DMEM medium on bone health parameters in vitro using MG-63 cells. The parameters of bone health tested are Alkaline Phosphatise Enzyme (ALP) activity, collagen levels, and bone mineralization. The Test Items (TI) i.e. vitamin D3 and DMEM medium were divided into two parts. The test samples received Consciousness Energy Healing Treatment by Krista Joanne Callas and samples were defined as the Bio-field Energy Treated (BT) samples, while the other parts of each sample were denoted as the untreated test items (UT). Cell viability using MTT assay exhibited increased cell viability range from 72% to 122% with safe and nontoxic profile among test samples on the MG-63 cell line. was significantly increased by 129.6%, 392%, and 255.7%in the UT-DMEM+BT-TI, BT-DMEM+UT-TI, and BT-DMEM+BT-TI groups, respectively at 100μg/mL as compared with the untreated group.
Similar to Evaluation of Phosphodiesterase-5 Inhibitory Potential of Biofield Energy Treated DMEM by Determining cGMP Level in Human Endothelial Cell Line_ Crimson Publishers (20)
This editorial discusses the risks of Brazilian butt lift procedures:
1) They are the deadliest aesthetic procedures, with 1 in 3000 patients dying from a fat embolism caused by injecting fat into the buttocks.
2) Most of the 33 reported deaths have been attributed to unqualified doctors performing the procedures, though underreporting is likely.
3) Other risks include sepsis, gangrene, and in rare cases lymphoma from breast implants used in butt augmentations.
4) The risks of butt augmentations outweigh the benefits, as enhancing the brain is preferable to enhancing the buttocks.
Exploring Young People’s Views on Emergency Contraceptives_ Crimson PublishersCrimsonpublishers-IGRWH
1) The document explores young people's views on emergency contraceptives through interviews with 22 undergraduate students in Ghana.
2) While all students understood regular contraceptives, only 4 could define emergency contraceptives, showing a lack of clarity on the distinction.
3) Views on emergency contraceptives varied, but many agreed they were appropriate to prevent unplanned pregnancies from rape or naivety. However, some had concerns about availability, authenticity, and religious opposition.
Bilateral Gonadblastoma and Dysgerminoma in an 18-Year-Old Female Patient wit...Crimsonpublishers-IGRWH
This case report describes a rare case of an 18-year-old female patient with 46XY, SRY gene mutation who was found to have bilateral gonadoblastoma and dysgerminoma during a planned prophylactic gonadectomy. Additional imaging found no signs of metastasis. After multidisciplinary consultation, an expectant management approach was chosen without additional surgery or chemotherapy given the controversial need for these treatments and the ability to effectively treat recurrence with chemotherapy. During 1.5 years of follow-up so far, there have been no signs of recurrence. This case contributes limited data on managing this rare type of germ cell tumor.
Rate of Different Types of Abortion in Madinah Maternity and Children Hospita...Crimsonpublishers-IGRWH
This document discusses a retrospective study conducted at Madinah Maternity and Children Hospital (MMCH) in Saudi Arabia in 2016 to determine the rates of different types of abortion. The study found that abortion accounted for 95% of early pregnancy bleeding cases at MMCH. The most common type of abortion was incomplete abortion, which was likely due to the advanced age and high parity of many of the patients. Over half of abortion patients were aged 38-45 years old and had 5 or more pregnancies. The second most common type was missed abortion. The study concludes that incomplete abortion is the most frequent type of abortion seen at MMCH, likely due to social norms contributing to older age and high parity among patients in the region.
Indications and Outcomes of Emergency Caesarean Section at St Paul’s Hospital...Crimsonpublishers-IGRWH
Indications and Outcomes of Emergency Caesarean Section at St Paul’s HospitalMedical College, Addis Ababa, Ethiopia 2017: (Afoul Month Retrospective Cohort Study) by Bizuneh Ayano in Womens Health Journal
This document summarizes research on the relationship between childhood abuse and obesity/food addiction. It finds that adverse childhood experiences like physical, emotional, or sexual abuse are associated with higher risks of obesity in adulthood, possibly due to induced stress, inflammation, and metabolic disturbances. Studies also find similarities between addictive-like eating behaviors and substance abuse disorders. The concept of "food addiction" is discussed and operationalized using the Yale Food Addiction Scale. Prevalence of food addiction varies in studies but is higher in obese individuals, particularly those with binge eating disorder. Childhood abuse is strongly linked to reports of food addiction in adulthood.
Two Useful Safe Products for Maintaining Healthy Vagina and Prevention of Inf...Crimsonpublishers-IGRWH
Two Useful Safe Products for Maintaining Healthy Vagina and Prevention of Infection with Human Papilloma Virus leading to Carcinoma of Cervix by Talwar GP in Womens Health Journal
Effect of Antenatal Pelvic Floor Muscle Exercise on Postnatal Stress Urinary ...Crimsonpublishers-IGRWH
Effect of Antenatal Pelvic Floor Muscle Exercise on Postnatal Stress Urinary Incontinence in Primigravida - An Comparative Experimental Study by Rejisha TR in Womens health Journal
Effects of KRAS Gene Mutations in Gynaecological Malignancies_ Crimson Publis...Crimsonpublishers-IGRWH
This document summarizes research on mutations in the KRAS gene that are associated with various gynecological cancers. It first provides background on KRAS, describing it as a proto-oncogene involved in cell signaling pathways. It then reviews studies finding specific KRAS mutations linked to cervical cancer (e.g. G12D), ovarian cancer (e.g. G12 mutations), endometrial cancer (10-30% of cases have KRAS mutations), and breast cancer (18% of breast cancer cell lines have KRAS mutations, often at codon 12). The document concludes that focusing on KRAS variants may help early cancer diagnosis and prognosis, and guide therapeutic approaches.
The Pregnancy Microbiome: The Link Between Maternal Periodontitis and Adverse...Crimsonpublishers-IGRWH
The Pregnancy Microbiome: The Link Between Maternal Periodontitis and Adverse Pregnancy Outcomes: Opinion by Irosha Rukmali Perera in Gynecology journal
Old Wine in a New Bottle-Focus on Candidial Vaccine_ Crimson PublishersCrimsonpublishers-IGRWH
This document discusses the development of a vaccine for Candida infections. It first provides background on vaginal anatomy and how Candida normally lives commensally but can cause infection. Risk factors for recurrent vulvovaginal candidiasis include excessive carbohydrates, hormonal therapy, douching, antibiotics, and immunosuppressants. Candida species produce various virulence factors like adhesion molecules and enzymes that contribute to pathogenesis. Current antifungal treatments can fail due to drug resistance. Researchers are working to develop a vaccine targeting Candida proteins like Sap that are involved in virulence and may help prevent recurrent infections. Phase I trials of vaccines containing Sap and Als proteins have shown promise.
The Level of Expression of Ki-67 in Invasive Cervical Cancers and Cervical I...Crimsonpublishers-IGRWH
The Level of Expression of Ki-67 in Invasive Cervical Cancers and Cervical Intraepithelial Neoplasia in Ghanaian Women by Ama Afrah in Womens Health Journal
Phyllodes Tumors: What is the Best Therapeutic Option?_ Crimson PublishersCrimsonpublishers-IGRWH
1) Phyllodes tumors of the breast are rare fibroepithelial tumors that resemble fibroadenomas. They are classified as benign, borderline, or malignant based on histological features.
2) Surgical resection is considered the best therapeutic option due to the high recurrence rate of 27% for malignant phyllodes tumors. For small (<5cm) benign tumors, tumor resection with 1-2cm margins is recommended, while mastectomy is recommended for malignant tumors or those >5cm.
3) The role of adjuvant therapies after surgery is still unclear due to limited studies with small sample sizes. Individualization of adjuvant treatment based on tumor characteristics may be considered.
Endometrioid Borderline Tumor Related to Ovarian Endometriosis_ Crimson publi...Crimsonpublishers-IGRWH
This case report describes a 26-year-old woman diagnosed with an endometrioid borderline tumor (EBT) in her left ovary that was related to ovarian endometriosis. She presented with chronic pelvic pain and was found to have a large cystic mass in her left ovary. Pathological examination after surgery confirmed the presence of both an EBT showing early stage cancerous changes without invasion, as well as typical endometriosis lesions. Immunohistochemical staining supported the diagnosis. She received postoperative hormone therapy and had no recurrence after 3 years of follow-up. This case implies an association between endometriosis and EBT and highlights the importance of accurate diagnosis and treatment to preserve fertility in
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Evaluation of Phosphodiesterase-5 Inhibitory Potential of Biofield Energy Treated DMEM by Determining cGMP Level in Human Endothelial Cell Line_ Crimson Publishers