Thermoelectric coolers operate using the Peltier effect where running a current through the device transfers heat from one side to the other, cooling one side below room temperature. While thermoelectric coolers have applications in military, medical, and scientific equipment due to their compact size, they are limited to low heat applications and have lower efficiency compared to vapor compression systems. Research is ongoing to develop more environmentally friendly refrigerants and systems to replace older halogenated refrigerants.